Protein Alignment BRWD3 and Brwd1

DIOPT Version :10

• Sequence 1: NP_732982.1
• Gene: BRWD3 / 42898
• FlyBaseID: FBgn0011785
• Length: 2232
• Species: Drosophila melanogaster
• Sequence 2: XP_006248248.1
• Gene: Brwd1 / 304061
• RGDID: 1309030
• Length: 2303
• Species: Rattus norvegicus
• Alignment Length: 2448
• Identity: 824/2448 - (33%)
• Similarity: 1233/2448 - (50%)
• Gaps: 414/2448 - (16%)

  Fly    12 LKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELERKYKHIGANHL 76
            ::.||||||:::|:|||....|:||::|||:.::||:||||:||||.:::|||....||:..:||
  Rat    14 IESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHL 78

  Fly    77 LEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLRT----KETVY-------CHRSLRDYCTRLN 130
            |:||.|:||::|:|.|||:..:.||||.|||:||||    :.||:       .||.        .
  Rat    79 LQICQRIGPMLDKEAPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRG--------R 135

  Fly   131 GVSLPDSVLTKPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLSSVYCVLFDRTG 195
            ...:|  |...|..:|..:..|::..|........|..:|:..|:.||.:||||:||||.|||||
  Rat   136 PPEMP--VNYGPPPSLVDIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTG 198

  Fly   196 RYIITGADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHILRVWDMQTTSPI 260
            ..|.||:||.|:||||..:||||:||||.|:||:|:|:|.:||::||||.|.|:|||.::|.:|:
  Rat   199 HRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTLIAAGSCDKIIRVWCLRTCAPV 263

  Fly   261 AVLSAHTGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKPTQYHEKLRPGQ 325
            |||..|||.|||:.|.|..:...:|:|:|..||::.|||:..   :.:.|:|:|.::.||.|||
  Rat   264 AVLQGHTGSITSLQFSPMAKGPQRYMVSTGADGTVCFWQWDL---ESLKFSPRPLKFTEKPRPG- 324

  Fly   326 AQMMCTTFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSHRGLRFISGSKD 390
            .||:|::||.||:|||.||.||.:|:|.:|.:.|::|.|.|::||.|||:|:.:.|.||:|||:|
  Rat   325 VQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRD 389

  Fly   391 GTAHIWTFESQQWKSSKLCMTERLASCPEPEEGK--RLKVTMVAWDASDRYVITAVNDFTIKIWD 453
            |||.||.||..:|||..|.|..|::.....||.:  :.||||:||:..|..|:|||||..:|:|.
  Rat   390 GTARIWRFEQLEWKSILLDMAARISGDTSAEEERFMKPKVTMIAWNQDDSTVVTAVNDHVLKVWS 454

  Fly   454 SKSAKLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFLNDIDGQGHGSV 518
            |.:.:|...|.||.||::|||::|.|..::|||||||.:|:|||.:|:.:.::.|.|:|||||:|
  Rat   455 SYTGQLLHNLLGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGIKMKHYFNMIEGQGHGAV 519

  Fly   519 FDAKWSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQHHVVDEQTQIM 583
            ||.|:|.||...|.||||||:||||.| |.:.|:.:|.::|||||:|||:||:.::|:|||||..
  Rat   520 FDCKFSQDGQHFACTDSHGHLLIFGFG-CSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQA 583

  Fly   584 PHLMPPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNLTVGVDGVVIDDGGAGGDAVVAAAPA 648
            |||||||||||.||||||::|||.|||||:.:.:.|:|.|     |.|....|...:.|::....
  Rat   584 PHLMPPPFLVDVDGNPHPTKFQRLVPGRENSADEHLVPQL-----GYVATSDGEVIEQVISLHTN 643

  Fly   649 EAPPAALPPAAAGGPQGANYSHIDRMIAALANRQSV------NVNAN-----DANPTNGNQSFER 702
            ::..|:        |:.   |.:|.||..|..:|.:      :|.||     :..|..|  ||.|
  Rat   644 DSGDAS--------PES---SVLDGMIRQLQQQQDLRLGVDQDVTANGLPNEEGTPRRG--SFRR 695

  Fly   703 LT-NRQMPDSNGRQSSRGNVLG----------SRLSTPR--QGWGAAAAAPVEDQAGPSQPPAEP 754
            |: :.|.|.:.|.:.| |.|.|          |:::|.|  |.|......|
  Rat   696 LSLDIQSPPNIGLRRS-GQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVP-------------- 745

  Fly   755 AAEPGQAQVQQALPLKFIRRTYVRPMKYPQLQNLKQTIYSAGQFEKQEYKREMRRRPIMINTASA 819
                      :|.|..|.|...:|..:..:.:||    |..|: :|:.::...:...:::.:.|
  Rat   746 ----------EAPPGVFRRLEDIRIERGEEERNL----YVIGR-KKKTFQLPQKSNSMVLVSQS- 794

  Fly   820 ASSQQPGSVGRPRNTRGNGGGARAGRRRGPQ---PAGGQPQPAYRTRAVRDQEPEHYDEVAPPPE 881
                      |.|..|..  .|...||...|   .:|.:...:.|.....||..
  Rat   795 ----------RQRTCRRK--YANYSRRNAGQCELSSGNESSGSVRHETSCDQSE----------- 836

  Fly   882 EEEEDVSSNSSGDTSYSNVEENLEDSSDESETDSSDYSDWVADTPGPNLEPPKR-SKRKPLSRRP 945
                  .|.||.|..:.:...:..||...||: ||.||||.||| |.:||||.| |.|:.::|..
  Rat   837 ------GSCSSEDDEWRSDRRSGSDSDSPSES-SSQYSDWTADT-GVHLEPPLRTSCRRRVTRFC 893

  Fly   946 RSSDDS------SDDERAGRSRGGQVTARKVGRKTVLFPPTDANGEIPELYRPAEWLSEVIPRKA 1004
            .:|:|.      |..:|..:.|......|:..|:|.  |...||.|....:.|..|:::...||:
  Rat   894 STSEDEMSTENISPPKRRRKRRKESKPKRESLRRTT--PAELANMEPLYEFHPPVWITDTTLRKS 956

  Fly  1005 PYYPQMGDEVVYFRQGHAKYLDAVRLKKVYKLSHSSEPWNFHTLRDHELVRVIGIKYEIRPPRLC 1069
            |:.|||||||:||||||..|::|||...:|:|:.:.|||....|||.|||:::|::||:.||.||
  Rat   957 PFVPQMGDEVMYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGLRYEVGPPTLC 1021

  Fly  1070 CLKLAIID-EEGNMTGTTFKIKYHDMPDVLDFLVLRQTFDLAVQRNWSIGDRFRCMIVDGWWMGQ 1133
            |||||.|| ..|.:|..:|.|:|||||||:|||||||.:|.|.||||...||||.:|.|.||.|.
  Rat  1022 CLKLAFIDPATGRLTDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQPSDRFRSIIDDAWWFGT 1086

  Fly  1134 IESRHALSADFPDSSFMCFRVRWDNGEYEFMSPWDMEPI-DQQRVPDEVGGAVPVLPEEIRATLY 1197
            :.|:......:|||.|.|:.|||||.|.|.:|||||||| |....|:|:|.::.|..:|:...||
  Rat  1087 VLSQEPYQPQYPDSHFQCYSVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISVTSDELEKLLY 1151

  Fly  1198 QPKSEEWHRGDRDGTCRRIINGLEQVMRLSIAEHFLAPVDLNIYPDYAYLIEYPIDLTTIKSRFE 1262
            :|:..||.:..||..|.|||:|::|::.|.||..|..||||..||.|..::.||.||.||:.|..
  Rat  1152 KPQDGEWGQRSRDEECERIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLV 1216

  Fly  1263 NHFYRRITSAQFDVRYLATNAEQYNRRHAIIVKHSRIVTDLCLRIIREPDEIDVAAVYHQLADVY 1327
            :.||||:::..::|||:..||..:|...::|.:.::.:||..|:.|:..|..::.    :|.:..
  Rat  1217 HRFYRRLSALIWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFIKNQDCTNIL----ELCNTS 1277

  Fly  1328 HS-SESENEVDSDVVPSTSTGPTTSAAAAAARQRVSSARRSTRIHS--EGDWRADCRQLLDLMWA 1389
            .| .:|.:::|...:|.||:|          |:||.:.:|.:|..|  |.|||..|:.||.|::.
  Rat  1278 DSDGDSADDLDDSDLPKTSSG----------RRRVHNWKRRSRGSSCIESDWRRQCKALLILIFQ 1332

  Fly  1390 RTDSAPFREPVDTIDFPDYLEIIATPMDLRTVKEDLLGGNYDDPLDFAKDVRLIFQNSKNYNTNK 1454
            ..||.|||:|||.:::|||.:||.||||..||:|.|..||||.|::|.||:||||.|:|.|..||
  Rat  1333 CEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLEAGNYDSPVEFCKDIRLIFSNAKAYTPNK 1397

  Fly  1455 RSRIYAMTLRLSALFESHIKTVV------TSWKAALRRANKNKSGSSGGG--------------- 1498
            ||:||:||||||||||..:|.:.      ..:|..|||:.:.|......|
  Rat  1398 RSKIYSMTLRLSALFEEKMKKISFDFKIGQKFKEKLRRSQRFKQRQKCNGAVPVDRSMRSVKQKQ 1462

  Fly  1499 -RGGSSSSPNKRVKKERSTRRNQKPTAAARRLPVANSSEDEDEEDDDDDDDDDDEEEASTRGRSR 1562
             |..:...|.......:|| .::.|.:|.|:.....||         .....|..:.|.:..|.|
  Rat  1463 FRSQTKVIPQLMCSPSQST-SSKVPLSATRKTSAGVSS---------GCTSGDSSDSAGSLERVR 1517

  Fly  1563 R------RNGVAVSASSSGSNRVTSSSAAQQRRGKSSSSEEEEEEETSAQATSDASSDEEERAQS 1621
            |      |:|..:..|.......||||::      ||:|.:|.:|.:.||..|..|      ...
  Rat  1518 RHRAETLRSGSVLFGSEMEDFLATSSSSS------SSNSSDESKESSGAQECSLRS------GVL 1570

  Fly  1622 NDSSPQQTRTRRARQ----------------RQR--LSDDSNINDSEDSYNPNEGRGSRR--RPG 1666
            ..|:.:.||||.||:                |:|  |||..|.:...|....::...||:  |..
  Rat  1571 RSSNLRVTRTRAARRKAGSVSLENGCGRKATRKRVYLSDSDNHSVETDENLKSKAGSSRKVLRKC 1635

  Fly  1667 AARPSSNRQTNGHSSKRRRLNKSPANAAPGPSLPRRTRRIAGSSAEEAASHSQHDESTQ-DSQIG 1730
            ||..:|..:.  .|......::||.:   |..||.|.   |.:.|.:...|:..|:|.: :::..
  Rat  1636 AAVAASKIKL--MSDAEDSSSESPCS---GRKLPHRN---ASAVARKKLLHNSDDQSLKSETEEV 1692

  Fly  1731 RRKGRS---ASSRSIGNGPSTSAAAAANSSLESPSRNTRANGTRTSSHLGA-------------- 1778
            |.:.::   :|..::.|..|.|   .::|.|::..:...|||  .:||..|
  Rat  1693 RDRNQALLMSSPHAVQNCISDS---ESDSDLQAARKTWHANG--CTSHPAAACKAKSRPIESSEE 1752

  Fly  1779 -----ENDH---SYHLPVRNGRIIESDT----------DSPVIRPTRQSAKRALMDWGRGSDIEE 1825
                 |:||   |...|:.:|:.:.:|:          .|.:.:.|..|.|..::     ||.|:
  Rat  1753 DSRCHESDHGPSSTVDPLTSGQKLGADSISEEADSEPGSSALGKNTHLSKKAKIL-----SDSED 1812

  Fly  1826 EEEEEEEDSEEAEEILPTPTKDDLPSTSRAALAQAAAGPSRQLRTNRNTVVRPAQSDDDDDDDSD 1890
            .||:..|  ....|:..:|..:.|..........:..||...:.::.:.|...:.|:.:|....:
  Rat  1813 CEEKYGE--RRGPEVEGSPVSEALREAVIVPQCLSHHGPETDVDSDGSAVREKSHSNVNDSVSRE 1875

  Fly  1891 NEPLANNQQKNYQSPAKSSSTATVAPHPLSLRRRLASPPERNTHMTRSHATSTTSSAAASRAEQQ 1955
            |.......:|.:.|....|:...:...|:.     .:.|.|   :|||....|..:...|.||..
  Rat  1876 NGQRKKVSRKRFCSSDSESNLQVIQKSPID-----QTSPSR---ITRSAGMVTDKTKLTSDAEDV 1932

  Fly  1956 PAVSTHDHNYLGNVNSSRAPRR--------------ILSRHQRNAD-ELDTSLDVLENSRLLSAI 2005
            ...|.          .:|:.||              |.|...::|. |:..     |.|...|::
  Rat  1933 SLESV----------CTRSKRRRKKPVRFACTTAKSIPSSEGKHARCEVPE-----EQSACRSSL 1982

  Fly  2006 ANHRRPTSTTNSNSASNVVTRRLRGRAS--QANSHDEDHEEEEAAASDEGTDGGSSSQSYED--- 2065
            |...:..|..|::.|:| ......|.:|  |..|..:...:.....:...|...|:..|.||
  Rat  1983 AEPEQQGSAENASQAAN-ADLDFEGSSSFEQTKSIQKRQMDSVCIRAPSKTQNSSAGPSQEDPKS 2046

  Fly  2066 EDEDSD--------------SEDN--QPLTSYVSPSNGRPRR---KAK-------TSSSSATTQE 2104
            ..:|||              .|:|  :.|...:...|||..|   ||.       |.|..|..:.
  Rat  2047 HTQDSDISLSSESVLAQKAIGENNFEEELNYGLRRWNGRRLRTYGKAPLSRTAPVTPSLQAAAEV 2111

  Fly  2105 RPLRRTRRP---------------------PSNNSIANDNDDDDDYV--VPRSRRANRGG----- 2141
            |..||...|                     |.::.:.:..:.|.|..  ....||..|.|
  Rat  2112 RVKRRRVHPEVDGEDIPGQMGSSGCGPDTSPKSSDLGSVTESDVDCTDNTKAQRRKKRKGKTRVL 2176

  Fly  2142 NQRAGRNQKRPRYNEQS---EEEEAAAGYSHRSK------RI-RNGDAHASSQERSQASTERDQE 2196
            :|.:.|..:.|....:.   .|:||...:|...|      :| |...|.|:::.::..:.:
  Rat  2177 SQESVRKDREPHTKTRPCMFNEKEAVQMHSDTLKPKTVPEKIPRRCAAIAANKIKTMCNLK---- 2237

  Fly  2197 EEEDGTSVDSEEQQVNVSSRGR---VRKPSAKAR----GIFKE 2232
                  .|.|..:.|.:.:..|   .|:.||.|:    .::||
  Rat  2238 ------EVVSGPENVGIRTNSRKLPYRQASAAAKKKLLSVYKE 2274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BRWD3	NP_732982.1	WD40	171..541	CDD:441893	189/371 (51%)
		WD40 repeat	186..223	CDD:293791	25/36 (69%)
		WD40 repeat	229..265	CDD:293791	19/35 (54%)
		WD40 repeat	270..311	CDD:293791	13/40 (33%)
		WD40 repeat	331..364	CDD:293791	16/32 (50%)
		WD40 repeat	372..413	CDD:293791	23/40 (58%)
		WD40 repeat	428..464	CDD:293791	16/35 (46%)
		WD40 repeat	470..495	CDD:293791	13/24 (54%)
		Bromo_WDR9_I_like	1196..1311	CDD:99958	46/114 (40%)
		Bromo_WDR9_II	1371..1489	CDD:99928	66/125 (53%)
		PHA03307	1604..>1822	CDD:223039	60/273 (22%)
Brwd1	XP_006248248.1	WD40	<180..499	CDD:441893	165/322 (51%)
		WD40 repeat	189..226	CDD:293791	25/36 (69%)
		WD40 repeat	232..268	CDD:293791	19/35 (54%)
		WD40 repeat	273..318	CDD:293791	16/47 (34%)
		WD40 repeat	326..365	CDD:293791	20/38 (53%)
		WD40 repeat	371..408	CDD:293791	21/36 (58%)
		WD40 repeat	429..468	CDD:293791	18/38 (47%)
		WD40 repeat	471..496	CDD:293791	13/24 (54%)
		Bromo_WDR9_I_like	1150..1265	CDD:99958	46/114 (40%)
		Bromo_WDR9_II	1316..1432	CDD:99928	62/115 (54%)