Protein Alignment Dis3 and Dis3l

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_001001295.2
• Gene: Dis3l / 213550
• MGIID: 2143272
• Length: 1053
• Species: Mus musculus
• Alignment Length: 1028
• Identity: 343/1028 - (33%)
• Similarity: 536/1028 - (52%)
• Gaps: 149/1028 - (14%)

  Fly    10 KTKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHANKSTLFKFPHYLVLDTNVVLDQ 74
            :|.:|..|:||||||||..:.|.|.||.:       ....::..|....:..||::.|..||.|.
Mouse    12 RTFQGRTLRIVREHYLRPSVPCNSPLCPQ-------PAACRNDGKLLAAEVTHYVIPDWKVVQDY 69

  Fly    75 IDVLEEDVLRNVVVLTTVLNEVKH-RSSAIYKRFNEIVHDRTRNFYVFVNEHHKETYADREPDET 138
            ::|||...|:.|:.:.|....|:| |....|.:...::.|...:..:|.||..:..|..||..|.
Mouse    70 LEVLEFPELKGVIFMQTACQAVQHQRGRRQYNKLRNLLKDARHDCVLFANEFQQHCYLPREKGEA 134

  Fly   139 ANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDD--AANRAKAEAEGILVTTAA 201
            ......|:|..:..||..|.:....             :|::|:|  |..:..:|.||:.|.:..
Mouse   135 MEKWQTRSIYNSAVWYYHHCEDRMP-------------IVMVTEDEEAIQKYGSETEGVFVISFK 186

  Fly   202 EY-------VKSLEDF--PLLMDKLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQA 257
            .|       :|:..|.  .:|..:...:|...|.:| .:||.||.::.|..|::..:.:||....
Mouse   187 NYLDNFWPDLKAAHDLCDSILQSRRERETESQETHG-KEYPEHLPLEVLEAGIKSGRYIQGILNV 250

  Fly   258 SRENYLEGTVNVEKFEK-------------GILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEI 309
            ::..     ..:|.|.:             .|||.|.::.||::.||:|.||:||::||..
Mouse   251 NKHR-----AQIEAFVRLHGASSKDSGLVSDILIHGSKARNRSIHGDVVVVEMLPKSEWKG---- 306

  Fly   310 VLEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIE- 373
                :.....|..|:::|..|:           .:|..||||:|||:::.||.|. :..||..|
Mouse   307 ----RTAALGENDSDDKASGES-----------PSEPMPTGRVVGILQKNWRDYV-VTFPSKEEV 355

  Fly   374 -----DTNRHIFVPADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDM 433
                 :..:.:..|.|.:||:|||.|:||..||:.|::|.||:|...|.||:|||||.||.:||:
Mouse   356 QSQGKNAQKILVTPWDYRIPKIRISTQQAEALQDFRVVVRIDSWEATSVYPNGHFVRVLGRIGDL 420

  Fly   434 ATENEVILLEHDVPHCKFSD----EVLSFLPKMPWTITDEDYSKRVDLRDLY-ICSVDPPGCTDI 493
            ..|...||:|:.:....||:    |:....|:.||.::.::..:|.|||..: :.|:||.||.|:
Mouse   421 EGEIATILVENSISVVPFSEAQMCEMPVNTPENPWKVSPKEEQERKDLRTTHLVFSIDPKGCEDV 485

  Fly   494 DDALHCKELPNGNLEVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSL 558
            ||.|..:.|.|||||:|||||||:||:.|.:.:|:||..|.||.||..:|.||:|.:||::||||
Mouse   486 DDTLSVRTLNNGNLELGVHIADVTHFVAPNSYIDVEARTRATTYYLADRRYDMLPSILSADLCSL 550

  Fly   559 VGGVERFAFSCVWEVDNEANVLSKRFH-KSVIKSKRAMTYEEAQ-------NIIDD--------- 606
            :|||:|:|.|.:||:|..:..:.|.:: :::|:|...:.||.||       :|:||
Mouse   551 LGGVDRYAVSVMWELDKTSYEIKKVWYGRTIIRSAYKLFYEAAQELLDGNFSIVDDIPELKALDK 615

  Fly   607 ATQQ---NEIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRFQVDSETH-------EPLEVEVK 661
            .:||   .|:..::..|..:|:.::.:|...|||.|...|:|.|:|.:.:       :||||
Mouse   616 QSQQAKLEELVWAIGKLTDIARHIRAKRDRCGALELEGVEVRVQLDDKKNIRDLIPKQPLEV--- 677

  Fly   662 QMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGL 726
              .||   |.|.|:|||..||:.|...|...|:||:||.|....|..|.:.|:.:||.:|..|..
Mouse   678 --HET---VAECMILANHWVAKKIWESFPHQALLRQHPPPHQEFFSELRECAKAKGFFIDTRSNK 737

  Fly   727 ELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFHYGLAAPIYTHFTSPIRRY 791
            .|:.|||......:|..|.::|.:.|:.|..|:||.:||..:|||.|||||...|||||||||||
Mouse   738 TLADSLDSANDPKDPLVNKLLRSMATQAMSNALYFSTGSCAEEEFHHYGLALDKYTHFTSPIRRY 802

  Fly   792 SDIMVHRLLAASIGADSTY---AQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFRGKE 853
            |||:|||||.|:|..|...   ..|...|:.||||.::|.|::.||.:.:.|..|...::|:.::
Mouse   803 SDIVVHRLLMAAISKDKKMEIKENLFSNKNLEELCRHINNRNRAAQRSQKQSTELFQCMYFKDRD 867

  Fly   854 EDEE------GYVLFVRKNALQVLIPKYGLEGTLYLKSDKD------GKDG--------VERVKS 898
            .:.|      |.:..:|.|.:.|.||::|::|..||| :||      |.:|        ::|.::
Mouse   868 AETEERCIADGVIYSIRTNGVLVFIPRFGIKGAAYLK-NKDSLVISCGPEGSSEWKPGSLQRSQN 931

  Fly   899 EIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLV--KPYI 949
            :|:.|      |.....|.||.||.||||:|:.:|....:.:...:|  |||:
Mouse   932 KIIST------TAGGQSVTFHLFDHVTVRISVQASRCHSDTIRLEIVSNKPYM 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211	53/195 (27%)
		VacB	247..946	CDD:440323	274/774 (35%)
Dis3l	NP_001001295.2	PIN_Rrp44-like	11..188	CDD:350211	53/195 (27%)
		VacB	238..899	CDD:440323	250/693 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..332		6/44 (14%)
		Rrp44_S1	875..958	CDD:435792	29/89 (33%)