DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5728 and SPCC1183.07

DIOPT Version :9

Sequence 1:	NP_651245.1	Gene:	CG5728 / 42899	FlyBaseID:	FBgn0039182	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_587890.1	Gene:	SPCC1183.07 / 2538897	PomBaseID:	SPCC1183.07	Length:	1690	Species:	Schizosaccharomyces pombe

Alignment Length:	1756	Identity:	375/1756 - (21%)
Similarity:	670/1756 - (38%)	Gaps:	438/1756 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NE--KSFPRGGTIH----------SEVKTDDVSLNIVFGASQKKVKKAPKVKENLLSYETEEQNG 56
            ||  :.|||||...          .|.|.|  .:....|.::...|..||.|.:..|.::|..|.
pombe    29 NEATQDFPRGGASSLTPLEYKEAVLEAKKD--FMESASGTAELSKKTRPKKKGSKKSSKSELDNE 91

  Fly    57 QLEAFSAETLNMDTLQEDMLVMGVVKELTATALQIALPGRMFARTLVADISD------------A 109
            :......::|....:....|::|.:.::....|.::||..:.....:.:|||            |
pombe    92 ENLKVHIQSLRYKNITPGSLILGQIAQINTLDLAVSLPNCLTGYVPITNISDKLSDRLDSIDNHA 156

  Fly   110 YTRVAKAAMSGDTSEYHDLTELFQLGRIVYGK--AIKTEK-LDTGRVSLLLSLKPADVHGNLHHK 171
            ....|.....| .::..||.:|:::|:.|...  |:.:|. ..||:..:.|||||.|.:|:....
pombe   157 EDNAATEEEDG-LNQIPDLMDLYKVGQWVRVSVTALGSENTTKTGKRHIELSLKPQDANGSAPEA 220

  Fly   172 S-IKKGFIFSGAVAEALEHGYVIESGVQGLQAFVPCEKPAQKLHVGQLAFLKVKTVHHDTHQSTC 235
            : ...|.:....|:...:||.|.:.|:.....|:      .|.|:....|::        .||..
pombe   221 ADFVAGSMIQAVVSSIEDHGIVFDIGINNYTGFL------SKKHINDFPFVE--------GQSLL 271

  Fly   236 TCVQVEQDQLRIKSQNET---------NLDYILPGSIVKFKVAKHLKDGLKGSIMN-ESFSAYVN 290
            ..|..::|::...|...|         ::..||||..:...|....:.|:....|. ...::.:.
pombe   272 CSVISKEDRIFHLSLTATSTKALEVMPSVQAILPGDYINVLVTDIKESGVIAKYMGVVDVTSDIY 336

  Fly   291 EHHLANALDTLDAYELNEDYNARVLYVMP------LTKLVYLTLNLDIKTGAAVAKDQDEEEQEV 349
            ........|..|.::|.:...||||:|:|      ....:...|..:..|......||
pombe   337 HSSPVKGEDLEDKFQLAKSVPARVLFVIPGDPPKIAVSFLPHVLTFNFATPNTPHPDQ------- 394

  Fly   350 EPIKVGSVVEKAKVLRLGSG-GVVL---------------LLNKKLKGIISYGSIRGNFKGNYDK 398
              :.:|.:|..|||..:.|. ||..               |.:||:.| ||..|      |.|..
pombe   395 --LDIGFIVNAAKVTYVSSSLGVFCDVGVPEISGFAHISRLSDKKVAG-ISPNS------GPYKV 450

  Fly   399 DEVLSKYGRKTKHKVRILGYDVIESLYYCSDDPNVVNEKLFCLEDINAGDLVTAKIFKKDDKIKG 463
            |         :.|:.||:.|..:::||..|...:|:|::...:|||..|..|...|.|...  :|
pombe   451 D---------STHEARIINYSYVDNLYILSFQQSVLNQQFLRIEDIEVGQFVDGTIAKLIP--QG 504

  Fly   464 WSVRIGK-VNGILEQFYLA------PNVRYDVGQSLKCRVLEVNAERKICYVSNRAEYLGKGIKI 521
            ..|.|.: :||::...::|      |..|:.||.|:|||||..|..||...::.:...|...:.:
pombe   505 IVVTISEGINGLVPSTHMADIALQFPERRFKVGSSVKCRVLSTNVLRKRVLLTLKKSLLNTDLPL 569

  Fly   522 LTDYASAHVGNVYMGTVVRCEDTYVLVKFGNGIKGVLHRQNLKE------NSSFFEGQT------ 574
            :.||..|..|...:||:.|..:...:|:|.|.::..|....:.|      ...|..|||
pombe   570 IYDYEQATPGTQTVGTLARIFEDGAIVEFYNSVRAFLPVSEMSEAYIRDAREHFKVGQTLSVTIV 634

  Fly   575 ------TKFR----------------------------ILTRNKDQITLTLPEDK----FQLGEI 601
                  .|.|                            :|.:.:|.:.:.| .||    ..||::
pombe   635 SCDPENRKMRVGCREQSWDAKRLERFENIKAGSVLSGIVLQKTEDSVIVDL-GDKVTGVITLGQL 698

  Fly   602 CP------VEITNALDA---------------------GLEVKITFAAEDDE------------- 626
            |.      .::.|.|.|                     .|:..:..||:::.
pombe   699 CDGDLNKCSKVMNKLRASTKLAEVLVLRKDTSKKLISLSLKKSLVEAAKENRMPINITDLKEGIK 763

  Fly   627 ---------------EDEDG----NPKL---EEFVGL----------IPLRLLSDHLELLHAQMR 659
                           |..||    .||.   ||:|.:          :....||..|....|.|.
pombe   764 YFGFVRNATTFGVFVEFCDGLVALVPKAYISEEYVPVPSAVYKPQQSVTCVCLSVELSQEKAFMS 828

  Fly   660 VHPAGSYTDAAC-IMQNIFSLRDVP----------YFSGQLTKDWQ------------------- 694
            ..|.....:.|. .|::.:.: |.|          |.:|::|  |.
pombe   829 FKPLAQKQEKAVEFMESKYDI-DNPVDETIKKTYDYVAGKIT--WAVVTSAKASQLNVDLAANVH 890

  Fly   695 -SVQVGDIIRSYVKHATDQVVDLMVCVRNYNKPVKVHVKMLRLNAVKN---APV--ELVPEQLLW 753
             .|.|.::..::     .::||....::.::|..|:.|::|.::..:|   .|:  .:.|:|.|.
pombe   891 GRVDVSEVFDNF-----GEIVDPNKPLKRFHKGDKIRVRVLGIHDSRNHKFLPISHRVSPKQFLE 950

  Fly   754 VKVLSKEVETKTLTVSAKLTDVWSGDLSDTAKLVEGYLNEVAQIKAGLEEASAPISKYSVGEKIN 818
            :.|....:..:..  |.|......||      .|.|::|.|              ||..|
pombe   951 LSVRPSILNMEPF--SMKEPQFKKGD------EVTGFVNNV--------------SKECV----- 988

  Fly   819 VVFKGIDATTNDWV-YTVEGNGKVSALLLSSLVGTAKAPEMGS--KH----EAVILWIEYSSDVL 876
                        || .|...||::..|.|     |....|:.|  ||    :|:..::..:.|.:
pombe   989 ------------WVSLTPSVNGRIPILDL-----TTDVKELNSLQKHFFLGKAIKCYVVNAEDSI 1036

  Fly   877 LIS-------------NKKL--DIAHISPSGEL-----------------------------STN 897
            .:|             ..:|  .:.:::.:|.:                             ..|
pombe  1037 TLSAIGPLQGFENLTPGSRLVGKVTNVNEAGAILQLPGHMSGRVSRIDMFDDYDILPETKFTRNN 1101

  Fly   898 LIGKAGMKAKVLLKLESVAVCSLKKGTNPLVICPIRLHPNDIENSGSAELRQGDFCNIA----FI 958
            |:|...:...|..:..:::..:.:..:.|:.|....:  |.:::....::.:|..||:|    |:
pombe  1102 LVGVCVLSVDVPNRKVALSARNSRTQSQPVEIKDKEI--NSVDDLKIGDICRGFVCNVANQGLFV 1164

  Fly   959 ---HDKL-HIAVPETV------WRLWRGVKRTAGTEVAPVKAKKAKVEESPKQKKTTIEETSAQK 1013
               |:.: .:.:.|..      |:....|.:.....:..:.....::|.|.||.|  |:::|...
pombe  1165 TIGHNLIARVKIGELFDTFIKDWKPHFHVNQLVKGSIVGIDNDSKRIEMSLKQSK--IKDSSEIT 1227

  Fly  1014 KVKAKAKVETKTEAKAIPTK------------------RKAEV-------VEKITNGQKKTQPLT 1053
            |..|...|.:..:...:...                  .|:|:       :.|:.:...|.:...
pombe  1228 KTFADIAVGSNLDGTVVKVGDYGVLIRIDGTDNIVGLCHKSEIADAVVLNISKLYSSGDKVRAHV 1292

  Fly  1054 NGIVKEKPKQNGKL---FFEDKTPAKNAKSETPKSNGAEGKSRLPGVSSFWEDDVN----QSKEG 1111
            ..:..||.:....|   :|:..:....:.:|......:|.:|.........:|||.    ::.|.
pombe  1293 LDVDSEKRRIALGLKSSYFDSDSDISMSDNEEDVEMRSEDQSDTSESEVGSKDDVQSEEVENLES 1357

  Fly  1112 SSDEDEELNVAETQKN---------AAKKKRLSAKEKAKAEIKEEQRLREIEERNADPKARLE-- 1165
            :.|||||...:..|.|         ...|.....::....|.:|.:|.:...:|..|.:..|:
pombe  1358 AGDEDEEEEPSALQANGFDWTDGSTVFDKLADDTEDSEDEEDEEPKRKKSKSDRFDDEEKDLDEI 1422

  Fly  1166 --TIDQYERLVIAQPNNSISWLKYIAFLLSNTEIEKARALARRAISTISFRETQELRNMWSALLN 1228
              |...:||.:::.||:|:.|:.|:|:.|:..|:::||.:.:||:|||::||..|..|:|.||||
pombe  1423 PSTAADFERQLLSSPNSSLLWISYMAYHLNLNELQEAREVGKRALSTINYREEDEKLNVWMALLN 1487

  Fly  1229 MELVY--SNNFDDVLKEALNCNDPLEIYISVVDILKKNKRKDRLSSVLTTVLNKFKTELRVWPVA 1291
            :|:.|  .::..:|.|||....|.|.:|..:..||.|..:.|.....:..:|..||....||...
pombe  1488 LEVAYGTEDSLKEVFKEACAYCDALIVYEKLCGILIKGGKVDLADEYMQLMLKNFKQVPSVWIQY 1552

  Fly  1292 AEAYFWLGKSDQVHNLLQRALRALPNQEHIPCIVSFAKLYAKHDNNDMAQTLLDDVVTSYPKRID 1356
            |.......|:::.|.||:|:|::||..||:..|..||.|..|:.:.:..:|:.:.:::|||||:|
pombe  1553 ATFLLNNDKAEKAHGLLERSLQSLPKSEHVGIIEKFAILEFKNGDPERGRTIFEGLLSSYPKRLD 1617

  Fly  1357 IWSVYVDMLIKAGLIDSARNVLERAVVQKLKPNKMQVIYKKYLQLEENHGTDATVAKVKQQAEQW 1421
            :|:|.:||.:|.......|.:.:|.:...|...|.:..:||:|..|:|.|.|....:||::|.::
pombe  1618 LWNVLIDMEMKQDDPSIVRRLFQRLLALNLSTKKAKFAFKKWLAYEKNIGDDEGAEQVKRRAIEY 1682

  Fly  1422 V 1422
            |
pombe  1683 V 1683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5728	NP_651245.1	S1_Rrp5_repeat_hs1_sc1	71..165	CDD:240198	26/108 (24%)
		S1_like	172..243	CDD:299122	13/71 (18%)
		S1_like	261..327	CDD:299122	13/72 (18%)
		S1	530..591	CDD:197648	17/106 (16%)
		TPR	1170..1403	CDD:223533	79/234 (34%)
		TPR repeat	1320..1350	CDD:276809	7/29 (24%)
		TPR repeat	1355..1382	CDD:276809	8/26 (31%)
SPCC1183.07	NP_587890.1	S1_Rrp5_repeat_hs1_sc1	106..214	CDD:240198	26/108 (24%)
		S1_Rrp5_repeat_hs2_sc2	222..292	CDD:240199	16/83 (19%)
		RpsA	278..859	CDD:223613	127/609 (21%)
		S1_like	398..472	CDD:299122	24/89 (27%)
		S1_Rrp5_repeat_hs5	490..558	CDD:240202	23/69 (33%)
		S1_Rrp5_repeat_hs6_sc5	579..648	CDD:240203	15/68 (22%)
		RpsA	654..1230	CDD:223613	102/632 (16%)
		S1	664..739	CDD:197648	11/75 (15%)
		S1_Rrp5_repeat_hs8_sc7	747..829	CDD:239908	13/81 (16%)
		S1_Rrp5_repeat_hs11_sc8	866..938	CDD:240207	12/78 (15%)
		S1_Rrp5_repeat_hs12_sc9	973..1042	CDD:240208	24/110 (22%)
		S1_Rrp5_repeat_sc10	1050..1122	CDD:240211	6/71 (8%)
		S1_Rrp5_repeat_sc11	1147..1214	CDD:240212	10/66 (15%)
		S1_Rrp5_repeat_sc12	1234..1311	CDD:240213	8/76 (11%)
		TPR	1510..>1682	CDD:223533	54/171 (32%)
		HAT	1596..1628	CDD:214642	11/31 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	70	1.000	Domainoid score	I2664
eggNOG	1	0.900	-	-		E1_COG0539
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I634
OMA	1	1.010	-	-		QHG57197
OrthoFinder	1	1.000	-	-		FOG0005259
OrthoInspector	1	1.000	-	-		oto100526
orthoMCL	1	0.900	-	-		OOG6_100538
Panther	1	1.100	-	-	LDO	PTHR23270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1223
SonicParanoid	1	1.000	-	-		X3781
TreeFam	1	0.960	-	-
	13	12.860