DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5728 and RRP5

DIOPT Version :9

Sequence 1:NP_651245.1 Gene:CG5728 / 42899 FlyBaseID:FBgn0039182 Length:1430 Species:Drosophila melanogaster
Sequence 2:NP_013956.1 Gene:RRP5 / 855269 SGDID:S000004842 Length:1729 Species:Saccharomyces cerevisiae


Alignment Length:1771 Identity:362/1771 - (20%)
Similarity:669/1771 - (37%) Gaps:433/1771 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EKSFPRGGT-----IHSEVKTDDVSLNIVFG-----ASQK-----KVKKAPKVKENLLSYETEEQ 54
            |.||||||.     :..:...::.:.:::||     ||:.     |.||..|...:..|..:...
Yeast    35 EVSFPRGGASALTPLELKQVANEAASDVLFGNESVKASEPASRPLKKKKTTKKSTSKDSEASSAN 99

  Fly    55 NGQLEAFSAETLNMDTLQEDMLVMGVVKELTATALQIALPGRMFARTLVADISDAYTRVAK---A 116
            :.:..|...|.:|..||:....::|.:..:|...|.|.....:.....:..||:.:|.:.:   .
Yeast   100 SDEARAGLIEHVNFKTLKNGSSLLGQISAITKQDLCITFTDGISGYVNLTHISEEFTSILEDLDE 164

  Fly   117 AMSGDT------------SEYH----------------DLTELFQLGRIVYGKAIKTEKLD---- 149
            .|..||            :||.                :|...|.:|:.:....||...|:    
Yeast   165 DMDSDTDAADEKKSKVEDAEYESSDDEDEKLDKSNELPNLRRYFHIGQWLRCSVIKNTSLEPSTK 229

  Fly   150 -TGRVSLLLSLKPADVHGNLH-HKSIKKGFIFSGAVAEALEHGYVIESGVQGLQAFVPCEKP--- 209
             :.:..:.|:::|:.|  |:: .:.:.|......||....:||..::.|:.|...|: .:|.   
Yeast   230 KSKKKRIELTIEPSSV--NIYADEDLVKSTSIQCAVKSIEDHGATLDVGLPGFTGFI-AKKDFGN 291

  Fly   210 AQKLHVGQLAFLKVKTVHHDTHQSTCTCVQVEQDQLRIKSQNETNLDYILPGSIVKFKVAKHLKD 274
            .:||..|.: ||...|...|    ....|..:....:.|....:::|.|:||.||........|:
Yeast   292 FEKLLPGAV-FLGNITKKSD----RSIVVNTDFSDKKNKITQISSIDAIIPGQIVDLLCESITKN 351

  Fly   275 GLKGSIMNESFSAYVNEHHLA--NALDTLDAYELNEDYNARVL---------YVMPLTKLVYLTL 328
            |:.|.:.. ..|..||..||.  :..|....:.:......|::         .|:.|:.|.:: |
Yeast   352 GIAGKVFG-LVSGVVNVSHLRTFSEEDLKHKFVIGSSIRCRIIACLENKSGDKVLILSNLPHI-L 414

  Fly   329 NLDIKTGAAVAKDQDEEEQEVEPIKVGSVVEKAKVLRLGSGGVVLLLNKKLKGIISYGSIRGNFK 393
            .|:         |.....:.::...:|...|...:....|..:.|.|:..     ..|.:..:..
Yeast   415 KLE---------DALRSTEGLDAFPIGYTFESCSIKGRDSEYLYLALDDD-----RLGKVHSSRV 465

  Fly   394 GNYDKDEVLSKYGRKTKHKVRILGYDVIESLYYCSDDPNVVNEKLFCLEDINAGDL--------- 449
            |..:..|.||.         |:|||..::.:|..|.||..:..|.....||..|:|         
Yeast   466 GEIENSENLSS---------RVLGYSPVDDIYQLSTDPKYLKLKYLRTNDIPIGELLPSCEITSV 521

  Fly   450 ----VTAKI-------------------------FKKDDKIKG---------------------- 463
                :..||                         ||...|:||                      
Yeast   522 SSSGIELKIFNGQFKASVPPLHISDTRLVYPERKFKIGSKVKGRVISVNSRGNVHVTLKKSLVNI 586

  Fly   464 -------------------------WSVRIGKVNG-----------------ILEQFYLAPNVRY 486
                                     .::::.|.||                 |.|.|...|....
Yeast   587 EDNELPLVSTYENAKNIKEKNEKTLATIQVFKPNGCIISFFGGLSGFLPNSEISEVFVKRPEEHL 651

  Fly   487 DVGQSLKCRVLEVNAERK----ICYVSNR--------AEYLGKGIKILTDYASAHVGNVYMGTVV 539
            .:||::..::|:|:|:|:    .|.|||.        .|.:..|..|:|    .||       :.
Yeast   652 RLGQTVIVKLLDVDADRRRIIATCKVSNEQAAQQKDTIENIVPGRTIIT----VHV-------IE 705

  Fly   540 RCEDTYVLVKFGNGIKGVLH------------RQNLK------ENSSFFEGQTTKFRILTRN--- 583
            :.:|:.::.....|::||::            |..||      |.:.....:.|:.|:...:   
Yeast   706 KTKDSVIVEIPDVGLRGVIYVGHLSDSRIEQNRAQLKKLRIGTELTGLVIDKDTRTRVFNMSLKS 770

  Fly   584 ---KDQITLTLP---EDKFQLGEICPVE--ITNALDAGLEVKI----------TFAAEDDEEDED 630
               ||....|||   :|...|.:..|:.  |.:..|.||.|..          ::|.:..:.|..
Yeast   771 SLIKDAKKETLPLTYDDVKDLNKDVPMHAYIKSISDKGLFVAFNGKFIGLVLPSYAVDSRDIDIS 835

  Fly   631 GNPKLEEFVGLIPLRLLSDHLELLHAQMRVHPAGSYTDAACIMQNIFSLRDVPYFSGQLTKDWQS 695
            ....:.:.|.:..||....:.:.|   :.:.......:...:..||    :.|..|.  .|.|..
Yeast   836 KAFYINQSVTVYLLRTDDKNQKFL---LSLKAPKVKEEKKKVESNI----EDPVDSS--IKSWDD 891

  Fly   696 VQVGDIIRSYVKHAT-------------------------DQVVDLMVCVRNYNKPVKVHVKMLR 735
            :.:|.|:::.:|...                         :::.|....:.||.|...:.||::.
Yeast   892 LSIGSIVKAKIKSVKKNQLNVILAANLHGRVDIAEVFDTYEEITDKKQPLSNYKKDDVIKVKIIG 956

  Fly   736 LNAVKNAPVELVPEQLLWVKVL----------SKEVETKTL---TVSAKLTDVWSGDLSDTAKLV 787
            .:.||:.....:..::....||          ||||.||:|   .:..:||...:....:...|.
Yeast   957 NHDVKSHKFLPITHKISKASVLELSMKPSELKSKEVHTKSLEEINIGQELTGFVNNSSGNHLWLT 1021

  Fly   788 EGYLNEVAQIKAGLEEASAPISKYS--------VGEKINVVFKGIDATTNDWVYTVEGNGKVSAL 844
               ::.|.:.:..|.:.:...|.:|        :|..:.|....||          ..:|.|:|:
Yeast  1022 ---ISPVLKARISLLDLADNDSNFSENIESVFPLGSALQVKVASID----------REHGFVNAI 1073

  Fly   845 LLSSLVGTAKAPEMGSKHEAVILWIEYSSDVLLISNKKLDIAHISPS-GELSTNLIGKAGMKAKV 908
            ..|.:.......::|.:....:|.|.....:|.:.||...|:.|:.: .:.|..|  |...:.|:
Yeast  1074 GKSHVDINMSTIKVGDELPGRVLKIAEKYVLLDLGNKVTGISFITDALNDFSLTL--KEAFEDKI 1136

  Fly   909 --LLKLESVAVCSLKKGTNPLVICPIRLHPNDIENSGSAELRQGDFCN-----------IAFIHD 960
              ::....::|....|... |.:.|.......|::  ..:|:||:..:           ..::..
Yeast  1137 NNVIPTTVLSVDEQNKKIE-LSLRPATAKTRSIKS--HEDLKQGEIVDGIVKNVNDKGIFVYLSR 1198

  Fly   961 KLHIAVP-----ETVWRLWRGVKRTAGTEVAPVKAKKAKVEESPKQKKTTIEETSAQKKVKAKAK 1020
            |:...||     ::..:.|:...:       |::....||....:..:.::  |..:.::....|
Yeast  1199 KVEAFVPVSKLSDSYLKEWKKFYK-------PMQYVLGKVVTCDEDSRISL--TLRESEINGDLK 1254

  Fly  1021 V-ETKTEAKA-------IPTKRKAEVVEKITNGQKKT--QPLTNGIVKEKPKQNGKLF-FEDK-- 1072
            | :|.::.||       |.:.....|..|:.|....|  ..:|. |..:||:....|| ..|:  
Yeast  1255 VLKTYSDIKAGDVFEGTIKSVTDFGVFVKLDNTVNVTGLAHITE-IADKKPEDLSALFGVGDRVK 1318

  Fly  1073 ------TPAKNAKSETPKSNGAEGKSRLPGVSSFW----------EDDVNQSKEGSSDEDEELNV 1121
                  .|.|...|.:.|::....::.|...::..          ||:| .:..|.:|.|.|.::
Yeast  1319 AIVLKTNPEKKQISLSLKASHFSKEAELASTTTTTTTVDQLEKEDEDEV-MADAGFNDSDSESDI 1382

  Fly  1122 AETQKNAAKKK--------RLSA--------KEKAKAEIKEEQ--------------RLRE--IE 1154
            .:.....|.:|        .|||        .::|:.|.:.:|              |.:|  ::
Yeast  1383 GDQNTEVADRKPETSSDGLSLSAGFDWTASILDQAQEEEESDQDQEDFTENKKHKHKRRKENVVQ 1447

  Fly  1155 ERNADPKARL-ETIDQYERLVIAQPNNSISWLKYIAFLLSNTEIEKARALARRAISTISFRETQE 1218
            ::..|...|. |::..:|||:|..||:|:.|:.|:||.|..:||||||.||.||:.||:|||..|
Yeast  1448 DKTIDINTRAPESVADFERLLIGNPNSSVVWMNYMAFQLQLSEIEKARELAERALKTINFREEAE 1512

  Fly  1219 LRNMWSALLNMELVY--SNNFDDVLKEALNCNDPLEIYISVVDILKKNKRKDRLSSVLTTVLNKF 1281
            ..|:|.|:||:|..:  ....::|...|....|...|:..::.|.:.:::.|:.:.:......||
Yeast  1513 KLNIWIAMLNLENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIYEISEKFDKAAELFKATAKKF 1577

  Fly  1282 KTE-LRVWPVAAEAYFWLGKSDQVHNLLQRALRALPNQEHIPCIVSFAKL-YAKHDNNDMAQTLL 1344
            ..| :.:|....:......:..:...:|..||:|||.:.||..:..||:| :||.| .:..::|.
Yeast  1578 GGEKVSIWVSWGDFLISHNEEQEARTILGNALKALPKRNHIEVVRKFAQLEFAKGD-PERGRSLF 1641

  Fly  1345 DDVVTSYPKRIDIWSVYVDMLIKAGLIDSARNVLERAVVQKLKPNKMQVIYKKYLQLEENHGTDA 1409
            :.:|...|||||:|:||||..:||.......::.||.:.:|:...:.:..:.|:||.||:.|.:.
Yeast  1642 EGLVADAPKRIDLWNVYVDQEVKAKDKKKVEDLFERIITKKITRKQAKFFFNKWLQFEESEGDEK 1706

  Fly  1410 TVAKVKQQAEQWVKNY 1425
            |:..||.:|.::|.::
Yeast  1707 TIEYVKAKATEYVASH 1722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5728NP_651245.1 S1_Rrp5_repeat_hs1_sc1 71..165 CDD:240198 21/129 (16%)
S1_like 172..243 CDD:299122 17/73 (23%)
S1_like 261..327 CDD:299122 16/76 (21%)
S1 530..591 CDD:197648 13/84 (15%)
TPR 1170..1403 CDD:223533 78/236 (33%)
TPR repeat 1320..1350 CDD:276809 10/30 (33%)
TPR repeat 1355..1382 CDD:276809 11/26 (42%)
RRP5NP_013956.1 S1_Rrp5_repeat_hs1_sc1 116..246 CDD:240198 22/131 (17%)
RpsA 276..888 CDD:223613 121/662 (18%)
RpsA 801..1385 CDD:223613 109/621 (18%)
TPR <1458..1667 CDD:223533 73/209 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157344840
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0539
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 225 1.000 Inparanoid score I756
Isobase 1 0.950 - 0 Normalized mean entropy S5233
OMA 1 1.010 - - QHG57197
OrthoFinder 1 1.000 - - FOG0005259
OrthoInspector 1 1.000 - - oto99034
orthoMCL 1 0.900 - - OOG6_100538
Panther 1 1.100 - - LDO PTHR23270
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1223
SonicParanoid 1 1.000 - - X3781
TreeFam 1 0.960 - -
1312.830

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