Protein Alignment Rrp5 and RRP5

DIOPT Version :10

• Sequence 1: NP_651245.1
• Gene: Rrp5 / 42899
• FlyBaseID: FBgn0039182
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_013956.1
• Gene: RRP5 / 855269
• SGDID: S000004842
• Length: 1729
• Species: Saccharomyces cerevisiae
• Alignment Length: 1791
• Identity: 365/1791 - (20%)
• Similarity: 667/1791 - (37%)
• Gaps: 473/1791 - (26%)

  Fly     5 EKSFPRGGT-----IHSEVKTDDVSLNIVFG-----ASQK-----KVKKAPKVKENLLSYETEEQ 54
            |.||||||.     :..:...::.:.:::||     ||:.     |.||..|...:..|..:...
Yeast    35 EVSFPRGGASALTPLELKQVANEAASDVLFGNESVKASEPASRPLKKKKTTKKSTSKDSEASSAN 99

  Fly    55 NGQLEAFSAETLNMDTLQEDMLVMGVVKELTATALQIALPGRMFARTLVADISDAYTRVAK---A 116
            :.:..|...|.:|..||:....::|.:..:|...|.|.....:.....:..||:.:|.:.:   .
Yeast   100 SDEARAGLIEHVNFKTLKNGSSLLGQISAITKQDLCITFTDGISGYVNLTHISEEFTSILEDLDE 164

  Fly   117 AMSGDT------------SEYH----------------DLTELFQLGRIVYGKAIKTEKLD---- 149
            .|..||            :||.                :|...|.:|:.:....||...|:
Yeast   165 DMDSDTDAADEKKSKVEDAEYESSDDEDEKLDKSNELPNLRRYFHIGQWLRCSVIKNTSLEPSTK 229

  Fly   150 -TGRVSLLLSLKPADVHGNLH-HKSIKKGFIFSGAVAEALEHGYVIESGVQGLQAFVPCEKP--- 209
             :.:..:.|:::|:.|  |:: .:.:.|......||....:||..::.|:.|...|: .:|.
Yeast   230 KSKKKRIELTIEPSSV--NIYADEDLVKSTSIQCAVKSIEDHGATLDVGLPGFTGFI-AKKDFGN 291

  Fly   210 AQKLHVGQLAFLKVKTVHHDTHQSTCTCVQVEQDQLRIKSQNETNLDYILPGSIVKFKVAKHLKD 274
            .:||..|.: ||...|...|    ....|..:....:.|....:::|.|:||.||........|:
Yeast   292 FEKLLPGAV-FLGNITKKSD----RSIVVNTDFSDKKNKITQISSIDAIIPGQIVDLLCESITKN 351

  Fly   275 GLKGSIMNESFSAYVNEHHLA--NALDTLDAYELNEDYNARVL---------YVMPLTKLVYLTL 328
            |:.|.:.. ..|..||..||.  :..|....:.:......|::         .|:.|:.|.:: |
Yeast   352 GIAGKVFG-LVSGVVNVSHLRTFSEEDLKHKFVIGSSIRCRIIACLENKSGDKVLILSNLPHI-L 414

  Fly   329 NLDIKTGAAVAKDQDEEEQEVEPIKVGSVVEKAKVLRLGSGGVVLLLNKKLKGIISYGSIRGNFK 393
            .|:         |.....:.::...:|...|...:....|..:.|.|:..     ..|.:..:..
Yeast   415 KLE---------DALRSTEGLDAFPIGYTFESCSIKGRDSEYLYLALDDD-----RLGKVHSSRV 465

  Fly   394 GNYDKDEVLSKYGRKTKHKVRILGYDVIESLYYCSDDPNVVNEKLFCLEDINAGDL--------- 449
            |..:..|.||.         |:|||..::.:|..|.||..:..|.....||..|:|
Yeast   466 GEIENSENLSS---------RVLGYSPVDDIYQLSTDPKYLKLKYLRTNDIPIGELLPSCEITSV 521

  Fly   450 ----VTAKI-------------------------FKKDDKIKG---------------------- 463
                :..||                         ||...|:||
Yeast   522 SSSGIELKIFNGQFKASVPPLHISDTRLVYPERKFKIGSKVKGRVISVNSRGNVHVTLKKSLVNI 586

  Fly   464 -------------------------WSVRIGKVNG-----------------ILEQFYLAPNVRY 486
                                     .::::.|.||                 |.|.|...|....
Yeast   587 EDNELPLVSTYENAKNIKEKNEKTLATIQVFKPNGCIISFFGGLSGFLPNSEISEVFVKRPEEHL 651

  Fly   487 DVGQSLKCRVLEVNAERK----ICYVSNR--------AEYLGKGIKILTDYASAHVGNVYMGTVV 539
            .:||::..::|:|:|:|:    .|.|||.        .|.:..|..|:|    .||       :.
Yeast   652 RLGQTVIVKLLDVDADRRRIIATCKVSNEQAAQQKDTIENIVPGRTIIT----VHV-------IE 705

  Fly   540 RCEDTYVLVKFGNGIKGVLH------------RQNLK------ENSSFFEGQTTKFRILTRN--- 583
            :.:|:.::.....|::||::            |..||      |.:.....:.|:.|:...:
Yeast   706 KTKDSVIVEIPDVGLRGVIYVGHLSDSRIEQNRAQLKKLRIGTELTGLVIDKDTRTRVFNMSLKS 770

  Fly   584 ---KDQITLTLP---EDKFQLGEICPVE--ITNALDAGLEVKITFAAEDDEEDEDGNPKLEEFVG 640
               ||....|||   :|...|.:..|:.  |.:..|.||.|..             |.|   |:|
Yeast   771 SLIKDAKKETLPLTYDDVKDLNKDVPMHAYIKSISDKGLFVAF-------------NGK---FIG 819

  Fly   641 LIPLRLLSDHLELLHAQMRVHPAGSYTDAACIMQNI---------------FSLR---------- 680
            |:......|..::           ..:.|..|.|::               .||:
Yeast   820 LVLPSYAVDSRDI-----------DISKAFYINQSVTVYLLRTDDKNQKFLLSLKAPKVKEEKKK 873

  Fly   681 -----DVPYFSGQLTKDWQSVQVGDIIRSYVKHAT-------------------------DQVVD 715
                 :.|..|.  .|.|..:.:|.|:::.:|...                         :::.|
Yeast   874 VESNIEDPVDSS--IKSWDDLSIGSIVKAKIKSVKKNQLNVILAANLHGRVDIAEVFDTYEEITD 936

  Fly   716 LMVCVRNYNKPVKVHVKMLRLNAVKNAPVELVPEQLLWVKVL----------SKEVETKTL---T 767
            ....:.||.|...:.||::..:.||:.....:..::....||          ||||.||:|   .
Yeast   937 KKQPLSNYKKDDVIKVKIIGNHDVKSHKFLPITHKISKASVLELSMKPSELKSKEVHTKSLEEIN 1001

  Fly   768 VSAKLTDVWSGDLSDTAKLVEGYLNEVAQIKAGLEEASAPISKYS--------VGEKINVVFKGI 824
            :..:||...:....:...|.   ::.|.:.:..|.:.:...|.:|        :|..:.|....|
Yeast  1002 IGQELTGFVNNSSGNHLWLT---ISPVLKARISLLDLADNDSNFSENIESVFPLGSALQVKVASI 1063

  Fly   825 DATTNDWVYTVEGNGKVSALLLSSLVGTAKAPEMGSKHEAVILWIEYSSDVLLISNKKLDIAHIS 889
            |          ..:|.|:|:..|.:.......::|.:....:|.|.....:|.:.||...|:.|:
Yeast  1064 D----------REHGFVNAIGKSHVDINMSTIKVGDELPGRVLKIAEKYVLLDLGNKVTGISFIT 1118

  Fly   890 PS-GELSTNLIGKAGMKAKV--LLKLESVAVCSLKKGTNPLVICPIRLHPNDIENSGSAELRQGD 951
            .: .:.|..|  |...:.|:  ::....::|....|... |.:.|.......|::  ..:|:||:
Yeast  1119 DALNDFSLTL--KEAFEDKINNVIPTTVLSVDEQNKKIE-LSLRPATAKTRSIKS--HEDLKQGE 1178

  Fly   952 FCN-----------IAFIHDKLHIAVP-----ETVWRLWRGVKRTAGTEVAPVKAKKAKVEESPK 1000
            ..:           ..::..|:...||     ::..:.|:...:       |::....||....:
Yeast  1179 IVDGIVKNVNDKGIFVYLSRKVEAFVPVSKLSDSYLKEWKKFYK-------PMQYVLGKVVTCDE 1236

  Fly  1001 QKKTTIEETSAQKKVKAKAKV-ETKTEAKA-------IPTKRKAEVVEKITNGQKKT--QPLTNG 1055
            ..:.::  |..:.::....|| :|.::.||       |.:.....|..|:.|....|  ..:|.
Yeast  1237 DSRISL--TLRESEINGDLKVLKTYSDIKAGDVFEGTIKSVTDFGVFVKLDNTVNVTGLAHITE- 1298

  Fly  1056 IVKEKPKQNGKLF-FEDK--------TPAKNAKSETPKSNGAEGKSRLPGVSSFW---------- 1101
            |..:||:....|| ..|:        .|.|...|.:.|::....::.|...::..
Yeast  1299 IADKKPEDLSALFGVGDRVKAIVLKTNPEKKQISLSLKASHFSKEAELASTTTTTTTVDQLEKED 1363

  Fly  1102 EDDVNQSKEGSSDEDEELNVAETQKNAAKKK--------RLSA--------KEKAKAEIKEEQ-- 1148
            ||:| .:..|.:|.|.|.::.:.....|.:|        .|||        .::|:.|.:.:|
Yeast  1364 EDEV-MADAGFNDSDSESDIGDQNTEVADRKPETSSDGLSLSAGFDWTASILDQAQEEEESDQDQ 1427

  Fly  1149 ------------RLRE--IEERNADPKARL-ETIDQYERLVIAQPNNSISWLKYIAFLLSNTEIE 1198
                        |.:|  ::::..|...|. |::..:|||:|..||:|:.|:.|:||.|..:|||
Yeast  1428 EDFTENKKHKHKRRKENVVQDKTIDINTRAPESVADFERLLIGNPNSSVVWMNYMAFQLQLSEIE 1492

  Fly  1199 KARALARRAISTISFRETQELRNMWSALLNMELVY--SNNFDDVLKEALNCNDPLEIYISVVDIL 1261
            |||.||.||:.||:|||..|..|:|.|:||:|..:  ....::|...|....|...|:..::.|.
Yeast  1493 KARELAERALKTINFREEAEKLNIWIAMLNLENTFGTEETLEEVFSRACQYMDSYTIHTKLLGIY 1557

  Fly  1262 KKNKRKDRLSSVLTTVLNKFKTE-LRVWPVAAEAYFWLGKSDQVHNLLQRALRALPNQEHIPCIV 1325
            :.:::.|:.:.:......||..| :.:|....:......:..:...:|..||:|||.:.||..:.
Yeast  1558 EISEKFDKAAELFKATAKKFGGEKVSIWVSWGDFLISHNEEQEARTILGNALKALPKRNHIEVVR 1622

  Fly  1326 SFAKL-YAKHDNNDMAQTLLDDVVTSYPKRIDIWSVYVDMLIKAGLIDSARNVLERAVVQKLKPN 1389
            .||:| :||.| .:..::|.:.:|...|||||:|:||||..:||.......::.||.:.:|:...
Yeast  1623 KFAQLEFAKGD-PERGRSLFEGLVADAPKRIDLWNVYVDQEVKAKDKKKVEDLFERIITKKITRK 1686

  Fly  1390 KMQVIYKKYLQLEENHGTDATVAKVKQQAEQWVKNY 1425
            :.:..:.|:||.||:.|.:.|:..||.:|.::|.::
Yeast  1687 QAKFFFNKWLQFEESEGDEKTIEYVKAKATEYVASH 1722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rrp5	NP_651245.1	S1_Rrp5_repeat_hs1_sc1	71..165	CDD:240198	21/129 (16%)
		S1_like	172..243	CDD:471952	17/73 (23%)
		S1_like	261..327	CDD:471952	16/76 (21%)
		S1	530..591	CDD:197648	13/84 (15%)
		PTZ00121	<981..>1220	CDD:173412	74/300 (25%)
		LapB	1134..1344	CDD:442196	69/238 (29%)
		TPR repeat	1320..1350	CDD:276809	10/30 (33%)
		TPR repeat	1355..1382	CDD:276809	11/26 (42%)
RRP5	NP_013956.1	S1_Rrp5_repeat_hs1_sc1	116..246	CDD:240198	22/131 (17%)
		S1_Rrp5_repeat_hs2_sc2	252..325	CDD:240199	17/78 (22%)
		S1	337..408	CDD:197648	15/71 (21%)
		S1_like	510..579	CDD:471952	9/68 (13%)
		S1_Rrp5_repeat_hs6_sc5	607..676	CDD:240203	13/68 (19%)
		rpsA	<624..779	CDD:235775	32/165 (19%)
		S1_Rrp5_repeat_hs8_sc7	777..862	CDD:239908	20/111 (18%)
		S1_Rrp5_repeat_hs11_sc8	895..967	CDD:240207	11/71 (15%)
		S1_Rrp5_repeat_hs12_sc9	1003..1071	CDD:240208	12/80 (15%)
		RpsA	1081..>1337	CDD:440305	48/270 (18%)
		LapB	1459..1712	CDD:442196	83/253 (33%)