DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BRWD3 and brwd3

DIOPT Version :9

Sequence 1:NP_732982.1 Gene:BRWD3 / 42898 FlyBaseID:FBgn0011785 Length:2232 Species:Drosophila melanogaster
Sequence 2:XP_002940482.3 Gene:brwd3 / 733720 XenbaseID:XB-GENE-5757854 Length:1778 Species:Xenopus tropicalis


Alignment Length:1920 Identity:726/1920 - (37%)
Similarity:1044/1920 - (54%) Gaps:258/1920 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELERKYKHIGANHL 76
            ::.||||||::||.:||...:|:||..||||.:::|.||||:|.||.:|:::|....|||.:::|
 Frog     1 MEAELYFLIARFLQSGPCRRSAQVLAEELEEYRLIPPRLDWEGKEHRRTYQDLVAANKHIPSDYL 65

  Fly    77 LEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLRTKE---------TVYC--HRSLRDYCTRLN 130
            |:||.|.||::|:|:|.||||::||||.|:|:|||:|:         |.:.  ||.        .
 Frog    66 LKICERFGPILDQEIPQSVPGLHSLLGLGKQSLLRSKKDCKNTPWKGTAFAALHRG--------R 122

  Fly   131 GVSLPDSVLTKPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLSSVYCVLFDRTG 195
            ...||.: ..||. |:..:...|...|......:.|:..|::.|:.:|.:|||||||||.|||||
 Frog   123 PPELPVN-YGKPL-NVVNITCARYQTGYAHYHRIFPSSTYQQMKMHKRILGHLSSVYCVAFDRTG 185

  Fly   196 RYIITGADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHILRVWDMQTTSPI 260
            |.|.||:||.|:|||::.|||||:||||.|:||:|:|:|.:||::||||.|.::|||.::|.:||
 Frog   186 RRIFTGSDDCLVKIWASDDGRLLSTLRGHSAEISDLAVNHENTLIAAGSCDKVVRVWCLRTCAPI 250

  Fly   261 AVLSAHTGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKPTQYHEKLRPGQ 325
            |||..||..|||:.|||..:...:||.:|..||:|.||::   ....:||..:|.::.|:.||| 
 Frog   251 AVLQGHTASITSIQFCPGTKEKTRYLTSTGADGTICFWEW---HADTMTFNDRPVKFAERSRPG- 311

  Fly   326 AQMMCTTFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSHRG--LRFISGS 388
            .|:.|::||.||:|:|.||.||.:|:|.:|...|::|.|.||:.|.|.::|:.:..  |.|:|||
 Frog   312 VQISCSSFSSGGMFIATGSTDHVIRIYYLGSGSPEKIAELEAHLDKVVAIQFCNNSDRLCFVSGS 376

  Fly   389 KDGTAHIWTFESQQWKSSKLCMTERLASCP---EPEEGKRLKVTMVAWDASDRYVITAVNDFTIK 450
            :||||.||.::.|:||.:.|.||.::|...   ..::..:|||||||||.||..||||||:|.:|
 Frog   377 RDGTARIWQYQQQEWKMTVLDMTAKMAGSSVINTEDKVTKLKVTMVAWDRSDSSVITAVNNFFLK 441

  Fly   451 IWDSKSAKLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFLNDIDGQGH 515
            :|:|.:.:|..:|.||.||::|||.:|.|..:|:||||||.:|:||:|.|..:.|:.|.|:||||
 Frog   442 VWNSHTGELLHILSGHDDEVFVLEPHPFDPRILISAGHDGNIFVWDLETGTKIRNYFNMIEGQGH 506

  Fly   516 GSVFDAKWSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQHHVVDEQT 580
            |:|||.|:||||...|.||||||:|:||.| |.:.|:.:|.::|||||||||:||:..:|:||||
 Frog   507 GAVFDCKFSPDGQNFACTDSHGHLLLFGFG-CSKPYEKIPEQMFFHTDFRPLIRDSNSYVLDEQT 570

  Fly   581 QIMPHLMPPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNLTVGVDGVVIDDGGAGGDAVVAA 645
            |..|||||||||||.||||||:||||.|||||:|..:||||.|....:|        .||.|...
 Frog   571 QQAPHLMPPPFLVDVDGNPHPTRFQRLVPGRENCKDEQLIPQLGYMSNG--------NGDVVEQV 627

  Fly   646 APAEAPPAALPPAAAGGPQGANY--SHIDRMIAALANRQSVNVNANDANPTNGNQSFERLTNR-- 706
            .               |.|..|.  |.:|.:|..|...|.                 ||.||.  
 Frog   628 I---------------GQQTGNQEESILDGIIRELQREQD-----------------ERHTNEAE 660

  Fly   707 --QMPDSNGRQSSRGNVLGS---RLSTPRQGWGAAAAAPVED--QAGPSQPPAEPAAEPGQAQVQ 764
              ..|..| |..||..||.|   .||:| ...|...:..:|.  |...:.|.::.|.|...    
 Frog   661 DVDTPRYN-RTDSRNGVLRSISLDLSSP-PNVGLRRSGQIEGVRQMHSNAPRSQIATERDL---- 719

  Fly   765 QALPLKFIRRTYVRPMKYPQLQNLKQTIYSAGQFEKQEYKREMRRRPIMINTASAASSQQPGSVG 829
                :.:.||..|..:....::..::...|.|:.|...|..|.:|:|  .|.|.....|..|.  
 Frog   720 ----MAWSRRVVVNELHPGVIRVQEECRISKGEMEISLYNTEKKRKP--TNPAQRNDYQAFGG-- 776

  Fly   830 RPRNTRGNGGGARAGRRRGPQPAGGQPQPAYRTRAVRDQEPE------HYDEVAPPPEEEEEDVS 888
              |:.|      |..|:|         |.||:||:..:.:..      :.::....|||||...|
 Frog   777 --RSLR------RIQRKR---------QHAYQTRSTIEHDARAKVPSTNGEDSQSSPEEEESQHS 824

  Fly   889 SNSSGDTSYSNVEENLEDSSDESETDSSDYSDWVADTPGPNLEPPKRSKRKPLSRRPRSSDDSSD 953
            :.:|||.:.:..:     |...|...||:||||.||. |.||:||||..|:...:...||:|.:.
 Frog   825 TEASGDEAAAQWQ-----SETSSSNSSSEYSDWTADA-GINLQPPKRQTRQTTRKMCSSSEDENA 883

  Fly   954 DERAGRSRGGQVTARKVGRKTVLFPPTDANGEIPELYRPAEWLSEVIPRKAPYYPQMGDEVVYFR 1018
            .|.. :.|..::|.||...:.:     ...||..|.:.|.:|:.:.|||::|:.|||||||:|||
 Frog   884 KEEE-KPRKHKLTRRKKQSERL-----SMEGEPSEEWIPPQWILDTIPRRSPFVPQMGDEVIYFR 942

  Fly  1019 QGHAKYLDAVRLKKVYKLSHSSEPWNFHTLRDHELVRVIGIKYEIRPPRLCCLKLAIID-EEGNM 1082
            |||..|:.|||..|:|.::...||||...|||.|..:::|||||:.||.|||||||::| ..|.:
 Frog   943 QGHEAYVRAVRKAKIYNINPQKEPWNKTDLRDQEFAKIVGIKYEVGPPTLCCLKLALLDPTSGKI 1007

  Fly  1083 TGTTFKIKYHDMPDVLDFLVLRQTFDLAVQRNWSIGDRFRCMIVDGWWMGQIESRHALSADFPDS 1147
            |..:|.:||||||||:|||||.|.:..|.:|||.||||||.:|.|.||.|.:||:.....::|||
 Frog  1008 TADSFSVKYHDMPDVIDFLVLYQFYKEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQTEYPDS 1072

  Fly  1148 SFMCFRVRWDNGEYEFMSPWDMEPI-DQQRVPDEVGGAVPVLPEEIRATLYQPKSEEWHRGDRDG 1211
            .|.|:.|.|||.|.|.||||||||| |...:|||:|..|||..:|:::..|:|:..||....||.
 Frog  1073 LFQCYSVHWDNNERENMSPWDMEPIPDGTALPDEMGAGVPVTSDELKSLQYKPEEGEWGLYSRDE 1137

  Fly  1212 TCRRIINGLEQVMRLSIAEHFLAPVDLNIYPDYAYLIEYPIDLTTIKSRFENHFYRRITSAQFDV 1276
            .|.|:|.|::|::.|..|..|.|||||:.||.|..::.||.||:|.:.|.|:|:|||:::..::|
 Frog  1138 VCERVIQGIDQLLTLDFASPFSAPVDLSAYPLYCTVVAYPTDLSTTRKRLESHYYRRLSALIWEV 1202

  Fly  1277 RYLATNAEQYNRRHAIIVKHSRIVTDLCLRIIREPDEIDVAAVYHQLADVYHSSESENEVDSDVV 1341
            ||:..||..:|.....||:.::||||:.||.|.:.:..|:..:|:|: ....:..:|:| :...|
 Frog  1203 RYIEHNARTFNEPDTPIVRTAKIVTDVLLRYIGDENCNDILEIYNQV-KTEDTGNTEDE-EGGAV 1265

  Fly  1342 PSTSTGPTTSAAAAAARQRVSSARRSTRIHSEGDWRADCRQLLDLMWARTDSAPFREPVDTIDFP 1406
            ...|..|.||:..|..|:......||    :...|:..|::||||::.|.||.|||:||:.:.:|
 Frog  1266 DMESDAPGTSSGRAVTRRTKRDLLRS----NPDSWKDKCKELLDLIYEREDSEPFRQPVNQVSYP 1326

  Fly  1407 DYLEIIATPMDLRTVKEDLLGGNYDDPLDFAKDVRLIFQNSKNYNTNKRSRIYAMTLRLSALFES 1471
            ||.:||.||||..|||..|..|||.|||:||.||||||.|||.|..||:||||:||||||||.|:
 Frog  1327 DYQDIIETPMDFSTVKTTLEAGNYSDPLEFAADVRLIFSNSKAYTPNKKSRIYSMTLRLSALCET 1391

  Fly  1472 HIKTVVTSWKAAL------RRANKNKSGSSGGGRGGSSSSPNKRVKKERSTRRNQKPTAAARR-- 1528
            :||.:::.:|.|:      ||..:.:..||......||||.|:|    ||:..:...::|:.|  
 Frog  1392 YIKDIISDYKLAMQLQQRTRRKYRRRIRSSSSSSSSSSSSSNRR----RSSSSSSSSSSASSRAS 1452

  Fly  1529 ----------------------LPVANSS-----EDEDEEDDDDDDDDDDEEEASTRGRS----- 1561
                                  ||.::||     .|.|.|.|.....:|.::|.|:.|.|     
 Frog  1453 SPDTKPRKMKLQPKLNQNPPHPLPRSSSSSTSQMSDTDVEPDGKPFSEDMDQEPSSSGCSKPETH 1517

  Fly  1562 RRRNGVAVSASSSGSNRVTS---------SSAAQQRRGKSSSSEEEEEEETSAQATSDAS--SDE 1615
            :.:..|..|.:|......|:         ::...:|:..|||.:|..|:....:...|.|  ...
 Frog  1518 KEQENVTKSKNSPVKEEHTNGPLTNGDGGNTPKTKRKLLSSSEDESPEDGEQMEEKPDKSPACSR 1582

  Fly  1616 EERAQSNDSSPQQTRTRRARQRQRLSDDSNINDSEDSYN-----------------PNEGRGSRR 1663
            |..::|:.||..::.:..:...:.:..|.:..|.:..|:                 ...|||..|
 Frog  1583 ERDSESSLSSKSESESESSSDSESIKSDQDYIDGDHHYSKEPRTKFKRKFCKSGEAKTRGRGRGR 1647

  Fly  1664 RPGAARPSS-NRQTNGHSSKRRRLNKSPANAAPGPSLPRRTRRIAGSSAEEAASHSQHDESTQDS 1727
            ..|..|... ||.......|.|...:.....| ....|.||..:..:...:.......|:...|.
 Frog  1648 GRGRGRAKGYNRGVEEELKKGRGRGRGRGRGA-WKKEPSRTPALKRAQLTDDEDDDNVDDEESDC 1711

  Fly  1728 QIGRRKGRSASSRSIGNGPSTSAAAAANSSLESPSRNTRANGTRTSSHLG-AENDH----SYHLP 1787
            ...|||                          .|..|||..|.||..:.. ::|:|    .|..|
 Frog  1712 VEQRRK--------------------------KPRINTRNQGRRTVLYNDESDNEHDGAGQYDDP 1750

  Fly  1788 V-----RNGRIIESDTDSPVIRPTRQSAKRALMDW 1817
            :     |:||         |.:.|.::....||.|
 Frog  1751 LNLGTSRSGR---------VRKMTEKARVSHLMGW 1776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BRWD3NP_732982.1 WD40 176..496 CDD:238121 160/324 (49%)
WD40 181..544 CDD:225201 188/367 (51%)
WD40 repeat 186..223 CDD:293791 26/36 (72%)
WD40 repeat 229..265 CDD:293791 19/35 (54%)
WD40 repeat 270..311 CDD:293791 15/40 (38%)
WD40 repeat 331..364 CDD:293791 15/32 (47%)
WD40 repeat 372..413 CDD:293791 19/42 (45%)
WD40 repeat 428..464 CDD:293791 20/35 (57%)
WD40 repeat 470..495 CDD:293791 13/24 (54%)
Auxin_resp 1083..1167 CDD:284030 46/83 (55%)
Bromo_WDR9_I_like 1196..1311 CDD:99958 48/114 (42%)
Bromo_WDR9_II 1371..1489 CDD:99928 66/123 (54%)
brwd3XP_002940482.3 WD40 165..487 CDD:238121 160/325 (49%)
WD40 repeat 176..213 CDD:293791 26/36 (72%)
WD40 repeat 219..255 CDD:293791 19/35 (54%)
WD40 repeat 260..300 CDD:293791 16/42 (38%)
WD40 repeat 315..352 CDD:293791 17/36 (47%)
WD40 repeat 358..397 CDD:293791 16/38 (42%)
WD40 repeat 419..455 CDD:293791 20/35 (57%)
WD40 repeat 461..486 CDD:293791 13/24 (54%)
Bromo_WDR9_I_like 1123..1234 CDD:99958 47/110 (43%)
Bromodomain 1296..1409 CDD:413371 64/112 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 481 1.000 Domainoid score I411
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1191 1.000 Inparanoid score I198
OMA 1 1.010 - - QHG52858
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001192
OrthoInspector 1 1.000 - - otm48540
Panther 1 1.100 - - O PTHR16266
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5357
SonicParanoid 1 1.000 - - X735
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.100

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