Protein Alignment Dis3 and Dis3l2

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_001165628.1
• Gene: Dis3l2 / 208718
• MGIID: 2442555
• Length: 884
• Species: Mus musculus
• Alignment Length: 858
• Identity: 263/858 - (30%)
• Similarity: 422/858 - (49%)
• Gaps: 152/858 - (17%)

  Fly   216 KLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQG 280
            |..:|:...:|..:  :..::|.:::.|||::..|:||..:.:.:.:.|..:.....::.|.|.|
Mouse    36 KSKNKSMRGKKKSI--FETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDG 98

  Fly   281 RESLNRAVDGDLVAVELLPEAEW------SAPSEIVLE----EKN------VYADEVP------- 322
            ..:.|||::||||.|:||||.:|      |.|..:.|:    |.|      .|..::|
Mouse    99 VVARNRALNGDLVVVKLLPEDQWKPRITLSLPGVLGLQAVKPESNDKEIEATYEADIPEEGCGHH 163

  Fly   323 ------------------------SEERAKDENEMLNQVRAAALSA---------------ERTP 348
                                    ||:|..:.:.:::.|:..::|.               |.||
Mouse   164 PLQQSRKGWSGPDVIIEAQFDDSDSEDRHGNTSGLVDGVKKLSISTPDRGKEDSSTPVMKDENTP 228

  Fly   349 ---------------TGRIVGIVRRKW-RQYCGILQPSLIEDTNRH------IFVPADRKIPRIR 391
                           :.::|.|:.:|. |...|||:  |:.|.|..      :|.|:|.::|||.
Mouse   229 IPQDTRGLSEKSLQKSAKVVYILEKKHSRAATGILK--LLADKNSDLFKKYALFSPSDHRVPRIY 291

  Fly   392 IETRQAAM--------LQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPH 448
            :..:....        ..|...|..|..|..:..:..|...:|||..|::..|.|.||.|:.|..
Mouse   292 VPLKDCPQDFMTRPKDFANTLFICRIIDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDF 356

  Fly   449 CKFSDEVLSFLPK-MPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVH 512
            ..||.|||..||: :||||..::..||.|||...|.::||....|:||||.|:.|.:|..|||||
Mouse   357 SDFSSEVLECLPQSLPWTIPPDEVGKRRDLRKDCIFTIDPSTARDLDDALACRRLTDGTFEVGVH 421

  Fly   513 IADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEA 577
            |||||:|:..|::||..||.|.|:||||.|.:.|:|.||...||||....::..||.:|::..|.
Mouse   422 IADVSYFVPEGSSLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMTDKLTFSVIWKLTPEG 486

  Fly   578 NVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQ---------------NEIAKSLRNLNRLAKIL 627
            .:|.:.|.:::|:|...::|:.||::|::.|::               .|:.:::.||:.:||.|
Mouse   487 KILEEWFGRTIIRSCTKLSYDHAQSMIENPTEKIPEEELPPISPEHSVEEVHQAVLNLHSIAKQL 551

  Fly   628 KKRRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSEC 692
            :::|..:|||.|...::.|.:|.||..|....:.:.|::|.:|||||||||:.||..|...|.|.
Mouse   552 RRQRFVDGALRLDQLKLAFTLDHETGLPQGCHIYEYRDSNKLVEEFMLLANMAVAHKIFRTFPEQ 616

  Fly   693 AVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILT---TRC 754
            |:|||||.|.......||:.....|..:|::|...|:.||.|.. .|:.|......:||   :|.
Mouse   617 ALLRRHPPPQTKMLSDLVEFCDQMGLPMDVSSAGALNKSLTKTF-GDDKYSLARKEVLTNMYSRP 680

  Fly   755 MMQAVYFISGSLQ-KEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLD--- 815
            |..|:||.||.|| :|:|.||.|..|:||||||||||::|::|||||||::|    |::..|
Mouse   681 MQMALYFCSGMLQDQEQFRHYALNVPLYTHFTSPIRRFADVIVHRLLAAALG----YSEQPDVEP 741

  Fly   816 --RKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFR--GKEE---DEEGYVLFVRKNALQVLIP 873
              .:...:.|::.....|..|       .|:..|||.  .||.   :.|..|:.|...|..||:.
Mouse   742 DTLQKQADHCNDRRMASKRVQ-------ELSIGLFFAVLVKESGPLESEAMVMGVLNQAFDVLVL 799

  Fly   874 KYGLEGTLY-----LKS---DKDGKDGVERVKSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSL 930
            ::|::..:|     |:|   .|.||      |.|:...:..:|..:.....|...|..|.|.|..
Mouse   800 RFGVQKRIYCNALALRSYSFQKVGK------KPELTLVWEPDDLEEEPTQQVITIFSLVDVVLQA 858

  Fly   931 DSSNVQHEKLIFR 943
            :::.:::..::.|
Mouse   859 EATALKYSAILKR 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211
		VacB	247..946	CDD:440323	256/827 (31%)
Dis3l2	NP_001165628.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		2/8 (25%)
		Rrp44_CSD1	50..250	CDD:375054	40/199 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..237		8/53 (15%)
		VacB	228..757	CDD:440323	192/535 (36%)
		Dis3l2_C_term	778..867	CDD:465547	21/94 (22%)