DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5728 and Pdcd11

DIOPT Version :9

Sequence 1:	NP_651245.1	Gene:	CG5728 / 42899	FlyBaseID:	FBgn0039182	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_035183.2	Gene:	Pdcd11 / 18572	MGIID:	1341788	Length:	1862	Species:	Mus musculus

Alignment Length:	1935	Identity:	435/1935 - (22%)
Similarity:	736/1935 - (38%)	Gaps:	601/1935 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EKSFPRGGT--IHSEVKTDD--VSLNIVFGAS-------QKKVKKAPKVKENLLSYETEEQNGQL 58
            |:|||||||  :|...|:..  |..:.:|..|       :||.:|.|...:.|...:.:......
Mouse     5 EESFPRGGTRKLHKSEKSSQQVVEQDNLFDVSTEEGPIKRKKSQKGPAKTKKLKIEKRKSIKSIK 69

  Fly    59 EAFSAETLNMDTLQEDMLVMGVVKELTATALQIALPGRMFARTLVADISDAYTRV--AKAAMSGD 121
            |.|  |.|::::|.|.|.::|.|||::...|.::||..:.....|.::.||||:.  .:.|....
Mouse    70 EKF--EILSLESLCEGMRILGCVKEVSELELVVSLPNGLQGFVQVTEVCDAYTQKLNEQVAQEEP 132

  Fly   122 TSEYHDLTELFQLGRIVYGKAIKTEKLDTGRVSLLLSLKPADVHGNLHHKSIKKGFIFSGAVAEA 186
            ..:...|.|||..|.:|.......:..::|:.|:.||:.|..|:..|...:::.|.:.:|.|:..
Mouse   133 LEDLLRLPELFSPGMLVRCVVSSLDVTESGKKSVKLSVNPKRVNKVLSADALRPGMLLTGTVSSL 197

  Fly   187 LEHGYVIESGVQGLQAFVPCEKPAQ---------KLHVGQLAFLKVKTVHHDTHQSTCTCVQVEQ 242
            .:|||:::.||.|.:||:..:|..:         |..|||.....|:.|     :|....|.:..
Mouse   198 EDHGYLVDIGVGGTRAFLSLKKAQEYIRQKNKGAKFKVGQYLTCVVEEV-----KSNGGVVSLSV 257

  Fly   243 DQLRIKS-----QNETNLDYILPGSIVKFKVAKHLKDGLKGSIMNESFSAYVNEHHLANALDTLD 302
            :...:.|     :...||:.:|||.:||.:|.|..:.||:.:.:. .|...|:..||..  ..:.
Mouse   258 EHSEVSSAFATEEQSWNLNNLLPGLLVKAQVQKVTQFGLQLNFLT-FFKGLVDFMHLEP--KKMG 319

  Fly   303 AYELNEDYNARVLYVMPLTKLVYLTLN-LDIKTGAAVAKDQDEEEQEVEPIKVGSVVEKAKVLR- 365
            :|..|:...|.:|.|.|.|::|.|:|. :.:..|..:.:        :...::|:|::...|..
Mouse   320 SYSSNQTVKACILCVHPRTRVVRLSLRPIFLHPGRPLTR--------ISYQQLGAVLDDVPVQGF 376

  Fly   366 LGSGGVVLLLNKKLKGIISYGSIR--GNFKGNYDKDEVLSKYGRKTKHKVRILGYDVIESLYYCS 428
            ..:.|.:..|.   .|:::|..:.  .:.|..::.:..  |.|  :.||.||:.|..::.|...|
Mouse   377 FKNAGAIFRLK---DGVLAYARVSHLSDSKKAFNAEAF--KPG--STHKCRIIDYSQMDELALLS 434

  Fly   429 DDPNVVNEKLFCLEDINAGDLVTAKIFKKDDKIK--GWSVRIG-KVNGILEQFYLA------PNV 484
            ...:::........||..|.:|...:.    .||  |..|::| ::.|::...:||      |..
Mouse   435 LRKSIIAAPFLRYHDIKIGTVVKGTVL----AIKPFGILVKVGEQIKGLVPSMHLADIMMKNPEK 495

  Fly   485 RYDVGQSLKCRVLEVNAERKICYVSNRAEYLGKGIKILTDYASAHVGNVYMGTVVRCEDTYVLVK 549
            :|..|..:|||||..:.|.|...::.:...:...:.::|.|..|..|....|.::|.:|...:||
Mouse   496 KYSPGDEVKCRVLLCDPEAKKLIMTLKKTLVTSKLSLITCYEGAKPGLQTHGVIIRVKDYGCIVK 560

  Fly   550 FGNGIKGVLHRQNLK------ENSSFFEGQTTKFRILT--RNKDQITLTL-------PED----- 594
            |.|.::|::.:..|.      ..:.|:.||..|..:|:  .:|:::.|:.       |:|
Mouse   561 FYNDVQGLVPKHELSTQHIPDPETVFYTGQVVKVAVLSCEPSKERMLLSFRLLSDSRPKDPGVES 625

  Fly   595 ------KFQLGEICPVEITNALDAGLEVKITFAAEDDEEDEDGNPKLEEFVGLIPLRLLSDHL-- 651
                  ..::|::..|::......||||.|.         ....|      ..:|...||||.
Mouse   626 SQKKTGAVRIGQLVDVKVLEKTKTGLEVAIL---------PHNTP------AFLPTPHLSDHAAN 675

  Fly   652 -ELLHAQMRVHPAGSYTDAACIMQ---NIFSLRDVPYFS----GQLTKDWQSVQVGDIIRSYVKH 708
             .|||..::.  ..:.....|:.|   :|...|.....|    ||..|....:|.|.::..:||
Mouse   676 GPLLHHWLQT--GDTLHRVLCLSQSERHILLCRKPALVSTVEGGQDPKSLSEIQPGMLLIGFVK- 737

  Fly   709 ATDQVVDLMVCVRNYNKPVK-------VHVKMLRLNAVKNAPVE-LVPEQLLWVKVLSKEVETKT 765
                      |::.|...|:       :..|.:..:.....|.| .|..|.:..||.:.:...:.
Mouse   738 ----------CIKEYGVFVQFPSGLSGLSPKTIMSDKFVTTPSEHFVEGQTVVAKVTNVDESKQR 792

  Fly   766 LTVSAKLTDVWSGDLSDTAKL--------VEG-----------YLNEVAQIKAG----------L 801
            :.:|.:|:|...||.:.|:.|        ::|           .:..:|.:..|          |
Mouse   793 MLLSLRLSDCSLGDSASTSFLLLCQCLEELQGIRSLMSNQDSVLIQTLADMTPGMVLDAVVHEVL 857

  Fly   802 EEASA-----PI-------SKY-------SVGEKINVVFKGID--------ATTNDWV------- 832
            |:.|.     |:       |:|       ..|:|..||...:|        :...|.|
Mouse   858 EDGSVVFSSDPVPDLVLRASRYHRAGQEVEPGQKKKVVVLHVDMLKLEVHVSLHQDLVNRKTRKL 922

  Fly   833 --------------------YTVEGNGKVSALLLSSL------------VG-----TAKAPE--- 857
                                ..||....|:..|:|.|            ||     |.|..|
Mouse   923 RKSSRHQGIVQHLEESFAVASLVETGHLVAFSLISHLNDTFHFDSEKLRVGQGVCLTLKTTEPGV 987

  Fly   858 ----------------------------------------------------------MGSKHEA 864
                                                                      :|.|...
Mouse   988 TGLILAVEGPASKRTRMPVQRDSETVDDKGEEKEEEEEEEEKEEENLTVKSKKRHSLAIGDKVTG 1052

  Fly   865 VILWIEYSSDVLLISNKKLDIAHIS------PSGELSTNLIGKAGMKAK---------------- 907
            .|..::.:..|:.:::..:...|.|      |.|...|..: |||.|..
Mouse  1053 TIKAVKATHVVVTLADGFVGCIHASRILDDVPVGTSPTTTL-KAGKKVTARVIGGRDVKTSKFLP 1116

  Fly   908 ------VLLKLE--------------------------------SVAVCSLKK------------ 922
                  ||..||                                ....|..||
Mouse  1117 ISHPRFVLTILELSVRPSELKGSYSALNTHSESPVEKIRQYQAGQTVTCFFKKYNVMKKWLEVDI 1181

  Fly   923 -----GTNPLVICPIRL----HPN----------------DIENS-------GSAELRQG----- 950
                 |..||::..:..    ||:                |:..:       |...|.:|
Mouse  1182 GPDIRGRIPLLLTSLSFKVLKHPDKKFQVGQAIEATVVDPDVPRAFLCLSLIGPYRLEEGEVAMG 1246

  Fly   951 --------------------------------------DFCN--------IAFIHDKLHIAV--- 966
                                                  |||.        ::..|..|.:::
Mouse  1247 RVMKVVPNRGLTVSFPFGKIGKVSMFHLSDSYSEAPLEDFCPQKIVRCYILSTAHRVLALSLRSS 1311

  Fly   967 ------------PE-------TVWRLWRG---------------------VKRTAGTEVAP---- 987
                        ||       ...:|.||                     .|.:..:|..|
Mouse  1312 RTNRETKNRIEDPEINSIEDVKEGQLLRGYVKCVLPSSVIIGLGPSVLGLAKYSHVSECVPPEKE 1376

  Fly   988 -----------VKAKKAKVE------------------------ESPKQKKTTIEETS--AQKKV 1015
                       |.||..:|.                        ..|||     ||.|  |::..
Mouse  1377 LYNGCLPEGKLVTAKVLRVNPMKNLIELSLLPSDTGRPDVFSPAPEPKQ-----EERSGGAEEGQ 1436

  Fly  1016 KAKAKVETKTEAKAIPTKRKAEVVEKITNGQKKTQPLTN--GIVKEKPKQNG---------KLFF 1069
            |.|.|.:.:.|.|..|.|.     ::...|:::.|...:  .:|.::||::|         ::::
Mouse  1437 KRKEKNQKRREEKEEPQKS-----QRGGRGKRERQESESEQELVNKRPKKSGAAEEDDSGVEVYY 1496

  Fly  1070 --------EDKTP--AKNAKS-ETPKSNGAEGKSRLPGVSSFWE---DDVNQS---KEGSSDEDE 1117
                    |.|.|  .|..|| |.|:.:.:.|        ..|:   |.:..:   :|.|||.::
Mouse  1497 REGEDEVGEPKLPPRGKQTKSTEVPRLHLSSG--------FLWDVGLDSLTPALPLREESSDSED 1553

  Fly  1118 ELNVAETQKNAAKKKRLSAKEKAKAEIKEEQRLREIEERNADPKARLETIDQYERLVIAQPNNSI 1182
            |      |.:.||||: ..||:...:.|.|:.|..|||...||..:.|:.|.::|||::.||:||
Mouse  1554 E------QPHQAKKKK-GKKERELEKQKAEKELSRIEEALMDPGRQPESADDFDRLVLSSPNSSI 1611

  Fly  1183 SWLKYIAFLLSNTEIEKARALARRAISTISFRETQELRNMWSALLNMELVYSN--NFDDVLKEAL 1245
            .||:|:||.|..||||||||:|.||:.||||||.||..|:|.||||:|.:|.:  :...|.:.|:
Mouse  1612 LWLQYMAFHLQATEIEKARAVAERALKTISFREEQEKLNVWVALLNLENMYGSQESLTKVFERAV 1676

  Fly  1246 NCNDPLEIYISVVDILKKNKRKDRLSSVLTTVLNKFKTELRVWPVAAEAYFWLGKSD--QVHNLL 1308
            ..|:||::::.:.||..|:::......:...:|.:|:.|..||  .....|.||:|.  ..|.:|
Mouse  1677 QYNEPLKVFLHLADIYTKSEKYKEAGELYNRMLKRFRQEKAVW--IKYGAFVLGRSQAGASHRVL 1739

  Fly  1309 QRALRALPNQEHIPCIVSFAKLYAKHDNNDMAQTLLDDVVTSYPKRIDIWSVYVDMLIKAGLIDS 1373
            ||||..||.:||:..||.||:|..:..:.:.|:.:.::.:::||||.|:||||:||.||.|...:
Mouse  1740 QRALECLPAKEHVDVIVKFAQLEFQLGDVERAKAIFENTLSTYPKRTDVWSVYIDMTIKHGSQTA 1804

  Fly  1374 ARNVLERAVVQKLKPNKMQVIYKKYLQLEENHGTDATVAKVKQQAEQWVK 1423
            .|::.||.:...|.|.:|:..:|:||..|:.|||:..|..||.:|.::|:
Mouse  1805 VRDIFERVIHLSLAPKRMKFFFKRYLDYEKQHGTEKDVQAVKAKALEYVE 1854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5728	NP_651245.1	S1_Rrp5_repeat_hs1_sc1	71..165	CDD:240198	27/95 (28%)
		S1_like	172..243	CDD:299122	20/79 (25%)
		S1_like	261..327	CDD:299122	19/65 (29%)
		S1	530..591	CDD:197648	17/68 (25%)
		TPR	1170..1403	CDD:223533	96/236 (41%)
		TPR repeat	1320..1350	CDD:276809	7/29 (24%)
		TPR repeat	1355..1382	CDD:276809	13/26 (50%)
Pdcd11	NP_035183.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		17/50 (34%)
		S1_Rrp5_repeat_hs1_sc1	80..176	CDD:240198	27/95 (28%)
		RpsA	183..798	CDD:223613	147/669 (22%)
		S1_Rrp5_repeat_hs2_sc2	183..263	CDD:240199	20/84 (24%)
		S1_Rrp5_repeat_hs3	284..344	CDD:240200	18/62 (29%)
		S1_Rrp5_repeat_hs4	365..435	CDD:240201	16/76 (21%)
		S1_Rrp5_repeat_hs5	453..521	CDD:240202	20/71 (28%)
		RpsA	540..1115	CDD:223613	104/603 (17%)
		S1_Rrp5_repeat_hs6_sc5	542..611	CDD:240203	17/68 (25%)
		S1_like	636..707	CDD:299122	19/87 (22%)
		S1_Rrp5_repeat_hs8_sc7	715..797	CDD:239908	17/92 (18%)
		S1_like	846..910	CDD:299122	12/63 (19%)
		S1_like	926..993	CDD:299122	11/66 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	999..1036		0/36 (0%)
		S1_Rrp5_repeat_hs11_sc8	1047..1116	CDD:240207	13/69 (19%)
		S1_Rrp5_repeat_hs12_sc9	1160..1234	CDD:240208	9/73 (12%)
		S1_Rrp5_repeat_hs13	1238..1309	CDD:240209	7/70 (10%)
		S1_like	1332..1405	CDD:299122	10/72 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1406..1520		26/123 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1577		13/38 (34%)
		TPR	<1579..1784	CDD:223533	82/206 (40%)
		HAT 1	1590..1622		14/31 (45%)
		TPR repeat	1612..1638	CDD:276809	17/25 (68%)
		TPR repeat	1651..1678	CDD:276809	9/26 (35%)
		TPR repeat	1683..1710	CDD:276809	3/26 (12%)
		HAT 2	1696..1728		6/33 (18%)
		TPR repeat	1715..1745	CDD:276809	13/31 (42%)
		Suf	1718..>1858	CDD:283497	54/139 (39%)
		TPR repeat	1752..1780	CDD:276809	6/27 (22%)
		HAT 3	1766..1798		12/31 (39%)
		HAT 4	1800..1835		11/34 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842651
Domainoid	1	1.000	79	1.000	Domainoid score	I8680
eggNOG	1	0.900	-	-		E1_COG0539
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1901
Isobase	1	0.950	-	0	Normalized mean entropy	S5233
OMA	1	1.010	-	-		QHG57197
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005259
OrthoInspector	1	1.000	-	-		oto92101
orthoMCL	1	0.900	-	-		OOG6_100538
Panther	1	1.100	-	-	LDO	PTHR23270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1223
SonicParanoid	1	1.000	-	-		X3781
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740