Protein Alignment BRWD3 and phip

DIOPT Version :10

• Sequence 1: NP_732982.1
• Gene: BRWD3 / 42898
• FlyBaseID: FBgn0011785
• Length: 2232
• Species: Drosophila melanogaster
• Sequence 2: XP_021329407.2
• Gene: phip / 569727
• ZFINID: ZDB-GENE-050208-261
• Length: 1807
• Species: Danio rerio
• Alignment Length: 2258
• Identity: 780/2258 - (34%)
• Similarity: 1088/2258 - (48%)
• Gaps: 509/2258 - (22%)

  Fly    12 LKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELERKYKHIGANHL 76
            ||.||||||::||.|||.::.|:.||||:::|::||:|:||.|.||..::|.|.:.|:||..:||
Zfish    11 LKSELYFLIARFLEAGPCQDAAETLIREVQQKELLPKRIDWTGKEHPGSYENLVKLYRHISPDHL 75

  Fly    77 LEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLRT----KETVYCHRSLRD-YCTRLNGVSLPD 136
            |::|.|:.||::||:|.||||:|||||||||::|||    |..|:...:|.. :|.|   ...|.
Zfish    76 LQVCERVSPLLEREVPASVPGVNSLLGTGRQSVLRTNKSCKHVVWKGSALAALHCGR---PPEPP 137

  Fly   137 SVLTKPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLSSVYCVLFDRTGRYIITG 201
            .:...|. |:...:..|...|..|...||||.:|:..|:.:|.:|||||||||.||||||.|.||
Zfish   138 VIFGSPP-NIAETIHSRRLNGSYRLGQLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTG 201

  Fly   202 ADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHILRVWDMQTTSPIAVLSAH 266
            :||.|:|||:..||.|||||||.::||:|:|:|.:||:|||||.|.::|||.:||.:|:|||..|
Zfish   202 SDDCLVKIWATDDGHLLATLRGHAAEISDMAVNYENTLLAAGSCDKMIRVWCLQTCAPLAVLEGH 266

  Fly   267 TGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKPTQYHEKLRPGQAQMMCT 331
            ...|||:.|.|....:.::|.:|..||:|.|||:.   .:.:.|..:|:::.|:.||| .||:|:
Zfish   267 AASITSLQFSPLCSGNKRFLSSTGADGTICFWQWD---ARTLKFGQRPSKFIERPRPG-VQMICS 327

  Fly   332 TFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSHRGLRFISGSKDGTAHIW 396
            :||.||:|||.||.||.:|||..|...|::|.|.|::||.|||:|:||.|.||:|||:||||.||
Zfish   328 SFSAGGMFLATGSTDHIIRVYYFGGGQPEKISELESHTDKVDSIQFSHSGDRFVSGSRDGTARIW 392

  Fly   397 TFESQQWKSSKLCMTERLAS--CPEPEEGK--RLKVTMVAWDASDRYVITAVNDFTIKIWDSKSA 457
            ..:.|.|:|..|.|..:|..  .|.|.|.|  :|||||||||.:|..||||.|:.|:|:|:|.:.
Zfish   393 QLQQQDWRSILLDMATKLPGKYNPPPLEDKVTKLKVTMVAWDCNDNTVITAANNLTLKVWNSYTG 457

  Fly   458 KLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFLNDIDGQGHGSVFDAK 522
            .|..||.||:||::|||.:|.|..||.||||||...:||:.:||.:.::.|.|:|||||:|||.|
Zfish   458 NLIHVLMGHEDEVFVLEPHPFDSRVLFSAGHDGNAIVWDLARGVKIRSYFNMIEGQGHGAVFDCK 522

  Fly   523 WSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQHHVVDEQTQIMPHLM 587
            .||||...|.||||||:||||.| ...:|..:..::|||||:|||:|||.:.|:|||||..||||
Zfish   523 CSPDGQHFACTDSHGHLLIFGFG-SSSRYDKIADQMFFHTDYRPLIRDAHNFVLDEQTQQAPHLM 586

  Fly   588 PPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNLTVGVDGVVIDDGGAGGDAVVAAAPAEAPP 652
            |||||||.||||||.||||.|||||:|..:||||.:.:...|:         :.||:...||..
Zfish   587 PPPFLVDVDGNPHPPRFQRLVPGRENCREEQLIPQMGLTSSGL---------NQVVSQQAAEGS- 641

  Fly   653 AALPPAAAGGPQGANYSHIDRMIAALANRQSVNVNANDANPTNGNQSFERLTNRQMPDSNGRQSS 717
                            |.:|.||..|...|...: .:|:....|:.|..  |....|.:.|.:.|
Zfish   642 ----------------SPLDSMIQRLQQEQDQRL-GSDSRANRGSVSSP--TEVTSPPNVGLRRS 687

  Fly   718 RGNVLGSRLSTPRQGWGAAAAAPVEDQAGPSQPPAEPAAEPGQAQVQQALPLKFIRRTYVRPMKY 782
             |.:.|.|                  |...:.|.:|.|.|...        :.:.||..|
Zfish   688 -GQIEGVR------------------QMHSNAPRSEIATERDL--------VAWSRRVLV----- 720

  Fly   783 PQLQ---NLKQTIY--SAGQFEKQEYKREMRRRPIMINTASAASSQQPGSVGRPRNTRGNGGGAR 842
            |:|.   ..||.|:  :.|:.|...|:.|.|||.:        .||.     ...|.......|.
Zfish   721 PELSLAIACKQEIWRTAKGEEEINIYRSERRRRSL--------HSQY-----HRENRHAIENAAE 772

  Fly   843 AGRRRGPQPAGGQPQPAYRTRAV-----RDQEPEHYDEVAPPPEEEEEDVSSNSSGDTSYSNVEE 902
            .|||.    .|.|..  |.||..     |..||...:..|...|.|....|..||.:.  ...:|
Zfish   773 EGRRH----QGNQHN--YHTRLAVEETSRQSEPNEEEHSASEGETEVRPPSRESSDEE--REEKE 829

  Fly   903 NLEDSSDESETDSSDYSDWVADTPGPNLEPPKR-SKRKPLSRRPRSSDDSSDDERAGRSRGGQVT 966
            ...|.:..|...|||||||.||. |.||||||: |.:|...:...||::..:.::..:....:..
Zfish   830 PWPDENSSSSDYSSDYSDWTADA-GINLEPPKKTSVKKKKKKNASSSEEDGEKKKDSKKERRKEK 893

  Fly   967 ARKVGRKTVLFPPTDANGEIPEL---------YRPAEWLSEVIPRKAPYYPQMGDEVVYFRQGHA 1022
            ..|.|.......|.:....||||         :.|:.|:::.:||:.|:.|||||||.||||||.
Zfish   894 PDKDGALPKKKKPKEKRKRIPELQNQGLTLEEWLPSNWITDTMPRRCPFTPQMGDEVYYFRQGHE 958

  Fly  1023 KYLDAVRLKKVYKLSHSSEPWNFHTLRDHELVRVIGIKYEIRPPRLCCLKLAIID-EEGNMTGTT 1086
            .|::..:..|::.::...:||:...||:.||::::|||||:..|.|||||||.:| :.|.:||.:
Zfish   959 AYVEMAKKNKIFSINPKKQPWHKLELREQELLKIVGIKYEVGLPTLCCLKLAFLDPDSGKLTGGS 1023

  Fly  1087 FKIKYHDMPDVLDFLVLRQTFDLAVQRNWSIGDRFRCMIVDGWWMGQIESRHALSADFPDSSFMC 1151
            |.|||||||||:|||||||.||.|.||||.||||||.:|.|.||.|.|||:....|::|||.|.|
Zfish  1024 FSIKYHDMPDVIDFLVLRQQFDNARQRNWMIGDRFRAVIDDAWWFGTIESQEPYQAEYPDSLFQC 1088

  Fly  1152 FRVRWDNGEYEFMSPWDMEPI-DQQRVPDEVGGAVPVLPEEIRATLYQPKSEEWHRGDRDGTCRR 1215
            :.|.||||:.|.|||||||.: |:...|:|:|.::.:..:|.:|.||:|...||....|:..|.|
Zfish  1089 YNVCWDNGDTEKMSPWDMEEVPDEVVFPEELGLSMALTQDEQKALLYKPLDGEWGSRTRNQECER 1153

  Fly  1216 IINGLEQVMRLSIAEHFLAPVDLNIYPDYAYLIEYPIDLTTIKSRFENHFYRRITSAQFDVRYLA 1280
            ||.|:.|:..|.:|:.|..||||..||.|..::.|..||:||:.|.||.||||::|..::|||:.
Zfish  1154 IIRGINQLCTLDVAKPFELPVDLQAYPTYCTVVAYVTDLSTIRQRLENRFYRRMSSLMWEVRYIE 1218

  Fly  1281 TNAEQYNRRHAIIVKHSRIVTDLCLRIIREPDEIDVAAVYHQLADVYHS----SESENEVDSDVV 1341
            .||:.:|...|.||:.::.|:||.|:.|::....|:..:|:.:.....|    .|.|:|.:....
Zfish  1219 HNAQTFNEPGAFIVRTAKFVSDLMLQFIKDQSCTDIIPLYNSMKKTAFSDSSDDEDEDEDEEHEA 1283

  Fly  1342 PSTSTGPTTSAAAAAARQRVSSARRSTRIHSEGD---WRADCRQLLDLMWARTDSAPFREPVDTI 1403
            |.||.       ....||:.....||.|.....|   |:..||:||:|::...||.|||:|||..
Zfish  1284 PCTSN-------RNKKRQQQQPMLRSLRSKPSSDPQAWKERCRELLELIFQCEDSEPFRQPVDLD 1341

  Fly  1404 DFPDYLEIIATPMDLRTVKEDLLGGNYDDPLDFAKDVRLIFQNSKNYNTNKRSRIYAMTLRLSAL 1468
            ::||||:|:.||||..||...||.|.||.|:|..|||||||.|||.|..:|:||||:|:||||||
Zfish  1342 EYPDYLDIVDTPMDFGTVLNRLLAGEYDTPMDLCKDVRLIFSNSKAYTPSKKSRIYSMSLRLSAL 1406

  Fly  1469 FESHIKTVVTSWKAALRRANKNKSGSSGGGRGGSSSSPNKRVKKERSTRRNQKPTAAARRLPVAN 1533
            ||.||.:::|.:|||                        :.:..||.||         :||
Zfish  1407 FEEHISSILTDFKAA------------------------QSLHSERLTR---------QRL---- 1434

  Fly  1534 SSEDEDEEDDDDDDDDDDEEEASTRGRSRRRNGVAVSASSSGSNRVTSSSAAQQRRGKSSSSEEE 1598
                                                     .::|:|..|..::||..||.|
Zfish  1435 -----------------------------------------HTDRLTRQSVKKRRRRSSSHS--- 1455

  Fly  1599 EEEETSAQATSDASSDEEERAQSNDSSPQQTRTRRARQRQRLSDDSNINDSEDSYNPNEGRGSRR 1663
                      |.|||.|.:|..|:.:.|            ||          ||..|....|..|
Zfish  1456 ----------SSASSPERKRRVSSRAPP------------RL----------DSAAPPTPAGPSR 1488

  Fly  1664 RPGAARPSSNRQTNGHSSKRRRLNKSPANAAPGPSLPRRTRRIAGSSAEEAASHSQHDESTQDSQ 1728
            .|...:  ::.|.||              .|..|.:|.|||
Zfish  1489 APSLRQ--THPQING--------------KAETPVVPGRTR------------------------ 1513

  Fly  1729 IGRRKGRSASSRSIGNGPSTSAAAAANSS---LESPSRNTRANGTRTSSHLGAENDHSYHLPVRN 1790
                     ||...|: |.|..|.|.::.   :||.|          |..|..:|.||
Zfish  1514 ---------SSARFGS-PITDVAPAQSAPPPLVESSS----------SRVLRTQNPHS------- 1551

  Fly  1791 GRIIESDTDSPVIRPTRQSAKRALMDWGRGSDIEEEEEEEEEDSEEAEEILPTPTKDDLPSTSRA 1855
             ..:..:.:|..:.|:.....|                       |:...|.||.|
Zfish  1552 -TAVSRENESSAVPPSNGGGAR-----------------------ESRRKLRTPVK--------- 1583

  Fly  1856 ALAQAAAGPSRQLRTNRNTVVRPAQSDDDDDDDSDNEPLANNQQKNYQSPAKSSSTATVAPHPLS 1920
                                                                      :.|.|:.
Zfish  1584 ----------------------------------------------------------LTPGPVD 1590

  Fly  1921 LRRRLASPPERNTHMTRSHATSTTSSAAASRAEQQPAVSTHDHNYLGNVNSSRAPRRILSRHQRN 1985
                .:|||:.:.|: ..|:..|..                                 :.|..|.
Zfish  1591 ----HSSPPQNSLHL-NGHSQVTVG---------------------------------MVRRGRG 1617

  Fly  1986 ADELDTSLDVLENSRLLSAIANHRRPTSTTNSNSASNVVTRRLRGRASQANSHDEDHEEEEAAAS 2050
            ...|||.::        :.:.....|...|:|..     ..|...:.:::...:..||||....:
Zfish  1618 RPRLDTQIE--------TPVDTPPPPLPKTSSKK-----KERKSKKDTESPRRNFSHEEELMLPT 1669

  Fly  2051 DEGTDGGSSSQSYEDEDEDSDSEDNQPLTSYVSPSNGRPRRKAKTSSSSATTQERPLRRTRRPPS 2115
              |.|||:||.:     :||:..|    :.....:.||| |..||..:.|            |||
Zfish  1670 --GDDGGASSTA-----QDSNLSD----SGEYPKARGRP-RITKTIDTPA------------PPS 1710

  Fly  2116 NNSIANDNDDDDDYVVPRSRRANRGGNQRAGRNQKRPRYNEQSEEEEAAAGYSHRSKRIRNGDAH 2180
            ..::               ||::|.||:....:...   :.||||.|...|....||    |...
Zfish  1711 PKTL---------------RRSSRRGNEEITPHTSG---SAQSEEPEVYIGEDGSSK----GQMK 1753

  Fly  2181 ASSQERSQA-STERDQEEEEDGTSVDSEEQQVNVSSRGRVRKPSAKAR 2227
            ..:|.|..| ..|.|.|||:.....:........||:|||||.:.||:
Zfish  1754 TRNQGRRTAFYNEEDSEEEQRQLLFEDASITFGTSSKGRVRKLTEKAK 1801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BRWD3	NP_732982.1	WD40	171..541	CDD:441893	194/373 (52%)
		WD40 repeat	186..223	CDD:293791	26/36 (72%)
		WD40 repeat	229..265	CDD:293791	20/35 (57%)
		WD40 repeat	270..311	CDD:293791	13/40 (33%)
		WD40 repeat	331..364	CDD:293791	17/32 (53%)
		WD40 repeat	372..413	CDD:293791	23/40 (58%)
		WD40 repeat	428..464	CDD:293791	19/35 (54%)
		WD40 repeat	470..495	CDD:293791	13/24 (54%)
		Bromo_WDR9_I_like	1196..1311	CDD:99958	49/114 (43%)
		Bromo_WDR9_II	1371..1489	CDD:99928	64/120 (53%)
		PHA03307	1604..>1822	CDD:223039	43/220 (20%)
phip	XP_021329407.2	None