Protein Alignment Dis3 and DIS3

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_055768.3
• Gene: DIS3 / 22894
• HGNCID: 20604
• Length: 958
• Species: Homo sapiens
• Alignment Length: 987
• Identity: 540/987 - (54%)
• Similarity: 698/987 - (70%)
• Gaps: 45/987 - (4%)

  Fly     5 REFTRKTKRGNILKIVREHYLRDDIGCGSELCREC-FQNEVYQLTSQHAN-KSTLFKFPHYLVLD 67
            :.|.:||:.|.::|||||||||||||||:..|..| ..:|...|..|..: .|::...||||:.|
Human     5 KTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVCPQPHYLLPD 69

  Fly    68 TNVVLDQIDVLEEDVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFYVFVNEHHKETYAD 132
            |||:|.||||||:..:|||:||.|||.||::||:.:|||..::.:::.::||.|.||||:|||.:
Human    70 TNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDVTNNQEKHFYTFTNEHHRETYVE 134

  Fly   133 REPDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDDAANRAKAEAEGILV 197
            :|..|.||||||||||:|.|||::||:...:..:.:        |:.:|:|..|:.||..|||..
Human   135 QEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQ--------VIFITNDRRNKEKAIEEGIPA 191

  Fly   198 TTAAEYVKSLEDFPLLMDKLSHKTFDSEKNGLPQ----YPPHLSMKELLEGLRQNKLLQGTFQAS 258
            .|..||||||...|.|:|:|:  ....|.|.:..    :..||.:.:|.:|::....|||||:||
Human   192 FTCEEYVKSLTANPELIDRLA--CLSEEGNEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRAS 254

  Fly   259 RENYLEGTV-----NVEKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLEEKNVYA 318
            ||||||.||     |.|  .|.|::||.:.|||||..|:|||||||:::|.|||.:||.
Human   255 RENYLEATVWIHGDNEE--NKEIILQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLH------ 311

  Fly   319 DEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIEDTNRHIFVPA 383
            ||..:||..:.|.|....::.|.......||||:|||::|.||.|||:|..|.|:::.||:|.||
Human   312 DEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPA 376

  Fly   384 DRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPH 448
            |::|||||||||||:.|:.:||||.||.||||||||:|||||:||.:|:..||.||:||||||||
Human   377 DKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPH 441

  Fly   449 CKFSDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVHI 513
            ..||..||||||||||:||::|...|.|||.|.||||||||||||||||||:||.||||||||||
Human   442 QPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHI 506

  Fly   514 ADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEAN 578
            ||||||||||||||.|:|.|||||||..|||||||||||||||||...|:|.||||:||:::.|.
Human   507 ADVSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEMNHNAE 571

  Fly   579 VLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNGALVLASPE 643
            :|..:|.||||.||.::||.|||..||.|...::|..|||.||:|||||||||::.|||.|:|||
Human   572 ILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPE 636

  Fly   644 IRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDP 708
            :||.:|||||:|::::.|::||||||||||||||||:||:.|..||||.|:||:||.|||:|::.
Human   637 VRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEI 701

  Fly   709 LVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFH 773
            |||:||.:..::..::...|:.|||:......||.||::|||.||||||||||.||  ...:|.|
Human   702 LVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSG--MDNDFHH 764

  Fly   774 YGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGR 838
            ||||:|||||||||||||:|::||||||.:||||.||.:|.|:....::|.|||:||||||||.|
Human   765 YGLASPIYTHFTSPIRRYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQR 829

  Fly   839 ASVALNTHLFFRGKE-EDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERVKSEIVF 902
            ||||.:|.|||:.|. ..||.|:|||||||:.|||||||||||::.:         |:.|.....
Human   830 ASVAFHTQLFFKSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFE---------EKDKPNPQL 885

  Fly   903 TFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKPYIKGFSVETTTEGTDSQAVS 967
            .:::|..:.:..|.|||.||.|.|::.|||||:||:|:...||:|.|.|.|:.|.|...|..
Human   886 IYDDEIPSLKIEDTVFHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLN--- 947

  Fly   968 AAPPSKKTKKDK 979
             .|..||.|..|
Human   948 -GPKKKKMKLGK 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211	92/195 (47%)
		VacB	247..946	CDD:440323	418/704 (59%)
DIS3	NP_055768.3	PIN_Rrp44-like	9..197	CDD:350211	92/195 (47%)
		VacB	206..929	CDD:440323	427/743 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	938..958		7/23 (30%)