Protein Alignment Nab2 and ZC3H14

DIOPT Version :10

• Sequence 1: NP_651243.1
• Gene: Nab2 / 42897
• FlyBaseID: FBgn0028471
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: NP_079100.2
• Gene: ZC3H14 / 79882
• HGNCID: 20509
• Length: 736
• Species: Homo sapiens
• Alignment Length: 1048
• Identity: 251/1048 - (23%)
• Similarity: 378/1048 - (36%)
• Gaps: 372/1048 - (35%)

  Fly     5 LGSEIGQKMRSAVKAKLLELGTGGSAGFIDDELPDYVMVMVANKRTKQQMNAELNLFLGDQTDLF 69
            :|:||.:|:|||:|.||.|||     .::|:|||||:|||||||:::.||..:|:||||:.|..|
Human     3 IGTEISRKIRSAIKGKLQELG-----AYVDEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRF 62

  Fly    70 VTWLHEVLQKLQEVTLPTSS-------------ASSKKRKSRGQEKDKKGSKKDKRPHRKSGDEL 121
            ..|||.||.||:.||...||             .|:|...|||          |:|.|..:...|
Human    63 TVWLHGVLDKLRSVTTEPSSLKSSDTNIFDSNVPSNKSNFSRG----------DERRHEAAVPPL 117

  Fly   122 SEPQPSSSDAMPIVSSITDVFAEELLEKAKKTMDIDLSAKDEILHKKKNRKSIEDEDASANRALD 186
            :.|                                  ||:.|....:.:..|.|.:..:..:..|
Human   118 AIP----------------------------------SARPEKRDSRVSTSSQESKTTNVRQTYD 148

  Fly   187 VPAVSEIISTTIGVNRQKDLAELAEIQKKIHAAKKHLRQIGEIGDESDE-YDEDLLNLSAREESV 250
            ..|.:.::||.      |.|.|.|..:..|           :|..|.|: .||||       ..|
Human   149 DGAATRLMSTV------KPLREPAPSEDVI-----------DIKPEPDDLIDEDL-------NFV 189

  Fly   251 DQEPEEDPPKLEAPPRKAKSPIIFNRREKTPEKRPEAEPEIDSRQEEAEEKSPKKDSSADKA--- 312
            .:.|                         ..:|:|.......|.:...|...|....:||..
Human   190 QENP-------------------------LSQKKPTVTLTYGSSRPSIEIYRPPASRNADSGVHL 229

  Fly   313 --KEDRSERRSVHDRLGSKAQTPADRSQRNQKELYVPTHRRRSEPEATKERSQRERTRERRSSRD 375
              .:.:.::.|:|           ...|.:.:..:|....|..|||......:......|.:|..
Human   230 NRLQFQQQQNSIH-----------AAKQLDMQSSWVYETGRLCEPEVLNSLEETYSPFFRNNSEK 283

  Fly   376 TSRDTNRNQRQRRSPSPEAPSTKQRIVSQVIVAVNK----PPEPSDDEDMAEK--PVNSVIKV-- 432
            .|.: :.|.|:|:.|          :||.| |.|.|    ..|..:|:|...:  .::|.:.|
Human   284 MSME-DENFRKRKLP----------VVSSV-VKVKKFNHDGEEEEEDDDYGSRTGSISSSVSVPA 336

  Fly   433 KP--RPNVSPRRQACKNLLLRAVADAQRS---TILAKTSTQKEDEDVGKIISSLGKRKSEDKNDQ 492
            ||  ||::.|.:||.|||:|:|:::||.|   |....|..||:...|..
Human   337 KPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSTVPQKQTLPVAP---------------- 385

  Fly   493 IRKRNRERKRRKRSAQGNELFRRTTRELVVNVTQRDGKRERRSNERRAEIKVVEEEYTPSLMTEG 557
                      |.|::|         .||:..|.|...:..|.|.      .:.|||      |:|
Human   386 ----------RTRTSQ---------EELLAEVVQGQSRTPRISP------PIKEEE------TKG 419

  Fly   558 VETYVPQLLTNVDELDLHISSHDEPSPNSGALKTQFVVTLNGDKALGGKNVKGGASRKRPSNSRK 622
                                  |....|.|..:.|.:..|..|..:
Human   420 ----------------------DSVEKNQGTQQRQLLSRLQIDPVM------------------- 443

  Fly   623 RSTSPVSTPQVSSSNIEPTSTT-VDKR----RRSNRDRSFSPSPRQSSGSPSLPTTRSIN----- 677
                 ..|.|:|....:..|.. .|.|    ::.........:|.|.||..:..:.|.::
Human   444 -----AETLQMSQDYYDMESMVHADTRSFILKKPKLSEEVVVAPNQESGMKTADSLRVLSGHLMQ 503

  Fly   678 -RNEVRRQPQEIKKIIIKNDTDEDDEMHGSPKKRSPNKRQPAAANGHKDNKDKGKIEEGSTTPPL 741
             |:.|:.......|.|:..|        |.|   ||        .|:..::::....||
Human   504 TRDLVQPDKPASPKFIVTLD--------GVP---SP--------PGYMSDQEEDMCFEG------ 543

  Fly   742 PAKPKARAEKKASSKEKSVRSNSAETSSAAKSVSASTSVSTTTKAKHTPIRFTLKSEDEPSASKK 806
                                                                 :|..::.:||.|
Human   544 -----------------------------------------------------MKPVNQTAASNK 555

  Fly   807 RRSGSPDRDVAAPERRRVSIRNPEDRKYDNLPALSAVSVDSTVLKV-NKPK---ERCKYHPNCTK 867
            ...|     :..|::..:..|..||      |..|..:.:.:.|.| .||:   |||||.|.|..
Human   556 GLRG-----LLHPQQLHLLSRQLED------PNGSFSNAEMSELSVAQKPEKLLERCKYWPACKN 609

  Fly   868 -QFCEYYHPTAPCKSFPNCKFADKCMYSHPKCKFDMACMSIDCNYAHGGQRDLSHVQLAAPPLSS 931
             ..|.|:||.:|||:|||||||:||::.||.||:|..|...||.:.|..:|
Human   610 GDECAYHHPISPCKAFPNCKFAEKCLFVHPNCKYDAKCTKPDCPFTHVSRR-------------- 660

  Fly   932 HVIPVQNYKSISAPVTSTTATTMCKYYPNCSKLGCTFYHPKPCRFGKNCVNKLECIFYHPEM--- 993
              |||.:.|...||....:::.:|:|:|.|.|:.|.|||||.|||...| .:.:|.||||.:
Human   661 --IPVLSPKPAVAPPAPPSSSQLCRYFPACKKMECPFYHPKHCRFNTQC-TRPDCTFYHPTINVP 722

  Fly   994 -QSKFKWV 1000
             :...||:
Human   723 PRHALKWI 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nab2	NP_651243.1	PTZ00449	<211..>435	CDD:185628	45/239 (19%)
		PTZ00449	<686..>843	CDD:185628	21/156 (13%)
		zf-CCCH_2	878..896	CDD:464217	12/17 (71%)
		zf-CCCH_2	955..971	CDD:464217	8/15 (53%)
		zf-CCCH_2	973..991	CDD:464217	7/17 (41%)
ZC3H14	NP_079100.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..145		18/111 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..350		10/39 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..430		12/65 (18%)
		zf-CCCH_2	601..618	CDD:464217	7/16 (44%)
		zf-CCCH_2	621..639	CDD:464217	12/17 (71%)
		zf-CCCH_2	681..698	CDD:464217	8/16 (50%)