DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and dis3

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	NP_001120564.1	Gene:	dis3 / 100145718	XenbaseID:	XB-GENE-5925331	Length:	951	Species:	Xenopus tropicalis

Alignment Length:	984	Identity:	541/984 - (54%)
Similarity:	706/984 - (71%)	Gaps:	50/984 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 REFTRKTKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHANKSTLFKFPHYLVLDTN 69
            :.|.:||:.|.||||||||||||||.||.:.|.|| |.|...|..:...:|:|....|||:.|||
Frog     5 KTFMKKTRSGGILKIVREHYLRDDITCGCKGCDEC-QQERAILELEPILESSLCTTAHYLLPDTN 68

  Fly    70 VVLDQIDVLEEDVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFYVFVNEHHKETYADRE 134
            |:|.|||:||:.:|:||::|.|||.||:.||:.:|||..:::|:..:.||.|.||||:|||.::|
Frog    69 VLLHQIDILEDPILKNVILLQTVLQEVRSRSAPVYKRIKDLLHNPDKCFYAFTNEHHRETYLEQE 133

  Fly   135 PDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDDAANRAKAEAEGILVTT 199
            ..|.||||||||||.|||||:.||:.|..        .|..:|:|:|:|..|:.||..|||:..|
Frog   134 QGENANDRNDRAIRTATKWYNKHLKKSPK--------MADVQVILITNDRRNKEKAVEEGIVAYT 190

  Fly   200 AAEYVKSLEDFPLLMDKLSHKTFDSEKN----GLPQYPPHLSMKELLEGLRQNKLLQGTFQASRE 260
            ..||:|||...|.|:|:|:  ..:.|||    |...:..||.:.:|.:|::....|||||:|||:
Frog   191 CEEYIKSLTANPELVDRLA--CVNDEKNEVESGRLIFAEHLPLSKLQQGIKSGAYLQGTFRASRD 253

  Fly   261 NYLEGTVNV---EKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLEEKNVYADEVP 322
            ||||.||.|   ....|.|::||..:||||:..|:|||:||.:..|...|.:||:::. .:|::.
Frog   254 NYLEATVWVHGDSAENKEIIVQGLRNLNRAMHEDIVAVQLLDKENWVTMSSVVLQDEG-DSDDIE 317

  Fly   323 SEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIEDTNRHIFVPADRKI 387
            |.|   ::.:||.    .|:::.:.|:|::|||::|.||.|||:|..|.|:::.||:|.||:|:|
Frog   318 SVE---EKEKMLK----TAVNSVKKPSGQVVGIIKRNWRPYCGMLSKSQIKESTRHLFTPAERRI 375

  Fly   388 PRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPHCKFS 452
            ||||||||||:.|:.|||||.:|.||||||||:||||:|||..||..||.||:||||||||..||
Frog   376 PRIRIETRQASTLEGQRIIVAVDGWPRNSRYPNGHFVKSLGTAGDKETETEVLLLEHDVPHQPFS 440

  Fly   453 DEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVHIADVS 517
            ..|||||||||||||.||...|:|||.||:|||||||||||||||||:||.||.|||||||||||
Frog   441 QAVLSFLPKMPWTITPEDMKNRIDLRHLYVCSVDPPGCTDIDDALHCRELENGTLEVGVHIADVS 505

  Fly   518 HFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSK 582
            ||||||||||.|::.|||||||..|||||||||||||||||...|:|.||||:||||..||:|:.
Frog   506 HFIRPGNALDQESSNRGTTVYLCDKRIDMVPELLSSNLCSLRSNVDRLAFSCIWEVDENANILNT 570

  Fly   583 RFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRFQ 647
            :|.||||.||.::||.|||..||.....:||.:|||.||:|||||||||:|||||.|:|||:||.
Frog   571 KFTKSVINSKASLTYAEAQMRIDSPNMNDEITQSLRLLNKLAKILKKRRIDNGALTLSSPEVRFH 635

  Fly   648 VDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVKS 712
            :|||||:|::::.|:::|||||||||||||||:||:.|..||||.|:||:||.|||.|:|.|||:
Frog   636 MDSETHDPIDLQTKELKETNSMVEEFMLLANISVAQKIYDEFSEYALLRKHPSPPPANYDILVKA 700

  Fly   713 ARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFHYGLA 777
            |:.:...:..:|...|:.||||......||.||::|||.||||||||||.||  ...:|.|||||
Frog   701 AKSKNLDIKTDSAKALADSLDKAESPGFPYMNTLLRILATRCMMQAVYFCSG--MDNDFHHYGLA 763

  Fly   778 APIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVA 842
            :|||||||||||||:||:||||||.::||||||..|.|:....::|.|:|:|||||||:.|||||
Frog   764 SPIYTHFTSPIRRYADIIVHRLLAVAVGADSTYPDLTDKHKIADICKNINFRHKMAQYSQRASVA 828

  Fly   843 LNTHLFFRGKE-EDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERVKSEIVFTFNE 906
            .:|.|||:.:. .:|||::|||||||:.|||||:|||||::.: :||.|      |:.:|  ||:
Frog   829 FHTQLFFKNRGIVNEEGFILFVRKNAIVVLIPKFGLEGTVFFE-EKDKK------KTNLV--FND 884

  Fly   907 EDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKPYIKGFS----VETTTEGTDSQAVS 967
            |....:..:..||.||.|.|::|||:||:||:|:...||:|.|.|.:    :.|.|.|
Frog   885 EVPFLKVENTTFHMFDKVKVKISLDASNIQHQKIRMALVEPEIPGVTSHEDIATNTNG------- 942

  Fly   968 AAPPSKKTK 976
             .|..||:|
Frog   943 -EPVPKKSK 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032	97/193 (50%)
		VacB	249..945	CDD:223631	414/699 (59%)
		RNB	474..802	CDD:279157	221/327 (68%)
dis3	NP_001120564.1	PIN_Rrp44-like	9..194	CDD:350211	97/193 (50%)
dis3	NP_001120564.1	VacB	244..925	CDD:223631	416/699 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	454	1.000	Domainoid score	I497
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6910
Inparanoid	1	1.050	1040	1.000	Inparanoid score	I267
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1104619at2759
OrthoFinder	1	1.000	-	-		FOG0000674
OrthoInspector	1	1.000	-	-		oto105527
Panther	1	1.100	-	-	LDO	PTHR23355
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R319
SonicParanoid	1	1.000	-	-		X1261
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190