DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and disl-2

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_498160.2	Gene:	disl-2 / 175748	WormBaseID:	WBGene00018612	Length:	848	Species:	Caenorhabditis elegans

Alignment Length:	869	Identity:	258/869 - (29%)
Similarity:	408/869 - (46%)	Gaps:	153/869 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 TTAAEYVKSLEDFPLLMDKLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQASRENY 262
            |.|..|||     |...:.|.: .|:..|    .:..::|.:|...|:....:.:|..:.:.:||
Worm    41 TKAKPYVK-----PQNANNLQN-NFNPRK----IFTEYISKEETDAGIEDGSMFKGVLRINPKNY 95

  Fly   263 LE-------GTVNVEKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLEEKNVYADE 320
            .|       ||.:.:     :|:.|::. |||:.||:|||::.|:.:|...          |.:.
Worm    96 QECFLDHPKGTNHPD-----VLVLGQDR-NRAMQGDVVAVKIKPKEDWLVN----------YVEY 144

  Fly   321 VP--SEERAKDENE---------------MLNQVRAAALSAERTP------TGRIVGIVRRK-WR 361
            |.  :|.:..|.|.               :.|:::...::::..|      .|.||.|:.:| :|
Worm   145 VKWWAEHKKGDRNSGKTDNNSPNKTEKRCLRNEIQDNGVTSDEVPDSCLITIGAIVHILEKKHFR 209

  Fly   362 QYCGILQPSLIEDTNRHIFVPADRKIPRIRIETRQ------AAMLQNQRIIVT--IDTWPRNSRY 418
            ...|.||..........:||..|.::|||.|....      :.....:|.:.|  |..|...|.|
Worm   210 VAAGKLQLMPNSANPNVLFVATDSRVPRILIPKSDVDKEFFSRPKDFERFLYTAKITDWRAESVY 274

  Fly   419 PHGHFVRSLGPLGDMATENEVILLEHDVPHCKFSDEVLSFLP---KMPWTITDEDYSKRVDLRDL 480
            ..|..|:.||..|::.||.|.|:.||.:.|.:||||.|..||   ...|.:.|.::..|.|.|..
Worm   275 ADGRLVKLLGMSGEIDTETERIVYEHQIDHREFSDECLESLPITTAENWKVPDAEFEYRRDFRSD 339

  Fly   481 YICSVDPPGCTDIDDALHCKELPN------GNLEVGVHIADVSHFIRPGNALDMEAAARGTTVYL 539
            .:.::||....|:|||||.|.:.:      ..||:|||||||:.|::.|..||..|:.||.:.||
Worm   340 IVFTIDPKTARDLDDALHAKHIDDCDGKGTPGLEIGVHIADVTFFLKEGTELDKWASERGNSTYL 404

  Fly   540 VGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKRFHKSVIKSKRAMTYEEAQNII 604
            ....|.|:|.:|...||||..||:|.:||.|:::..||.:....|.:|||:|:..:.||.||:.|
Worm   405 SQTVIPMLPRILCEQLCSLNPGVDRLSFSTVFKMSYEAELYDVWFGRSVIRSRVKLAYEHAQDFI 469

  Fly   605 D---------------DATQQNEIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRFQVDSETHE 654
            :               |.....||.:....|:|:|::|:::|.|:|||.:..|.::|.:| |..:
Worm   470 ENPEKDFTCDELPDISDGNTPFEIKEKTLMLHRIAQVLRQKREDSGALRIELPRLKFALD-EDKK 533

  Fly   655 PLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVKSARYQGFQ 719
            |..|.:.:::::|.:|||||||||:.||:.||..|.|.|:||.||.|.......:.:.....||.
Worm   534 PQGVSIYEIKDSNKLVEEFMLLANMEVAKKIAENFPEHALLRNHPPPKEKMIKDVAEQCARIGFP 598

  Fly   720 VD-INSGLELSHS---------LDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFHY 774
            :| ..||| ||.|         ||.|::       .:|..||.:.|.||.||.:..:....:.|:
Worm   599 LDGRTSGL-LSTSLRKYQGKSRLDMCIR-------QVISSLTIKPMQQAKYFCTFEMPLSFYHHF 655

  Fly   775 GLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNE--ELCHNLNYRHKMAQYAG 837
            .|....|||||||||||.|::|||.|||::|    |.:..:|...|  |:|...|.....::.|.
Worm   656 ALNVDHYTHFTSPIRRYPDVIVHRQLAAALG----YNERSERVPEEIQEICTRCNDTKLASKEAS 716

  Fly   838 RASVALNTHLFFRGKEEDE-EGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERVKSEIV 901
            ..|..|...:|.......: :..||.|...:..|||.:||:...:|          |:::|.:
Worm   717 DESAMLYFGVFIHQTGPMKCQAVVLGVMDLSFDVLIVEYGVVKRVY----------VDKMKRD-- 769

  Fly   902 FTFNEEDHTQRCGDVVFHSFDPVTVRLSLD--SSNVQHEKLIFRLVKPYIKGFSVETTTEGTDSQ 964
              ||:.  |::.  .::...||.....:.:  ||::|...:::.::.|| |...|..|
Worm   770 --FNKS--TEKL--TIYWPADPNAESGNREEFSSSIQMCNVVYVILVPY-KSIEVSAT------- 820

  Fly   965 AVSAAPPS-------KKTKKDKKK 981
               ...||       |.|.||.|:
Worm   821 ---IVRPSLEQRNILKSTLKDMKE 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032	2/4 (50%)
		VacB	249..945	CDD:223631	234/773 (30%)
		RNB	474..802	CDD:279157	134/358 (37%)
disl-2	NP_498160.2	VacB	76..770	CDD:223631	227/736 (31%)
disl-2	NP_498160.2	RNB	333..685	CDD:279157	136/360 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0557
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104619at2759
OrthoFinder	1	1.000	-	-		FOG0000674
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820