DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BRWD3 and phip

DIOPT Version :9

Sequence 1:NP_732982.1 Gene:BRWD3 / 42898 FlyBaseID:FBgn0011785 Length:2232 Species:Drosophila melanogaster
Sequence 2:XP_009295279.1 Gene:phip / 569727 ZFINID:ZDB-GENE-050208-261 Length:1807 Species:Danio rerio


Alignment Length:2258 Identity:780/2258 - (34%)
Similarity:1088/2258 - (48%) Gaps:509/2258 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELERKYKHIGANHL 76
            ||.||||||::||.|||.::.|:.||||:::|::||:|:||.|.||..::|.|.:.|:||..:||
Zfish    11 LKSELYFLIARFLEAGPCQDAAETLIREVQQKELLPKRIDWTGKEHPGSYENLVKLYRHISPDHL 75

  Fly    77 LEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLRT----KETVYCHRSLRD-YCTRLNGVSLPD 136
            |::|.|:.||::||:|.||||:|||||||||::|||    |..|:...:|.. :|.|   ...|.
Zfish    76 LQVCERVSPLLEREVPASVPGVNSLLGTGRQSVLRTNKSCKHVVWKGSALAALHCGR---PPEPP 137

  Fly   137 SVLTKPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLSSVYCVLFDRTGRYIITG 201
            .:...|. |:...:..|...|..|...||||.:|:..|:.:|.:|||||||||.||||||.|.||
Zfish   138 VIFGSPP-NIAETIHSRRLNGSYRLGQLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRIFTG 201

  Fly   202 ADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHILRVWDMQTTSPIAVLSAH 266
            :||.|:|||:..||.|||||||.::||:|:|:|.:||:|||||.|.::|||.:||.:|:|||..|
Zfish   202 SDDCLVKIWATDDGHLLATLRGHAAEISDMAVNYENTLLAAGSCDKMIRVWCLQTCAPLAVLEGH 266

  Fly   267 TGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKPTQYHEKLRPGQAQMMCT 331
            ...|||:.|.|....:.::|.:|..||:|.|||:.   .:.:.|..:|:::.|:.||| .||:|:
Zfish   267 AASITSLQFSPLCSGNKRFLSSTGADGTICFWQWD---ARTLKFGQRPSKFIERPRPG-VQMICS 327

  Fly   332 TFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSHRGLRFISGSKDGTAHIW 396
            :||.||:|||.||.||.:|||..|...|::|.|.|::||.|||:|:||.|.||:|||:||||.||
Zfish   328 SFSAGGMFLATGSTDHIIRVYYFGGGQPEKISELESHTDKVDSIQFSHSGDRFVSGSRDGTARIW 392

  Fly   397 TFESQQWKSSKLCMTERLAS--CPEPEEGK--RLKVTMVAWDASDRYVITAVNDFTIKIWDSKSA 457
            ..:.|.|:|..|.|..:|..  .|.|.|.|  :|||||||||.:|..||||.|:.|:|:|:|.:.
Zfish   393 QLQQQDWRSILLDMATKLPGKYNPPPLEDKVTKLKVTMVAWDCNDNTVITAANNLTLKVWNSYTG 457

  Fly   458 KLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFLNDIDGQGHGSVFDAK 522
            .|..||.||:||::|||.:|.|..||.||||||...:||:.:||.:.::.|.|:|||||:|||.|
Zfish   458 NLIHVLMGHEDEVFVLEPHPFDSRVLFSAGHDGNAIVWDLARGVKIRSYFNMIEGQGHGAVFDCK 522

  Fly   523 WSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQHHVVDEQTQIMPHLM 587
            .||||...|.||||||:||||.| ...:|..:..::|||||:|||:|||.:.|:|||||..||||
Zfish   523 CSPDGQHFACTDSHGHLLIFGFG-SSSRYDKIADQMFFHTDYRPLIRDAHNFVLDEQTQQAPHLM 586

  Fly   588 PPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNLTVGVDGVVIDDGGAGGDAVVAAAPAEAPP 652
            |||||||.||||||.||||.|||||:|..:||||.:.:...|:         :.||:...||.. 
Zfish   587 PPPFLVDVDGNPHPPRFQRLVPGRENCREEQLIPQMGLTSSGL---------NQVVSQQAAEGS- 641

  Fly   653 AALPPAAAGGPQGANYSHIDRMIAALANRQSVNVNANDANPTNGNQSFERLTNRQMPDSNGRQSS 717
                            |.:|.||..|...|...: .:|:....|:.|..  |....|.:.|.:.|
Zfish   642 ----------------SPLDSMIQRLQQEQDQRL-GSDSRANRGSVSSP--TEVTSPPNVGLRRS 687

  Fly   718 RGNVLGSRLSTPRQGWGAAAAAPVEDQAGPSQPPAEPAAEPGQAQVQQALPLKFIRRTYVRPMKY 782
             |.:.|.|                  |...:.|.:|.|.|...        :.:.||..|     
Zfish   688 -GQIEGVR------------------QMHSNAPRSEIATERDL--------VAWSRRVLV----- 720

  Fly   783 PQLQ---NLKQTIY--SAGQFEKQEYKREMRRRPIMINTASAASSQQPGSVGRPRNTRGNGGGAR 842
            |:|.   ..||.|:  :.|:.|...|:.|.|||.:        .||.     ...|.......|.
Zfish   721 PELSLAIACKQEIWRTAKGEEEINIYRSERRRRSL--------HSQY-----HRENRHAIENAAE 772

  Fly   843 AGRRRGPQPAGGQPQPAYRTRAV-----RDQEPEHYDEVAPPPEEEEEDVSSNSSGDTSYSNVEE 902
            .|||.    .|.|..  |.||..     |..||...:..|...|.|....|..||.:.  ...:|
Zfish   773 EGRRH----QGNQHN--YHTRLAVEETSRQSEPNEEEHSASEGETEVRPPSRESSDEE--REEKE 829

  Fly   903 NLEDSSDESETDSSDYSDWVADTPGPNLEPPKR-SKRKPLSRRPRSSDDSSDDERAGRSRGGQVT 966
            ...|.:..|...|||||||.||. |.||||||: |.:|...:...||::..:.::..:....:..
Zfish   830 PWPDENSSSSDYSSDYSDWTADA-GINLEPPKKTSVKKKKKKNASSSEEDGEKKKDSKKERRKEK 893

  Fly   967 ARKVGRKTVLFPPTDANGEIPEL---------YRPAEWLSEVIPRKAPYYPQMGDEVVYFRQGHA 1022
            ..|.|.......|.:....||||         :.|:.|:::.:||:.|:.|||||||.||||||.
Zfish   894 PDKDGALPKKKKPKEKRKRIPELQNQGLTLEEWLPSNWITDTMPRRCPFTPQMGDEVYYFRQGHE 958

  Fly  1023 KYLDAVRLKKVYKLSHSSEPWNFHTLRDHELVRVIGIKYEIRPPRLCCLKLAIID-EEGNMTGTT 1086
            .|::..:..|::.::...:||:...||:.||::::|||||:..|.|||||||.:| :.|.:||.:
Zfish   959 AYVEMAKKNKIFSINPKKQPWHKLELREQELLKIVGIKYEVGLPTLCCLKLAFLDPDSGKLTGGS 1023

  Fly  1087 FKIKYHDMPDVLDFLVLRQTFDLAVQRNWSIGDRFRCMIVDGWWMGQIESRHALSADFPDSSFMC 1151
            |.|||||||||:|||||||.||.|.||||.||||||.:|.|.||.|.|||:....|::|||.|.|
Zfish  1024 FSIKYHDMPDVIDFLVLRQQFDNARQRNWMIGDRFRAVIDDAWWFGTIESQEPYQAEYPDSLFQC 1088

  Fly  1152 FRVRWDNGEYEFMSPWDMEPI-DQQRVPDEVGGAVPVLPEEIRATLYQPKSEEWHRGDRDGTCRR 1215
            :.|.||||:.|.|||||||.: |:...|:|:|.::.:..:|.:|.||:|...||....|:..|.|
Zfish  1089 YNVCWDNGDTEKMSPWDMEEVPDEVVFPEELGLSMALTQDEQKALLYKPLDGEWGSRTRNQECER 1153

  Fly  1216 IINGLEQVMRLSIAEHFLAPVDLNIYPDYAYLIEYPIDLTTIKSRFENHFYRRITSAQFDVRYLA 1280
            ||.|:.|:..|.:|:.|..||||..||.|..::.|..||:||:.|.||.||||::|..::|||:.
Zfish  1154 IIRGINQLCTLDVAKPFELPVDLQAYPTYCTVVAYVTDLSTIRQRLENRFYRRMSSLMWEVRYIE 1218

  Fly  1281 TNAEQYNRRHAIIVKHSRIVTDLCLRIIREPDEIDVAAVYHQLADVYHS----SESENEVDSDVV 1341
            .||:.:|...|.||:.::.|:||.|:.|::....|:..:|:.:.....|    .|.|:|.:....
Zfish  1219 HNAQTFNEPGAFIVRTAKFVSDLMLQFIKDQSCTDIIPLYNSMKKTAFSDSSDDEDEDEDEEHEA 1283

  Fly  1342 PSTSTGPTTSAAAAAARQRVSSARRSTRIHSEGD---WRADCRQLLDLMWARTDSAPFREPVDTI 1403
            |.||.       ....||:.....||.|.....|   |:..||:||:|::...||.|||:|||..
Zfish  1284 PCTSN-------RNKKRQQQQPMLRSLRSKPSSDPQAWKERCRELLELIFQCEDSEPFRQPVDLD 1341

  Fly  1404 DFPDYLEIIATPMDLRTVKEDLLGGNYDDPLDFAKDVRLIFQNSKNYNTNKRSRIYAMTLRLSAL 1468
            ::||||:|:.||||..||...||.|.||.|:|..|||||||.|||.|..:|:||||:|:||||||
Zfish  1342 EYPDYLDIVDTPMDFGTVLNRLLAGEYDTPMDLCKDVRLIFSNSKAYTPSKKSRIYSMSLRLSAL 1406

  Fly  1469 FESHIKTVVTSWKAALRRANKNKSGSSGGGRGGSSSSPNKRVKKERSTRRNQKPTAAARRLPVAN 1533
            ||.||.:::|.:|||                        :.:..||.||         :||    
Zfish  1407 FEEHISSILTDFKAA------------------------QSLHSERLTR---------QRL---- 1434

  Fly  1534 SSEDEDEEDDDDDDDDDDEEEASTRGRSRRRNGVAVSASSSGSNRVTSSSAAQQRRGKSSSSEEE 1598
                                                     .::|:|..|..::||..||.|   
Zfish  1435 -----------------------------------------HTDRLTRQSVKKRRRRSSSHS--- 1455

  Fly  1599 EEEETSAQATSDASSDEEERAQSNDSSPQQTRTRRARQRQRLSDDSNINDSEDSYNPNEGRGSRR 1663
                      |.|||.|.:|..|:.:.|            ||          ||..|....|..|
Zfish  1456 ----------SSASSPERKRRVSSRAPP------------RL----------DSAAPPTPAGPSR 1488

  Fly  1664 RPGAARPSSNRQTNGHSSKRRRLNKSPANAAPGPSLPRRTRRIAGSSAEEAASHSQHDESTQDSQ 1728
            .|...:  ::.|.||              .|..|.:|.|||                        
Zfish  1489 APSLRQ--THPQING--------------KAETPVVPGRTR------------------------ 1513

  Fly  1729 IGRRKGRSASSRSIGNGPSTSAAAAANSS---LESPSRNTRANGTRTSSHLGAENDHSYHLPVRN 1790
                     ||...|: |.|..|.|.::.   :||.|          |..|..:|.||       
Zfish  1514 ---------SSARFGS-PITDVAPAQSAPPPLVESSS----------SRVLRTQNPHS------- 1551

  Fly  1791 GRIIESDTDSPVIRPTRQSAKRALMDWGRGSDIEEEEEEEEEDSEEAEEILPTPTKDDLPSTSRA 1855
             ..:..:.:|..:.|:.....|                       |:...|.||.|         
Zfish  1552 -TAVSRENESSAVPPSNGGGAR-----------------------ESRRKLRTPVK--------- 1583

  Fly  1856 ALAQAAAGPSRQLRTNRNTVVRPAQSDDDDDDDSDNEPLANNQQKNYQSPAKSSSTATVAPHPLS 1920
                                                                      :.|.|:.
Zfish  1584 ----------------------------------------------------------LTPGPVD 1590

  Fly  1921 LRRRLASPPERNTHMTRSHATSTTSSAAASRAEQQPAVSTHDHNYLGNVNSSRAPRRILSRHQRN 1985
                .:|||:.:.|: ..|:..|..                                 :.|..|.
Zfish  1591 ----HSSPPQNSLHL-NGHSQVTVG---------------------------------MVRRGRG 1617

  Fly  1986 ADELDTSLDVLENSRLLSAIANHRRPTSTTNSNSASNVVTRRLRGRASQANSHDEDHEEEEAAAS 2050
            ...|||.::        :.:.....|...|:|..     ..|...:.:::...:..||||....:
Zfish  1618 RPRLDTQIE--------TPVDTPPPPLPKTSSKK-----KERKSKKDTESPRRNFSHEEELMLPT 1669

  Fly  2051 DEGTDGGSSSQSYEDEDEDSDSEDNQPLTSYVSPSNGRPRRKAKTSSSSATTQERPLRRTRRPPS 2115
              |.|||:||.:     :||:..|    :.....:.||| |..||..:.|            |||
Zfish  1670 --GDDGGASSTA-----QDSNLSD----SGEYPKARGRP-RITKTIDTPA------------PPS 1710

  Fly  2116 NNSIANDNDDDDDYVVPRSRRANRGGNQRAGRNQKRPRYNEQSEEEEAAAGYSHRSKRIRNGDAH 2180
            ..::               ||::|.||:....:...   :.||||.|...|....||    |...
Zfish  1711 PKTL---------------RRSSRRGNEEITPHTSG---SAQSEEPEVYIGEDGSSK----GQMK 1753

  Fly  2181 ASSQERSQA-STERDQEEEEDGTSVDSEEQQVNVSSRGRVRKPSAKAR 2227
            ..:|.|..| ..|.|.|||:.....:........||:|||||.:.||:
Zfish  1754 TRNQGRRTAFYNEEDSEEEQRQLLFEDASITFGTSSKGRVRKLTEKAK 1801

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BRWD3NP_732982.1 WD40 176..496 CDD:238121 167/323 (52%)
WD40 181..544 CDD:225201 195/366 (53%)
WD40 repeat 186..223 CDD:293791 26/36 (72%)
WD40 repeat 229..265 CDD:293791 20/35 (57%)
WD40 repeat 270..311 CDD:293791 13/40 (33%)
WD40 repeat 331..364 CDD:293791 17/32 (53%)
WD40 repeat 372..413 CDD:293791 23/40 (58%)
WD40 repeat 428..464 CDD:293791 19/35 (54%)
WD40 repeat 470..495 CDD:293791 13/24 (54%)
Auxin_resp 1083..1167 CDD:284030 54/83 (65%)
Bromo_WDR9_I_like 1196..1311 CDD:99958 49/114 (43%)
Bromo_WDR9_II 1371..1489 CDD:99928 64/120 (53%)
phipXP_009295279.1 WD40 repeat 229..265 CDD:293791 20/35 (57%)
WD40 repeat 270..315 CDD:293791 15/47 (32%)
WD40 repeat 323..362 CDD:293791 21/38 (55%)
WD40 repeat 368..415 CDD:293791 24/46 (52%)
WD40 repeat 470..495 CDD:293791 13/24 (54%)
Bromo_WDR9_I_like 1134..1249 CDD:99958 49/114 (43%)
Bromodomain 1310..1422 CDD:295360 64/135 (47%)
SP2 1479..>1553 CDD:281067 28/141 (20%)
WD40 175..496 CDD:238121 167/324 (52%)
WD40 178..542 CDD:225201 194/367 (53%)
WD40 repeat 186..223 CDD:293791 26/36 (72%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170596514
Domainoid 1 1.000 539 1.000 Domainoid score I260
eggNOG 1 0.900 - - E2759_KOG0644
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1162 1.000 Inparanoid score I196
OMA 1 1.010 - - QHG52858
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001192
OrthoInspector 1 1.000 - - otm25326
orthoMCL 1 0.900 - - OOG6_101711
Panther 1 1.100 - - O PTHR16266
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5357
SonicParanoid 1 1.000 - - X735
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1413.790

Return to query results.
Submit another query.