DRSC/TRiP Functional Genomics Resources

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Protein Alignment BRWD3 and Brwd1

DIOPT Version :9

Sequence 1:NP_732982.1 Gene:BRWD3 / 42898 FlyBaseID:FBgn0011785 Length:2232 Species:Drosophila melanogaster
Sequence 2:XP_006523176.1 Gene:Brwd1 / 93871 MGIID:1890651 Length:2769 Species:Mus musculus


Alignment Length:2423 Identity:822/2423 - (33%)
Similarity:1206/2423 - (49%) Gaps:415/2423 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELERKYKHIGANHL 76
            ::.||||||:::|:|||....|:||::|||:.::||:||||:||||.:::|||....||:..:||
Mouse    14 IESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHL 78

  Fly    77 LEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLRT----KETVY-------CHRSLRDYCTRLN 130
            |:||.|:||::|:|:|||:..:.||||.|||:||||    :.||:       .||.        .
Mouse    79 LQICQRIGPMLDKEVPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRG--------R 135

  Fly   131 GVSLPDSVLTKPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLSSVYCVLFDRTG 195
            ...:|  |...|..:|..:..||:..|........|..:|:..|:.||.:||||:||||.|||||
Mouse   136 PPEMP--VNYGPPPSLVEIHRGRQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTG 198

  Fly   196 RYIITGADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHILRVWDMQTTSPI 260
            ..|.||:||.|:||||..:||||:||||.|:||:|:|:|.:||::||||.|.|:|||.::|.:|:
Mouse   199 HRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTLIAAGSCDKIIRVWCLRTCAPV 263

  Fly   261 AVLSAHTGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKPTQYHEKLRPGQ 325
            |||..|||.|||:.|.|..:...:|:|:|..||::.|||:..   :.:.|:|:|.::.||.||| 
Mouse   264 AVLQGHTGSITSLQFSPMAKGPQRYMVSTGADGTVCFWQWDL---ESLKFSPRPLKFTEKPRPG- 324

  Fly   326 AQMMCTTFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSHRGLRFISGSKD 390
            .||:|::||.||:|||.||.||.:|:|.:|.|.|::|.|.|::||.|||:|:.:.|.||:|||:|
Mouse   325 VQMLCSSFSVGGMFLATGSTDHVIRMYFLGFDAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRD 389

  Fly   391 GTAHIWTFESQQWKSSKLCMTERLASCPEPEEGK--RLKVTMVAWDASDRYVITAVNDFTIKIWD 453
            |||.||.||..:|:|..|.|:.|::.....||.:  :.||||:||:..|..|:|||||..:|:|.
Mouse   390 GTARIWRFEQLEWRSILLDMSARISGDTSSEEERFMKPKVTMIAWNQDDSTVVTAVNDHVLKVWS 454

  Fly   454 SKSAKLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFLNDIDGQGHGSV 518
            |.:.:|...|.||.||::|||::|.|..::|||||||.:|:|||.:|:.:.::.|.|:|||||:|
Mouse   455 SYTGQLLHNLLGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGIKMKHYFNMIEGQGHGAV 519

  Fly   519 FDAKWSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQHHVVDEQTQIM 583
            ||.|:|.||...|.||||||:||||.| |.:.|:.:|.::|||||:|||:||:.::|:|||||..
Mouse   520 FDCKFSQDGQHFACTDSHGHLLIFGFG-CSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQA 583

  Fly   584 PHLMPPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNL--TVGVDGVVIDD-----GGAGGDA 641
            |||||||||||.||||||::|||.|||||:.:.:.|:|.|  ....||.||:.     ....|||
Mouse   584 PHLMPPPFLVDVDGNPHPTKFQRLVPGRENSADEHLVPQLGYVATSDGEVIEQIISLHTNDSGDA 648

  Fly   642 VVAAAPAEAPPAALPPAAAGGPQGANYSHIDRMIAALANRQSVNVNANDANPTNG---------N 697
                                .|:.   |.:|.||..|..:|...:..:.....||         .
Mouse   649 --------------------SPES---SVLDGMIRQLQQQQDQRLGVDQDGTANGLPSGEGTPRR 690

  Fly   698 QSFERLT-NRQMPDSNGRQSSRGNVLG----------SRLSTPR--QGWGAAAAAPVEDQAGPSQ 749
            .||.||: :.|.|.:.|.:.| |.|.|          |:::|.|  |.|......          
Mouse   691 GSFRRLSLDIQSPPNIGLRRS-GQVEGVRQMHQNAPRSQIATERDLQAWKRRVVV---------- 744

  Fly   750 PPAEPAAEPGQAQVQQALPLKFIRRTYVRPMKYPQLQNLKQTIYSAGQFEKQEYKREMRRRPIMI 814
                |.|.||.                     :.:|::::   ...|:.|:..|....:::...:
Mouse   745 ----PEAPPGM---------------------FRRLEDIR---IERGEEERNLYVIGRKKKTFQV 781

  Fly   815 NTASAASSQQPGSVGRPRNTRGNGGGARAGRRRGPQ---PAGGQPQPAYRTRAVRDQEPEHYDEV 876
            ...|  :|....|..|.|..|..  .|...||...|   .:|.:...:.|.....||..      
Mouse   782 PQKS--NSMVLVSQSRQRTCRRK--YANYSRRNADQCELSSGNESSGSVRHETSYDQSE------ 836

  Fly   877 APPPEEEEEDVSSNSSGDTSYSNVEENLEDSSDESETDSSDYSDWVADTPGPNLEPPKR-SKRKP 940
                       .|.||.|..:.|...:..| ||.|...||.||||.||| |.||:||.| |.|:.
Mouse   837 -----------GSCSSEDDEWRNDRRSGSD-SDSSSDSSSQYSDWTADT-GINLQPPLRMSCRRR 888

  Fly   941 LSRRPRSSDD-------SSDDERAGRSRGGQVTARKVGRKTVLFPPTDANGEIPELYRPAEWLSE 998
            ::|...:|:|       |....|..|.:..:.....:.|.|   |...||.|....:.|..|:::
Mouse   889 VTRFCSTSEDEMSMENISPPKRRRKRRKESKPKRESLRRMT---PAELANMEHLYEFHPPVWITD 950

  Fly   999 VIPRKAPYYPQMGDEVVYFRQGHAKYLDAVRLKKVYKLSHSSEPWNFHTLRDHELVRVIGIKYEI 1063
            ...||:|:.|||||||:||||||..|::|||...:|:|:...|||....|||.|||:::|::||:
Mouse   951 TTLRKSPFVPQMGDEVMYFRQGHEAYIEAVRRNNIYELNPHKEPWRKMDLRDQELVKIVGLRYEV 1015

  Fly  1064 RPPRLCCLKLAIID-EEGNMTGTTFKIKYHDMPDVLDFLVLRQTFDLAVQRNWSIGDRFRCMIVD 1127
            .||.|||||||.|| ..|.:|..:|.|:|||||||:|||||||.:|.|.||||...||||.:|.|
Mouse  1016 GPPTLCCLKLAFIDPATGRLTDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQPCDRFRSIIDD 1080

  Fly  1128 GWWMGQIESRHALSADFPDSSFMCFRVRWDNGEYEFMSPWDMEPI-DQQRVPDEVGGAVPVLPEE 1191
            .||.|.:.|:......:|||.|.|:.|||||.|.|.:|||||||| |....|:|:|.::.|..:|
Mouse  1081 AWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTETEKLSPWDMEPIPDNVDPPEELGASISVTSDE 1145

  Fly  1192 IRATLYQPKSEEWHRGDRDGTCRRIINGLEQVMRLSIAEHFLAPVDLNIYPDYAYLIEYPIDLTT 1256
            :...||:|:..||.:..||..|.|||:|::|::.|.||..|..||||..||.|..::.||.||.|
Mouse  1146 LEKLLYKPQEGEWGQRSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAYPTDLYT 1210

  Fly  1257 IKSRFENHFYRRITSAQFDVRYLATNAEQYNRRHAIIVKHSRIVTDLCLRIIREPDEIDVAAVYH 1321
            |:.|..|.||||:::..::|||:..||..:|...::|.:.::.:||..|:.|:..|..:::    
Mouse  1211 IRMRLVNRFYRRLSALIWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFIKNQDCTNIS---- 1271

  Fly  1322 QLADVYHSSE--SENEVDSDVVPSTSTGPTTSAAAAAARQRVSSARRSTRIHS--EGDWRADCRQ 1382
            :|.:...:.|  |.:::|...:|.||:|          |::|.:.:|.:|...  |.|||..|:.
Mouse  1272 ELCNTSDNDEDDSADDLDDSDLPKTSSG----------RRKVHNWKRRSRASGCIESDWRRQCKA 1326

  Fly  1383 LLDLMWARTDSAPFREPVDTIDFPDYLEIIATPMDLRTVKEDLLGGNYDDPLDFAKDVRLIFQNS 1447
            ||.|::...||.|||:|||..::|||.:||.||||..||:|.|..||||.|::|.||:||||.|:
Mouse  1327 LLILIFQCEDSEPFRQPVDLDEYPDYRDIIDTPMDFGTVRETLEAGNYDSPVEFCKDIRLIFSNA 1391

  Fly  1448 KNYNTNKRSRIYAMTLRLSALFESHIKTVV------TSWKAALRRANKNKSGSS-GGGRGGSSSS 1505
            |.|..||||:||:||||||||||..:|.:.      ..:|..|||:.:.|...: .|...|....
Mouse  1392 KAYTPNKRSKIYSMTLRLSALFEEKMKKISFDFKIGQKFKEKLRRSQRFKQRQNCNGAVPGDRRR 1456

  Fly  1506 PNKRVKKERSTRR--------------NQKPTAAARRLPVANSSEDEDEEDDDDDDDDDDEEEAS 1556
            .|.:.|:.:|..:              ::.|.:|.|:.....||         .....|..:.|.
Mouse  1457 RNVKQKQFKSQTKVIPQLMCPPSQSTSSKVPLSATRKTSAGVSS---------GFTSGDSSDSAG 1512

  Fly  1557 TRGRSRR------RNGVAVSASSSGSNRVTSSSAAQQRRGKSSSSEEEEEEETSAQATSDASSDE 1615
            :..|.||      |:|..:..|.......||||::      :|:|.||.:....|:.:|..|   
Mouse  1513 SLERVRRQRPEVLRSGSVLFGSEMEDFLATSSSSS------ASNSSEESKASPGARESSLRS--- 1568

  Fly  1616 EERAQSNDSSPQQTRTRRARQ----------------RQRL----SDDSNINDSEDSYNPNEGRG 1660
               .....|:...||||.||:                |:|:    ||::::...|:..|      
Mouse  1569 ---GVLRGSNLGVTRTRAARRKAGSVSLENGCGRKATRKRVYLSDSDNNSVETDENLKN------ 1624

  Fly  1661 SRRRPGAARPSSNRQTNGHSSKRRRLNKSPANAAPGP----SLPRRTRRIAGSSAEEAASHSQHD 1721
              |:.|::|....:.....:||.:.::.:..:::..|    .||.|.   |.:.|.:...|:..|
Mouse  1625 --RKCGSSRKVLRKCAAVAASKIKLMSDAEDSSSESPCSGRKLPHRN---ASAVARKKLLHNSDD 1684

  Fly  1722 ESTQDSQIGRRKGRSASSRSIGNGPSTSAAAAANSSLESPSRNTR----ANGTRTSSHLGA---- 1778
            :|.: |:....|.::.|  .:.:||.:...:.::|..:|..|.||    |||  .:||..|    
Mouse  1685 QSLK-SETEELKDQNQS--LLISGPHSVHNSISDSESDSDLRATRKTWNANG--CTSHTAATCKT 1744

  Fly  1779 --------ENDHSYH----------LPVRNGRIIESDT---------DSPVIRPTRQSAKRA--L 1814
                    |.|...|          .|..:|:.:.:|:         :|.|:.......|:|  |
Mouse  1745 KSRPIESSEEDSRCHGSDHGPSSTGDPSTSGQKLRADSISEEADSEPESSVLCKNTHLCKKAKIL 1809

  Fly  1815 MDWGRGSDIEEE-------EEEEEEDSEEAEEILPTP-------TKDDLPSTSRAALAQAAAGPS 1865
            .|   ..|.||:       |.|....||...|.:..|       ::.|:.|...|...::.:..:
Mouse  1810 SD---SEDCEEKCGERRGPEVEGSPVSEALREAILAPQCLSHRGSETDVDSDGGAVREKSYSNEN 1871

  Fly  1866 RQL---RTNRNTVVRPAQSDDDDDDDSDNEPLANNQQKNYQSPAKSSSTATVAPHPLSL------ 1921
            ..:   ...|..|.|.:.||.:     .|..:.....|:..||::.:..|:||...:.|      
Mouse  1872 GSVSLENGQRRKVSRKSSSDKE-----SNLQVTQKSPKDRSSPSRITQRASVATDKMKLTSDAED 1931

  Fly  1922 ------------RR----RLASPPERNTHM-TRSHATSTTSSAAASRAE----QQPAV------- 1958
                        ||    |.|..|.|.|.. ..|..||..||.:|...|    |:|.|       
Mouse  1932 LSLESVCTRSKRRRKKPARFACTPTRKTSAGVSSGFTSGDSSVSAGSLERVRRQRPEVLRSGSVL 1996

  Fly  1959 -STHDHNYLGNVNSSRAPRRI-LSRHQRNADELDTSLDVLENSRL--LSAIANHRRPTSTTNSNS 2019
             .:...::|...:||.|.... .|:....|.|......||..|.|  ....|..|:..|.:..|.
Mouse  1997 FGSEMEDFLATSSSSSASNSSEESKASPGARESSLRSGVLRGSNLGVTRTRAARRKAGSVSLENG 2061

  Fly  2020 ASNVVTRRLRGRASQANSHDEDHEEEEAAASDEGTDGGSSSQ-------------SYEDEDEDSD 2071
            .....||:      :....|.|:...|...:.:....|||.:             ....:.|||.
Mouse  2062 CGRKATRK------RVYLSDSDNNSVETDENLKNRKCGSSRKVLRKCAAVAASKIKLMSDAEDSS 2120

  Fly  2072 SEDNQPLTSYVSPSNGR--PRRKA-----------------KTSSSSATTQERPLRRTRRPPSNN 2117
            ||         ||.:||  |.|.|                 |:.:.....|.:.|..:.....:|
Mouse  2121 SE---------SPCSGRKLPHRNASAVARKKLLHNSDDQSLKSETEELKDQNQSLLISGPHSVHN 2176

  Fly  2118 SIANDNDDDDDYVVPRSRRANRGGNQRAGRNQKRPRYNEQSEEEEAAAGYSHRSKRIRNGDAHAS 2182
            ||::...|.|.....::..||...:..|...:.:.|..|.|||:....|..|...  ..||...|
Mouse  2177 SISDSESDSDLRATRKTWNANGCTSHTAATCKTKSRPIESSEEDSRCHGSDHGPS--STGDPSTS 2239

  Fly  2183 SQE--RSQASTERDQEEE 2198
            .|:  ....|.|.|.|.|
Mouse  2240 GQKLRADSISEEADSEPE 2257

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BRWD3NP_732982.1 WD40 176..496 CDD:238121 163/321 (51%)
WD40 181..544 CDD:225201 189/364 (52%)
WD40 repeat 186..223 CDD:293791 25/36 (69%)
WD40 repeat 229..265 CDD:293791 19/35 (54%)
WD40 repeat 270..311 CDD:293791 13/40 (33%)
WD40 repeat 331..364 CDD:293791 17/32 (53%)
WD40 repeat 372..413 CDD:293791 22/40 (55%)
WD40 repeat 428..464 CDD:293791 16/35 (46%)
WD40 repeat 470..495 CDD:293791 13/24 (54%)
Auxin_resp 1083..1167 CDD:284030 46/83 (55%)
Bromo_WDR9_I_like 1196..1311 CDD:99958 47/114 (41%)
Bromo_WDR9_II 1371..1489 CDD:99928 65/125 (52%)
Brwd1XP_006523176.1 WD40 178..497 CDD:238121 163/322 (51%)
WD40 repeat 189..226 CDD:293791 25/36 (69%)
WD40 repeat 232..268 CDD:293791 19/35 (54%)
WD40 repeat 273..318 CDD:293791 16/47 (34%)
WD40 repeat 326..365 CDD:293791 21/38 (55%)
WD40 repeat 371..408 CDD:293791 20/36 (56%)
WD40 repeat 429..468 CDD:293791 18/38 (47%)
WD40 repeat 471..496 CDD:293791 13/24 (54%)
Bromo_WDR9_I_like 1150..1265 CDD:99958 47/114 (41%)
Bromo_WDR9_II 1317..1433 CDD:99928 62/115 (54%)
Spc7_N <2334..2507 CDD:373822
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167850547
Domainoid 1 1.000 475 1.000 Domainoid score I436
eggNOG 1 0.900 - - E2759_KOG0644
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1179 1.000 Inparanoid score I198
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001192
OrthoInspector 1 1.000 - - otm43396
orthoMCL 1 0.900 - - OOG6_101711
Panther 1 1.100 - - LDO PTHR16266
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X735
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.840

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