DRSC/TRiP Functional Genomics Resources

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Protein Alignment BRWD3 and PHIP

DIOPT Version :10

Sequence 1:NP_732982.1 Gene:BRWD3 / 42898 FlyBaseID:FBgn0011785 Length:2232 Species:Drosophila melanogaster
Sequence 2:NP_060404.4 Gene:PHIP / 55023 HGNCID:15673 Length:1821 Species:Homo sapiens


Alignment Length:2300 Identity:775/2300 - (33%)
Similarity:1099/2300 - (47%) Gaps:577/2300 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 DLKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELERKYKHIGANH 75
            :|:.||||||::||..||.::.|:|||||:.||::||||.||.|.||.:|::.|.:.|:|:..:|
Human    10 ELRSELYFLIARFLEDGPCQQAAQVLIREVAEKELLPRRTDWTGKEHPRTYQNLVKYYRHLAPDH 74

  Fly    76 LLEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLRT----KETVYCHRSLRD-YCTRLNGVSLP 135
            ||:||.|||||:::|:|.||||:.:|||.|||:||||    |..|:...:|.. :|.|     .|
Human    75 LLQICHRLGPLLEQEIPQSVPGVQTLLGAGRQSLLRTNKSCKHVVWKGSALAALHCGR-----PP 134

  Fly   136 DSVLT--KPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLSSVYCVLFDRTGRYI 198
            :|.:.  .|....| .|..|:..|:.|.:.||||.:|:..|:.:|.:|||||||||.||||||.|
Human   135 ESPVNYGSPPSIAD-TLFSRKLNGKYRLERLVPTAVYQHMKMHKRILGHLSSVYCVTFDRTGRRI 198

  Fly   199 ITGADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHILRVWDMQTTSPIAVL 263
            .||:||.|:|||:..||||||||||.::||:|:|:|.:|||:||||.|.::|||.::|.:|:|||
Human   199 FTGSDDCLVKIWATDDGRLLATLRGHAAEISDMAVNYENTMIAAGSCDKMIRVWCLRTCAPLAVL 263

  Fly   264 SAHTGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKPTQYHEKLRPGQAQM 328
            ..|:..|||:.|.|......:||.:|..||:|.||.:.   ...:...|:|.::.|:.||| .||
Human   264 QGHSASITSLQFSPLCSGSKRYLSSTGADGTICFWLWD---AGTLKINPRPAKFTERPRPG-VQM 324

  Fly   329 MCTTFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSHRGLRFISGSKDGTA 393
            :|::||.||:|||.||.||.:|||..|...|::|.|.|.:||.|||:|:|:...||:|||:||||
Human   325 ICSSFSAGGMFLATGSTDHIIRVYFFGSGQPEKISELEFHTDKVDSIQFSNTSNRFVSGSRDGTA 389

  Fly   394 HIWTFESQQWKSSKLCMTERLASCPEPEEG-----KRLKVTMVAWDASDRYVITAVNDFTIKIWD 453
            .||.|:.::|||..|.|..|.|.  :..:|     .::||||||||..|..||||||:.|:|:|:
Human   390 RIWQFKRREWKSILLDMATRPAG--QNLQGIEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWN 452

  Fly   454 SKSAKLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFLNDIDGQGHGSV 518
            |.:.:|..||.||:||::|||.:|.|..||.||||||.|.:||:.:||.:.::.|.|:|||||:|
Human   453 SYTGQLIHVLMGHEDEVFVLEPHPFDPRVLFSAGHDGNVIVWDLARGVKIRSYFNMIEGQGHGAV 517

  Fly   519 FDAKWSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQHHVVDEQTQIM 583
            ||.|.||||...|.||||||:||||.| ...||..:..::|||:|:|||:|||.:.|:|||||..
Human   518 FDCKCSPDGQHFACTDSHGHLLIFGFG-SSSKYDKIADQMFFHSDYRPLIRDANNFVLDEQTQQA 581

  Fly   584 PHLMPPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNLTVGVDGVVIDDGGAGGDAVVAAAPA 648
            |||||||||||.||||||||:||.|||||:|..:||||.:.|...|:         :.|::    
Human   582 PHLMPPPFLVDVDGNPHPSRYQRLVPGRENCREEQLIPQMGVTSSGL---------NQVLS---- 633

  Fly   649 EAPPAALPPAAAGGPQGAN--YSHIDRMIAALANRQSVNVNANDANPTNGNQSFERLTNRQMPDS 711
                           |.||  .|.:|.||..|...|.:            .:|.|.:.      |
Human   634 ---------------QQANQEISPLDSMIQRLQQEQDL------------RRSGEAVI------S 665

  Fly   712 NGRQSSRGNVLG-SRLSTPRQGWGAAAAAPVED--QAGPSQPPAEPAAEPGQAQVQQALPLKFIR 773
            |..:.|||::.. |.:.:| ...|...:..:|.  |...:.|.:|.|.|...        :.:.|
Human   666 NTSRLSRGSISSTSEVHSP-PNVGLRRSGQIEGVRQMHSNAPRSEIATERDL--------VAWSR 721

  Fly   774 RTYVRPMKYPQLQNLKQTIYSAGQFEKQE-------------YKREMRRRPIMI---NTASAASS 822
            |..|     |:|        |||...:||             |:.|.:|:.:.:   |.....|.
Human   722 RVVV-----PEL--------SAGVASRQEEWRTAKGEEEIKTYRSEEKRKHLTVPKENKIPTVSK 773

  Fly   823 QQPG----SVGRPRNTRGNGGGARAGRRRGPQPAGGQPQPAYRTRAVRDQEPEHYDEVAPPPEEE 883
            ....    .:|..:..:.|                   |..||||:..::.|.        |.||
Human   774 NHAHEHFLDLGESKKQQTN-------------------QHNYRTRSALEETPR--------PSEE 811

  Fly   884 EEDVSSNS--------SGDTSYSNVEENLEDSSDESETD-SSDYSDWVADTPGPNLEPPKRSKRK 939
            .|:.||:|        ||.||   .||.....||.|.:| |||||||.||. |.||:|||:..:.
Human   812 IENGSSSSDEGEVVAVSGGTS---EEEERAWHSDGSSSDYSSDYSDWTADA-GINLQPPKKVPKN 872

  Fly   940 PLSRRPRSSDDSSDDE------------RAGRSRGGQVTARK------------VGRKTVLFPPT 980
            ...:...|||:..:.|            :....:.|.::.:|            ||..|      
Human   873 KTKKAESSSDEEEESEKQKQKQIKKEKKKVNEEKDGPISPKKKKPKERKQKRLAVGELT------ 931

  Fly   981 DANGEIPELYRPAEWLSEVIPRKAPYYPQMGDEVVYFRQGHAKYLDAVRLKKVYKLSHSSEPWNF 1045
             .||...|.:.|:.|:::.|||:.|:.|||||||.||||||..|::..|..|:|.::...:||:.
Human   932 -ENGLTLEEWLPSTWITDTIPRRCPFVPQMGDEVYYFRQGHEAYVEMARKNKIYSINPKKQPWHK 995

  Fly  1046 HTLRDHELVRVIGIKYEIRPPRLCCLKLAIID-EEGNMTGTTFKIKYHDMPDVLDFLVLRQTFDL 1109
            ..||:.||::::|||||:..|.|||||||.:| :.|.:||.:|.:||||||||:|||||||.||.
Human   996 MELREQELMKIVGIKYEVGLPTLCCLKLAFLDPDTGKLTGGSFTMKYHDMPDVIDFLVLRQQFDD 1060

  Fly  1110 AVQRNWSIGDRFRCMIVDGWWMGQIESRHALSADFPDSSFMCFRVRWDNGEYEFMSPWDMEPIDQ 1174
            |..|.|:||||||.:|.|.||.|.|||:..|..::|||.|.|:.|.||||:.|.|||||||.|..
Human  1061 AKYRRWNIGDRFRSVIDDAWWFGTIESQEPLQLEYPDSLFQCYNVCWDNGDTEKMSPWDMELIPN 1125

  Fly  1175 QRV-PDEVGGAVPVLPEEIRATLYQPKSEEWHRGDRDGTCRRIINGLEQVMRLSIAEHFLAPVDL 1238
            ..| |:|:|.:||:...|.|:.:|:|...||....||..|.||:.|:.|:|.|.||..|:|||||
Human  1126 NAVFPEELGTSVPLTDGECRSLIYKPLDGEWGTNPRDEECERIVAGINQLMTLDIASAFVAPVDL 1190

  Fly  1239 NIYPDYAYLIEYPIDLTTIKSRFENHFYRRITSAQFDVRYLATNAEQYNRRHAIIVKHSRIVTDL 1303
            ..||.|..::.||.||:|||.|.||.||||::|..::|||:..|...:|...:.|||.::.||||
Human  1191 QAYPMYCTVVAYPTDLSTIKQRLENRFYRRVSSLMWEVRYIEHNTRTFNEPGSPIVKSAKFVTDL 1255

  Fly  1304 CLRIIREPDEIDVAAVYHQLADVYHSSESENEVDSDVVPSTSTGPTTSAAAAAARQRVSSARRST 1368
            .|..|::....::..:|:.:.....|...:.|.|:| ||.||   |........|:|:.:..:|.
Human  1256 LLHFIKDQTCYNIIPLYNSMKKKVLSDSEDEEKDAD-VPGTS---TRKRKDHQPRRRLRNRAQSY 1316

  Fly  1369 RIHSEGDWRADCRQLLDLMWARTDSAPFREPVDTIDFPDYLEIIATPMDLRTVKEDLLGGNYDDP 1433
            .|.:   |:..|.:||:|::...||.|||:|||.:::|||.:||.||||..||:|.|..|||:.|
Human  1317 DIQA---WKKQCEELLNLIFQCEDSEPFRQPVDLLEYPDYRDIIDTPMDFATVRETLEAGNYESP 1378

  Fly  1434 LDFAKDVRLIFQNSKNYNTNKRSRIYAMTLRLSALFESHIKTVVTSWKAALRRANKNKSGSSGGG 1498
            ::..|||||||.|||.|..:||||||:|:|||||.||.||.:|::.:|:|||...:|        
Human  1379 MELCKDVRLIFSNSKAYTPSKRSRIYSMSLRLSAFFEEHISSVLSDYKSALRFHKRN-------- 1435

  Fly  1499 RGGSSSSPNKRVKKERSTRRNQKPTAAARRLPVANSSEDEDEEDDDDDDDDDDEEEASTRGRSRR 1563
                                                                    ..|:.|.:|
Human  1436 --------------------------------------------------------TITKRRKKR 1444

  Fly  1564 RNGVAVSASSSGSNRVTSSSAAQQRRGKSSSSEEEEEEETSAQATSDASSDEEERAQSNDSSPQQ 1628
            ....:||:|::.|         .:|:.:....:.:.|..|||.:|...|......|...:...:.
Human  1445 NRSSSVSSSAASS---------PERKKRILKPQLKSESSTSAFSTPTRSIPPRHNAAQINGKTES 1500

  Fly  1629 TRTRRARQRQRLSDDSNINDSEDSYNPNEGRGSRRRPGAARPSSNRQTNGHSSKRRRLNKSPANA 1693
            :...|.|..:.:.|                           |....|.:..|:.:..:.|:.|:|
Human  1501 SSVVRTRSNRVVVD---------------------------PVVTEQPSTSSAAKTFITKANASA 1538

  Fly  1694 APGPSLPRRTRRIAGSSAEEAASHSQHDESTQDSQIGRRKGRSASSRSIGNGPSTSAAAAANSSL 1758
            .||.::           .|.:..||:                                  |.::|
Human  1539 IPGKTI-----------LENSVKHSK----------------------------------ALNTL 1558

  Fly  1759 ESPSRNTRANGTRTSSHLGAENDHSYHLPVRNGRIIESDTDSPVIRPTRQSAKRALMDWGRGSDI 1823
            .||.:::.::|||.:|  ..||               .:.:.||.|..:.|              
Human  1559 SSPGQSSFSHGTRNNS--AKEN---------------MEKEKPVKRKMKSS-------------- 1592

  Fly  1824 EEEEEEEEEDSEEAEEILPTPTKDDLPSTSRAALAQAAAGPSRQLRTNRNTVVRPAQSDDDDDDD 1888
                            :||   |....|.|.|.:.|.                           |
Human  1593 ----------------VLP---KASTLSKSSAVIEQG---------------------------D 1611

  Fly  1889 SDNEPLANNQQKNYQSPAKSSSTATVAPH---PLSLRRRLASPPERNTHMTRSHATSTTSSAAAS 1950
            ..|..|.             ..|..|..|   |..|.:|   .|.|                   
Human  1612 CKNNALV-------------PGTIQVNGHGGQPSKLVKR---GPGR------------------- 1641

  Fly  1951 RAEQQPAVSTHDHNYLGNVNS--------SRAPRRILSRHQRNADELDTSLDVLENSRLLSAIAN 2007
                :|.|..       |.||        .|.|:::  ::.:..|        ||.:. :..|.:
Human  1642 ----KPKVEV-------NTNSGEIIHKKRGRKPKKL--QYAKPED--------LEQNN-VHPIRD 1684

  Fly  2008 HRRPTSTTNSNSASNVVTRRLRGRASQANSHDEDHEEEEAAASDEGTDGGSSSQSYEDEDEDSDS 2072
            ...|:||.|..|.:|.|...|..:.::                     ||.              
Human  1685 EVLPSSTCNFLSETNNVKEDLLQKKNR---------------------GGR-------------- 1714

  Fly  2073 EDNQPLTSYVSPSNGRPRRKAKTSSSSATTQERPLRRTRRPPSNNSIANDNDDDDDYVVPRSRRA 2137
                           :|:||.||...                           |.|.:||.|.:.
Human  1715 ---------------KPKRKMKTQKL---------------------------DADLLVPASVKV 1737

  Fly  2138 NRGGNQRAGRNQKRPRYNEQSEEEEAAAGYSHRSKRIRNGDAHASSQERSQASTERDQEEEEDGT 2202
            .|    |:.|.:.....:|:.|.||......|  .|.||      ...|:....|.|.|||:...
Human  1738 LR----RSNRKKIDDPIDEEEEFEELKGSEPH--MRTRN------QGRRTAFYNEDDSEEEQRQL 1790

  Fly  2203 SVDSEEQQVNVSSRGRVRKPSAKAR 2227
            ..:........||||||||.:.||:
Human  1791 LFEDTSLTFGTSSRGRVRKLTEKAK 1815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BRWD3NP_732982.1 WD40 171..541 CDD:441893 192/374 (51%)
WD40 repeat 186..223 CDD:293791 27/36 (75%)
WD40 repeat 229..265 CDD:293791 19/35 (54%)
WD40 repeat 270..311 CDD:293791 13/40 (33%)
WD40 repeat 331..364 CDD:293791 17/32 (53%)
WD40 repeat 372..413 CDD:293791 22/40 (55%)
WD40 repeat 428..464 CDD:293791 20/35 (57%)
WD40 repeat 470..495 CDD:293791 14/24 (58%)
Bromo_WDR9_I_like 1196..1311 CDD:99958 53/114 (46%)
Bromo_WDR9_II 1371..1489 CDD:99928 62/117 (53%)
PHA03307 1604..>1822 CDD:223039 33/217 (15%)
PHIPNP_060404.4 WD40 118..497 CDD:441893 185/390 (47%)
WD 1 181..222 31/40 (78%)
WD40 repeat 186..223 CDD:293791 27/36 (75%)
WD 2 224..262 18/37 (49%)
WD40 repeat 229..265 CDD:293791 19/35 (54%)
WD 3 265..310 14/47 (30%)
WD40 repeat 270..315 CDD:293791 15/47 (32%)
WD 4 319..360 23/41 (56%)
WD40 repeat 323..362 CDD:293791 21/38 (55%)
WD 5 363..402 21/38 (55%)
WD40 repeat 368..416 CDD:293791 24/49 (49%)
WD 6 422..461 20/38 (53%)
WD 7 464..504 22/39 (56%)
WD40 repeat 469..494 CDD:293791 14/24 (58%)
WD 8 512..551 26/39 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..689 9/37 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 751..927 51/206 (25%)
Mediates interaction with IRS1. /evidence=ECO:0000250 924..1129 107/211 (51%)
Bromo_WDR9_I_like 1148..1263 CDD:99958 53/114 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1280..1310 11/33 (33%)
Bromo_WDR9_II 1316..1434 CDD:99928 63/120 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1435..1507 17/144 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1555..1597 15/91 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1623..1646 8/48 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1784 11/40 (28%)

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