DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BRWD3 and BRWD3

DIOPT Version :9

Sequence 1:	NP_732982.1	Gene:	BRWD3 / 42898	FlyBaseID:	FBgn0011785	Length:	2232	Species:	Drosophila melanogaster
Sequence 2:	NP_694984.5	Gene:	BRWD3 / 254065	HGNCID:	17342	Length:	1802	Species:	Homo sapiens

Alignment Length:	1938	Identity:	720/1938 - (37%)
Similarity:	1057/1938 - (54%)	Gaps:	277/1938 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LKPELYFLISKFLAAGPLEETAKVLIRELEEKKVLPRRLDWQGNEHEQTFEELERKYKHIGANHL 76
            ::.|||:||::||.:||..::|:||::||||.:::||||||:|.||.::||:|.....||..::|
Human     8 IEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHIPPDYL 72

  Fly    77 LEICSRLGPLVDRELPPSVPGINSLLGTGRQNLLR----TKETVY-------CHRSLRDYCTRLN 130
            |:||.|:|||:|:|:|.||||:.:|||.|||:|||    .|.|::       .||.        .
Human    73 LKICERIGPLLDKEIPQSVPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRG--------R 129

  Fly   131 GVSLPDSVLTKPTHNLDRVLTGREHGGEVRRKLLVPTDLYRRTKLLRRTVGHLSSVYCVLFDRTG 195
            ...||.:.:..|  |:..:.:.|:..|..|...:.|:..|:..|:.:|.:|||||||||.|||:|
Human   130 PPELPVNYVKPP--NVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHLSSVYCVAFDRSG 192

  Fly   196 RYIITGADDLLIKIWSAADGRLLATLRGASSEITDIAINLDNTMLAAGSLDHILRVWDMQTTSPI 260
            |.|.||:||.|:|||:..||||||||||.|:||:|:|:|.:||::||||.|.::|||.::|.:|:
Human   193 RRIFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPV 257

  Fly   261 AVLSAHTGMITSVNFCPSPRSDLKYLVTTSTDGSIAFWQYSTPRGQKITFAPKPTQYHEKLRPGQ 325
            |||..|:..|||:.||||.:...:||.:|..||:|.|||:..   :.:.|..:|.::.|:.|||
Human   258 AVLQGHSASITSIQFCPSTKGTNRYLTSTGADGTICFWQWHV---KTMKFRDRPVKFTERSRPG- 318

  Fly   326 AQMMCTTFSPGGIFLAAGSADHHVRVYMMGEDGPKRILETEAYTDAVDSVQWSHRG--LRFISGS 388
            .|:.|::||.||:|:..||.||.:|:|.:|.:.|::|.|.|::||.|.:||:.:.|  |||:|||
Human   319 VQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGS 383

  Fly   389 KDGTAHIWTFESQQWKSSKLCMTERLA--SCPEPEEG-KRLKVTMVAWDASDRYVITAVNDFTIK 450
            :||||.||.::.|:|||..|.|..::.  :.|..|:. .:|||||||||..|..||||||:|.:|
Human   384 RDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLK 448

  Fly   451 IWDSKSAKLHRVLRGHKDELYVLESNPRDEHVLLSAGHDGQVFLWDIEQGVCVANFLNDIDGQGH 515
            :|:|.:.:|...|.||.||::|||::|.|:.::|||||||.:|:||:::|..:.|:.|.|:||||
Human   449 VWNSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGH 513

  Fly   516 GSVFDAKWSPDGTMIAATDSHGHILIFGLGVCIEKYKMLPTELFFHTDFRPLLRDAQHHVVDEQT 580
            |:|||.|:||||...|.||||||:|:||.| |.:.|:.:|.::|||||:|||:|||.::|:||||
Human   514 GAVFDCKFSPDGNHFACTDSHGHLLLFGFG-CSKYYEKIPDQMFFHTDYRPLIRDANNYVLDEQT 577

  Fly   581 QIMPHLMPPPFLVDADGNPHPSRFQRFVPGRESCSLDQLIPNLTVGVDGVVIDDGGAGGDAVVAA 645
            |..|||||||||||.||||||::|||.|||||:|..:||||.|     |.|.:..|...:.|:
Human   578 QQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQL-----GYVANGDGEVVEQVI-- 635

  Fly   646 APAEAPPAALPPAAAGGPQ--GANYSHIDRMIAALANRQSVN-VNANDANPTNGNQSFERLTNRQ 707
                            |.|  ..:.|.:|.:|..|...|.:. :|..|......|:::.  .|..
Human   636 ----------------GQQTNDQDESILDGIIRELQREQDLRLINEGDVPHLPVNRAYS--VNGA 682

  Fly   708 MPDSNGRQSSRGNVLGSRLSTPRQGWGAAAAAPVEDQAGPSQPPAEPAAEPGQAQVQQALPLKFI 772
            :...|...||..|:...|.|:..:|         ..|...:.|.::.|.|...        :.:.
Human   683 LRSPNMDISSSPNIRLRRHSSQIEG---------VRQMHNNAPRSQMATERDL--------MAWS 730

  Fly   773 RRTYVRPMKYPQLQNLKQTIYSAGQFEKQEYKREMRRRPIMINTASAASSQQPGSVGRPRNTRGN 837
            ||..|..:.....:..::...:.|..|...|..|.:::|   :..:..:..:| |.||...
Human   731 RRVVVNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKP---SYTTQRNDYEP-SCGRSLR---- 787

  Fly   838 GGGARAGRRRGPQPAGGQPQPAYRTRAVRDQEPEHYDEVAPPPEEEEEDVSSNSSGDTSYSNVEE 902
                |..|:|         |..|:||:    ..||..:.:......:||..|:|..|.:....:.
Human   788 ----RTQRKR---------QHTYQTRS----NIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDA 835

  Fly   903 NLED-----SSDESETD-SSDYSDWVADTPGPNLEPPKRSKRKPLSRRPRSSDD---SSDDERAG 958
            ::||     .|:.|.:| ||:||||.||. |.||:||||..|:...:...|||:   .|.:||..
Human   836 SVEDPVVEWQSESSSSDSSSEYSDWTADA-GINLQPPKRQTRQTTRKICSSSDEENLKSLEERQK 899

  Fly   959 RSRGGQVTARKVGRKTVLFPPTDANGEIPELYRPAEWLSEVIPRKAPYYPQMGDEVVYFRQGHAK 1023
            :.:  |...:|.|..::...|.:      |.:.| :|:.:.|||::|:.||||||::||||||..
Human   900 KPK--QTRKKKGGLVSIAGEPNE------EWFAP-QWILDTIPRRSPFVPQMGDELIYFRQGHEA 955

  Fly  1024 YLDAVRLKKVYKLSHSSEPWNFHTLRDHELVRVIGIKYEIRPPRLCCLKLAIIDE-EGNMTGTTF 1087
            |:.|||..|:|.::...:|||...||:.|.|:::|||||:.||.|||||||.:|. .|.|||.:|
Human   956 YVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESF 1020

  Fly  1088 KIKYHDMPDVLDFLVLRQTFDLAVQRNWSIGDRFRCMIVDGWWMGQIESRHALSADFPDSSFMCF 1152
            .|||||||||:|||||.|.::.|.:|||.||||||.:|.|.||.|.:||:.....::|||||.|:
Human  1021 SIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCY 1085

  Fly  1153 RVRWDNGEYEFMSPWDMEPIDQ-QRVPDEVGGAVPVLPEEIRATLYQPKSEEWHRGDRDGTCRRI 1216
            .|.|||.|.|.|||||||||.: ...|||||..|||..||:.|.||:|:..||....||..|.|:
Human  1086 SVHWDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERV 1150

  Fly  1217 INGLEQVMRLSIAEHFLAPVDLNIYPDYAYLIEYPIDLTTIKSRFENHFYRRITSAQFDVRYLAT 1281
            |.|:..::.|..|..|..||||:.||.|..::.||.||.||:.|.||.|||||::..::|||:..
Human  1151 IQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRISALMWEVRYIEH 1215

  Fly  1282 NAEQYNRRHAIIVKHSRIVTDLCLRIIREPDEIDVAAVYHQL-ADVYHSSESENEVDSDVVPSTS 1345
            ||..:|...:.|||.::||||:.||.|.:....|:...|::: |:..:|:::|.  |:::|...|
Human  1216 NARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEERNSTDAEE--DTEIVDLDS 1278

  Fly  1346 TGPTTSAAAAAARQRVSSARRSTRIHSEGDWRADCRQLLDLMWARTDSAPFREPVDTIDFP---- 1406
            .||.||   :..:.:....|:|.:.:.:. |:..|::||.|::.|.||.|||:|.|.:.:|
Human  1279 DGPGTS---SGRKVKCRGRRQSLKCNPDA-WKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQE 1339

  Fly  1407 ---------------------DYLEIIATPMDLRTVKEDLLGGNYDDPLDFAKDVRLIFQNSKNY 1450
                                 ||.::|.||:|..||||.|..|||..||:|.||||.||.|||.|
Human  1340 QEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAY 1404

  Fly  1451 NTNKRSRIYAMTLRLSALFESHIKTVVTSWKAAL--------RRANKNKSGSSGGGRGGSSSSPN 1507
            .:||:||||:|.||||||||||||.:::.:|:|:        |...:.:|.||.....|:.|...
Human  1405 TSNKKSRIYSMMLRLSALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKG 1469

  Fly  1508 KRVKKERSTRRNQKPTAAARRLPVANSSEDEDEEDD-----DDDDDDDDEEEASTRGRSRRRNGV 1567
            |:.:.:...:.:|..:.:..|.....||...|..:.     .||:.|.....:|..|.||..|..
Human  1470 KQKQMKLQPKNDQNTSVSHARTSSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSH 1534

  Fly  1568 AVSASSSGSNRV-------------TSSSAAQQRRG-----KSSSSEEE-------EEEET---- 1603
            ....:.|..|||             |:....:.|.|     .|:|.|:|       |::||
Human  1535 DPGKAKSFRNRVLPVKQDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKS 1599

  Fly  1604 --------------SAQATSDASSDEEERAQSND---------SSPQQTRTRRARQRQRLSDDSN 1645
                          |:::|..:.||.|..::::.         |...|||.:|..::|..:...|
Human  1600 HLSTSESGELGSSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRN 1664

  Fly  1646 INDSEDSYNPNEG------RGSRRRPGAARPSSNRQTNGHSSKRRRLNKSPANAAPGPSLPRRTR 1704
            ............|      ||.|.|.|..|.|..|  .|..::.|...:....|:.|.:..:|.
Human  1665 WKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGR--GGGGTRGRGRGRGGRGASRGATRAKRA- 1726

  Fly  1705 RIAGSSAEEAASHSQHDE-----STQDSQIGRRKGRSASSRSIGNGPSTSAAAAANSSLESPSRN 1764
            |||            .||     |.:.|::.|.|.|:...|::              .....|.|
Human  1727 RIA------------DDEFDTMFSGRFSRLPRIKTRNQGRRTV--------------LYNDDSDN 1765

  Fly  1765 TRANGTRTSSHLGAENDHSYHLPVRNGRIIESDTDSPVIRPTRQSAKRALMDW 1817
            .....|....:||..         |:||         |.:.|.::....||.|
Human  1766 DNFVSTEDPLNLGTS---------RSGR---------VRKMTEKARVSHLMGW 1800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BRWD3	NP_732982.1	WD40	176..496	CDD:238121	161/324 (50%)
		WD40	181..544	CDD:225201	188/367 (51%)
		WD40 repeat	186..223	CDD:293791	26/36 (72%)
		WD40 repeat	229..265	CDD:293791	18/35 (51%)
		WD40 repeat	270..311	CDD:293791	16/40 (40%)
		WD40 repeat	331..364	CDD:293791	14/32 (44%)
		WD40 repeat	372..413	CDD:293791	22/42 (52%)
		WD40 repeat	428..464	CDD:293791	19/35 (54%)
		WD40 repeat	470..495	CDD:293791	13/24 (54%)
		Auxin_resp	1083..1167	CDD:284030	49/83 (59%)
		Bromo_WDR9_I_like	1196..1311	CDD:99958	51/114 (45%)
		Bromo_WDR9_II	1371..1489	CDD:99928	63/150 (42%)
BRWD3	NP_694984.5	WD 1	170..209		25/38 (66%)
		WD40	172..494	CDD:238121	163/326 (50%)
		WD40 repeat	183..220	CDD:293791	26/36 (72%)
		WD 2	213..251		23/37 (62%)
		WD40 repeat	226..262	CDD:293791	18/35 (51%)
		WD 3	255..297		21/41 (51%)
		WD40 repeat	267..313	CDD:293791	17/45 (38%)
		WD 4	307..347		16/39 (41%)
		WD40 repeat	321..359	CDD:293791	15/37 (41%)
		WD 5	353..393		21/41 (51%)
		WD40 repeat	365..425	CDD:293791	28/64 (44%)
		WD 6	400..452		26/54 (48%)
		WD40 repeat	426..462	CDD:293791	18/35 (51%)
		WD 7	456..495		20/38 (53%)
		WD40 repeat	468..493	CDD:293791	14/24 (58%)
		WD 8	502..542		25/39 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..910		30/146 (21%)
		Bromo_WDR9_I_like	1130..1242	CDD:99958	55/112 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1262..1292		12/29 (41%)
		Bromodomain	1301..1442	CDD:351801	54/166 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1326..1361		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1438..1500		32/69 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1520..1725		59/272 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160174
Domainoid	1	1.000	476	1.000	Domainoid score	I436
eggNOG	1	0.900	-	-		E2759_KOG0644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1171	1.000	Inparanoid score	I200
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52858
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001192
OrthoInspector	1	1.000	-	-		otm41337
orthoMCL	1	0.900	-	-		OOG6_101711
Panther	1	1.100	-	-	O	PTHR16266
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5357
SonicParanoid	1	1.000	-	-		X735
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790