Protein Alignment Dis3 and dis-3

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_501835.2
• Gene: dis-3 / 177875
• WormBaseID: WBGene00001001
• Length: 961
• Species: Caenorhabditis elegans
• Alignment Length: 978
• Identity: 432/978 - (44%)
• Similarity: 623/978 - (63%)
• Gaps: 67/978 - (6%)

  Fly    10 KTKRGNILKIVREHYLRDDIGCGSELCRECFQ---NEVYQLTSQHANKSTLFKFPHYLVLDTNVV 71
            :.:.|.:.|...|.|||:|:.||...|..|..   |.:.::.:...|...   ..|.|::|:..:
 Worm    21 QNRSGKVYKRAEERYLRNDLSCGLAQCGTCKDFGTNPLLKIENPVRNAKV---GRHALIVDSTSL 82

  Fly    72 LDQIDVLEEDVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRTRN-FYVFVNEHHKETYADREP 135
            :...|:.:..:||:::|..||...||.::...||:.|.:.::..:: |:||:||.|.||:::...
 Worm    83 IRFYDLFDSSLLRDLIVTQTVWEGVKAKAVPAYKKMNSLCYEDAKDRFHVFMNEFHCETFSESSK 147

  Fly   136 DETANDRND----RAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDDAANRAKAEAEGIL 196
            .|..:...:    .|:.|.|.|               :....|..|::..:|:..|.:...:.::
 Worm   148 FEDLSRGEELLLSTALYLKTHW---------------QKHNVAPVVLVFDEDSKKRMENHYQHVM 197

  Fly   197 VTTAAEYVKSLEDFP---LLMDKLSHKTFDSEKNGLPQ--YPPHLSMKELLEGLRQNKLLQGTFQ 256
            .  ..||:::||| |   .|:|:::  .::|..||..:  :..:||...::||:....:.:|.|.
 Worm   198 Y--LKEYIQNLED-PGKQALLDQMA--AYESSGNGNEKQIFDEYLSHDRIMEGIASGTIKRGNFS 257

  Fly   257 ASRENYLEGTVNVEKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIV----LEEKNVY 317
            .|||||.|.||.::.......|.| .:.||||:||.|||:||||.:|:||.:.:    :||....
 Worm   258 VSRENYREATVIIDDQLTSWFITG-NNCNRAVNGDTVAVQLLPEDQWTAPEKKIRLRDVEEYVKT 321

  Fly   318 ADEVPSEERAKDENEMLNQVRAAALSAERT-PTGRIVGIVRRKWRQYCGILQPSLIEDTNRHIFV 381
            ||::.:|:   :||:..|....|..|.:.| .|.::|||::|.||:|||:|.||.::...||:|.
 Worm   322 ADDMGNED---EENDDENDEPKAKKSKKMTVSTAKVVGIIKRNWREYCGMLLPSTVKGARRHLFC 383

  Fly   382 PADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDV 446
            ||:|.||||||||.||..|..|||:|.||.|||:|:||.||:|||:|.:|...|||||:|||||:
 Worm   384 PAERLIPRIRIETEQAETLSQQRIVVAIDHWPRDSKYPLGHYVRSIGEMGSRETENEVLLLEHDI 448

  Fly   447 PHCKFSDEVLSFLPKMPWTITDEDYSK------RVDLRDLYICSVDPPGCTDIDDALHCKELPNG 505
            ||..||:.||..||:..|   :.|.::      |||||||.||||||.||||||||||||::...
 Worm   449 PHAPFSESVLDCLPREEW---EPDLTENRGPLPRVDLRDLTICSVDPLGCTDIDDALHCKQIGED 510

  Fly   506 NLEVGVHIADVSHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCV 570
            ..|||||||||:||:|||.|:|.|||.|||||||..:||||:|.|||||||||.|..||:||||:
 Worm   511 LFEVGVHIADVTHFVRPGTAIDDEAALRGTTVYLCDRRIDMLPCLLSSNLCSLRGEEERYAFSCI 575

  Fly   571 WEVDNEANVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNG 635
            |.:.:.|::.|.::|||:||||.|:|||:||.||||..:||::|..||.|.:|:|:|..||..||
 Worm   576 WTMTSSADIQSVKYHKSLIKSKAALTYEKAQEIIDDPKEQNDVALGLRGLMKLSKVLNARRTGNG 640

  Fly   636 ALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPR 700
            ||.|||.|:||.:|.|:..|.:|..||..:|:||||||||||||:|||.|..|:.:||:|||||.
 Worm   641 ALTLASSEVRFDMDWESRTPKKVMEKQHLDTHSMVEEFMLLANISVAEKILEEYPDCALLRRHPV 705

  Fly   701 PPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGS 765
            |...::.|||::||::||::.:.||..|:.||::||...||..|.::|:||||||.|||||.:|:
 Worm   706 PLKESYKPLVEAARHRGFEIIVESGKGLADSLNRCVDKKNPMLNRLLRMLTTRCMTQAVYFSAGT 770

  Fly   766 LQKEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRH 830
            :...::.|:|||..||||||||||||:|::|||||||:||||...:.||::....::|.|:||||
 Worm   771 VPVPQYQHFGLACAIYTHFTSPIRRYADVIVHRLLAAAIGADDIQSGLLNQARCTKICTNINYRH 835

  Fly   831 KMAQYAGRASVALNTHLFFRGKEEDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVER 895
            |.|||||||||.||...:|:||.|..||:|:.||.|.:||.:||||||..:.|::.......::
 Worm   836 KQAQYAGRASVQLNVVRYFKGKVETCEGFVMGVRNNGIQVFVPKYGLESIIVLQTSAASGTTID- 899

  Fly   896 VKSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKPYIKGFSVE---TT 957
                     .||...:..||||....:|||||:|::..|.|..::..:|:||.|.|.||:   ::
 Worm   900 ---------VEEMSVKVNGDVVIKELEPVTVRISVNEKNQQRPRVELQLIKPAIPGLSVDFDLSS 955

  Fly   958 TEG 960
            :||
 Worm   956 SEG 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211	44/200 (22%)
		VacB	247..946	CDD:440323	365/709 (51%)
dis-3	NP_501835.2	PIN_Rrp44-like	20..202	CDD:350211	44/200 (22%)
		Rrp44_CSD1	233..361	CDD:375054	47/131 (36%)
		OB_Dis3	381..447	CDD:436091	42/65 (65%)
		RNB	479..809	CDD:459934	199/329 (60%)
		Rrp44_S1	862..937	CDD:435792	29/84 (35%)