DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BRWD3 and Brwd1

DIOPT Version :9

Sequence 1:NP_732982.1 Gene:BRWD3 / 42898 FlyBaseID:FBgn0011785 Length:2232 Species:Drosophila melanogaster
Sequence 2:XP_006248248.1 Gene:Brwd1 / 304061 RGDID:1309030 Length:2303 Species:Rattus norvegicus


Alignment Length:2448 Identity:824/2448 - (33%)
Similarity:1233/2448 - (50%) Gaps:414/2448 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELERKYKHIGANHL 76
            ::.||||||:::|:|||....|:||::|||:.::||:||||:||||.:::|||....||:..:||
  Rat    14 IESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHL 78

  Fly    77 LEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLRT----KETVY-------CHRSLRDYCTRLN 130
            |:||.|:||::|:|.|||:..:.||||.|||:||||    :.||:       .||.        .
  Rat    79 LQICQRIGPMLDKEAPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRG--------R 135

  Fly   131 GVSLPDSVLTKPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLSSVYCVLFDRTG 195
            ...:|  |...|..:|..:..|::..|........|..:|:..|:.||.:||||:||||.|||||
  Rat   136 PPEMP--VNYGPPPSLVDIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTG 198

  Fly   196 RYIITGADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHILRVWDMQTTSPI 260
            ..|.||:||.|:||||..:||||:||||.|:||:|:|:|.:||::||||.|.|:|||.::|.:|:
  Rat   199 HRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTLIAAGSCDKIIRVWCLRTCAPV 263

  Fly   261 AVLSAHTGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKPTQYHEKLRPGQ 325
            |||..|||.|||:.|.|..:...:|:|:|..||::.|||:..   :.:.|:|:|.::.||.||| 
  Rat   264 AVLQGHTGSITSLQFSPMAKGPQRYMVSTGADGTVCFWQWDL---ESLKFSPRPLKFTEKPRPG- 324

  Fly   326 AQMMCTTFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSHRGLRFISGSKD 390
            .||:|::||.||:|||.||.||.:|:|.:|.:.|::|.|.|::||.|||:|:.:.|.||:|||:|
  Rat   325 VQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRD 389

  Fly   391 GTAHIWTFESQQWKSSKLCMTERLASCPEPEEGK--RLKVTMVAWDASDRYVITAVNDFTIKIWD 453
            |||.||.||..:|||..|.|..|::.....||.:  :.||||:||:..|..|:|||||..:|:|.
  Rat   390 GTARIWRFEQLEWKSILLDMAARISGDTSAEEERFMKPKVTMIAWNQDDSTVVTAVNDHVLKVWS 454

  Fly   454 SKSAKLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFLNDIDGQGHGSV 518
            |.:.:|...|.||.||::|||::|.|..::|||||||.:|:|||.:|:.:.::.|.|:|||||:|
  Rat   455 SYTGQLLHNLLGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGIKMKHYFNMIEGQGHGAV 519

  Fly   519 FDAKWSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQHHVVDEQTQIM 583
            ||.|:|.||...|.||||||:||||.| |.:.|:.:|.::|||||:|||:||:.::|:|||||..
  Rat   520 FDCKFSQDGQHFACTDSHGHLLIFGFG-CSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQA 583

  Fly   584 PHLMPPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNLTVGVDGVVIDDGGAGGDAVVAAAPA 648
            |||||||||||.||||||::|||.|||||:.:.:.|:|.|     |.|....|...:.|::....
  Rat   584 PHLMPPPFLVDVDGNPHPTKFQRLVPGRENSADEHLVPQL-----GYVATSDGEVIEQVISLHTN 643

  Fly   649 EAPPAALPPAAAGGPQGANYSHIDRMIAALANRQSV------NVNAN-----DANPTNGNQSFER 702
            ::..|:        |:.   |.:|.||..|..:|.:      :|.||     :..|..|  ||.|
  Rat   644 DSGDAS--------PES---SVLDGMIRQLQQQQDLRLGVDQDVTANGLPNEEGTPRRG--SFRR 695

  Fly   703 LT-NRQMPDSNGRQSSRGNVLG----------SRLSTPR--QGWGAAAAAPVEDQAGPSQPPAEP 754
            |: :.|.|.:.|.:.| |.|.|          |:::|.|  |.|......|              
  Rat   696 LSLDIQSPPNIGLRRS-GQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVP-------------- 745

  Fly   755 AAEPGQAQVQQALPLKFIRRTYVRPMKYPQLQNLKQTIYSAGQFEKQEYKREMRRRPIMINTASA 819
                      :|.|..|.|...:|..:..:.:||    |..|: :|:.::...:...:::.:.| 
  Rat   746 ----------EAPPGVFRRLEDIRIERGEEERNL----YVIGR-KKKTFQLPQKSNSMVLVSQS- 794

  Fly   820 ASSQQPGSVGRPRNTRGNGGGARAGRRRGPQ---PAGGQPQPAYRTRAVRDQEPEHYDEVAPPPE 881
                      |.|..|..  .|...||...|   .:|.:...:.|.....||..           
  Rat   795 ----------RQRTCRRK--YANYSRRNAGQCELSSGNESSGSVRHETSCDQSE----------- 836

  Fly   882 EEEEDVSSNSSGDTSYSNVEENLEDSSDESETDSSDYSDWVADTPGPNLEPPKR-SKRKPLSRRP 945
                  .|.||.|..:.:...:..||...||: ||.||||.||| |.:||||.| |.|:.::|..
  Rat   837 ------GSCSSEDDEWRSDRRSGSDSDSPSES-SSQYSDWTADT-GVHLEPPLRTSCRRRVTRFC 893

  Fly   946 RSSDDS------SDDERAGRSRGGQVTARKVGRKTVLFPPTDANGEIPELYRPAEWLSEVIPRKA 1004
            .:|:|.      |..:|..:.|......|:..|:|.  |...||.|....:.|..|:::...||:
  Rat   894 STSEDEMSTENISPPKRRRKRRKESKPKRESLRRTT--PAELANMEPLYEFHPPVWITDTTLRKS 956

  Fly  1005 PYYPQMGDEVVYFRQGHAKYLDAVRLKKVYKLSHSSEPWNFHTLRDHELVRVIGIKYEIRPPRLC 1069
            |:.|||||||:||||||..|::|||...:|:|:.:.|||....|||.|||:::|::||:.||.||
  Rat   957 PFVPQMGDEVMYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGLRYEVGPPTLC 1021

  Fly  1070 CLKLAIID-EEGNMTGTTFKIKYHDMPDVLDFLVLRQTFDLAVQRNWSIGDRFRCMIVDGWWMGQ 1133
            |||||.|| ..|.:|..:|.|:|||||||:|||||||.:|.|.||||...||||.:|.|.||.|.
  Rat  1022 CLKLAFIDPATGRLTDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQPSDRFRSIIDDAWWFGT 1086

  Fly  1134 IESRHALSADFPDSSFMCFRVRWDNGEYEFMSPWDMEPI-DQQRVPDEVGGAVPVLPEEIRATLY 1197
            :.|:......:|||.|.|:.|||||.|.|.:|||||||| |....|:|:|.::.|..:|:...||
  Rat  1087 VLSQEPYQPQYPDSHFQCYSVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISVTSDELEKLLY 1151

  Fly  1198 QPKSEEWHRGDRDGTCRRIINGLEQVMRLSIAEHFLAPVDLNIYPDYAYLIEYPIDLTTIKSRFE 1262
            :|:..||.:..||..|.|||:|::|::.|.||..|..||||..||.|..::.||.||.||:.|..
  Rat  1152 KPQDGEWGQRSRDEECERIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLV 1216

  Fly  1263 NHFYRRITSAQFDVRYLATNAEQYNRRHAIIVKHSRIVTDLCLRIIREPDEIDVAAVYHQLADVY 1327
            :.||||:::..::|||:..||..:|...::|.:.::.:||..|:.|:..|..::.    :|.:..
  Rat  1217 HRFYRRLSALIWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFIKNQDCTNIL----ELCNTS 1277

  Fly  1328 HS-SESENEVDSDVVPSTSTGPTTSAAAAAARQRVSSARRSTRIHS--EGDWRADCRQLLDLMWA 1389
            .| .:|.:::|...:|.||:|          |:||.:.:|.:|..|  |.|||..|:.||.|::.
  Rat  1278 DSDGDSADDLDDSDLPKTSSG----------RRRVHNWKRRSRGSSCIESDWRRQCKALLILIFQ 1332

  Fly  1390 RTDSAPFREPVDTIDFPDYLEIIATPMDLRTVKEDLLGGNYDDPLDFAKDVRLIFQNSKNYNTNK 1454
            ..||.|||:|||.:::|||.:||.||||..||:|.|..||||.|::|.||:||||.|:|.|..||
  Rat  1333 CEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLEAGNYDSPVEFCKDIRLIFSNAKAYTPNK 1397

  Fly  1455 RSRIYAMTLRLSALFESHIKTVV------TSWKAALRRANKNKSGSSGGG--------------- 1498
            ||:||:||||||||||..:|.:.      ..:|..|||:.:.|......|               
  Rat  1398 RSKIYSMTLRLSALFEEKMKKISFDFKIGQKFKEKLRRSQRFKQRQKCNGAVPVDRSMRSVKQKQ 1462

  Fly  1499 -RGGSSSSPNKRVKKERSTRRNQKPTAAARRLPVANSSEDEDEEDDDDDDDDDDEEEASTRGRSR 1562
             |..:...|.......:|| .::.|.:|.|:.....||         .....|..:.|.:..|.|
  Rat  1463 FRSQTKVIPQLMCSPSQST-SSKVPLSATRKTSAGVSS---------GCTSGDSSDSAGSLERVR 1517

  Fly  1563 R------RNGVAVSASSSGSNRVTSSSAAQQRRGKSSSSEEEEEEETSAQATSDASSDEEERAQS 1621
            |      |:|..:..|.......||||::      ||:|.:|.:|.:.||..|..|      ...
  Rat  1518 RHRAETLRSGSVLFGSEMEDFLATSSSSS------SSNSSDESKESSGAQECSLRS------GVL 1570

  Fly  1622 NDSSPQQTRTRRARQ----------------RQR--LSDDSNINDSEDSYNPNEGRGSRR--RPG 1666
            ..|:.:.||||.||:                |:|  |||..|.:...|....::...||:  |..
  Rat  1571 RSSNLRVTRTRAARRKAGSVSLENGCGRKATRKRVYLSDSDNHSVETDENLKSKAGSSRKVLRKC 1635

  Fly  1667 AARPSSNRQTNGHSSKRRRLNKSPANAAPGPSLPRRTRRIAGSSAEEAASHSQHDESTQ-DSQIG 1730
            ||..:|..:.  .|......::||.:   |..||.|.   |.:.|.:...|:..|:|.: :::..
  Rat  1636 AAVAASKIKL--MSDAEDSSSESPCS---GRKLPHRN---ASAVARKKLLHNSDDQSLKSETEEV 1692

  Fly  1731 RRKGRS---ASSRSIGNGPSTSAAAAANSSLESPSRNTRANGTRTSSHLGA-------------- 1778
            |.:.::   :|..::.|..|.|   .::|.|::..:...|||  .:||..|              
  Rat  1693 RDRNQALLMSSPHAVQNCISDS---ESDSDLQAARKTWHANG--CTSHPAAACKAKSRPIESSEE 1752

  Fly  1779 -----ENDH---SYHLPVRNGRIIESDT----------DSPVIRPTRQSAKRALMDWGRGSDIEE 1825
                 |:||   |...|:.:|:.:.:|:          .|.:.:.|..|.|..::     ||.|:
  Rat  1753 DSRCHESDHGPSSTVDPLTSGQKLGADSISEEADSEPGSSALGKNTHLSKKAKIL-----SDSED 1812

  Fly  1826 EEEEEEEDSEEAEEILPTPTKDDLPSTSRAALAQAAAGPSRQLRTNRNTVVRPAQSDDDDDDDSD 1890
            .||:..|  ....|:..:|..:.|..........:..||...:.::.:.|...:.|:.:|....:
  Rat  1813 CEEKYGE--RRGPEVEGSPVSEALREAVIVPQCLSHHGPETDVDSDGSAVREKSHSNVNDSVSRE 1875

  Fly  1891 NEPLANNQQKNYQSPAKSSSTATVAPHPLSLRRRLASPPERNTHMTRSHATSTTSSAAASRAEQQ 1955
            |.......:|.:.|....|:...:...|:.     .:.|.|   :|||....|..:...|.||..
  Rat  1876 NGQRKKVSRKRFCSSDSESNLQVIQKSPID-----QTSPSR---ITRSAGMVTDKTKLTSDAEDV 1932

  Fly  1956 PAVSTHDHNYLGNVNSSRAPRR--------------ILSRHQRNAD-ELDTSLDVLENSRLLSAI 2005
            ...|.          .:|:.||              |.|...::|. |:..     |.|...|::
  Rat  1933 SLESV----------CTRSKRRRKKPVRFACTTAKSIPSSEGKHARCEVPE-----EQSACRSSL 1982

  Fly  2006 ANHRRPTSTTNSNSASNVVTRRLRGRAS--QANSHDEDHEEEEAAASDEGTDGGSSSQSYED--- 2065
            |...:..|..|::.|:| ......|.:|  |..|..:...:.....:...|...|:..|.||   
  Rat  1983 AEPEQQGSAENASQAAN-ADLDFEGSSSFEQTKSIQKRQMDSVCIRAPSKTQNSSAGPSQEDPKS 2046

  Fly  2066 EDEDSD--------------SEDN--QPLTSYVSPSNGRPRR---KAK-------TSSSSATTQE 2104
            ..:|||              .|:|  :.|...:...|||..|   ||.       |.|..|..:.
  Rat  2047 HTQDSDISLSSESVLAQKAIGENNFEEELNYGLRRWNGRRLRTYGKAPLSRTAPVTPSLQAAAEV 2111

  Fly  2105 RPLRRTRRP---------------------PSNNSIANDNDDDDDYV--VPRSRRANRGG----- 2141
            |..||...|                     |.::.:.:..:.|.|..  ....||..|.|     
  Rat  2112 RVKRRRVHPEVDGEDIPGQMGSSGCGPDTSPKSSDLGSVTESDVDCTDNTKAQRRKKRKGKTRVL 2176

  Fly  2142 NQRAGRNQKRPRYNEQS---EEEEAAAGYSHRSK------RI-RNGDAHASSQERSQASTERDQE 2196
            :|.:.|..:.|....:.   .|:||...:|...|      :| |...|.|:::.::..:.:    
  Rat  2177 SQESVRKDREPHTKTRPCMFNEKEAVQMHSDTLKPKTVPEKIPRRCAAIAANKIKTMCNLK---- 2237

  Fly  2197 EEEDGTSVDSEEQQVNVSSRGR---VRKPSAKAR----GIFKE 2232
                  .|.|..:.|.:.:..|   .|:.||.|:    .::||
  Rat  2238 ------EVVSGPENVGIRTNSRKLPYRQASAAAKKKLLSVYKE 2274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BRWD3NP_732982.1 WD40 176..496 CDD:238121 163/321 (51%)
WD40 181..544 CDD:225201 189/364 (52%)
WD40 repeat 186..223 CDD:293791 25/36 (69%)
WD40 repeat 229..265 CDD:293791 19/35 (54%)
WD40 repeat 270..311 CDD:293791 13/40 (33%)
WD40 repeat 331..364 CDD:293791 16/32 (50%)
WD40 repeat 372..413 CDD:293791 23/40 (58%)
WD40 repeat 428..464 CDD:293791 16/35 (46%)
WD40 repeat 470..495 CDD:293791 13/24 (54%)
Auxin_resp 1083..1167 CDD:284030 46/83 (55%)
Bromo_WDR9_I_like 1196..1311 CDD:99958 46/114 (40%)
Bromo_WDR9_II 1371..1489 CDD:99928 66/125 (53%)
Brwd1XP_006248248.1 WD40 178..497 CDD:238121 163/322 (51%)
WD40 181..540 CDD:225201 186/362 (51%)
WD40 repeat 189..226 CDD:293791 25/36 (69%)
WD40 repeat 232..268 CDD:293791 19/35 (54%)
WD40 repeat 273..318 CDD:293791 16/47 (34%)
WD40 repeat 326..365 CDD:293791 20/38 (53%)
WD40 repeat 371..408 CDD:293791 21/36 (58%)
WD40 repeat 429..468 CDD:293791 18/38 (47%)
WD40 repeat 471..496 CDD:293791 13/24 (54%)
Bromo_WDR9_I_like 1150..1265 CDD:99958 46/114 (40%)
Bromo_WDR9_II 1316..1432 CDD:99928 62/115 (54%)
CDC27 <1697..1999 CDD:286580 66/336 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166354244
Domainoid 1 1.000 472 1.000 Domainoid score I422
eggNOG 1 0.900 - - E2759_KOG0644
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1166 1.000 Inparanoid score I191
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001192
OrthoInspector 1 1.000 - - otm45466
orthoMCL 1 0.900 - - OOG6_101711
Panther 1 1.100 - - LDO PTHR16266
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X735
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.840

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