Protein Alignment ASCL1 and net

DIOPT Version :10

• Sequence 1: NP_004307.2
• Gene: ASCL1 / 429
• HGNCID: 738
• Length: 236
• Species: Homo sapiens
• Sequence 2: NP_524820.2
• Gene: net / 45339
• FlyBaseID: FBgn0002931
• Length: 360
• Species: Drosophila melanogaster
• Alignment Length: 224
• Identity: 54/224 - (24%)
• Similarity: 83/224 - (37%)
• Gaps: 52/224 - (23%)

Human     3 SSAKMESGG---------------------AGQQPQPQP--------QQPFLPPAACFFATAAAA 38
            |||.|.:.|                     |...|.|..        |...:|..|..:......
  Fly   105 SSASMNATGPLKKRIRYTSSADSAVVLTPPAIDSPPPNSCIPSTLRLQHEIMPNPAHIYVRHPGV 169

Human    39 AAAAAAAAAQSAQQQ------QQQQQQQQQAPQLRPAA----DGQPSGGGHKSAPKQVKRQRSSS 93
            .....:.||...|.:      .::|...|..|::...:    ..|||  ..|:..::.:::.:||
  Fly   170 TTLHRSLAAHPEQLEPLALVTTKKQCVDQAGPKIEAFSALLIGKQPS--AKKTLKERTQKESTSS 232

Human    94 P--ELMRCKRRLNFSGFG-YSLPQQ-----QPAAVARR---NERERNRVKLVNLGFATLREHVPN 147
            .  |.......||.:|.. .|.|.|     :.....||   |.|||.||..::..:.|||:.||.
  Fly   233 SFLEASLSDEDLNKTGLAPISRPHQHQRNYKNMTRERRIEANARERTRVHTISAAYETLRQAVPA 297

Human   148 GAANKKMSKVETLRSAVEYIRALQQLLDE 176
            .|:.:|:||:..||.|..||..|.::..|
  Fly   298 YASTQKLSKLSVLRVACSYILTLSRMAGE 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASCL1	NP_004307.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		9/51 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..98		13/67 (19%)
		bHLH_TS_ASCL1_Mash1	115..185	CDD:381585	25/70 (36%)
net	NP_524820.2	bHLH_TS_ATOH8	262..329	CDD:381427	24/65 (37%)