Protein Alignment Dis3 and Helz2

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: XP_006500664.1
• Gene: Helz2 / 229003
• MGIID: 2385169
• Length: 2970
• Species: Mus musculus
• Alignment Length: 929
• Identity: 211/929 - (22%)
• Similarity: 358/929 - (38%)
• Gaps: 224/929 - (24%)

  Fly    88 VLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFY-VFVN---EHHKETYADREPDETANDRNDRAIR 148
            ||.||:...:.:..|:............||.: .|:.   |||...     |:|.:.::.::.:.
Mouse  1143 VLNTVMTRAQSQLVAVGDAVALCSSGACRNLWRSFIRECIEHHSAF-----PEELSLEQIEQGVA 1202

  Fly   149 LATKWYDDHLQASQSSKEFERSGKAATRVV----LLTDDAANRAKAEAEGILVTTAAE------- 202
            ....|....|:|.....|.:...:...|::    ::|..|..||:|.|:......|||
Mouse  1203 QRQNWASLTLKARGPETEQKSMAQGPQRLIAEGTMVTVKAETRAEAAAKAQTAAVAAEDTASGNS 1267

  Fly   203 -------YVKSLE---------------DFPL---------LMDKLSHKTFDSEKNGL------- 229
                   .|.:||               |:.|         |:|:....|....::||
Mouse  1268 ASRDAAAEVSTLEGGMSEEDSESDFWPSDWELNADDAILKELLDESQQVTVTVREDGLLDTVVCS 1332

  Fly   230 -PQYP---PHLSMKELLEGLRQN-------KLLQGTFQASRENYLEGTVNVEKFEKGILIQGRES 283
             ||..   .:|....|.:.||.|       ..||.||:.:....|:     :.....|.::||.:
Mouse  1333 APQKAREYTNLPSSVLWKFLRSNSKQFRRCSFLQETFERALATPLD-----DMASSPIQVRGRLN 1392

  Fly   284 LNRAVDGDLVAVELLPEAEWSAPSEIVLEEKNVYADE--VPSEERAKDENEMLNQVRAAALSAER 346
            ...|..||.|.|::|..|                .|:  ||...:
Mouse  1393 CGMAFTGDEVLVQILGPA----------------GDDRCVPGSLQ-------------------- 1421

  Fly   347 TPTGRIVGIVRRKWRQYCGILQPSLIEDTNRHIFVP----------ADRKIP------------- 388
               ||::|:::|:..:...:.:   :::.:..|.:|          |:.|.|
Mouse  1422 ---GRVMGVLKRRRHELAFVCR---MDEWDPRIMIPINGSVTKIFVAEMKDPQQVPIHRLIQGQV 1480

  Fly   389 -RIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVIL-LEHDV-PHCK 450
             |:|.||.:......:...|.|..|.....||.| .|..:.|......:...|| |||.: .|..
Mouse  1481 QRVRHETLKPEDRSTRLFWVRIVLWRERFYYPLG-IVLEVLPKAITWEQGLYILDLEHGLKAHTP 1544

  Fly   451 FSDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNL-EVGVHIA 514
            ....|...|.:....: :.....|.|.|.....:|||.|..::||||..::|  |.: ||.||||
Mouse  1545 DPASVSKALQRYRSEL-NTAAGHREDYRHFLTFTVDPQGACNLDDALSVRDL--GPVYEVAVHIA 1606

  Fly   515 DVSHFIRPGNALDMEAAARGTTVYLVGKR-IDMVPELLSSNLCSLVGGVERFAFSCVWEVD-NEA 577
            ||:..:....|||:||..:||..|...:. :.|:|..|..:..||:.|.:|.|.|....:: ...
Mouse  1607 DVASLVPKDGALDVEARQQGTVFYAPNREPVLMLPASLCQDALSLLPGQDRLAISLFLTMEKGGG 1671

  Fly   578 NVLSKRFHKSVIKSKRAMTYEEAQNIID-------------DATQQNEIAKSLRNLNRLAKILKK 629
            .:.|.||..|:|:|.|.::||||:.:|.             |:.:...:|...     .:.:|::
Mouse  1672 QIKSLRFAPSIIRSDRQLSYEEAEELIKRHPGAGLELPAHLDSVEACVVAACY-----FSWMLRR 1731

  Fly   630 RRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIAT--EFSEC 692
            :|:  .|.....|            |.|..|...|..:.||:|:|:..|..|||.:.:  .....
Mouse  1732 QRL--SAACYYEP------------PDEDSVLGFRTAHIMVQEYMIQFNSHVAEFLVSNKHTQTL 1782

  Fly   693 AVLRRHPRPPPTNFDPLVKSARYQGF-----------QVDI--NSGLELSHSLDKCVK--ADNPY 742
            ..||..|.|.....|.:.|  :|:|.           ..|.  |..|.|..||.|.|:  |....
Mouse  1783 TPLRWQPTPSRQQLDSVFK--KYRGLVPLSLHLCHHSNTDYTPNKQLHLLTSLWKQVQLAAGTQD 1845

  Fly   743 FNTMIRILTT---------------RCMMQAVYFISGSLQKEEFFHYGLAAPIYTHFTSPIRRYS 792
            ::.|:.::..               |.:.::|:..|...:::...|:.|....||..|||||||.
Mouse  1846 YSQMVDLIAADDMHPSLAPACLDLRRALGRSVFGRSSQGKQQPAVHHSLQVDWYTWATSPIRRYL 1910

  Fly   793 DIMVHRLLAASIG-ADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFRGKEEDE 856
            |:::.||:..::| ..|||:    .:..:.||.:.:.::..||...|.:.:|:..:..:.:.:::
Mouse  1911 DVVLQRLILLALGHRGSTYS----NRDIDGLCLDFSRQYASAQSYQRRAYSLHLAIQLKSQPQNK 1971

  Fly   857 EGYVLFVRKNA--LQVLIP 873
            .|:|:.|...|  .:||.|
Mouse  1972 LGFVVDVEMGARCFKVLFP 1990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211	27/136 (20%)
		VacB	247..946	CDD:440323	168/713 (24%)
Helz2	XP_006500664.1	DEAD-like_helicase_N	760..990	CDD:475120
		AAA_12	961..1161	CDD:463780	5/17 (29%)
		RNB	1567..1924	CDD:214935	103/379 (27%)
		DEXXc_HELZ2-C	2448..2724	CDD:350798
		AAA_12	2704..2909	CDD:463780