DRSC/TRiP Functional Genomics Resources

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Protein Alignment ASCL1 and HLH54F

DIOPT Version :9

Sequence 1:NP_004307.2 Gene:ASCL1 / 429 HGNCID:738 Length:236 Species:Homo sapiens
Sequence 2:NP_477302.1 Gene:HLH54F / 37027 FlyBaseID:FBgn0022740 Length:242 Species:Drosophila melanogaster


Alignment Length:146 Identity:42/146 - (28%)
Similarity:66/146 - (45%) Gaps:26/146 - (17%)


- Green bases have known domain annotations that are detailed below.


Human    87 KRQRSSSP-ELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAA 150
            :::||||| |....    :|.....|...|.|......|.|||.|:::::..:..|:..:||...
  Fly     3 RKKRSSSPTEFFDD----DFDEDASSQSSQPPVQRNAANARERMRMRVLSSAYGRLKTKLPNIPP 63

Human   151 NKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYS--NDLNSMAGSPVSSY- 212
            :.|:||::|||.|..||:   ||:       .|.:.|..|.....|::  :.||....|..||. 
  Fly    64 DTKLSKLDTLRLATLYIK---QLI-------TAVETGSHSQNHPHNHNQHHSLNHSHSSTTSSEG 118

Human   213 --------SSDEGSYD 220
                    ||..|:|:
  Fly   119 LDTSHMADSSGGGNYN 134

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ASCL1NP_004307.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..98 6/11 (55%)
bHLH_TS_ASCL1_Mash1 115..185 CDD:381585 22/69 (32%)
HLH54FNP_477302.1 HLH 32..83 CDD:278439 17/53 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4029
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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