Protein Alignment Dis3 and DIS3L2

DIOPT Version :10

• Sequence 1: NP_651246.2
• Gene: Dis3 / 42900
• FlyBaseID: FBgn0039183
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: NP_689596.4
• Gene: DIS3L2 / 129563
• HGNCID: 28648
• Length: 885
• Species: Homo sapiens
• Alignment Length: 872
• Identity: 273/872 - (31%)
• Similarity: 417/872 - (47%)
• Gaps: 152/872 - (17%)

  Fly   216 KLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQG 280
            |..:::...:|..:  :..::|.:::.|||::..|:||..:.:.:.:.|..:.....::.|.|.|
Human    36 KSKNRSTRGKKKSI--FETYMSKEDVSEGLKRGTLIQGVLRINPKKFHEAFIPSPDGDRDIFIDG 98

  Fly   281 RESLNRAVDGDLVAVELLPEAEWSAPSEIVLEEKN------VYADEVPSE--------------- 324
            ..:.|||::||||.|:||||..|    ::|..|.|      .|..::|.|
Human    99 VVARNRALNGDLVVVKLLPEEHW----KVVKPESNDKETEAAYESDIPEELCGHHLPQQSLKSYN 159

  Fly   325 ---------------------------------------ER---------AKDENEMLNQVRAAA 341
                                                   |:         .|||...::|...|.
Human   160 DSPDVIVEAQFDGSDSEDGHGITQNVLVDGVKKLSVCVSEKGREDGDAPVTKDETTCISQDTRAL 224

  Fly   342 LSAERTPTGRIVGIVRRKW-RQYCGILQPSLIEDTNRH------IFVPADRKIPRIRIETRQAAM 399
            .......:.::|.|:.:|. |...|.|:  |:.|.|..      :|.|:|.::|||.:..:....
Human   225 SEKSLQRSAKVVYILEKKHSRAATGFLK--LLADKNSELFRKYALFSPSDHRVPRIYVPLKDCPQ 287

  Fly   400 --------LQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPHCKFSDEVL 456
                    ..|...|..|..|..:..:..|...:|||..|::..|.|.||.|:.|....||.|||
Human   288 DFVARPKDYANTLFICRIVDWKEDCNFALGQLAKSLGQAGEIEPETEGILTEYGVDFSDFSSEVL 352

  Fly   457 SFLPK-MPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVHIADVSHFI 520
            ..||: :||||..|::|||.|||...|.::||....|:||||.||.|.:||.:|||||||||:|:
Human   353 ECLPQGLPWTIPPEEFSKRRDLRKDCIFTIDPSTARDLDDALSCKPLADGNFKVGVHIADVSYFV 417

  Fly   521 RPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKRFH 585
            ..|:.||..||.|.|:||||.|.:.|:|.||...||||....::..||.:|.:..|..:|.:.|.
Human   418 PEGSDLDKVAAERATSVYLVQKVVPMLPRLLCEELCSLNPMSDKLTFSVIWTLTPEGKILDEWFG 482

  Fly   586 KSVIKSKRAMTYEEAQNIIDDATQQ---------------NEIAKSLRNLNRLAKILKKRRMDNG 635
            :::|:|...::||.||::|:..|::               .|:.:::.||:.:||.|:::|..:|
Human   483 RTIIRSCTKLSYEHAQSMIESPTEKIPAKELPPISPEHSSEEVHQAVLNLHGIAKQLRQQRFVDG 547

  Fly   636 ALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPR 700
            ||.|...::.|.:|.||..|....:.:.||:|.:|||||||||:.||..|...|.|.|:|||||.
Human   548 ALRLDQLKLAFTLDHETGLPQGCHIYEYRESNKLVEEFMLLANMAVAHKIHRAFPEQALLRRHPP 612

  Fly   701 PPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRC---MMQAVYFI 762
            |.......||:.....|..||.:|...|:.||.:.. .|:.|......:||..|   |..|:||.
Human   613 PQTRMLSDLVEFCDQMGLPVDFSSAGALNKSLTQTF-GDDKYSLARKEVLTNMCSRPMQMALYFC 676

  Fly   763 SGSLQ-KEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDR-----KSNEE 821
            ||.|| ..:|.||.|..|:||||||||||::|::|||||||::|    |.:.||.     :...:
Human   677 SGLLQDPAQFRHYALNVPLYTHFTSPIRRFADVLVHRLLAAALG----YRERLDMAPDTLQKQAD 737

  Fly   822 LCHNLNYRHKMAQYAGRASVALNTHLFFR--GKEE---DEEGYVLFVRKNALQVLIPKYGLEGTL 881
            .|::.....|..|       .|:|.|||.  .||.   :.|..|:.:.|.|..||:.:||::..:
Human   738 HCNDRRMASKRVQ-------ELSTSLFFAVLVKESGPLESEAMVMGILKQAFDVLVLRYGVQKRI 795

  Fly   882 Y-----LKS---DKDGKDGVERVKSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHE 938
            |     |:|   .|.||      |.|:...:..||..|.....|...|..|.|.|..:|:.:::.
Human   796 YCNALALRSHHFQKVGK------KPELTLVWEPEDMEQEPAQQVITIFSLVEVVLQAESTALKYS 854

  Fly   939 KLIFRLVKPYIKG-FSVETTTEGTDSQ 964
            .:   |.:|..:| ...|...|.:|.:
Human   855 AI---LKRPGTQGHLGPEKEEEESDGE 878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_651246.2	PIN_Rrp44-like	9..203	CDD:350211
		VacB	247..946	CDD:440323	262/820 (32%)
DIS3L2	NP_689596.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		1/8 (13%)
		Rrp44_CSD1	50..238	CDD:375054	37/191 (19%)
		VacB	231..745	CDD:440323	195/520 (38%)
		Dis3l2_C_term	766..855	CDD:465547	25/94 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	860..885		5/19 (26%)