DRSC/TRiP Functional Genomics Resources

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Protein Alignment BRWD3 and BRWD1

DIOPT Version :10

Sequence 1:NP_732982.1 Gene:BRWD3 / 42898 FlyBaseID:FBgn0011785 Length:2232 Species:Drosophila melanogaster
Sequence 2:NP_061836.2 Gene:BRWD1 / 54014 HGNCID:12760 Length:2320 Species:Homo sapiens


Alignment Length:2403 Identity:806/2403 - (33%)
Similarity:1228/2403 - (51%) Gaps:389/2403 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 QPSSGDD----LKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELE 65
            :|||...    ::.||||||:::|:|||....|:||::|||:.::||:||||:||||.:::|||.
Human     3 EPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELV 67

  Fly    66 RKYKHIGANHLLEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLRT----KETVY-------CH 119
            ...||:..:|||:||.|:||::|:|:|||:..:.||||.|||:||||    :.||:       .|
Human    68 LSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALH 132

  Fly   120 RSLRDYCTRLNGVSLPDSVLTKPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLS 184
            |.        ....:|.:..:.|  ||..:..|::..|........|..:|:..|:.||.:||||
Human   133 RG--------RPPEMPVNYGSPP--NLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLS 187

  Fly   185 SVYCVLFDRTGRYIITGADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHIL 249
            :||||.|||||..|.||:||.|:||||..:||||:||||.|:||:|:|:|.:|||:||||.|.|:
Human   188 AVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKII 252

  Fly   250 RVWDMQTTSPIAVLSAHTGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKP 314
            |||.::|.:|:|||..|||.|||:.|.|..:...:|:|:|..||::.|||:..   :.:.|:|:|
Human   253 RVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDL---ESLKFSPRP 314

  Fly   315 TQYHEKLRPGQAQMMCTTFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSH 379
            .::.||.||| .||:|::||.||:|||.||.||.:|:|.:|.:.|::|.|.|::||.|||:|:.:
Human   315 LKFTEKPRPG-VQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCN 378

  Fly   380 RGLRFISGSKDGTAHIWTFESQQWKSSKLCMTERLAS--CPEPEEGKRLKVTMVAWDASDRYVIT 442
            .|.||:|||:||||.||.||..:|:|..|.|..|::.  ..|.|...:.||||:||:.:|..|:|
Human   379 NGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVT 443

  Fly   443 AVNDFTIKIWDSKSAKLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFL 507
            ||||..:|:|:|.:.:|...|.||.||::|||::|.|..::|||||||.:|:|||.:|..:.::.
Human   444 AVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYF 508

  Fly   508 NDIDGQGHGSVFDAKWSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQ 572
            |.|:|||||:|||.|:|.||...|.||||||:||||.| |.:.|:.:|.::|||||:|||:||:.
Human   509 NMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFG-CSKPYEKIPDQMFFHTDYRPLIRDSN 572

  Fly   573 HHVVDEQTQIMPHLMPPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNLTVGVDGVVIDDGGA 637
            ::|:|||||..|||||||||||.||||||:::||.|||||:.:.:.|||.|     |.|....|.
Human   573 NYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKYQRLVPGRENSADEHLIPQL-----GYVATSDGE 632

  Fly   638 GGDAVVAAAPAE----APPAALPPAAAGGPQGANYSHIDRMIAALANRQSVNVNAN-DANP---T 694
            ..:.:::....:    :|.:::               :|.||..|..:|...:.|: |..|   :
Human   633 VIEQIISLQTNDNDERSPESSI---------------LDGMIRQLQQQQDQRMGADQDTIPRGLS 682

  Fly   695 NGNQS----FERLT-NRQMPDSNGRQSSRGNVLG----------SRLSTPR--QGWGAAAAAPVE 742
            ||.::    |.||: :.|.|.:.|.:.| |.|.|          |:::|.|  |.|......| |
Human   683 NGEETPRRGFRRLSLDIQSPPNIGLRRS-GQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVP-E 745

  Fly   743 DQAGPSQPPAEPAAEPGQAQVQQALPLKFIRRTYV--RPMKYPQLQNLKQTIYSAGQFEKQEYKR 805
            ...|..:...:...|.|:.:          |..|:  |..|..||.:...::....|..::..:|
Human   746 VPLGIFRKLEDFRLEKGEEE----------RNLYIIGRKRKTLQLSHKSDSVVLVSQSRQRTCRR 800

  Fly   806 EMRRRPIMINTASAASSQQPGSVGRPRNTRGNGGGARAGRRRGPQPAGGQPQPAYRTRAVRDQEP 870
            :.                       |...|.|    |:.|...   :|.:...:.|.....||..
Human   801 KY-----------------------PNYGRRN----RSWRELS---SGNESSSSVRHETSCDQSE 835

  Fly   871 EHYDEVAPPPEEEEEDVSSNSSGDTSYSNVEENLEDSSDESETDSSDYSDWVADTPGPNLEPPKR 935
                  .....||:|..|...|  .|||      |.|||    .||.||||.||. |.||:||.|
Human   836 ------GSGSSEEDEWRSDRKS--ESYS------ESSSD----SSSRYSDWTADA-GINLQPPLR 881

  Fly   936 -SKRKPLSRRPRSSDDSSDDE-------RAGRSRGGQVTARKVGRKTVLFPPTDANGEIPELYRP 992
             |.|:.::|...||:|....|       |..|.:..:.....:.|.|   |...||.|....:.|
Human   882 TSCRRRITRFCSSSEDEISTENLSPPKRRRKRKKENKPKKENLRRMT---PAELANMEHLYEFHP 943

  Fly   993 AEWLSEVIPRKAPYYPQMGDEVVYFRQGHAKYLDAVRLKKVYKLSHSSEPWNFHTLRDHELVRVI 1057
            ..|:::...||:|:.|||||||:||||||..|::|||...:|:|:.:.|||....|||.|||:::
Human   944 PVWITDTTLRKSPFVPQMGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIV 1008

  Fly  1058 GIKYEIRPPRLCCLKLAIID-EEGNMTGTTFKIKYHDMPDVLDFLVLRQTFDLAVQRNWSIGDRF 1121
            ||:||:.||.|||||||.|| ..|.:...:|.|:|||||||:|||||||.:|.|.||||...|||
Human  1009 GIRYEVGPPTLCCLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRF 1073

  Fly  1122 RCMIVDGWWMGQIESRHALSADFPDSSFMCFRVRWDNGEYEFMSPWDMEPI-DQQRVPDEVGGAV 1185
            |.:|.|.||.|.:.|:......:|||.|.|:.|||||.|.|.:|||||||| |....|:|:|.::
Human  1074 RSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASI 1138

  Fly  1186 PVLPEEIRATLYQPKSEEWHRGDRDGTCRRIINGLEQVMRLSIAEHFLAPVDLNIYPDYAYLIEY 1250
            .|..:|:...||:|::.||.:..||..|.|||:|::|::.|.||..|..||||..||.|..::.|
Human  1139 SVTTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAY 1203

  Fly  1251 PIDLTTIKSRFENHFYRRITSAQFDVRYLATNAEQYNRRHAIIVKHSRIVTDLCLRIIREPDEID 1315
            |.||.||:.|..|.||||:::..::|||:..||..:|...::|.:.::.:||..|:.|:.....:
Human  1204 PTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFIKNQHCTN 1268

  Fly  1316 VAAVYHQLADVYHSSESEN------EVDSDVVPSTSTGPTTSAAAAAARQRVSSARRSTRI--HS 1372
            ::.:         |:.|||      ::|...:|.||:|          |:||...::|.|.  :.
Human  1269 ISEL---------SNTSENDEQNAEDLDDSDLPKTSSG----------RRRVHDGKKSIRATNYV 1314

  Fly  1373 EGDWRADCRQLLDLMWARTDSAPFREPVDTIDFPDYLEIIATPMDLRTVKEDLLGGNYDDPLDFA 1437
            |.:|:..|::|::|::...||.|||:|||.:::|||.:||.||||..||:|.|..||||.||:|.
Human  1315 ESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFC 1379

  Fly  1438 KDVRLIFQNSKNYNTNKRSRIYAMTLRLSALFESHIKTVVTSWKAA------LRRANKNKSGSSG 1496
            ||:||||.|:|.|..||||:||:||||||||||..:|.:.:.:|..      |||:.:.|...:.
Human  1380 KDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNC 1444

  Fly  1497 GGRGGSSSSPNKRVKKERSTRRNQKP---TAAARRLPVANSSEDEDEEDDDDDDDDDDEEEASTR 1558
            .|    .|.|||.:       ||.||   .:..:.:|....|               ..:..|:|
Human  1445 KG----DSQPNKSI-------RNLKPKRLKSQTKIIPELVGS---------------PTQSTSSR 1483

  Fly  1559 ----GRSRRRNGVAVSASSSGSNRVTSSSAAQQRRGK-----SSSSEEEEEEETSAQATSDASSD 1614
                |..:...|:: |..:||.:..::.|:.:::|.:     |:.||.|.|:..:...:|.|||.
Human  1484 TAYLGTHKTSAGIS-SGVTSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSS 1547

  Fly  1615 EEERAQSNDSSPQQTRTRRARQRQRLSDDSNINDSEDSYNPNEGRGSRRRPGAARPSSNRQTNGH 1679
            .||       |.:.:|.|.:..|..||..||:..:..       |.::|:.|   |.|.....|.
Human  1548 SEE-------SKESSRARESSSRSGLSRSSNLRVTRT-------RAAQRKTG---PVSLANGCGR 1595

  Fly  1680 SSKRRR--LNKSPANA-APGPSLPRR---TRRIAGSSAEEAASHSQHDESTQDSQIGRRKGRSAS 1738
            .:.|:|  |:.|..|: ..|..|..|   .|::....|..||:..:.....::         ::|
Human  1596 KATRKRVYLSDSDNNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEE---------NSS 1651

  Fly  1739 SRSIGNG---PSTSAAAAANSSLESPSRNTRANGTRTSSHLGAE--NDHSYHLPVRNGRIIESDT 1798
            |.|:.:|   |..:|:|.|...|...|.:.::    ..|.:..|  .|.:..|||.:....:|:.
Human  1652 SESVCSGRKLPHRNASAVARKKLLHNSEDEQS----LKSEIEEEELKDENQLLPVSSSHTAQSNV 1712

  Fly  1799 DSPVIRPTRQSA--KRALMDW------------GRGSDIEEEEEEEEEDSEEAEEILPTPTKDDL 1849
            |....|.:...:  :.|..:|            .:...::.|..||:..|.:::...   .:...
Human  1713 DESENRDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHAC---NRTAG 1774

  Fly  1850 PSTSRAAL------AQAAAGPSRQLRTNRNTVVRPA----------QSDDDDDDDSDNEPLANNQ 1898
            ||||...|      .:|.:.|.|......||..:.|          .|:|.:.::.|.|      
Human  1775 PSTSVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDSESEEQDRE------ 1833

  Fly  1899 QKNYQSPAKSSSTATVAPHPLSLRRRLASPPERNTHMTRSHATSTTSSAAASRAEQQPAVSTHDH 1963
                     ......:..:|:|  ..|...|...:..:..|...|...:...:.|:       .:
Human  1834 ---------DGKCHKMEMNPIS--GNLNCDPIAMSQCSSDHGCETDLDSDDDKIEK-------PN 1880

  Fly  1964 NYL-GNVNSSRAPRRILSRHQRNADELDTSLDVLENS------------RLLSAIANHRRPTSTT 2015
            |:: .:.:......|.:||.:..:.:.|:||.|::.|            |..:..||..:..|..
Human  1881 NFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDV 1945

  Fly  2016 NSNSASNVVTRRLRGRAS----------------QANSHDEDHEEE---EAAASDEGTDGGSS-- 2059
            ...|..||.||...||..                :.:.|.|...|:   |....|..::|.:.  
Human  1946 EDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTKVL 2010

  Fly  2060 SQSYEDEDEDSDSED---------NQPLTSYVSPSNGRPRRKAK--TSSSSATTQERPLRRTRRP 2113
            ||:.   :.||||||         :..:....:||    :||:.  |||...:....|...|.|.
Human  2011 SQAL---NGDSDSEDMLNSEHKHRHTNIHKIDAPS----KRKSSSVTSSGEDSKSHIPGSETDRT 2068

  Fly  2114 -PSNNSIANDNDDDDDYVVPRSRRANRGGNQRAGRNQKRP-------RYNEQSEEEEAAAGYSH- 2169
             .|.:::|.....::::.|..:....|...:|.....|.|       ..::::.|:|.....|| 
Human  2069 FSSESTLAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHP 2133

  Fly  2170 RSKRIRNGDAHASSQERSQASTERDQEEEEDGTSVDSEEQQVNVSSRGRVRKPSAKARGIFKE 2232
            ..:.::..:...:|:.|...|:     :..|..||...:.....:::.:.||...||:.:.||
Human  2134 ELENVKISETTGNSKFRPDTSS-----KSSDLGSVTESDIDCTDNTKTKRRKTKGKAKVVRKE 2191

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BRWD3NP_732982.1 WD40 171..541 CDD:441893 189/371 (51%)
WD40 repeat 186..223 CDD:293791 25/36 (69%)
WD40 repeat 229..265 CDD:293791 20/35 (57%)
WD40 repeat 270..311 CDD:293791 13/40 (33%)
WD40 repeat 331..364 CDD:293791 16/32 (50%)
WD40 repeat 372..413 CDD:293791 22/40 (55%)
WD40 repeat 428..464 CDD:293791 16/35 (46%)
WD40 repeat 470..495 CDD:293791 13/24 (54%)
Bromo_WDR9_I_like 1196..1311 CDD:99958 47/114 (41%)
Bromo_WDR9_II 1371..1489 CDD:99928 63/123 (51%)
PHA03307 1604..>1822 CDD:223039 53/242 (22%)
BRWD1NP_061836.2 WD40 <180..499 CDD:441893 165/322 (51%)
WD 1 184..223 27/38 (71%)
WD40 repeat 189..226 CDD:293791 25/36 (69%)
WD 2 226..265 21/38 (55%)
WD40 repeat 232..268 CDD:293791 20/35 (57%)
WD 3 268..311 16/45 (36%)
WD40 repeat 273..318 CDD:293791 16/47 (34%)
WD 4 322..365 23/43 (53%)
WD40 repeat 326..365 CDD:293791 20/38 (53%)
WD 5 366..405 21/38 (55%)
WD40 repeat 371..417 CDD:293791 23/45 (51%)
WD 6 424..463 17/38 (45%)
WD40 repeat 429..465 CDD:293791 16/35 (46%)
WD 7 466..506 21/39 (54%)
WD40 repeat 471..496 CDD:293791 13/24 (54%)
WD 8 514..553 25/39 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 668..691 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 809..867 22/82 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 895..925 5/29 (17%)
Bromo_WDR9_I_like 1149..1264 CDD:99958 47/114 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1304 12/51 (24%)
Bromo_WDR9_II 1313..1431 CDD:99928 60/117 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1434..1593 46/202 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1670..1805 26/141 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1817..1839 4/36 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1862..1899 5/43 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2014..2077 17/69 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2112..2184 12/76 (16%)

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