Protein Alignment BRWD3 and bet-1

DIOPT Version :10

• Sequence 1: NP_732982.1
• Gene: BRWD3 / 42898
• FlyBaseID: FBgn0011785
• Length: 2232
• Species: Drosophila melanogaster
• Sequence 2: NP_001366626.1
• Gene: bet-1 / 172054
• WormBaseID: WBGene00022473
• Length: 857
• Species: Caenorhabditis elegans
• Alignment Length: 932
• Identity: 209/932 - (22%)
• Similarity: 327/932 - (35%)
• Gaps: 274/932 - (29%)

  Fly  1211 GTCRRIINGLEQVMRLSIAE-----H---FLAPVD---LNIYPDYAYLIEYPIDLTTIKSRFENH 1264
            |...|..|.|:.:|...:.|     |   |..|||   |.| |.|...:..|:||.||::|.::.
 Worm    35 GKPTRHTNKLDYIMTTVLKEAGKHKHVWPFQKPVDAVALCI-PLYHERVARPMDLKTIENRLKST 98

  Fly  1265 FYRRITSAQFDVRYLATNAEQYNRRHAIIVKHSRIVTDLCLRII----REPDEIDV--------- 1316
            :|........|:..:..|...:|.:...:...::.|.::..:.:    ||..::||
 Worm    99 YYTCAQECIDDIETVFQNCYTFNGKEDDVTIMAQNVHEVIKKSLEQAPREEHDMDVYWGKNKKKP 163

  Fly  1317 -------AAVYHQLADVYHSSESENEVDSD---VVPSTSTGPTTS-AAAAAARQRVSSARRST-- 1368
                   .:...:..|....||:.:|..|:   |..:::..||.| :|:.||:.....|.:.|
 Worm   164 AKSDGGSKSSSSKKNDARGPSEAPSEAGSEVSSVTTASAAAPTVSESASVAAKPERKVAGKKTGK 228

  Fly  1369 -RIHSEGDWRAD-------------------------CRQLL---------DLMWARTDSAPFRE 1398
             :..||.|.:.:                         |.:||         :..|      ||.|
 Worm   229 RKAESEDDEKPEPLRAKREVAVVKKEVHQPLLPSMKPCLKLLNDFSTKKYQEFAW------PFNE 287

  Fly  1399 PVDT--IDFPDYLEIIATPMDLRTVKEDLLGGNYDDPLDFAKDVRLIFQNSKNYNTNKRSRIYAM 1461
            |||.  :...||.:||..||||:::|..:..|.|.:|.||..||||:.:|...||. ....:::.
 Worm   288 PVDAEQLGLHDYHKIIKEPMDLKSMKAKMESGAYKEPSDFEHDVRLMLRNCFLYNP-VGDPVHSF 351

  Fly  1462 TLRLSALFESHIKTVVTSWKAALRRANKNKSGSSGGGRGGSSSSPNKRVKKERSTRRNQKPTAAA 1526
            .||...:|:..       | |.|                |.|||      :..|......|.|..
 Worm   352 GLRFQEVFDRR-------W-AEL----------------GDSSS------RASSVAPQSAPIAPT 386

  Fly  1527 RRLPVANSSEDEDEEDDDDDDDDDDEEEASTRGRSRRRNGVAVSASSSGSNRVTSSSAAQQRRGK 1591
            .:  ||.||..::.::                  ||:.:....:..:||:.   |....|.....
 Worm   387 PK--VAKSSAPKEPKE------------------SRKEHKKETTFEASGAK---SEDLMQINNAL 428

  Fly  1592 SSSSEEEEE---EETSAQATSDASSDEEERAQSNDSSP------QQTRTRRARQRQRLSDDSNIN 1647
            |...|.||:   |..:|||..|..:..:.|.:.|.:.|      .:||.....|..:.:..|
 Worm   429 SMIREREEKLKAELAAAQAIKDKLTSVKNRREDNPNEPFPEKLINETRALCTTQVGQNASSS--- 490

  Fly  1648 DSEDSYNPNEGRGSRRRPGAAR---------PSSNRQTNGHSSKRRRLNKSPANAAPGPSL---- 1699
             |..|.....||.  ::..:||         ...|:....:..||...|.  .|..|...|
 Worm   491 -SASSAALRNGRS--KKAASARLYGYEFDSDDEDNKMALTYEEKRNLSNL--INNLPNNQLNTII 550

  Fly  1700 ---PRRTRRIAGSSAEEAASHSQHDESTQD---SQIG----RRKGRSASSRSI----GNG----- 1745
               .||.|        .|....|.|:|..:   ..:|    |..|  |..::|    |||
 Worm   551 SIIQRRER--------SALMQQQLDDSEVELDFESLGDMCLREMG--AFIKTIPTLNGNGDDEKP 605

  Fly  1746 -----PSTSAAAAA--NSSLESPSRNTRANGTRTSSHLGAENDHSYHLPVRNGRIIESDTDSPVI 1803
                 |::|.|..:  :|||||      .||.:||.              :|..:.||..|.
 Worm   606 KTSSNPTSSGATGSKGSSSLES------KNGKKTSE--------------KNFNMSESSDDE--- 647

  Fly  1804 RPTRQSAKRALMDWGRGSDIEEEEEEEEEDSEEAEEILPTPTKDDLPSTSRAALAQAAAGPSR-- 1866
              |..|.||...:   .|:.:.....:::..:|...|...|.|...|.::.....|::|.|.|
 Worm   648 --TSNSRKRRKRE---SSESQSSSSSDDDSDDEDRPISGIPRKSGQPPSTSREWNQSSAPPPRMG 707

  Fly  1867 ----QLRTNRNTVVRPAQSDDDDDDDSDNEPLANNQQKNYQS------PAKSSSTATVAPHPLSL 1921
                |...:|    .||.|.........|...|::  .:||:      ||.:||....||.|.|.
 Worm   708 GMGGQPPMSR----VPASSSTSVSAIGKNNAAASS--NSYQAPKPAPVPAPTSSRPPAAPRPPSK 766

  Fly  1922 RRRL---------------ASPPERNTHMTRSHATSTTSSAAASRAEQQPAVSTHDHNYLGNVNS 1971
            .::.               ||||:      ...:..|||:...|..|.||.....:...:..:
 Worm   767 PKKTGGASILDTLLPDTFGASPPQ------FFQSQPTTSATIRSPTESQPGNGEDEQTRIQRM-- 823

  Fly  1972 SRAPRRILSRHQRNADELDTSL 1993
                |....|.::..||...||
 Worm   824 ----RMEAKRARQKEDEGSVSL 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BRWD3	NP_732982.1	WD40	171..541	CDD:441893
		WD40 repeat	186..223	CDD:293791
		WD40 repeat	229..265	CDD:293791
		WD40 repeat	270..311	CDD:293791
		WD40 repeat	331..364	CDD:293791
		WD40 repeat	372..413	CDD:293791
		WD40 repeat	428..464	CDD:293791
		WD40 repeat	470..495	CDD:293791
		Bromo_WDR9_I_like	1196..1311	CDD:99958	27/114 (24%)
		Bromo_WDR9_II	1371..1489	CDD:99928	40/153 (26%)
		PHA03307	1604..>1822	CDD:223039	59/262 (23%)
bet-1	NP_001366626.1	Bromo_Brdt_I_like	39..145	CDD:99929	25/106 (24%)
		PLN02967	95..>240	CDD:215521	26/144 (18%)
		Bromo_Brdt_II_like	262..363	CDD:99930	34/114 (30%)
		Ribosomal_P1_P2_L12p	<371..416	CDD:473891	11/70 (16%)
		BET	526..592	CDD:435704	17/77 (22%)