DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and Dis3l

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001001295.2	Gene:	Dis3l / 213550	MGIID:	2143272	Length:	1053	Species:	Mus musculus

Alignment Length:	1028	Identity:	343/1028 - (33%)
Similarity:	536/1028 - (52%)	Gaps:	149/1028 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KTKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHANKSTLFKFPHYLVLDTNVVLDQ 74
            :|.:|..|:||||||||..:.|.|.||.:       ....::..|....:..||::.|..||.|.
Mouse    12 RTFQGRTLRIVREHYLRPSVPCNSPLCPQ-------PAACRNDGKLLAAEVTHYVIPDWKVVQDY 69

  Fly    75 IDVLEEDVLRNVVVLTTVLNEVKH-RSSAIYKRFNEIVHDRTRNFYVFVNEHHKETYADREPDET 138
            ::|||...|:.|:.:.|....|:| |....|.:...::.|...:..:|.||..:..|..||..|.
Mouse    70 LEVLEFPELKGVIFMQTACQAVQHQRGRRQYNKLRNLLKDARHDCVLFANEFQQHCYLPREKGEA 134

  Fly   139 ANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDD--AANRAKAEAEGILVTTAA 201
            ......|:|..:..||..|.:....             :|::|:|  |..:..:|.||:.|.:..
Mouse   135 MEKWQTRSIYNSAVWYYHHCEDRMP-------------IVMVTEDEEAIQKYGSETEGVFVISFK 186

  Fly   202 EY-------VKSLEDF--PLLMDKLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQA 257
            .|       :|:..|.  .:|..:...:|...|.:| .:||.||.::.|..|::..:.:||....
Mouse   187 NYLDNFWPDLKAAHDLCDSILQSRRERETESQETHG-KEYPEHLPLEVLEAGIKSGRYIQGILNV 250

  Fly   258 SRENYLEGTVNVEKFEK-------------GILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEI 309
            ::..     ..:|.|.:             .|||.|.::.||::.||:|.||:||::||..
Mouse   251 NKHR-----AQIEAFVRLHGASSKDSGLVSDILIHGSKARNRSIHGDVVVVEMLPKSEWKG---- 306

  Fly   310 VLEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIE- 373
                :.....|..|:::|..|:           .:|..||||:|||:::.||.|. :..||..|
Mouse   307 ----RTAALGENDSDDKASGES-----------PSEPMPTGRVVGILQKNWRDYV-VTFPSKEEV 355

  Fly   374 -----DTNRHIFVPADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDM 433
                 :..:.:..|.|.:||:|||.|:||..||:.|::|.||:|...|.||:|||||.||.:||:
Mouse   356 QSQGKNAQKILVTPWDYRIPKIRISTQQAEALQDFRVVVRIDSWEATSVYPNGHFVRVLGRIGDL 420

  Fly   434 ATENEVILLEHDVPHCKFSD----EVLSFLPKMPWTITDEDYSKRVDLRDLY-ICSVDPPGCTDI 493
            ..|...||:|:.:....||:    |:....|:.||.::.::..:|.|||..: :.|:||.||.|:
Mouse   421 EGEIATILVENSISVVPFSEAQMCEMPVNTPENPWKVSPKEEQERKDLRTTHLVFSIDPKGCEDV 485

  Fly   494 DDALHCKELPNGNLEVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSL 558
            ||.|..:.|.|||||:|||||||:||:.|.:.:|:||..|.||.||..:|.||:|.:||::||||
Mouse   486 DDTLSVRTLNNGNLELGVHIADVTHFVAPNSYIDVEARTRATTYYLADRRYDMLPSILSADLCSL 550

  Fly   559 VGGVERFAFSCVWEVDNEANVLSKRFH-KSVIKSKRAMTYEEAQ-------NIIDD--------- 606
            :|||:|:|.|.:||:|..:..:.|.:: :::|:|...:.||.||       :|:||
Mouse   551 LGGVDRYAVSVMWELDKTSYEIKKVWYGRTIIRSAYKLFYEAAQELLDGNFSIVDDIPELKALDK 615

  Fly   607 ATQQ---NEIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRFQVDSETH-------EPLEVEVK 661
            .:||   .|:..::..|..:|:.::.:|...|||.|...|:|.|:|.:.:       :||||
Mouse   616 QSQQAKLEELVWAIGKLTDIARHIRAKRDRCGALELEGVEVRVQLDDKKNIRDLIPKQPLEV--- 677

  Fly   662 QMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGL 726
              .||   |.|.|:|||..||:.|...|...|:||:||.|....|..|.:.|:.:||.:|..|..
Mouse   678 --HET---VAECMILANHWVAKKIWESFPHQALLRQHPPPHQEFFSELRECAKAKGFFIDTRSNK 737

  Fly   727 ELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFHYGLAAPIYTHFTSPIRRY 791
            .|:.|||......:|..|.::|.:.|:.|..|:||.:||..:|||.|||||...|||||||||||
Mouse   738 TLADSLDSANDPKDPLVNKLLRSMATQAMSNALYFSTGSCAEEEFHHYGLALDKYTHFTSPIRRY 802

  Fly   792 SDIMVHRLLAASIGADSTY---AQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFRGKE 853
            |||:|||||.|:|..|...   ..|...|:.||||.::|.|::.||.:.:.|..|...::|:.::
Mouse   803 SDIVVHRLLMAAISKDKKMEIKENLFSNKNLEELCRHINNRNRAAQRSQKQSTELFQCMYFKDRD 867

  Fly   854 EDEE------GYVLFVRKNALQVLIPKYGLEGTLYLKSDKD------GKDG--------VERVKS 898
            .:.|      |.:..:|.|.:.|.||::|::|..||| :||      |.:|        ::|.::
Mouse   868 AETEERCIADGVIYSIRTNGVLVFIPRFGIKGAAYLK-NKDSLVISCGPEGSSEWKPGSLQRSQN 931

  Fly   899 EIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLV--KPYI 949
            :|:.|      |.....|.||.||.||||:|:.:|....:.:...:|  |||:
Mouse   932 KIIST------TAGGQSVTFHLFDHVTVRISVQASRCHSDTIRLEIVSNKPYM 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032	53/195 (27%)
		VacB	249..945	CDD:223631	273/769 (36%)
		RNB	474..802	CDD:279157	150/355 (42%)
Dis3l	NP_001001295.2	PIN_SF	12..188	CDD:301351	53/195 (27%)
		VacB	265..899	CDD:223631	246/661 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..332		6/44 (14%)
		RNB	465..815	CDD:279157	151/357 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0557
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104619at2759
OrthoFinder	1	1.000	-	-		FOG0000674
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1261
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820