DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5728 and AT3G11964

DIOPT Version :9

Sequence 1:	NP_651245.1	Gene:	CG5728 / 42899	FlyBaseID:	FBgn0039182	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001326789.1	Gene:	AT3G11964 / 820370	AraportID:	AT3G11964	Length:	1920	Species:	Arabidopsis thaliana

Alignment Length:	1970	Identity:	408/1970 - (20%)
Similarity:	701/1970 - (35%)	Gaps:	647/1970 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VPNEKSFPRGG--------------TIHSEVKTDD-VSLNIVFGASQKKVKKAPKVKENLLSYET 51
            ||:   |||||              .:.:|...|: ||.....|.|:|::   |...::|.....
plant    48 VPD---FPRGGGTSLSKKEREKLYEEVDAEFDADERVSKKSKGGKSKKRI---PSDLDDLGLLFG 106

  Fly    52 EEQNGQLEAFSAETLNMDTLQEDMLVMGVVKELTATALQIALPGRMFARTLVADISDAYTRVAKA 116
            ...:|:...: |..:....:...|.::|||.|:....:.|:|||.:......:::||...|
plant   107 GGLHGKRPRY-ANKITTKNISPGMKLLGVVTEVNQKDIVISLPGGLRGLVRASEVSDFTDR---- 166

  Fly   117 AMSGDTSEYHDLTELFQLGRIV--YGKAIKTEKLDTGRVSLLLSLKPADVHGNLHHKSIKKGFIF 179
            .:..|.:|.  |.::|.:|::|  ....:..:|.:.|:..:.|||:.:.:|......|.:.|.:|
plant   167 GIEDDENEL--LGDIFSVGQLVPCIVLELDDDKKEAGKRKIWLSLRLSLLHKGFSFDSFQLGMVF 229

  Fly   180 SGAVAEALEHGYVIESGVQGLQAFVPCEKPAQK---LHVGQL---AFLKV----KTVHHDTH-QS 233
            |..|....:||.::..|:..:..|:.......:   :..|||   ...|:    |.||..:. .|
plant   230 SANVKSIEDHGSILHFGLPSITGFIEISDDGNQESGMKTGQLIQGVVTKIDRDRKIVHLSSDPDS 294

  Fly   234 TCTCVQVEQDQLRIKSQNETNLDYILPGSIVKFKVAKHLKDGLKGSIMNESFSAYVNEHHLANAL 298
            ...|:        .|..:..:.|.::||.:|..:|...|::|:....:. .|:..|:..||.|.|
plant   295 VAKCL--------TKDLSGMSFDLLIPGMMVNARVQSVLENGILFDFLT-YFNGTVDLFHLKNPL 350

  Fly   299 DT---LDAYELNEDYNARVLYVMPLTKLVYLTLNLDIKTGAAVAKDQDEEEQEVEPIKV--GSVV 358
            ..   .|.|..|:..|||:|::.|.::.|.|||:..:....|            .|:.|  |.:.
plant   351 SNKSWKDEYNQNKTVNARILFIDPSSRAVGLTLSPHVVCNKA------------PPLHVFSGDIF 403

  Fly   359 EKAKVLRLGSGGVVLLLNKKLKGIISYGSIRGNFKGNYDK--DEV--LSKYGRKTKH-KVRILGY 418
            ::|||:|:...|::|.|..|.....:|.|       .||.  |||  |.|..::..| :||:||.
plant   404 DEAKVVRIDKSGLLLELPSKPTPTPAYVS-------TYDAAGDEVTKLEKKFKEGNHIRVRVLGL 461

  Fly   419 DVIESLYYCSDDPNVVNEKLFCLEDINAGDLVTAKIFKKDD-----KIKGWSVRIGKVNGILEQF 478
            ..:|.|...:...:.....:|...|:..|.:..||:...|.     :..|....:..:..:.|..
plant   462 KQMEGLAVGTLKESAFEGPVFTHSDVKPGMVTKAKVISVDTFGAIVQFSGGLKAMCPLRHMSEFE 526

  Fly   479 YLAPNVRYDVGQSLKCRVLEVNAERKICYVSNRAEYLGKGIKILTDYASAHVGNVYMGTVVRCED 543
            ...|..::.||..|..|||...::|  ..|:.:...:...:.||:.|..|..|.|..|.:.:.|.
plant   527 VTKPRKKFKVGAELVFRVLGCKSKR--ITVTYKKTLVKSKLPILSSYTDATEGLVTHGWITKIEK 589

  Fly   544 TYVLVKFGNGIKGVLHRQNL------KENSSFFEGQTTKFRILT--RNKDQITLTL--------P 592
            ....|:|.||::|.:.|..|      ..:|.|..|:..|.|:.:  ....:|||:.        .
plant   590 HGCFVRFYNGVQGFVPRFELGLEPGSDPDSVFHVGEVVKCRVTSAVHGTQRITLSFMIKPSSVSE 654

  Fly   593 EDKFQLGEICPVEITNALDAGLEVKI--------TFAAE---DDEED------------------ 628
            :|..:||.|....|.......:.|::        |.:||   |..|.
plant   655 DDSIKLGSIVSGIIDTITSQAVIVRVKSKSVVKGTISAEHLADHHEQAKLIMSLLRPGYELDKLL 719

  Fly   629 ----EDGNPKLEEFVGLIPL--RLLSDHLELLHAQMRVH-------------------------- 661
                |..|..|.....||.|  .|.|| ...|.....||
plant   720 VLDIEGNNMALSSKYSLIKLAEELPSD-FNQLQPNSVVHGYVCNLIENGCFVRFLGRLTGFAPRS 783

  Fly   662 -----PAGSYTDAACIMQNI---------------FSLRD-----------VPYF---------- 685
                 |....:::..:.|::               .||:.           ..||
plant   784 KAIDDPKADVSESFFVGQSVRANIVDVNQEKSRITLSLKQSSCASVDASFVQEYFLMDEKISDLQ 848

  Fly   686 SGQLTK---DW-QSVQVGDIIRSYVKHATD----------------------------------- 711
            |..:||   .| :...:|.:|:..::...|
plant   849 SSDITKSDCSWVEKFSIGSLIKGTIQEQNDLGVVVNFDNINNVLGFIPQHHMGGATLVPGSVVNA 913

  Fly   712 ---------QVVDLMV---CVRNYNKPVKVHVKMLRLNAVK---------NAPVELVPEQLLWVK 755
                     ::|||.:   .:.|..|.|....|..|...:.         :|.||:|.||.|
plant   914 VVLDISRAERLVDLSLRPELLNNLTKEVSNSSKKKRKRGISKELEVHQRVSAVVEIVKEQHL--- 975

  Fly   756 VLS-----------------------KEVET-KTLTVSAK-------------LTDVWSGDLSDT 783
            |||                       |:..| :::..|.|             |.|..|| .|:|
plant   976 VLSIPEHGYTIGYASVSDYNTQKLPVKQFSTGQSVVASVKAVQNPLTSGRLLLLLDSVSG-TSET 1039

  Fly   784 AK--------------LVEGYLNEV----AQIKAG-----------LEEASA---PISKYSVGEK 816
            ::              :|...:.|:    .::..|           :.:||.   |.:|:.||:.
plant  1040 SRSKRAKKKSSCEVGSVVHAEITEIKPFELRVNFGNSFRGRIHITEVNDASTSDEPFAKFRVGQS 1104

  Fly   817 INV----------------------------------------------------VFKGIDATTN 829
            |:.                                                    |:| :|   .
plant  1105 ISARVVAKPCHTDIKKTQLWELSVKPAMLKDSSEFNDTQESEQLEFAAGQCVIGYVYK-VD---K 1165

  Fly   830 DWVY-TVEGNGKVSALLLSSLVGTAKAPEM---------GSKHEAVILWIEYSSDVLLISNKKLD 884
            :||: .|..|......:|.:   :.||.|:         |......:|........|.:..:.|.
plant  1166 EWVWLAVSRNVTARIFILDT---SCKAHELEEFERRFPIGKAVSGYVLTYNKEKKTLRLVQRPLL 1227

  Fly   885 IAHISPS------------------------------GELSTNLIGKAGMKAKV----------- 908
            ..|.|.:                              |.:|..|.|..|::.::
plant  1228 FIHKSIANGGGSKTDKPDSSIPGDDDTLFIHEGDILGGRISKILPGVGGLRVQLGPYVFGRVHFT 1292

  Fly   909 ------------------LLKLESVAVCSLKKGTNPLVICPIR---------------LHPND-- 938
                              .:|.:.:.:.|..|||..:.: .:|               |..||
plant  1293 EINDSWVPDPLDGFREGQFVKCKVLEISSSSKGTWQIEL-SLRTSLDGMSSADHLSEDLKNNDNV 1356

  Fly   939 -------------------IENSGS------------AELRQGDFCNIAFIHDKLHIAVPE---T 969
                               ::|:.|            |::|..:.|: .|:.:      ||   .
plant  1357 CKRFERIEDLSPDMGVQGYVKNTMSKGCFIILSRTVEAKVRLSNLCD-TFVKE------PEKEFP 1414

  Fly   970 VWRLWRG-------VKRTAGTEVAPVKAKKAKVEESPKQKK--------------------TTIE 1007
            |.:|..|       :.:.....:..|.|......||...||                    ..|:
plant  1415 VGKLVTGRVLNVEPLSKRIEVTLKTVNAGGRPKSESYDLKKLHVGDMISGRIRRVEPFGLFIDID 1479

  Fly  1008 ET-------------SAQKKVKAKAKVETKTEAKAIPTKRKAEVVEKITNGQK----------KT 1049
            :|             ...:.|:|:.|......||.:   :..|..::|:.|.|          |.
plant  1480 QTGMVGLCHISQLSDDRMENVQARYKAGESVRAKIL---KLDEEKKRISLGMKSSYLMNGDDDKA 1541

  Fly  1050 QPLTNGIVKEKPKQNGKLFFEDKT-----PAKNAKSET----------PKSNG-------AEGKS 1092
            |||:                ||.|     |..:.|||.          ..|.|       .|.::
plant  1542 QPLS----------------EDNTSMECDPINDPKSEVLAAVDDFGFQETSGGTSLVLAQVESRA 1590

  Fly  1093 RLPGVSSFWEDDVNQSKEGSSDEDEELNVAETQKNAAKKKRLSAKEKAKAEIKEEQRLREIEERN 1157
            .:|.:.... ||:.::...||...|:|      ..|.|.::...:||.|.:.:.|::::..|.|.
plant  1591 SIPPLEVDL-DDIEETDFDSSQNQEKL------LGANKDEKSKRREKQKDKEEREKKIQAAEGRL 1648

  Fly  1158 ADPKARLETIDQYERLVIAQPNNSISWLKYIAFLLSNTEIEKARALARRAISTISFRETQELRNM 1222
            .:..|. |..|::|:||.:.||:|..|:||:||:||..:|||||::|.||:.||:.||.:|..|:
plant  1649 LEHHAP-ENADEFEKLVRSSPNSSFVWIKYMAFMLSLADIEKARSIAERALRTINIREEEEKLNI 1712

  Fly  1223 WSALLNMELVYSNNFDDVLKEALN-----CNDPLEIYISVVDILKKNKRKDRLSSVLTTVLNKFK 1282
            |.|..|:|..:.|..::.:|:...     | ||.::|::::.:.::.::......:|..::.|||
plant  1713 WVAYFNLENEHGNPPEESVKKVFERARQYC-DPKKVYLALLGVYERTEQYKLADKLLDEMIKKFK 1776

  Fly  1283 TELRVWPVAAEAYFWLGK--------SDQVHNLLQRALRALPNQEHIPCIVSFAKLYAKHDNNDM 1339
            ...::         ||.|        .:.:.:::.|||..||..:||..|...|.|..|....|.
plant  1777 QSCKI---------WLRKIQSSLKQNEEAIQSVVNRALLCLPRHKHIKFISQTAILEFKCGVADR 1832

  Fly  1340 AQTLLDDVVTSYPKRIDIWSVYVDMLIKAGLIDSARNVLERAVVQKLKPNKMQVIYKKYLQLEEN 1404
            .::|.:.|:..||||.|:||||:|..|:.|..|..|::.|||:...|.|.||:.::||:|:.|::
plant  1833 GRSLFEGVLREYPKRTDLWSVYLDQEIRLGEDDVIRSLFERAISLSLPPKKMKFLFKKFLEYEKS 1897

  Fly  1405 HGTDATVAKVKQQAEQWVKN 1424
            .|.:..|..|||:|.::..:
plant  1898 VGDEERVEYVKQRAMEYANS 1917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5728	NP_651245.1	S1_Rrp5_repeat_hs1_sc1	71..165	CDD:240198	23/95 (24%)
		S1_like	172..243	CDD:299122	18/81 (22%)
		S1_like	261..327	CDD:299122	20/68 (29%)
		S1	530..591	CDD:197648	19/68 (28%)
		TPR	1170..1403	CDD:223533	82/245 (33%)
		TPR repeat	1320..1350	CDD:276809	9/29 (31%)
		TPR repeat	1355..1382	CDD:276809	12/26 (46%)
AT3G11964	NP_001326789.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	92	1.000	Domainoid score	I2605
eggNOG	1	0.900	-	-		E1_COG0539
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	308	1.000	Inparanoid score	I749
OMA	1	1.010	-	-		QHG57197
OrthoDB	1	1.010	-	-		D23482at2759
OrthoFinder	1	1.000	-	-		FOG0005259
OrthoInspector	1	1.000	-	-		oto3479
orthoMCL	1	0.900	-	-		OOG6_100538
Panther	1	1.100	-	-	LDO	PTHR23270
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3781
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840