DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and Dis3l2

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001165628.1	Gene:	Dis3l2 / 208718	MGIID:	2442555	Length:	884	Species:	Mus musculus

Alignment Length:	858	Identity:	263/858 - (30%)
Similarity:	422/858 - (49%)	Gaps:	152/858 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 KLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQG 280
            |..:|:...:|..:  :..::|.:::.|||::..|:||..:.:.:.:.|..:.....::.|.|.|
Mouse    36 KSKNKSMRGKKKSI--FETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDG 98

  Fly   281 RESLNRAVDGDLVAVELLPEAEW------SAPSEIVLE----EKN------VYADEVP------- 322
            ..:.|||::||||.|:||||.:|      |.|..:.|:    |.|      .|..::|
Mouse    99 VVARNRALNGDLVVVKLLPEDQWKPRITLSLPGVLGLQAVKPESNDKEIEATYEADIPEEGCGHH 163

  Fly   323 ------------------------SEERAKDENEMLNQVRAAALSA---------------ERTP 348
                                    ||:|..:.:.:::.|:..::|.               |.||
Mouse   164 PLQQSRKGWSGPDVIIEAQFDDSDSEDRHGNTSGLVDGVKKLSISTPDRGKEDSSTPVMKDENTP 228

  Fly   349 ---------------TGRIVGIVRRKW-RQYCGILQPSLIEDTNRH------IFVPADRKIPRIR 391
                           :.::|.|:.:|. |...|||:  |:.|.|..      :|.|:|.::|||.
Mouse   229 IPQDTRGLSEKSLQKSAKVVYILEKKHSRAATGILK--LLADKNSDLFKKYALFSPSDHRVPRIY 291

  Fly   392 IETRQAAM--------LQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPH 448
            :..:....        ..|...|..|..|..:..:..|...:|||..|::..|.|.||.|:.|..
Mouse   292 VPLKDCPQDFMTRPKDFANTLFICRIIDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDF 356

  Fly   449 CKFSDEVLSFLPK-MPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVH 512
            ..||.|||..||: :||||..::..||.|||...|.::||....|:||||.|:.|.:|..|||||
Mouse   357 SDFSSEVLECLPQSLPWTIPPDEVGKRRDLRKDCIFTIDPSTARDLDDALACRRLTDGTFEVGVH 421

  Fly   513 IADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEA 577
            |||||:|:..|::||..||.|.|:||||.|.:.|:|.||...||||....::..||.:|::..|.
Mouse   422 IADVSYFVPEGSSLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMTDKLTFSVIWKLTPEG 486

  Fly   578 NVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQ---------------NEIAKSLRNLNRLAKIL 627
            .:|.:.|.:::|:|...::|:.||::|::.|::               .|:.:::.||:.:||.|
Mouse   487 KILEEWFGRTIIRSCTKLSYDHAQSMIENPTEKIPEEELPPISPEHSVEEVHQAVLNLHSIAKQL 551

  Fly   628 KKRRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSEC 692
            :::|..:|||.|...::.|.:|.||..|....:.:.|::|.:|||||||||:.||..|...|.|.
Mouse   552 RRQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRDSNKLVEEFMLLANMAVAHKIFRTFPEQ 616

  Fly   693 AVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILT---TRC 754
            |:|||||.|.......||:.....|..:|::|...|:.||.|.. .|:.|......:||   :|.
Mouse   617 ALLRRHPPPQTKMLSDLVEFCDQMGLPMDVSSAGALNKSLTKTF-GDDKYSLARKEVLTNMYSRP 680

  Fly   755 MMQAVYFISGSLQ-KEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLD--- 815
            |..|:||.||.|| :|:|.||.|..|:||||||||||::|::|||||||::|    |::..|
Mouse   681 MQMALYFCSGMLQDQEQFRHYALNVPLYTHFTSPIRRFADVIVHRLLAAALG----YSEQPDVEP 741

  Fly   816 --RKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFR--GKEE---DEEGYVLFVRKNALQVLIP 873
              .:...:.|::.....|..|       .|:..|||.  .||.   :.|..|:.|...|..||:.
Mouse   742 DTLQKQADHCNDRRMASKRVQ-------ELSIGLFFAVLVKESGPLESEAMVMGVLNQAFDVLVL 799

  Fly   874 KYGLEGTLY-----LKS---DKDGKDGVERVKSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSL 930
            ::|::..:|     |:|   .|.||      |.|:...:..:|..:.....|...|..|.|.|..
Mouse   800 RFGVQKRIYCNALALRSYSFQKVGK------KPELTLVWEPDDLEEEPTQQVITIFSLVDVVLQA 858

  Fly   931 DSSNVQHEKLIFR 943
            :::.:::..::.|
Mouse   859 EATALKYSAILKR 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032
		VacB	249..945	CDD:223631	256/825 (31%)
		RNB	474..802	CDD:279157	142/346 (41%)
Dis3l2	NP_001165628.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		2/8 (25%)
		Rrp44_CSD1	50..250	CDD:375054	40/199 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..237		8/53 (15%)
		VacB	228..824	CDD:223631	211/609 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0557
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000674
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810