Protein Alignment ASCL1 and sage

DIOPT Version :10

• Sequence 1: NP_004307.2
• Gene: ASCL1 / 429
• HGNCID: 738
• Length: 236
• Species: Homo sapiens
• Sequence 2: NP_524287.1
• Gene: sage / 41105
• FlyBaseID: FBgn0037672
• Length: 268
• Species: Drosophila melanogaster
• Alignment Length: 251
• Identity: 58/251 - (23%)
• Similarity: 84/251 - (33%)
• Gaps: 82/251 - (32%)

Human    26 PPAACFFATAAAAAAAAAAAAAQSAQQQQQQQQQQQQAPQLR--PA--------ADG-------- 72
            ||......:|.......:..:...|:..:|....:..|||..  ||        |||
  Fly    16 PPPVLVPVSATTGGPYLSGGSEGEAESSEQPVLLELGAPQSSSCPAVSLNYTLTADGAGLLAYAP 80

Human    73 ------QPS--GGGHKSA-------------PKQVK-----RQRSSSPELMRCKR-------RLN 104
                  .||  ||..|.|             |:.|.     :..:.||..:.|.:       .:.
  Fly    81 THPHSYSPSVMGGYEKEAHNMGLLPPTYSVIPQPVSMWHAGQVATGSPVGLECNKPSELVPPPMY 145

Human   105 FSGFGYSLPQQQPAAVARRN--------------------ERERNRVKLVNLGFATLREHVPNGA 149
            .|..|.|:.......:|:.:                    :|||.|::.:|..|..||..:|...
  Fly   146 MSYSGGSIANSTEVDIAKEHNPAWREKALQMEKDYRRTACDRERTRMRDMNRAFDLLRSKLPISK 210

Human   150 AN-KKMSKVETLRSAVEYIRALQQLLDEHDAVS-----AAFQAGVLSPTISPNYSN 199
            .| ||.||:|:||.|:.||..||.:|.|.....     .|:..|..||     |.|
  Fly   211 PNGKKYSKIESLRIAINYINHLQAMLRESSVGQNGNGCCAWSGGSSSP-----YDN 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASCL1	NP_004307.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		58/251 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..98		20/99 (20%)
		bHLH_TS_ASCL1_Mash1	115..185	CDD:381585	26/95 (27%)
sage	NP_524287.1	bHLH_TS	181..236	CDD:381396	22/54 (41%)