DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BRWD3 and BRWD1

DIOPT Version :9

Sequence 1:	NP_732982.1	Gene:	BRWD3 / 42898	FlyBaseID:	FBgn0011785	Length:	2232	Species:	Drosophila melanogaster
Sequence 2:	NP_061836.2	Gene:	BRWD1 / 54014	HGNCID:	12760	Length:	2320	Species:	Homo sapiens

Alignment Length:	2403	Identity:	806/2403 - (33%)
Similarity:	1228/2403 - (51%)	Gaps:	389/2403 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QPSSGDD----LKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELE 65
            :|||...    ::.||||||:::|:|||....|:||::|||:.::||:||||:||||.:::|||.
Human     3 EPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELV 67

  Fly    66 RKYKHIGANHLLEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLRT----KETVY-------CH 119
            ...||:..:|||:||.|:||::|:|:|||:..:.||||.|||:||||    :.||:       .|
Human    68 LSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALH 132

  Fly   120 RSLRDYCTRLNGVSLPDSVLTKPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLS 184
            |.        ....:|.:..:.|  ||..:..|::..|........|..:|:..|:.||.:||||
Human   133 RG--------RPPEMPVNYGSPP--NLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLS 187

  Fly   185 SVYCVLFDRTGRYIITGADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHIL 249
            :||||.|||||..|.||:||.|:||||..:||||:||||.|:||:|:|:|.:|||:||||.|.|:
Human   188 AVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKII 252

  Fly   250 RVWDMQTTSPIAVLSAHTGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKP 314
            |||.::|.:|:|||..|||.|||:.|.|..:...:|:|:|..||::.|||:..   :.:.|:|:|
Human   253 RVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDL---ESLKFSPRP 314

  Fly   315 TQYHEKLRPGQAQMMCTTFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSH 379
            .::.||.||| .||:|::||.||:|||.||.||.:|:|.:|.:.|::|.|.|::||.|||:|:.:
Human   315 LKFTEKPRPG-VQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCN 378

  Fly   380 RGLRFISGSKDGTAHIWTFESQQWKSSKLCMTERLAS--CPEPEEGKRLKVTMVAWDASDRYVIT 442
            .|.||:|||:||||.||.||..:|:|..|.|..|::.  ..|.|...:.||||:||:.:|..|:|
Human   379 NGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVT 443

  Fly   443 AVNDFTIKIWDSKSAKLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFL 507
            ||||..:|:|:|.:.:|...|.||.||::|||::|.|..::|||||||.:|:|||.:|..:.::.
Human   444 AVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYF 508

  Fly   508 NDIDGQGHGSVFDAKWSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQ 572
            |.|:|||||:|||.|:|.||...|.||||||:||||.| |.:.|:.:|.::|||||:|||:||:.
Human   509 NMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFG-CSKPYEKIPDQMFFHTDYRPLIRDSN 572

  Fly   573 HHVVDEQTQIMPHLMPPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNLTVGVDGVVIDDGGA 637
            ::|:|||||..|||||||||||.||||||:::||.|||||:.:.:.|||.|     |.|....|.
Human   573 NYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKYQRLVPGRENSADEHLIPQL-----GYVATSDGE 632

  Fly   638 GGDAVVAAAPAE----APPAALPPAAAGGPQGANYSHIDRMIAALANRQSVNVNAN-DANP---T 694
            ..:.:::....:    :|.:::               :|.||..|..:|...:.|: |..|   :
Human   633 VIEQIISLQTNDNDERSPESSI---------------LDGMIRQLQQQQDQRMGADQDTIPRGLS 682

  Fly   695 NGNQS----FERLT-NRQMPDSNGRQSSRGNVLG----------SRLSTPR--QGWGAAAAAPVE 742
            ||.::    |.||: :.|.|.:.|.:.| |.|.|          |:::|.|  |.|......| |
Human   683 NGEETPRRGFRRLSLDIQSPPNIGLRRS-GQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVP-E 745

  Fly   743 DQAGPSQPPAEPAAEPGQAQVQQALPLKFIRRTYV--RPMKYPQLQNLKQTIYSAGQFEKQEYKR 805
            ...|..:...:...|.|:.:          |..|:  |..|..||.:...::....|..::..:|
Human   746 VPLGIFRKLEDFRLEKGEEE----------RNLYIIGRKRKTLQLSHKSDSVVLVSQSRQRTCRR 800

  Fly   806 EMRRRPIMINTASAASSQQPGSVGRPRNTRGNGGGARAGRRRGPQPAGGQPQPAYRTRAVRDQEP 870
            :.                       |...|.|    |:.|...   :|.:...:.|.....||..
Human   801 KY-----------------------PNYGRRN----RSWRELS---SGNESSSSVRHETSCDQSE 835

  Fly   871 EHYDEVAPPPEEEEEDVSSNSSGDTSYSNVEENLEDSSDESETDSSDYSDWVADTPGPNLEPPKR 935
                  .....||:|..|...|  .|||      |.|||    .||.||||.||. |.||:||.|
Human   836 ------GSGSSEEDEWRSDRKS--ESYS------ESSSD----SSSRYSDWTADA-GINLQPPLR 881

  Fly   936 -SKRKPLSRRPRSSDDSSDDE-------RAGRSRGGQVTARKVGRKTVLFPPTDANGEIPELYRP 992
             |.|:.::|...||:|....|       |..|.:..:.....:.|.|   |...||.|....:.|
Human   882 TSCRRRITRFCSSSEDEISTENLSPPKRRRKRKKENKPKKENLRRMT---PAELANMEHLYEFHP 943

  Fly   993 AEWLSEVIPRKAPYYPQMGDEVVYFRQGHAKYLDAVRLKKVYKLSHSSEPWNFHTLRDHELVRVI 1057
            ..|:::...||:|:.|||||||:||||||..|::|||...:|:|:.:.|||....|||.|||:::
Human   944 PVWITDTTLRKSPFVPQMGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIV 1008

  Fly  1058 GIKYEIRPPRLCCLKLAIID-EEGNMTGTTFKIKYHDMPDVLDFLVLRQTFDLAVQRNWSIGDRF 1121
            ||:||:.||.|||||||.|| ..|.:...:|.|:|||||||:|||||||.:|.|.||||...|||
Human  1009 GIRYEVGPPTLCCLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRF 1073

  Fly  1122 RCMIVDGWWMGQIESRHALSADFPDSSFMCFRVRWDNGEYEFMSPWDMEPI-DQQRVPDEVGGAV 1185
            |.:|.|.||.|.:.|:......:|||.|.|:.|||||.|.|.:|||||||| |....|:|:|.::
Human  1074 RSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASI 1138

  Fly  1186 PVLPEEIRATLYQPKSEEWHRGDRDGTCRRIINGLEQVMRLSIAEHFLAPVDLNIYPDYAYLIEY 1250
            .|..:|:...||:|::.||.:..||..|.|||:|::|::.|.||..|..||||..||.|..::.|
Human  1139 SVTTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAY 1203

  Fly  1251 PIDLTTIKSRFENHFYRRITSAQFDVRYLATNAEQYNRRHAIIVKHSRIVTDLCLRIIREPDEID 1315
            |.||.||:.|..|.||||:::..::|||:..||..:|...::|.:.::.:||..|:.|:.....:
Human  1204 PTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFIKNQHCTN 1268

  Fly  1316 VAAVYHQLADVYHSSESEN------EVDSDVVPSTSTGPTTSAAAAAARQRVSSARRSTRI--HS 1372
            ::.:         |:.|||      ::|...:|.||:|          |:||...::|.|.  :.
Human  1269 ISEL---------SNTSENDEQNAEDLDDSDLPKTSSG----------RRRVHDGKKSIRATNYV 1314

  Fly  1373 EGDWRADCRQLLDLMWARTDSAPFREPVDTIDFPDYLEIIATPMDLRTVKEDLLGGNYDDPLDFA 1437
            |.:|:..|::|::|::...||.|||:|||.:::|||.:||.||||..||:|.|..||||.||:|.
Human  1315 ESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFC 1379

  Fly  1438 KDVRLIFQNSKNYNTNKRSRIYAMTLRLSALFESHIKTVVTSWKAA------LRRANKNKSGSSG 1496
            ||:||||.|:|.|..||||:||:||||||||||..:|.:.:.:|..      |||:.:.|...:.
Human  1380 KDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNC 1444

  Fly  1497 GGRGGSSSSPNKRVKKERSTRRNQKP---TAAARRLPVANSSEDEDEEDDDDDDDDDDEEEASTR 1558
            .|    .|.|||.:       ||.||   .:..:.:|....|               ..:..|:|
Human  1445 KG----DSQPNKSI-------RNLKPKRLKSQTKIIPELVGS---------------PTQSTSSR 1483

  Fly  1559 ----GRSRRRNGVAVSASSSGSNRVTSSSAAQQRRGK-----SSSSEEEEEEETSAQATSDASSD 1614
                |..:...|:: |..:||.:..::.|:.:::|.:     |:.||.|.|:..:...:|.|||.
Human  1484 TAYLGTHKTSAGIS-SGVTSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSS 1547

  Fly  1615 EEERAQSNDSSPQQTRTRRARQRQRLSDDSNINDSEDSYNPNEGRGSRRRPGAARPSSNRQTNGH 1679
            .||       |.:.:|.|.:..|..||..||:..:..       |.::|:.|   |.|.....|.
Human  1548 SEE-------SKESSRARESSSRSGLSRSSNLRVTRT-------RAAQRKTG---PVSLANGCGR 1595

  Fly  1680 SSKRRR--LNKSPANA-APGPSLPRR---TRRIAGSSAEEAASHSQHDESTQDSQIGRRKGRSAS 1738
            .:.|:|  |:.|..|: ..|..|..|   .|::....|..||:..:.....::         ::|
Human  1596 KATRKRVYLSDSDNNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEE---------NSS 1651

  Fly  1739 SRSIGNG---PSTSAAAAANSSLESPSRNTRANGTRTSSHLGAE--NDHSYHLPVRNGRIIESDT 1798
            |.|:.:|   |..:|:|.|...|...|.:.::    ..|.:..|  .|.:..|||.:....:|:.
Human  1652 SESVCSGRKLPHRNASAVARKKLLHNSEDEQS----LKSEIEEEELKDENQLLPVSSSHTAQSNV 1712

  Fly  1799 DSPVIRPTRQSA--KRALMDW------------GRGSDIEEEEEEEEEDSEEAEEILPTPTKDDL 1849
            |....|.:...:  :.|..:|            .:...::.|..||:..|.:::...   .:...
Human  1713 DESENRDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHAC---NRTAG 1774

  Fly  1850 PSTSRAAL------AQAAAGPSRQLRTNRNTVVRPA----------QSDDDDDDDSDNEPLANNQ 1898
            ||||...|      .:|.:.|.|......||..:.|          .|:|.:.::.|.|
Human  1775 PSTSVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDSESEEQDRE------ 1833

  Fly  1899 QKNYQSPAKSSSTATVAPHPLSLRRRLASPPERNTHMTRSHATSTTSSAAASRAEQQPAVSTHDH 1963
                     ......:..:|:|  ..|...|...:..:..|...|...:...:.|:       .:
Human  1834 ---------DGKCHKMEMNPIS--GNLNCDPIAMSQCSSDHGCETDLDSDDDKIEK-------PN 1880

  Fly  1964 NYL-GNVNSSRAPRRILSRHQRNADELDTSLDVLENS------------RLLSAIANHRRPTSTT 2015
            |:: .:.:......|.:||.:..:.:.|:||.|::.|            |..:..||..:..|..
Human  1881 NFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDV 1945

  Fly  2016 NSNSASNVVTRRLRGRAS----------------QANSHDEDHEEE---EAAASDEGTDGGSS-- 2059
            ...|..||.||...||..                :.:.|.|...|:   |....|..::|.:.
Human  1946 EDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTKVL 2010

  Fly  2060 SQSYEDEDEDSDSED---------NQPLTSYVSPSNGRPRRKAK--TSSSSATTQERPLRRTRRP 2113
            ||:.   :.||||||         :..:....:||    :||:.  |||...:....|...|.|.
Human  2011 SQAL---NGDSDSEDMLNSEHKHRHTNIHKIDAPS----KRKSSSVTSSGEDSKSHIPGSETDRT 2068

  Fly  2114 -PSNNSIANDNDDDDDYVVPRSRRANRGGNQRAGRNQKRP-------RYNEQSEEEEAAAGYSH- 2169
             .|.:::|.....::::.|..:....|...:|.....|.|       ..::::.|:|.....||
Human  2069 FSSESTLAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHP 2133

  Fly  2170 RSKRIRNGDAHASSQERSQASTERDQEEEEDGTSVDSEEQQVNVSSRGRVRKPSAKARGIFKE 2232
            ..:.::..:...:|:.|...|:     :..|..||...:.....:::.:.||...||:.:.||
Human  2134 ELENVKISETTGNSKFRPDTSS-----KSSDLGSVTESDIDCTDNTKTKRRKTKGKAKVVRKE 2191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BRWD3	NP_732982.1	WD40	176..496	CDD:238121	163/321 (51%)
		WD40	181..544	CDD:225201	189/364 (52%)
		WD40 repeat	186..223	CDD:293791	25/36 (69%)
		WD40 repeat	229..265	CDD:293791	20/35 (57%)
		WD40 repeat	270..311	CDD:293791	13/40 (33%)
		WD40 repeat	331..364	CDD:293791	16/32 (50%)
		WD40 repeat	372..413	CDD:293791	22/40 (55%)
		WD40 repeat	428..464	CDD:293791	16/35 (46%)
		WD40 repeat	470..495	CDD:293791	13/24 (54%)
		Auxin_resp	1083..1167	CDD:284030	45/83 (54%)
		Bromo_WDR9_I_like	1196..1311	CDD:99958	47/114 (41%)
		Bromo_WDR9_II	1371..1489	CDD:99928	63/123 (51%)
BRWD1	NP_061836.2	WD40	178..497	CDD:238121	163/322 (51%)
		WD 1	184..223		27/38 (71%)
		WD40	<185..540	CDD:225201	184/358 (51%)
		WD40 repeat	189..226	CDD:293791	25/36 (69%)
		WD 2	226..265		21/38 (55%)
		WD40 repeat	232..268	CDD:293791	20/35 (57%)
		WD 3	268..311		16/45 (36%)
		WD40 repeat	273..318	CDD:293791	16/47 (34%)
		WD 4	322..365		23/43 (53%)
		WD40 repeat	326..365	CDD:293791	20/38 (53%)
		WD 5	366..405		21/38 (55%)
		WD40 repeat	371..417	CDD:293791	23/45 (51%)
		WD 6	424..463		17/38 (45%)
		WD40 repeat	429..465	CDD:293791	16/35 (46%)
		WD 7	466..506		21/39 (54%)
		WD40 repeat	471..496	CDD:293791	13/24 (54%)
		WD 8	514..553		25/39 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..691		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..867		22/82 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..925		5/29 (17%)
		Bromo_WDR9_I_like	1149..1264	CDD:99958	47/114 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1304		12/51 (24%)
		Bromo_WDR9_II	1313..1431	CDD:99928	60/117 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1593		46/202 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1670..1805		26/141 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1817..1839		4/36 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1862..1899		5/43 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2014..2077		17/69 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2112..2184		12/76 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160173
Domainoid	1	1.000	476	1.000	Domainoid score	I436
eggNOG	1	0.900	-	-		E2759_KOG0644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1171	1.000	Inparanoid score	I200
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001192
OrthoInspector	1	1.000	-	-		otm41337
orthoMCL	1	0.900	-	-		OOG6_101711
Panther	1	1.100	-	-	LDO	PTHR16266
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X735
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.840