DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and Helz2

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_006500664.1	Gene:	Helz2 / 229003	MGIID:	2385169	Length:	2970	Species:	Mus musculus

Alignment Length:	929	Identity:	211/929 - (22%)
Similarity:	358/929 - (38%)	Gaps:	224/929 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 VLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFY-VFVN---EHHKETYADREPDETANDRNDRAIR 148
            ||.||:...:.:..|:............||.: .|:.   |||...     |:|.:.::.::.:.
Mouse  1143 VLNTVMTRAQSQLVAVGDAVALCSSGACRNLWRSFIRECIEHHSAF-----PEELSLEQIEQGVA 1202

  Fly   149 LATKWYDDHLQASQSSKEFERSGKAATRVV----LLTDDAANRAKAEAEGILVTTAAE------- 202
            ....|....|:|.....|.:...:...|::    ::|..|..||:|.|:......|||
Mouse  1203 QRQNWASLTLKARGPETEQKSMAQGPQRLIAEGTMVTVKAETRAEAAAKAQTAAVAAEDTASGNS 1267

  Fly   203 -------YVKSLE---------------DFPL---------LMDKLSHKTFDSEKNGL------- 229
                   .|.:||               |:.|         |:|:....|....::||
Mouse  1268 ASRDAAAEVSTLEGGMSEEDSESDFWPSDWELNADDAILKELLDESQQVTVTVREDGLLDTVVCS 1332

  Fly   230 -PQYP---PHLSMKELLEGLRQN-------KLLQGTFQASRENYLEGTVNVEKFEKGILIQGRES 283
             ||..   .:|....|.:.||.|       ..||.||:.:....|:     :.....|.::||.:
Mouse  1333 APQKAREYTNLPSSVLWKFLRSNSKQFRRCSFLQETFERALATPLD-----DMASSPIQVRGRLN 1392

  Fly   284 LNRAVDGDLVAVELLPEAEWSAPSEIVLEEKNVYADE--VPSEERAKDENEMLNQVRAAALSAER 346
            ...|..||.|.|::|..|                .|:  ||...:
Mouse  1393 CGMAFTGDEVLVQILGPA----------------GDDRCVPGSLQ-------------------- 1421

  Fly   347 TPTGRIVGIVRRKWRQYCGILQPSLIEDTNRHIFVP----------ADRKIP------------- 388
               ||::|:::|:..:...:.:   :::.:..|.:|          |:.|.|
Mouse  1422 ---GRVMGVLKRRRHELAFVCR---MDEWDPRIMIPINGSVTKIFVAEMKDPQQVPIHRLIQGQV 1480

  Fly   389 -RIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVIL-LEHDV-PHCK 450
             |:|.||.:......:...|.|..|.....||.| .|..:.|......:...|| |||.: .|..
Mouse  1481 QRVRHETLKPEDRSTRLFWVRIVLWRERFYYPLG-IVLEVLPKAITWEQGLYILDLEHGLKAHTP 1544

  Fly   451 FSDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNL-EVGVHIA 514
            ....|...|.:....: :.....|.|.|.....:|||.|..::||||..::|  |.: ||.||||
Mouse  1545 DPASVSKALQRYRSEL-NTAAGHREDYRHFLTFTVDPQGACNLDDALSVRDL--GPVYEVAVHIA 1606

  Fly   515 DVSHFIRPGNALDMEAAARGTTVYLVGKR-IDMVPELLSSNLCSLVGGVERFAFSCVWEVD-NEA 577
            ||:..:....|||:||..:||..|...:. :.|:|..|..:..||:.|.:|.|.|....:: ...
Mouse  1607 DVASLVPKDGALDVEARQQGTVFYAPNREPVLMLPASLCQDALSLLPGQDRLAISLFLTMEKGGG 1671

  Fly   578 NVLSKRFHKSVIKSKRAMTYEEAQNIID-------------DATQQNEIAKSLRNLNRLAKILKK 629
            .:.|.||..|:|:|.|.::||||:.:|.             |:.:...:|...     .:.:|::
Mouse  1672 QIKSLRFAPSIIRSDRQLSYEEAEELIKRHPGAGLELPAHLDSVEACVVAACY-----FSWMLRR 1731

  Fly   630 RRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIAT--EFSEC 692
            :|:  .|.....|            |.|..|...|..:.||:|:|:..|..|||.:.:  .....
Mouse  1732 QRL--SAACYYEP------------PDEDSVLGFRTAHIMVQEYMIQFNSHVAEFLVSNKHTQTL 1782

  Fly   693 AVLRRHPRPPPTNFDPLVKSARYQGF-----------QVDI--NSGLELSHSLDKCVK--ADNPY 742
            ..||..|.|.....|.:.|  :|:|.           ..|.  |..|.|..||.|.|:  |....
Mouse  1783 TPLRWQPTPSRQQLDSVFK--KYRGLVPLSLHLCHHSNTDYTPNKQLHLLTSLWKQVQLAAGTQD 1845

  Fly   743 FNTMIRILTT---------------RCMMQAVYFISGSLQKEEFFHYGLAAPIYTHFTSPIRRYS 792
            ::.|:.::..               |.:.::|:..|...:::...|:.|....||..|||||||.
Mouse  1846 YSQMVDLIAADDMHPSLAPACLDLRRALGRSVFGRSSQGKQQPAVHHSLQVDWYTWATSPIRRYL 1910

  Fly   793 DIMVHRLLAASIG-ADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFRGKEEDE 856
            |:::.||:..::| ..|||:    .:..:.||.:.:.::..||...|.:.:|:..:..:.:.:::
Mouse  1911 DVVLQRLILLALGHRGSTYS----NRDIDGLCLDFSRQYASAQSYQRRAYSLHLAIQLKSQPQNK 1971

  Fly   857 EGYVLFVRKNA--LQVLIP 873
            .|:|:.|...|  .:||.|
Mouse  1972 LGFVVDVEMGARCFKVLFP 1990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032	27/136 (20%)
		VacB	249..945	CDD:223631	167/704 (24%)
		RNB	474..802	CDD:279157	103/375 (27%)
Helz2	XP_006500664.1	DEAD-like_helicase_N	760..990	CDD:391939
		AAA_12	961..1161	CDD:372468	5/17 (29%)
		RNB	1567..1924	CDD:214935	103/379 (27%)
		DEXXc_HELZ2-C	2448..2724	CDD:350798
		AAA_12	2704..2909	CDD:372468
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0557
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810