DRSC/TRiP Functional Genomics Resources

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Protein Alignment ASCL1 and Fer2

DIOPT Version :10

Sequence 1:NP_004307.2 Gene:ASCL1 / 429 HGNCID:738 Length:236 Species:Homo sapiens
Sequence 2:NP_001287359.1 Gene:Fer2 / 41961 FlyBaseID:FBgn0038402 Length:283 Species:Drosophila melanogaster


Alignment Length:195 Identity:46/195 - (23%)
Similarity:66/195 - (33%) Gaps:78/195 - (40%)


- Green bases have known domain annotations that are detailed below.


Human    63 APQLRPAADGQPSGGGHKSAPKQVKRQRSSSPELMRCKRRLNFSGFG-------YSLPQQQPAAV 120
            ||.:..:.....||||..:|..... ..:..|.          .|:|       .|...|:.|| 
  Fly   100 APLMCNSPSASSSGGGCGNAGSATP-GGAGGPN----------PGYGSVGAATASSYKMQRQAA- 152

Human   121 ARRNERERNRVK----------LVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLD 175
               |.|||.|::          .:|..|..||.|||.....|::||::|||.|:.||..|:::| 
  Fly   153 ---NVRERKRIQRSAPTGYTKCSINSAFDELRVHVPTFPYEKRLSKIDTLRLAIAYISLLREVL- 213

Human   176 EHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQEL-----LDFTNW 235
                                                    :..||||:..|:.|     .|..||
  Fly   214 ----------------------------------------QTDYDPLTYVEKCLRGEIKADRANW 238

Human   236  235
              Fly   239  238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ASCL1NP_004307.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..98 8/34 (24%)
bHLH_TS_ASCL1_Mash1 115..185 CDD:381585 26/79 (33%)
Fer2NP_001287359.1 bHLH_SF 144..216 CDD:469605 27/116 (23%)
Blue background indicates that the domain is not in the aligned region.

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