DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and DIS3L2

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_689596.4	Gene:	DIS3L2 / 129563	HGNCID:	28648	Length:	885	Species:	Homo sapiens

Alignment Length:	872	Identity:	273/872 - (31%)
Similarity:	417/872 - (47%)	Gaps:	152/872 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 KLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQG 280
            |..:::...:|..:  :..::|.:::.|||::..|:||..:.:.:.:.|..:.....::.|.|.|
Human    36 KSKNRSTRGKKKSI--FETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDG 98

  Fly   281 RESLNRAVDGDLVAVELLPEAEWSAPSEIVLEEKN------VYADEVPSE--------------- 324
            ..:.|||::||||.|:||||..|    ::|..|.|      .|..::|.|
Human    99 VVARNRALNGDLVVVKLLPEEHW----KVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYN 159

  Fly   325 ---------------------------------------ER---------AKDENEMLNQVRAAA 341
                                                   |:         .|||...::|...|.
Human   160 DSPDVIVEAQFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRAL 224

  Fly   342 LSAERTPTGRIVGIVRRKW-RQYCGILQPSLIEDTNRH------IFVPADRKIPRIRIETRQAAM 399
            .......:.::|.|:.:|. |...|.|:  |:.|.|..      :|.|:|.::|||.:..:....
Human   225 SEKSLQRSAKVVYILEKKHSRAATGFLK--LLADKNSELFRKYALFSPSDHRVPRIYVPLKDCPQ 287

  Fly   400 --------LQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPHCKFSDEVL 456
                    ..|...|..|..|..:..:..|...:|||..|::..|.|.||.|:.|....||.|||
Human   288 DFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVL 352

  Fly   457 SFLPK-MPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVHIADVSHFI 520
            ..||: :||||..|::|||.|||...|.::||....|:||||.||.|.:||.:|||||||||:|:
Human   353 ECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFV 417

  Fly   521 RPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKRFH 585
            ..|:.||..||.|.|:||||.|.:.|:|.||...||||....::..||.:|.:..|..:|.:.|.
Human   418 PEGSDLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFG 482

  Fly   586 KSVIKSKRAMTYEEAQNIIDDATQQ---------------NEIAKSLRNLNRLAKILKKRRMDNG 635
            :::|:|...::||.||::|:..|::               .|:.:::.||:.:||.|:::|..:|
Human   483 RTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLRQQRFVDG 547

  Fly   636 ALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPR 700
            ||.|...::.|.:|.||..|....:.:.||:|.:|||||||||:.||..|...|.|.|:|||||.
Human   548 ALRLDQLKLAFTLDHETGLPQGCHIYEYRESNKLVEEFMLLANMAVAHKIHRAFPEQALLRRHPP 612

  Fly   701 PPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRC---MMQAVYFI 762
            |.......||:.....|..||.:|...|:.||.:.. .|:.|......:||..|   |..|:||.
Human   613 PQTRMLSDLVEFCDQMGLPVDFSSAGALNKSLTQTF-GDDKYSLARKEVLTNMCSRPMQMALYFC 676

  Fly   763 SGSLQ-KEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDR-----KSNEE 821
            ||.|| ..:|.||.|..|:||||||||||::|::|||||||::|    |.:.||.     :...:
Human   677 SGLLQDPAQFRHYALNVPLYTHFTSPIRRFADVLVHRLLAAALG----YRERLDMAPDTLQKQAD 737

  Fly   822 LCHNLNYRHKMAQYAGRASVALNTHLFFR--GKEE---DEEGYVLFVRKNALQVLIPKYGLEGTL 881
            .|::.....|..|       .|:|.|||.  .||.   :.|..|:.:.|.|..||:.:||::..:
Human   738 HCNDRRMASKRVQ-------ELSTSLFFAVLVKESGPLESEAMVMGILKQAFDVLVLRYGVQKRI 795

  Fly   882 Y-----LKS---DKDGKDGVERVKSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHE 938
            |     |:|   .|.||      |.|:...:..||..|.....|...|..|.|.|..:|:.:::.
Human   796 YCNALALRSHHFQKVGK------KPELTLVWEPEDMEQEPAQQVITIFSLVEVVLQAESTALKYS 854

  Fly   939 KLIFRLVKPYIKG-FSVETTTEGTDSQ 964
            .:   |.:|..:| ...|...|.:|.:
Human   855 AI---LKRPGTQGHLGPEKEEEESDGE 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032
		VacB	249..945	CDD:223631	261/817 (32%)
		RNB	474..802	CDD:279157	144/346 (42%)
DIS3L2	NP_689596.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45		1/8 (13%)
		VacB	226..812	CDD:223631	216/599 (36%)
		RNB	371..719	CDD:279157	146/348 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	860..885		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0557
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104619at2759
OrthoFinder	1	1.000	-	-		FOG0000674
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820