Protein Alignment ASCL1 and twi

DIOPT Version :10

• Sequence 1: NP_004307.2
• Gene: ASCL1 / 429
• HGNCID: 738
• Length: 236
• Species: Homo sapiens
• Sequence 2: NP_523816.2
• Gene: twi / 37655
• FlyBaseID: FBgn0003900
• Length: 490
• Species: Drosophila melanogaster
• Alignment Length: 330
• Identity: 70/330 - (21%)
• Similarity: 108/330 - (32%)
• Gaps: 138/330 - (41%)

Human    14 QQPQPQPQQ----PFLPPAACFFATAAAAAAAAAAAAAQSA------------------------ 50
            ||.|.|.||    .:||      .|....|:|.:....||.
  Fly   180 QQQQQQHQQQIYVDYLP------TTVDEVASAQSCPGVQSTCTSPQSHFDFPDEELPEHKAQVFL 238

Human    51 -----QQQQQQQQQQQQAPQ--------------------------------------------- 65
                 ||||.||.||||..|
  Fly   239 PLYNNQQQQSQQLQQQQPHQQSHAQMHFQNAYRQSFEGYEPANSLNGSAYSSSDRDDMEYARHNA 303

Human    66 -----------LRPAA-----------DGQPSGG-GHKSAPKQVKRQRSSSPELMRCKRRLNFSG 107
                       :.||.           ||..:|| ..:...:::||:.|.:.|..      .||
  Fly   304 LSSVSDLNGGVMSPACLADDGSAGSLLDGSDAGGKAFRKPRRRLKRKPSKTEETD------EFS- 361

Human   108 FGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQ 172
                  .|:..|    |.|||.|.:.:|..|.:|::.:|. ..:.|:||::||:.|..||..|.:
  Fly   362 ------NQRVMA----NVRERQRTQSLNDAFKSLQQIIPT-LPSDKLSKIQTLKLATRYIDFLCR 415

Human   173 LLDEHD-AVSAAFQA-GVLSPTISPNYSNDLNSMAGSPVSSYSSD-----EGSYDPLSPEEQELL 230
            :|...| ::..|.:| |      ||:.....:|:..:..:...:|     :.:..|:.|.|:...
  Fly   416 MLSSSDISLLKALEAQG------SPSAYGSASSLLSAAANGAEADLKCLRKANGAPIIPPEKLSY 474

Human   231 DFTNW 235
            .|..|
  Fly   475 LFGVW 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASCL1	NP_004307.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		6/15 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..98		23/152 (15%)
		bHLH_TS_ASCL1_Mash1	115..185	CDD:381585	23/70 (33%)
twi	NP_523816.2	bHLH_TS_TWIST	363..421	CDD:381470	21/62 (34%)