DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ASCL1 and ac

DIOPT Version :9

Sequence 1:	NP_004307.2	Gene:	ASCL1 / 429	HGNCID:	738	Length:	236	Species:	Homo sapiens
Sequence 2:	NP_476824.1	Gene:	ac / 30981	FlyBaseID:	FBgn0000022	Length:	201	Species:	Drosophila melanogaster

Alignment Length:	173	Identity:	57/173 - (32%)
Similarity:	81/173 - (46%)	Gaps:	56/173 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   119 AVARRNERERNRVKLVNLGFATLREHVP--------NG------AANKKMSKVETLRSAVEYIRA 169
            :|.|||.|||||||.||.||:.||:|:|        ||      .||||:|||.||:.||||||.
  Fly    25 SVIRRNARERNRVKQVNNGFSQLRQHIPAAVIADLSNGRRGIGPGANKKLSKVSTLKMAVEYIRR 89

Human   170 LQQLLDEHDAVSAA----------FQ--------------AGVLSPTISPNYSNDLNSM------ 204
            ||::|.|:|.....          ||              ..:.|||.|.:..|.::|.
  Fly    90 LQKVLHENDQQKQKQLHLQQQHLHFQQQQQHQHLYAWHQELQLQSPTGSTSSCNSISSYCKPATS 154

Human   205 ----AGSPVSSYSSDEGSYDPL-------SPEEQELLDFTN-W 235
                |..|.:.::..|.|::..       ..|::::||:.: |
  Fly   155 TIPGATPPNNFHTKLEASFEDYRNNSCSSGTEDEDILDYISLW 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ASCL1	NP_004307.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..98
		bHLH_TS_ASCL1_Mash1	115..185	CDD:381585	41/89 (46%)
ac	NP_476824.1	HLH	30..96	CDD:197674	36/65 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158182
Domainoid	1	1.000	68	1.000	Domainoid score	I9706
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	87	1.000	Inparanoid score	I5142
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1131543at2759
OrthoFinder	1	1.000	-	-		FOG0001993
OrthoInspector	1	1.000	-	-		otm41464
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3926
SonicParanoid	1	1.000	-	-		X2717
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.790