DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5728 and Pdcd11

DIOPT Version :9

Sequence 1:	NP_651245.1	Gene:	CG5728 / 42899	FlyBaseID:	FBgn0039182	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001101074.2	Gene:	Pdcd11 / 309458	RGDID:	1304933	Length:	1876	Species:	Rattus norvegicus

Alignment Length:	1919	Identity:	434/1919 - (22%)
Similarity:	724/1919 - (37%)	Gaps:	556/1919 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EKSFPRGGT--IHSEVKTDD--VSLNIVFGAS-------QKKVKKAPKVKENLLSYETEEQNGQL 58
            |:|||||||  .|...|:..  |..:.:|..|       :||.:|.| .|...|..|..:.|..:
  Rat     5 EESFPRGGTRKPHKSEKSSQPVVEQDNLFDISTEEGSVKRKKSQKGP-AKTKKLKIEKRKSNKSM 68

  Fly    59 -EAFSAETLNMDTLQEDMLVMGVVKELTATALQIALPGRMFARTLVADISDAYTRV--AKAAMSG 120
             |.|  |.|::::|.|.|.::|.|||:....|.::||..:.....|.:|.||||:.  .:.|...
  Rat    69 KEKF--EILSLESLCEGMRILGCVKEVNELELVVSLPNGLQGFVQVTEICDAYTQKLNEQVAQEE 131

  Fly   121 DTSEYHDLTELFQLGRIVYGKAIKTEKLDTGRVSLLLSLKPADVHGNLHHKSIKKGFIFSGAVAE 185
            ...:...|.|||..|.:|.......:..::|:.|:.||:.|..|:..|..::::.|.:.:|.|:.
  Rat   132 PLEDLLRLPELFSPGMLVRCVVSSLDVTESGKKSVKLSVNPKRVNKVLSAEALRPGMLLTGTVSS 196

  Fly   186 ALEHGYVIESGVQGLQAFVPCEKPAQ---------KLHVGQLAFLKVKTVHHDTHQSTCTCVQVE 241
            ..:|||:::.||.|.:||:..:|..:         |..|||.....|:.:..:   .....:.||
  Rat   197 LEDHGYLVDIGVDGTRAFLSLQKAQEYIRQKNKGAKFKVGQYLTCVVEELKSN---GGVVSLSVE 258

  Fly   242 QDQLR---IKSQNETNLDYILPGSIVKFKVAKHLKDGLKGSIMNESFSAYVNEHHLANALDTLDA 303
            ..|:.   ...:...||:.:|||.:|:.:|.|..:.||:.:.:. .|:..|:..||..  ..:.:
  Rat   259 HSQVSSAFATEEQSWNLNNLLPGLVVRAQVQKVTQFGLQLNFLT-FFTGLVDFMHLEP--KKMGS 320

  Fly   304 YELNEDYNARVLYVMPLTKLVYLTLN-LDIKTGAAVAKDQDEEEQEVEPIKVGSVVEKAKVLR-L 366
            |...:...|.:|.|.|.|::|.|:|. :.:..|..:.:        :...::|:|::.|.|.. .
  Rat   321 YSSKQTVKACILCVHPRTRVVRLSLRPIFLHPGRPLTR--------ISYQQLGTVLDDASVEGFF 377

  Fly   367 GSGGVVLLLNKKLKGIISYGSIRGNFKGNYDKDEVLSKYGRK--TKHKVRILGYDVIESLYYCSD 429
            ...|.:..|.   .|:::|..:    ....|..:..|....|  :.|:.||:.|..::.|...|.
  Rat   378 EKAGAIFRLR---DGVLAYARL----SHLSDSKKAFSAEAFKLGSTHRCRIIDYSQMDELALLSL 435

  Fly   430 DPNVVNEKLFCLEDINAGDLVTAKIFKKDDKIKGWSVRIG-KVNGILEQFYLA------PNVRYD 487
            ..:::.......:||..|.:|..|:...  |..|..|::| ::.|::...:||      |..:::
  Rat   436 RKSIIAAPFLRYQDIKTGTIVKGKVLAL--KPFGMLVKVGEQMRGLVPSMHLADIMMKNPEKKFN 498

  Fly   488 VGQSLKCRVLEVNAERKICYVSNRAEYLGKGIKILTDYASAHVGNVYMGTVVRCEDTYVLVKFGN 552
            .|..:|||||..:.|.|...::.:...:...:..:|.|..|..|....|.::|.:|...||||.|
  Rat   499 TGDEVKCRVLLCDPEAKKLIMTLKKTLVTSKLPAITCYEDAKPGLQTHGVIIRVKDYGCLVKFYN 563

  Fly   553 GIKGVLHRQNLK------ENSSFFEGQTTKFRILT--RNKDQITLTL-------PEDK------- 595
            .::|::.:..|.      ....|:.||..|..:|.  .:|:::.|:.       |:|:
  Rat   564 DVQGLVPKHELSAQHIPDPERVFYTGQVVKVAVLNCEPSKERMLLSFKLLSGSEPKDESVKNSKK 628

  Fly   596 ----FQLGEICPVEITNALDAGLEVKITFAAEDDEEDEDGNPKLEEFVGLIPLRLLSDHL---EL 653
                ...|::..|::......||||.|.             |  ......:|...||||:   .|
  Rat   629 KGSTVNTGQLVDVKVLEKTKNGLEVAIL-------------P--HNIPAFLPTPHLSDHVANGPL 678

  Fly   654 LHAQMRVHPAGSYTDAACIMQ---NIFSLRDVPYFS----GQLTKDWQSVQVGDIIRSYVKHATD 711
            ||..::.  ..:.....|:.|   :|...|.....|    ||..|....:|.|.::..:||
  Rat   679 LHHWLQT--GDTLHRVLCLSQSEKHILLCRKPALVSTVEGGQDPKSLSEIQPGMLLIGFVK---- 737

  Fly   712 QVVDLMVCVRNYNKPVKVHVKMLRLNAVKNAPVE-LVPEQLLWVKVLSKEVETKTLTVSAKLTDV 775
            .:.|..|.|:..:....:..|.:..:.....|.| .|..|.:..||.:.:...:.:.:|.:|:|.
  Rat   738 SIKDYGVFVQFPSGLSGLSPKTIMSDKFVTTPSEHFVEGQTVVAKVTNVDESKQRMLLSLRLSDC 802

  Fly   776 WSGDLSDT------------------------------AKLVEGYLNEVAQIKAGLEEAS----- 805
            ..||.:.|                              |.:..|.:.: |.::..||..|
  Rat   803 SLGDSASTSFLLLCQCLEELQGIRSLMSNQDSVLIQTLADMTPGMVLD-AMVQEVLENGSVVFGG 866

  Fly   806 API-------SKY-------SVGEKINVVFKGIDATT--------NDWV---------------- 832
            .|:       |:|       ..|:|..||...:||..        .|.|
  Rat   867 GPVPDLILRASRYHRAGQELEPGQKKKVVVLHVDALKLEVHVSLHQDLVNRKARKLRKNSRHQGI 931

  Fly   833 -----------YTVEGNGKVSALLLSSL------------VG-----TAKAPE------------ 857
                       ..||....|:..|:|.|            ||     |.|..|
  Rat   932 VQHLEESFAVASLVETGHLVAFSLISHLNDTFHFDSEKLRVGQGVCLTLKTTEPGVTGLILAVEG 996

  Fly   858 -------------------------------------------MGSKHEAVILWIEYSSDVLLIS 879
                                                       :|.|....|..::.:..|:.:.
  Rat   997 PASKRIRMPAQRDSETVDDKGEEEEEEEEEDLTVRSKKSHSLAIGDKVTGTIKSVKATHAVVTLD 1061

  Fly   880 NKKLDIAHIS------PSGELSTNLIGKAGMK--AKVL--------------------------- 909
            :..:...|:|      |.|...|..: |||.|  |:|:
  Rat  1062 DGFIGCIHVSRILDDVPEGVSPTTTL-KAGKKVTARVIGGRDVKTSKFLPISHPRFVLTILELSV 1125

  Fly   910 -----------LKLESVA--------------VCSLKK-----------------GTNPLVICPI 932
                       |...||:              .|.|||                 |..||::..:
  Rat  1126 RPSELKGDYRALNTHSVSPMEKIRQYQAGQTVTCFLKKYNVMKKWLEVDIEPDIRGRIPLLLTSL 1190

  Fly   933 RL----HPN----------------DIENS-------GSAELRQGDFCN---IAFIHDK-LHIAV 966
            ..    ||:                ||..:       |..:|.:||...   :..:.:| |.::.
  Rat  1191 SFKVLKHPDKKFQIGQAIKATVVGPDIPRAFLCLSLIGPYKLEEGDVAMGRVLKVLPNKGLTVSF 1255

  Fly   967 P------ETVWRLWRGVKRTAGTEVAPVK--------------AKKAKVEESPKQKKTTIEE--- 1008
            |      .:|:.|.........|:..|.|              |...:...:.|:.|:.||:
  Rat  1256 PFGRIGKVSVFHLSDSYSEEPLTDFCPQKIVRCYILSTAHRMLALSLRSSRTNKETKSKIEDPEV 1320

  Fly  1009 --------------------------------------------TSAQKKVKAKAKVETKTEAKA 1029
                                                        .|.:|::..|...|.|.....
  Rat  1321 NSIEDIQAGQLLRGYVKSILPSSVVIGLGPSVMGLVKHSHVSQCVSREKELYDKCLPEGKLVTAR 1385

  Fly  1030 I----PTKRKAEV------------------------------VEKITNGQKKTQPLTNGIVKEK 1060
            :    |.|...|:                              .||...|:.|.........::.
  Rat  1386 VLCVNPKKNLIELSLLPSDTGKPDVFSASPEPPLPKQEGREGGTEKGLKGESKRSQRRREKNQKM 1450

  Fly  1061 PKQNGKLFFEDKTPAKN------------AKSETPKSNGAEGKSRLP-----GVSSFW---EDDV 1105
            .:::|....|.|.|.|:            ::||....|....||..|     ||..::   ||:|
  Rat  1451 REESGLYSQEKKEPRKSQRGGQSKRERQESESEQELVNKRPKKSGAPEDDDSGVEVYYREGEDEV 1515

  Fly  1106 NQSK-------------------------------------EGSSDEDEELNVAETQKNAAKKKR 1133
            .:.|                                     .|.|.:.||    :.|.:.||||:
  Rat  1516 EEPKVPPGGKQSKPTEVPRLQLSKGFIWDVGLDSLTPALPLRGESSDSEE----DEQPHQAKKKK 1576

  Fly  1134 LSAKEKAKAEIKEEQRLREIEERNADPKARLETIDQYERLVIAQPNNSISWLKYIAFLLSNTEIE 1198
             ..||:...:.|.|:.|..|||...||..:.|:.|.::|||::.||:||.||:|:||.|..||||
  Rat  1577 -GKKERELEKQKAEKELSRIEEALMDPGRQPESADDFDRLVLSSPNSSILWLQYMAFHLQATEIE 1640

  Fly  1199 KARALARRAISTISFRETQELRNMWSALLNMELVYSN--NFDDVLKEALNCNDPLEIYISVVDIL 1261
            ||||:|.||:.||||||.||..|:|.||||:|.:|.:  :...|.:.|:..|:||::::.:.||.
  Rat  1641 KARAVAERALKTISFREEQEKLNVWVALLNLENMYGSQESLAKVFERAVQYNEPLKVFLHLADIY 1705

  Fly  1262 KKNKRKDRLSSVLTTVLNKFKTELRVWPVAAEAYFWLGKSD--QVHNLLQRALRALPNQEHIPCI 1324
            .|:::......:...:|.:|:.|..||  .....|.||:|.  ..|.:|||||..||.:||:..|
  Rat  1706 TKSEKFKEAGELYNRMLKRFRQEKAVW--IKYGAFVLGRSQAGASHRVLQRALECLPTKEHVDVI 1768

  Fly  1325 VSFAKLYAKHDNNDMAQTLLDDVVTSYPKRIDIWSVYVDMLIKAGLIDSARNVLERAVVQKLKPN 1389
            |.||:|..:..:.:.|:.:.::.:|:||||.|:||||:||.||.|.....|::.||.:...|.|.
  Rat  1769 VKFAQLEFQLGDVERAKAIFENTLTTYPKRTDVWSVYIDMTIKHGSQKEVRDIFERVIHLSLAPK 1833

  Fly  1390 KMQVIYKKYLQLEENHGTDATVAKVKQQAEQWVK 1423
            :|:..:|:||..|:.|||:..|..||.:|.::|:
  Rat  1834 RMKFFFKRYLDYEKQHGTEKDVQAVKAKALEYVE 1867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5728	NP_651245.1	S1_Rrp5_repeat_hs1_sc1	71..165	CDD:240198	28/95 (29%)
		S1_like	172..243	CDD:299122	19/79 (24%)
		S1_like	261..327	CDD:299122	17/65 (26%)
		S1	530..591	CDD:197648	18/68 (26%)
		TPR	1170..1403	CDD:223533	97/236 (41%)
		TPR repeat	1320..1350	CDD:276809	7/29 (24%)
		TPR repeat	1355..1382	CDD:276809	13/26 (50%)
Pdcd11	NP_001101074.2	RpsA	65..633	CDD:223613	140/592 (24%)
		S1_Rrp5_repeat_hs1_sc1	80..176	CDD:240198	28/95 (29%)
		S1_Rrp5_repeat_hs2_sc2	183..263	CDD:240199	20/82 (24%)
		S1_Rrp5_repeat_hs3	281..344	CDD:240200	17/65 (26%)
		S1_Rrp5_repeat_hs4	365..435	CDD:240201	16/76 (21%)
		S1_Rrp5_repeat_hs5	453..521	CDD:240202	19/69 (28%)
		RpsA	537..1138	CDD:223613	108/623 (17%)
		S1_Rrp5_repeat_hs6_sc5	542..611	CDD:240203	18/68 (26%)
		S1_Rrp5_repeat_hs7	636..707	CDD:240204	19/87 (22%)
		S1_Rrp5_repeat_hs8_sc7	715..797	CDD:239908	17/85 (20%)
		S1_like	846..910	CDD:299122	14/64 (22%)
		S1_like	925..993	CDD:299122	11/67 (16%)
		S1_Rrp5_repeat_hs11_sc8	1041..1110	CDD:240207	15/69 (22%)
		S1_Rrp5_repeat_hs12_sc9	1154..1228	CDD:240208	11/73 (15%)
		S1_Rrp5_repeat_hs13	1232..1303	CDD:240209	12/70 (17%)
		S1_like	1326..1399	CDD:299122	8/72 (11%)
		TPR	<1592..1797	CDD:223533	83/206 (40%)
		TPR repeat	1625..1651	CDD:276809	17/25 (68%)
		TPR repeat	1664..1691	CDD:276809	9/26 (35%)
		TPR repeat	1696..1723	CDD:276809	3/26 (12%)
		TPR repeat	1728..1758	CDD:276809	13/31 (42%)
		Suf	1731..>1871	CDD:283497	55/139 (40%)
		TPR repeat	1765..1789	CDD:276809	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346112
Domainoid	1	1.000	109	1.000	Domainoid score	I6267
eggNOG	1	0.900	-	-		E1_COG0539
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	402	1.000	Inparanoid score	I1864
OMA	1	1.010	-	-		QHG57197
OrthoDB	1	1.010	-	-		D23482at2759
OrthoFinder	1	1.000	-	-		FOG0005259
OrthoInspector	1	1.000	-	-		oto95670
orthoMCL	1	0.900	-	-		OOG6_100538
Panther	1	1.100	-	-	LDO	PTHR23270
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3781
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770