DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BRWD3 and brwd3

DIOPT Version :9

Sequence 1:	NP_732982.1	Gene:	BRWD3 / 42898	FlyBaseID:	FBgn0011785	Length:	2232	Species:	Drosophila melanogaster
Sequence 2:	XP_009299685.1	Gene:	brwd3 / 553209	ZFINID:	ZDB-GENE-100921-43	Length:	1742	Species:	Danio rerio

Alignment Length:	1943	Identity:	717/1943 - (36%)
Similarity:	1051/1943 - (54%)	Gaps:	284/1943 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QPSSGDDLKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELERKYK 69
            :|.|  .::.|||:||::||.:||.:::|::|::||.|.:::|:|..|.|.:.:::|::.....:
Zfish     4 EPCS--QIEAELYYLIARFLQSGPCQKSAQMLLQELHEYEIIPKRWSWDGEQFKRSFDDWVLLNQ 66

  Fly    70 HIGANHLLEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLRTKETVYCHRSLRDYCTRLNGVSL 134
            ||.|::||.:|..:|||:|:.:||||||::||||||||:||||.:: ..|       |..:|.::
Zfish    67 HIPADYLLRVCKEVGPLIDKHIPPSVPGVHSLLGTGRQSLLRTAKS-SSH-------TLWSGSAV 123

  Fly   135 -----------PDSVLTKPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLSSVYC 188
                       |.|....|  |:..::..|:..|..|.....|:..|:..|:.||.:||||||||
Zfish   124 AALHRGRPPEPPISCAKSP--NIVSIIGARQKTGVARFGHAFPSCAYQHMKMHRRILGHLSSVYC 186

  Fly   189 VLFDRTGRYIITGADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHILRVWD 253
            |.||||||.|.||:||.|:|||:..:|||||||||.::||:|:.:|.:||:||:.|.|.|:|||.
Zfish   187 VAFDRTGRRIFTGSDDCLVKIWATDNGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVWC 251

  Fly   254 MQTTSPIAVLSAHTGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKPTQYH 318
            ::|.:|:|||..||..|||:.|.||.....::|.||..||.:.|||:::   ..:.|..||.::.
Zfish   252 LRTCAPVAVLQGHTASITSIQFSPSALGSSRFLATTGADGMVCFWQWNS---FSMKFVDKPVKFM 313

  Fly   319 EKLRPGQAQMMCTTFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSHR--G 381
            |:.||| .|:.|::||.||:|||.|..||.:|||.:|.:.|.:..:.:::||.|.::|:.:.  .
Zfish   314 ERSRPG-VQISCSSFSSGGLFLATGGTDHMIRVYYLGTEMPVKFSDLDSHTDKVVAIQFCNNTDS 377

  Fly   382 LRFISGSKDGTAHIWTFESQQWKSSKLCMTERL---ASCPEPEEGKRLKVTMVAWDASDRYVITA 443
            |||:|||:||||.||.::.|:|||:.|.||.||   |.....::..:|.|||||||..||.:|||
Zfish   378 LRFVSGSRDGTARIWHYQQQEWKSTVLDMTTRLPGSAVISGDDKSTKLVVTMVAWDRCDRSIITA 442

  Fly   444 VNDFTIKIWDSKSAKLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFLN 508
            |::..:|:|:|.:.:|..||.||.||::|||::|.|..:||||||||.:::||:.:|..:.||.|
Zfish   443 VSNCLLKVWNSTNGQLLHVLSGHDDEVFVLEAHPFDSRILLSAGHDGNIYVWDLSKGQKIRNFFN 507

  Fly   509 DIDGQGHGSVFDAKWSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQH 573
            .|:|||||:|||.|:|.||...|.||||||:||||.| |.:.|:::|.::|||||||||:||:.:
Zfish   508 MIEGQGHGAVFDCKFSVDGQHFACTDSHGHLLIFGFG-CSQPYEIIPDQMFFHTDFRPLIRDSNN 571

  Fly   574 HVVDEQTQIMPHLMPPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNLTVGVDGVVIDDGGAG 638
            .|:|||||..|||||||||||.||||||.|.||.|||||:|..:||:|.|     |.:.:..|..
Zfish   572 FVLDEQTQQAPHLMPPPFLVDVDGNPHPPRCQRLVPGRENCKEEQLVPQL-----GYMANGDGEV 631

  Fly   639 GDAVVAAAPAEAPPAALPPAAAGGPQGANYSHIDRMIAALANRQSVNVNANDANPTNGNQSFERL 703
            .:.|:....|:              :....|.:|.:|..|.|:|...|  |.|||..
Zfish   632 VEQVIGQQTAD--------------ESQEESPLDDLIRQLQNQQDERV--NQANPAG-------- 672

  Fly   704 TNRQMPDSNGRQSSRGNVLGSRLSTPRQGWGAAAAAPVEDQAGPSQPPAEPAAEPGQAQVQQALP 768
                           ..|.|..||.|..|...:.......|...:.|.::.|.|...
Zfish   673 ---------------AEVAGGPLSPPNVGLRRSGQVEGVRQMHNNAPRSQMATERDL-------- 714

  Fly   769 LKFIRRTYVRPMKYPQLQNLKQTIYSAGQFEKQEYKREMRRRPIMINTASAASSQQPGSVGRPRN 833
            |.:.||..|..::....:.::....:.|:.|:..|..|.:|:.:      .::..|||.     |
Zfish   715 LAWSRRVVVNEVQAGIFRVMEDCRLAKGEVERSYYIIEKKRKSV------PSTGSQPGD-----N 768

  Fly   834 TRGNGGGARAGRRRGPQPAGGQPQPAYRTRAV-------------RDQEPEHYDEVAPPPEEEEE 885
            .|         ..|.||....|.:.||:||:.             |::|.|...|   ...|:||
Zfish   769 VR---------TLRRPQRKAQQKRHAYQTRSTRTRRRSGSVQSFSRNEETEVESE---SEAEQEE 821

  Fly   886 DVSSNSSGDTSYSNVEENLEDSSDESETDSSDYSDWVADTPGPNLEPPKRSKRKPLSRRPRSSDD 950
            |.:.||.|.:......||...|||    .||:||||.||. |.||:||||:.|:|  .|...|..
Zfish   822 DQNENSDGTSEGETQWENDSSSSD----SSSEYSDWTADA-GINLQPPKRTTRRP--ARVAVSSS 879

  Fly   951 SSDDERAGRSRG--GQVTARKVGRKTVLFPPTDAN---GEIPELYRPAEWLSEVIPRKAPYYPQM 1010
            |.|:|..|:..|  .|.|.:...:|    .|...:   ||:.| :.|..|:.|.|||::|:.|||
Zfish   880 SEDEEGTGQGEGEAAQTTKQAEKKK----KPKQRSVPAGELEE-WLPPSWIMETIPRRSPFVPQM 939

  Fly  1011 GDEVVYFRQGHAKYLDAVRLKKVYKLSHSSEPWNFHTLRDHELVRVIGIKYEIRPPRLCCLKLAI 1075
            |||::||||||..|:.||...|.|.::...:|||...|||.|.|:|:|||||:.||.||||||||
Zfish   940 GDELIYFRQGHQAYVRAVSRAKAYSINPQKQPWNRLNLRDQESVKVVGIKYEVGPPTLCCLKLAI 1004

  Fly  1076 ID-EEGNMTGTTFKIKYHDMPDVLDFLVLRQTFDLAVQRNWSIGDRFRCMIVDGWWMGQIESRHA 1139
            :| ..|.||..:|.:||||||||:|||||:|.::.|.:|||..|.|||.:|.|.||.|.:|.:..
Zfish  1005 LDLTSGKMTNESFSLKYHDMPDVIDFLVLQQFYNEAKERNWQPGQRFRSIIDDAWWFGSLECQEP 1069

  Fly  1140 LSADFPDSSFMCFRVRWDNGEYEFMSPWDMEPIDQQR-VPDEVGGAVPVLPEEIRATLYQPKSEE 1203
            ..:::|||.|.|:.|||||||.|.|||||:|||.::. :|:|.|.:|||..:|::|.||.|:..|
Zfish  1070 FESEYPDSLFQCYIVRWDNGEREKMSPWDIEPIPEEAPLPEEDGDSVPVTEDELQALLYSPQEGE 1134

  Fly  1204 WHRGDRDGTCRRIINGLEQVMRLSIAEHFLAPVDLNIYPDYAYLIEYPIDLTTIKSRFENHFYRR 1268
            |....||..|.|:|..::|::.|.:|:.|..||:|..||.|..::.|..||:||::|..:.||||
Zfish  1135 WGLHTRDEECERVITAIDQLLTLDVAKAFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRR 1199

  Fly  1269 ITSAQFDVRYLATNAEQYNRRHAIIVKHSRIVTDLCLRIIREPDEIDVAAVYHQLADVYHSSESE 1333
            |::..::|||:..||..:|...:.||..::.|:|:.||.||:.:..|:..:|:::...:.|.|.|
Zfish  1200 ISALMWEVRYIEHNARTFNEPQSPIVTAAKTVSDVLLRFIRDQNCTDILDLYNKMKSEFSSEEDE 1264

  Fly  1334 NE---VDSDVVPSTSTGPTTSAAAAAARQRVSSARRSTR--IHSEGDWRADCRQLLDLMWARTDS 1393
            .|   |||| .|.||||           ||.|::....|  :.....|...|:.|:..|...:||
Zfish  1265 EETVDVDSD-TPGTSTG-----------QRRSNSTPQKRGVVLDINAWHKQCKDLVRRMIVSSDS 1317

  Fly  1394 APFREPVDTIDFPDYLEIIATPMDLRTVKEDLLGGNYDDPLDFAKDVRLIFQNSKNYNTNKRSRI 1458
            .|||:|||...:|||.:||.|||||.||.|.|.||||::|::|||||||||.|||.|..||:|||
Zfish  1318 EPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTPNKKSRI 1382

  Fly  1459 YAMTLRLSALFESHIKTVVTSWKAALRRANKNKSGSSGGGRGGSSSSPNKRVKKERSTRRNQKPT 1523
            |:|||.|||.||:.|..:::.:|:|::...:::.......| ..|||||....|::|.::..:.:
Zfish  1383 YSMTLSLSAFFENQIIPIISDYKSAVQNQRRSQQRLMCSKR-LQSSSPNSPKGKQKSGKKTLQMS 1446

  Fly  1524 AAARRLPVANSSEDEDEEDDDDDDDDDDEEEASTRGRSRRRNGVAVSASSSGSNRVTSSSAAQQR 1588
            |.||   ...||:|.:..    ..|:|.:..:|:...|...:..:.|:..:|:||||.|.....:
Zfish  1447 AKAR---TRKSSQDSNVA----QVDEDSQPSSSSSSSSSSSSSSSFSSEQAGANRVTRSQVTSSK 1504

  Fly  1589 R--------GKSSSSEE----EEEEETSAQATSDASSDEEERAQSNDSSPQQTRTRRARQRQRLS 1641
            .        |:||....    ||.|.:..::||.:||.....:.|:.:|
Zfish  1505 SSGVFLPNGGRSSRRRRAVLTEEGEVSECESTSSSSSSTSASSSSSATS---------------- 1553

  Fly  1642 DDSNINDSEDSYNPNEGRGSRRRPGAARPSSNRQTNGHSSKRRRLNKSPANAAPGPSLPRRTRRI 1706
              |:.::|:||        |....|.|....:..:.....|::  .|:||...|.|..|
Zfish  1554 --SSSSESDDS--------SAEVSGFADGGDHDYSKAPQHKQK--GKAPAPPPPSPPPP------ 1600

  Fly  1707 AGSSAEEAASHSQHDESTQDSQIGRRKGRSASSRSIGNGPSTSAAAAANSSLESPSRNTRANGTR 1771
                         ....|.|:...:|||....|                   ..|.:..|    |
Zfish  1601 -------------PPAPTIDNPKRKRKGEEEQS-------------------AEPEKRPR----R 1629

  Fly  1772 TSSHLGAENDHSYHLPVRNGRIIESDTDSPVIRPTRQSAKRALMDWGRGSDIEEEEEEEEEDSEE 1836
            |||....|.:.            |.:.|.   .|..:..          .|.|||.|||||:|::
Zfish  1630 TSSREEEEEEE------------EEEVDD---EPEEEEE----------PDEEEEPEEEEEESDD 1669

  Fly  1837 AEEILPTPTKDDLPSTSRAALAQAAAGPSRQLRTNRNTVVRPAQSDDDDDDDSDNEPL 1894
            ...|.|         :.|:......:|........|.||:   .:||.:::...::||
Zfish  1670 ENVISP---------SKRSNQRTPKSGRVNTRNQGRRTVL---YNDDSEEEGPTSDPL 1715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BRWD3	NP_732982.1	WD40	176..496	CDD:238121	157/324 (48%)
		WD40	181..544	CDD:225201	184/367 (50%)
		WD40 repeat	186..223	CDD:293791	26/36 (72%)
		WD40 repeat	229..265	CDD:293791	17/35 (49%)
		WD40 repeat	270..311	CDD:293791	14/40 (35%)
		WD40 repeat	331..364	CDD:293791	15/32 (47%)
		WD40 repeat	372..413	CDD:293791	21/42 (50%)
		WD40 repeat	428..464	CDD:293791	18/35 (51%)
		WD40 repeat	470..495	CDD:293791	13/24 (54%)
		Auxin_resp	1083..1167	CDD:284030	45/83 (54%)
		Bromo_WDR9_I_like	1196..1311	CDD:99958	45/114 (39%)
		Bromo_WDR9_II	1371..1489	CDD:99928	61/117 (52%)
brwd3	XP_009299685.1	WD40	173..495	CDD:238121	157/325 (48%)
		WD40	176..541	CDD:225201	183/368 (50%)
		WD40 repeat	184..221	CDD:293791	26/36 (72%)
		WD40 repeat	227..263	CDD:293791	17/35 (49%)
		WD40 repeat	268..314	CDD:293791	17/48 (35%)
		WD40 repeat	322..360	CDD:293791	16/37 (43%)
		WD40 repeat	366..405	CDD:293791	18/38 (47%)
		WD40 repeat	427..463	CDD:293791	18/35 (51%)
		WD40 repeat	469..494	CDD:293791	13/24 (54%)
		Bromo_WDR9_I_like	1127..1242	CDD:99958	45/114 (39%)
		Bromo_WDR9_II	1295..1413	CDD:99928	61/117 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596513
Domainoid	1	1.000	539	1.000	Domainoid score	I260
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1162	1.000	Inparanoid score	I196
OMA	1	1.010	-	-		QHG52858
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001192
OrthoInspector	1	1.000	-	-		otm25326
orthoMCL	1	0.900	-	-		OOG6_101711
Panther	1	1.100	-	-	O	PTHR16266
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X735
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900