DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dis3 and dis3

DIOPT Version :9

Sequence 1:	NP_001262910.1	Gene:	Dis3 / 42900	FlyBaseID:	FBgn0039183	Length:	982	Species:	Drosophila melanogaster
Sequence 2:	XP_001336850.2	Gene:	dis3 / 100003553	ZFINID:	ZDB-GENE-080213-3	Length:	950	Species:	Danio rerio

Alignment Length:	984	Identity:	545/984 - (55%)
Similarity:	707/984 - (71%)	Gaps:	47/984 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 REFTRKTKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHANKSTLFKFPHYLVLDTN 69
            :.|.:||:.|.:|||||||||||||.||||:|:|| ::|...|..:...:|.|..:||||:.|||
Zfish     5 KTFVKKTRSGGVLKIVREHYLRDDIWCGSEVCKEC-KDEAPVLQEETCIESNLCPYPHYLIPDTN 68

  Fly    70 VVLDQIDVLEEDVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFYVFVNEHHKETYADRE 134
            |||.|||:||:.::|||::|.|||.||:|||:.:|||..:.:|::.::||.|.||||:||:.:||
Zfish    69 VVLHQIDILEDPLIRNVIILQTVLQEVRHRSAPVYKRIKDAIHEKEKHFYTFTNEHHRETFIERE 133

  Fly   135 PDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDDAANRAKAEAEGILVTT 199
            ..|:||||||||||:|.|||.|||..:...        ...:|||||:|.||:.|||..|:.|..
Zfish   134 QGESANDRNDRAIRVAAKWYTDHLAKATDG--------GTLKVVLLTNDRANKEKAEQFGLTVYR 190

  Fly   200 AAEYVKSLEDFPLLMDKLSHKTFD-SEKNGLP-QYPPHLSMKELLEGLRQNKLLQGTFQASRENY 262
            ..||:|||...|.|:|:|:..:.| :|..|.. .:|.||.:..:..|::....:||||.|:|:||
Zfish   191 CEEYIKSLVGNPELVDRLAMTSDDQNEITGSKLLFPEHLPLSRIQTGIKNGVFIQGTFHANRDNY 255

  Fly   263 LEGTVNVEKFEKG-----ILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLEEKNVYADEVP 322
            |||||.|.:  :|     ||:||.::|||||:.|:|||||.|:..|.|||.:||::     |.:.
Zfish   256 LEGTVFVNR--EGEDINEILLQGLQNLNRAVNQDVVAVELFPKDRWVAPSSVVLQD-----DNLN 313

  Fly   323 SEERAKDENE-MLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIEDTNRHIFVPADRK 386
            .|:..:|||: .|..|  |:.|:...||||:|||::|.||.:||:|..|.|::..||:|.||||:
Zfish   314 DEDTEEDENDSKLKSV--ASESSVLKPTGRVVGIIKRNWRPFCGMLAQSQIKEATRHLFTPADRR 376

  Fly   387 IPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPHCKF 451
            ||||||||||||.|..|||:|.||.||:|||||:||||::||..||..||.||:||||||||..|
Zfish   377 IPRIRIETRQAATLIGQRIMVAIDGWPKNSRYPNGHFVKNLGTAGDKETETEVLLLEHDVPHQPF 441

  Fly   452 SDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCKELPNGNLEVGVHIADV 516
            |..||||||||||.||:||...|.|||.|.:|||||||||||||||||:||.|||||||||||||
Zfish   442 SQAVLSFLPKMPWGITEEDLKVRADLRHLCVCSVDPPGCTDIDDALHCRELENGNLEVGVHIADV 506

  Fly   517 SHFIRPGNALDMEAAARGTTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLS 581
            |||||||||||.|||.|||||||.||||||||||||||||||...|||.||||:||::::|.::.
Zfish   507 SHFIRPGNALDQEAANRGTTVYLCGKRIDMVPELLSSNLCSLRSNVERLAFSCIWEMNHKAEIIK 571

  Fly   582 KRFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRF 646
            ..|.||||.||.::||.|||..|||.|..::|.||||.||:||||||.:|:|.|||.|:|||:||
Zfish   572 THFTKSVINSKASLTYAEAQMRIDDTTMNDDITKSLRGLNKLAKILKAQRIDKGALTLSSPEVRF 636

  Fly   647 QVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVK 711
            .:|||||:|::::.|::.|||||||||||||||:||:.|..||||||:||:||.|||:|:|.|:|
Zfish   637 HIDSETHDPIDLQTKELMETNSMVEEFMLLANISVAQKIYDEFSECALLRKHPAPPPSNYDILIK 701

  Fly   712 SARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFHYGL 776
            :|:.:..::..:|...|:.||:.....:..||||::|||.||||||||||.||  ...:|.||||
Zfish   702 AAKSRDLEIHTDSAKALADSLNNATIENFAYFNTLLRILATRCMMQAVYFCSG--MDSDFHHYGL 764

  Fly   777 AAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASV 841
            |:|||||||||||||:||:||||||.:|.|||||..|:|:.....||:|:||||||||||.||||
Zfish   765 ASPIYTHFTSPIRRYADIIVHRLLAVAINADSTYPDLMDKHKQSALCNNINYRHKMAQYAQRASV 829

  Fly   842 ALNTHLFFRGKE-EDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERVKSEIVFTFN 905
            |.:|.|||:.|. .:|||::|||||||:.:||||:|||||::.    :.||     |.....:|:
Zfish   830 AFHTQLFFKNKGIINEEGFILFVRKNAIIILIPKFGLEGTVFF----ENKD-----KPSPRLSFD 885

  Fly   906 EEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKPYIKGFSVETTTEGTDSQAVSAAP 970
            .|..|.:..:..|..||.|.|.:|||:||:||:::...|.:|.|.|.||...         .:.|
Zfish   886 TEGPTLKVEEHTFRIFDRVKVTISLDASNLQHQRIRMALTEPVIPGVSVPIP---------ESEP 941

  Fly   971 PSKKTKKDK 979
            .:||.|.|:
Zfish   942 EAKKPKLDR 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dis3	NP_001262910.1	PIN_Rrp44	9..203	CDD:189032	100/193 (52%)
		VacB	249..945	CDD:223631	417/702 (59%)
		RNB	474..802	CDD:279157	218/327 (67%)
dis3	XP_001336850.2	PIN_Rrp44	9..194	CDD:189032	100/193 (52%)
dis3	XP_001336850.2	VacB	242..921	CDD:223631	417/698 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594649
Domainoid	1	1.000	452	1.000	Domainoid score	I488
eggNOG	1	0.900	-	-		E1_COG0557
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6910
Inparanoid	1	1.050	1060	1.000	Inparanoid score	I245
OMA	1	1.010	-	-		QHG53920
OrthoDB	1	1.010	-	-		D1104619at2759
OrthoFinder	1	1.000	-	-		FOG0000674
OrthoInspector	1	1.000	-	-		oto40673
orthoMCL	1	0.900	-	-		OOG6_101226
Panther	1	1.100	-	-	LDO	PTHR23355
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R319
SonicParanoid	1	1.000	-	-		X1261
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800