Protein Alignment Dis3 and sts5

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_587919.1
• Gene: sts5 / 2539180
• PomBaseID: SPCC16C4.09
• Length: 1066
• Species: Schizosaccharomyces pombe
• Alignment Length: 776
• Identity: 191/776 - (24%)
• Similarity: 319/776 - (41%)
• Gaps: 153/776 - (19%)

  Fly   222 FDSEKNGLPQ---YPPHLSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQGRES 283
            |.|..:|.|:   :.|:|....:...|.:.:|:.|....|::|..:..|:|:..:..:.|.|.:.
pombe   274 FSSGGSGNPRKNLFSPYLPQSSIPALLAERRLVTGILIVSKKNRSDAFVSVDGLDAEVFICGSKD 338

  Fly   284 LNRAVDGDLVAVELLPEAE-WSAPSEIVLEEK--------------NVYADEVPSEE------RA 327
            .|||::||:||:|||...| |:...|  .||.              |:..|.||.|.      :|
pombe   339 RNRALEGDVVAIELLDVDEVWAGKLE--KEENRRRKDPISTRGSFDNLRIDAVPFEVPQRSAIKA 401

  Fly   328 KDENEMLNQ----VRAAALSAERTP--TGRIVGIVRRKWRQY----CGILQPSLIEDTNRHI--- 379
            :|:.::..|    :....|.|:..|  .|.:|.:::|...|.    .|||:||...:..|..
pombe   402 RDDEQVEGQTLFLLDQKQLGADEKPKYAGHVVAVLQRAPGQVFSGTLGILRPSSAANKERQTSSG 466

  Fly   380 -----------------FVPADRKIPRIRIETRQAA--MLQN-----QRI-IVTIDTWPRNSRYP 419
                             |.|:|:::|.|.|.|.||.  .|.|     ||: :.:|..||..|.:|
pombe   467 NQGSSNNSGNDKPKIVWFKPSDKRVPLIAIPTEQAPTDFLGNDQAYAQRLFLASIKRWPVTSLHP 531

  Fly   420 HGHFVRSLGPLGDMATENEVILLEHDV-PHCK----------------FSDEVLS------FLPK 461
            .|..|..||.:..|:.:...:|  ||. .|.:                .||..|:      :..:
pombe   532 FGMLVGELGSMDSMSAQVSALL--HDTGVHSEPWEGSAATSAVTALNALSDNFLNVAGCADYRSE 594

  Fly   462 MPWTITDEDYSK-RVDLRDLYICSVDPPGCTD-IDDALHCKELPNGNLEVGVHIADVSHFIRPGN 524
            ..:.....|.|| .|.....:..:::....|| :..|.|.:....| ..||:|:.|||..|.||:
pombe   595 DVFLFVKNDVSKAAVSEVKQHESNINSSSATDFVSSAFHIRPTSTG-YHVGIHVTDVSRVIEPGS 658

  Fly   525 ALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKRFHKSVI 589
            .||.|...|...|.|..|.:.:.|..|...| ||....:.:..|.:.:|.:...:.......:||
pombe   659 PLDRELQRRSIAVNLCQKSVPLFPTTLGEAL-SLREDKDCYTMSLLLDVSSTGKIRGTWIGWAVI 722

  Fly   590 KSKRAMTYEEAQNIID-DATQQ--NEIAKSLRN--------LNRLAKILKKRRMDNGALVLASPE 643
            :.::|.|.:||..::. ||..:  :.::..||.        |:|..:::  ||.|..:......|
pombe   723 RPRKAYTMKEADELLQTDARLRLFHTVSSRLRTHHLGTDVPLSRYCRLV--RRWDEESCSFDPNE 785

  Fly   644 IRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDP 708
            ....:.|      .|||  :|||      .:..||..||.|:..||.|.|.||....|...|...
pombe   786 TNLFISS------AVEV--LRET------LLDAANRAVASHLRQEFRENAFLRTQRLPSRENCRI 836

  Fly   709 LVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYF--ISGSLQKEEF 771
            |...|...|..:|::|...|..||            ::|...|.|.::|..|:  ...::.:.:.
pombe   837 LQSMAIQMGCVLDLSSTKSLLRSL------------SLIEDDTVRNILQLYYYKVTPRAVYEMQK 889

  Fly   772 FHYGLAAPI-----------YTHFTSPIRRYSDIMVH---RLLAASIGADSTYAQLLDRKSNEEL 822
            :...||:.:           .||||:|:.||.||:||   :||.....|.....::..:.:|:
pombe   890 YKGNLASQMMSLGIEDESDDLTHFTAPLERYGDIVVHYQLQLLLRGELASEKRLRVWSQAAND-- 952

  Fly   823 CHNLNYRHKMAQYAGRASVALNTHLFFRGKEEDEEGYVLFVRKNALQVLIPKYGLEGTLYL 883
               .:.|..::::|...|:.:.....:...:..::|.|.||..:...|..|..|:|..::|
pombe   953 ---ASRRLVISKFAQETSIHIKIFSDWAESQVWQDGLVCFVAPSYFDVFFPSLGMEKRVHL 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211
		VacB	247..946	CDD:440323	184/748 (25%)
sts5	NP_587919.1	PHA03247	<28..260	CDD:223021
		OB_Dis3	482..557	CDD:436091	26/76 (34%)
		RNB	619..933	CDD:459934	91/343 (27%)
		Dis3l2_C_term	985..1049	CDD:465547	9/26 (35%)