Protein Alignment BRWD3 and brwd3

DIOPT Version :10

• Sequence 1: NP_732982.1
• Gene: BRWD3 / 42898
• FlyBaseID: FBgn0011785
• Length: 2232
• Species: Drosophila melanogaster
• Sequence 2: XP_002940482.3
• Gene: brwd3 / 733720
• XenbaseID: XB-GENE-5757854
• Length: 1778
• Species: Xenopus tropicalis
• Alignment Length: 1920
• Identity: 726/1920 - (37%)
• Similarity: 1044/1920 - (54%)
• Gaps: 258/1920 - (13%)

  Fly    12 LKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELERKYKHIGANHL 76
            ::.||||||::||.:||...:|:||..||||.:::|.||||:|.||.:|:::|....|||.:::|
 Frog     1 MEAELYFLIARFLQSGPCRRSAQVLAEELEEYRLIPPRLDWEGKEHRRTYQDLVAANKHIPSDYL 65

  Fly    77 LEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLRTKE---------TVYC--HRSLRDYCTRLN 130
            |:||.|.||::|:|:|.||||::||||.|:|:|||:|:         |.:.  ||.        .
 Frog    66 LKICERFGPILDQEIPQSVPGLHSLLGLGKQSLLRSKKDCKNTPWKGTAFAALHRG--------R 122

  Fly   131 GVSLPDSVLTKPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLSSVYCVLFDRTG 195
            ...||.: ..||. |:..:...|...|......:.|:..|::.|:.:|.:|||||||||.|||||
 Frog   123 PPELPVN-YGKPL-NVVNITCARYQTGYAHYHRIFPSSTYQQMKMHKRILGHLSSVYCVAFDRTG 185

  Fly   196 RYIITGADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHILRVWDMQTTSPI 260
            |.|.||:||.|:|||::.|||||:||||.|:||:|:|:|.:||::||||.|.::|||.::|.:||
 Frog   186 RRIFTGSDDCLVKIWASDDGRLLSTLRGHSAEISDLAVNHENTLIAAGSCDKVVRVWCLRTCAPI 250

  Fly   261 AVLSAHTGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKPTQYHEKLRPGQ 325
            |||..||..|||:.|||..:...:||.:|..||:|.||::   ....:||..:|.::.|:.|||
 Frog   251 AVLQGHTASITSIQFCPGTKEKTRYLTSTGADGTICFWEW---HADTMTFNDRPVKFAERSRPG- 311

  Fly   326 AQMMCTTFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSHRG--LRFISGS 388
            .|:.|::||.||:|:|.||.||.:|:|.:|...|::|.|.||:.|.|.::|:.:..  |.|:|||
 Frog   312 VQISCSSFSSGGMFIATGSTDHVIRIYYLGSGSPEKIAELEAHLDKVVAIQFCNNSDRLCFVSGS 376

  Fly   389 KDGTAHIWTFESQQWKSSKLCMTERLASCP---EPEEGKRLKVTMVAWDASDRYVITAVNDFTIK 450
            :||||.||.::.|:||.:.|.||.::|...   ..::..:|||||||||.||..||||||:|.:|
 Frog   377 RDGTARIWQYQQQEWKMTVLDMTAKMAGSSVINTEDKVTKLKVTMVAWDRSDSSVITAVNNFFLK 441

  Fly   451 IWDSKSAKLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFLNDIDGQGH 515
            :|:|.:.:|..:|.||.||::|||.:|.|..:|:||||||.:|:||:|.|..:.|:.|.|:||||
 Frog   442 VWNSHTGELLHILSGHDDEVFVLEPHPFDPRILISAGHDGNIFVWDLETGTKIRNYFNMIEGQGH 506

  Fly   516 GSVFDAKWSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQHHVVDEQT 580
            |:|||.|:||||...|.||||||:|:||.| |.:.|:.:|.::|||||||||:||:..:|:||||
 Frog   507 GAVFDCKFSPDGQNFACTDSHGHLLLFGFG-CSKPYEKIPEQMFFHTDFRPLIRDSNSYVLDEQT 570

  Fly   581 QIMPHLMPPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNLTVGVDGVVIDDGGAGGDAVVAA 645
            |..|||||||||||.||||||:||||.|||||:|..:||||.|....:|        .||.|...
 Frog   571 QQAPHLMPPPFLVDVDGNPHPTRFQRLVPGRENCKDEQLIPQLGYMSNG--------NGDVVEQV 627

  Fly   646 APAEAPPAALPPAAAGGPQGANY--SHIDRMIAALANRQSVNVNANDANPTNGNQSFERLTNR-- 706
            .               |.|..|.  |.:|.:|..|...|.                 ||.||.
 Frog   628 I---------------GQQTGNQEESILDGIIRELQREQD-----------------ERHTNEAE 660

  Fly   707 --QMPDSNGRQSSRGNVLGS---RLSTPRQGWGAAAAAPVED--QAGPSQPPAEPAAEPGQAQVQ 764
              ..|..| |..||..||.|   .||:| ...|...:..:|.  |...:.|.::.|.|...
 Frog   661 DVDTPRYN-RTDSRNGVLRSISLDLSSP-PNVGLRRSGQIEGVRQMHSNAPRSQIATERDL---- 719

  Fly   765 QALPLKFIRRTYVRPMKYPQLQNLKQTIYSAGQFEKQEYKREMRRRPIMINTASAASSQQPGSVG 829
                :.:.||..|..:....::..::...|.|:.|...|..|.:|:|  .|.|.....|..|.
 Frog   720 ----MAWSRRVVVNELHPGVIRVQEECRISKGEMEISLYNTEKKRKP--TNPAQRNDYQAFGG-- 776

  Fly   830 RPRNTRGNGGGARAGRRRGPQPAGGQPQPAYRTRAVRDQEPE------HYDEVAPPPEEEEEDVS 888
              |:.|      |..|:|         |.||:||:..:.:..      :.::....|||||...|
 Frog   777 --RSLR------RIQRKR---------QHAYQTRSTIEHDARAKVPSTNGEDSQSSPEEEESQHS 824

  Fly   889 SNSSGDTSYSNVEENLEDSSDESETDSSDYSDWVADTPGPNLEPPKRSKRKPLSRRPRSSDDSSD 953
            :.:|||.:.:..:     |...|...||:||||.||. |.||:||||..|:...:...||:|.:.
 Frog   825 TEASGDEAAAQWQ-----SETSSSNSSSEYSDWTADA-GINLQPPKRQTRQTTRKMCSSSEDENA 883

  Fly   954 DERAGRSRGGQVTARKVGRKTVLFPPTDANGEIPELYRPAEWLSEVIPRKAPYYPQMGDEVVYFR 1018
            .|.. :.|..::|.||...:.:     ...||..|.:.|.:|:.:.|||::|:.|||||||:|||
 Frog   884 KEEE-KPRKHKLTRRKKQSERL-----SMEGEPSEEWIPPQWILDTIPRRSPFVPQMGDEVIYFR 942

  Fly  1019 QGHAKYLDAVRLKKVYKLSHSSEPWNFHTLRDHELVRVIGIKYEIRPPRLCCLKLAIID-EEGNM 1082
            |||..|:.|||..|:|.::...||||...|||.|..:::|||||:.||.|||||||::| ..|.:
 Frog   943 QGHEAYVRAVRKAKIYNINPQKEPWNKTDLRDQEFAKIVGIKYEVGPPTLCCLKLALLDPTSGKI 1007

  Fly  1083 TGTTFKIKYHDMPDVLDFLVLRQTFDLAVQRNWSIGDRFRCMIVDGWWMGQIESRHALSADFPDS 1147
            |..:|.:||||||||:|||||.|.:..|.:|||.||||||.:|.|.||.|.:||:.....::|||
 Frog  1008 TADSFSVKYHDMPDVIDFLVLYQFYKEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQTEYPDS 1072

  Fly  1148 SFMCFRVRWDNGEYEFMSPWDMEPI-DQQRVPDEVGGAVPVLPEEIRATLYQPKSEEWHRGDRDG 1211
            .|.|:.|.|||.|.|.||||||||| |...:|||:|..|||..:|:::..|:|:..||....||.
 Frog  1073 LFQCYSVHWDNNERENMSPWDMEPIPDGTALPDEMGAGVPVTSDELKSLQYKPEEGEWGLYSRDE 1137

  Fly  1212 TCRRIINGLEQVMRLSIAEHFLAPVDLNIYPDYAYLIEYPIDLTTIKSRFENHFYRRITSAQFDV 1276
            .|.|:|.|::|::.|..|..|.|||||:.||.|..::.||.||:|.:.|.|:|:|||:::..::|
 Frog  1138 VCERVIQGIDQLLTLDFASPFSAPVDLSAYPLYCTVVAYPTDLSTTRKRLESHYYRRLSALIWEV 1202

  Fly  1277 RYLATNAEQYNRRHAIIVKHSRIVTDLCLRIIREPDEIDVAAVYHQLADVYHSSESENEVDSDVV 1341
            ||:..||..:|.....||:.::||||:.||.|.:.:..|:..:|:|: ....:..:|:| :...|
 Frog  1203 RYIEHNARTFNEPDTPIVRTAKIVTDVLLRYIGDENCNDILEIYNQV-KTEDTGNTEDE-EGGAV 1265

  Fly  1342 PSTSTGPTTSAAAAAARQRVSSARRSTRIHSEGDWRADCRQLLDLMWARTDSAPFREPVDTIDFP 1406
            ...|..|.||:..|..|:......||    :...|:..|::||||::.|.||.|||:||:.:.:|
 Frog  1266 DMESDAPGTSSGRAVTRRTKRDLLRS----NPDSWKDKCKELLDLIYEREDSEPFRQPVNQVSYP 1326

  Fly  1407 DYLEIIATPMDLRTVKEDLLGGNYDDPLDFAKDVRLIFQNSKNYNTNKRSRIYAMTLRLSALFES 1471
            ||.:||.||||..|||..|..|||.|||:||.||||||.|||.|..||:||||:||||||||.|:
 Frog  1327 DYQDIIETPMDFSTVKTTLEAGNYSDPLEFAADVRLIFSNSKAYTPNKKSRIYSMTLRLSALCET 1391

  Fly  1472 HIKTVVTSWKAAL------RRANKNKSGSSGGGRGGSSSSPNKRVKKERSTRRNQKPTAAARR-- 1528
            :||.:::.:|.|:      ||..:.:..||......||||.|:|    ||:..:...::|:.|
 Frog  1392 YIKDIISDYKLAMQLQQRTRRKYRRRIRSSSSSSSSSSSSSNRR----RSSSSSSSSSSASSRAS 1452

  Fly  1529 ----------------------LPVANSS-----EDEDEEDDDDDDDDDDEEEASTRGRS----- 1561
                                  ||.::||     .|.|.|.|.....:|.::|.|:.|.|
 Frog  1453 SPDTKPRKMKLQPKLNQNPPHPLPRSSSSSTSQMSDTDVEPDGKPFSEDMDQEPSSSGCSKPETH 1517

  Fly  1562 RRRNGVAVSASSSGSNRVTS---------SSAAQQRRGKSSSSEEEEEEETSAQATSDAS--SDE 1615
            :.:..|..|.:|......|:         ::...:|:..|||.:|..|:....:...|.|  ...
 Frog  1518 KEQENVTKSKNSPVKEEHTNGPLTNGDGGNTPKTKRKLLSSSEDESPEDGEQMEEKPDKSPACSR 1582

  Fly  1616 EERAQSNDSSPQQTRTRRARQRQRLSDDSNINDSEDSYN-----------------PNEGRGSRR 1663
            |..::|:.||..::.:..:...:.:..|.:..|.:..|:                 ...|||..|
 Frog  1583 ERDSESSLSSKSESESESSSDSESIKSDQDYIDGDHHYSKEPRTKFKRKFCKSGEAKTRGRGRGR 1647

  Fly  1664 RPGAARPSS-NRQTNGHSSKRRRLNKSPANAAPGPSLPRRTRRIAGSSAEEAASHSQHDESTQDS 1727
            ..|..|... ||.......|.|...:.....| ....|.||..:..:...:.......|:...|.
 Frog  1648 GRGRGRAKGYNRGVEEELKKGRGRGRGRGRGA-WKKEPSRTPALKRAQLTDDEDDDNVDDEESDC 1711

  Fly  1728 QIGRRKGRSASSRSIGNGPSTSAAAAANSSLESPSRNTRANGTRTSSHLG-AENDH----SYHLP 1787
            ...|||                          .|..|||..|.||..:.. ::|:|    .|..|
 Frog  1712 VEQRRK--------------------------KPRINTRNQGRRTVLYNDESDNEHDGAGQYDDP 1750

  Fly  1788 V-----RNGRIIESDTDSPVIRPTRQSAKRALMDW 1817
            :     |:||         |.:.|.::....||.|
 Frog  1751 LNLGTSRSGR---------VRKMTEKARVSHLMGW 1776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BRWD3	NP_732982.1	WD40	171..541	CDD:441893	188/374 (50%)
		WD40 repeat	186..223	CDD:293791	26/36 (72%)
		WD40 repeat	229..265	CDD:293791	19/35 (54%)
		WD40 repeat	270..311	CDD:293791	15/40 (38%)
		WD40 repeat	331..364	CDD:293791	15/32 (47%)
		WD40 repeat	372..413	CDD:293791	19/42 (45%)
		WD40 repeat	428..464	CDD:293791	20/35 (57%)
		WD40 repeat	470..495	CDD:293791	13/24 (54%)
		Bromo_WDR9_I_like	1196..1311	CDD:99958	48/114 (42%)
		Bromo_WDR9_II	1371..1489	CDD:99928	66/123 (54%)
		PHA03307	1604..>1822	CDD:223039	47/244 (19%)
brwd3	XP_002940482.3	WD40	<171..490	CDD:441893	161/322 (50%)
		WD40 repeat	176..213	CDD:293791	26/36 (72%)
		WD40 repeat	219..255	CDD:293791	19/35 (54%)
		WD40 repeat	260..300	CDD:293791	16/42 (38%)
		WD40 repeat	315..352	CDD:293791	17/36 (47%)
		WD40 repeat	358..397	CDD:293791	16/38 (42%)
		WD40 repeat	419..455	CDD:293791	20/35 (57%)
		WD40 repeat	461..486	CDD:293791	13/24 (54%)
		Bromo_WDR9_I_like	1123..1234	CDD:99958	47/110 (43%)
		Bromodomain	1296..1409	CDD:445827	64/112 (57%)