DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nab2 and Zc3h14

DIOPT Version :9

Sequence 1:	NP_651243.1	Gene:	Nab2 / 42897	FlyBaseID:	FBgn0028471	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	XP_006516390.3	Gene:	Zc3h14 / 75553	MGIID:	1919824	Length:	793	Species:	Mus musculus

Alignment Length:	1016	Identity:	239/1016 - (23%)
Similarity:	366/1016 - (36%)	Gaps:	362/1016 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DDELPDYVMVMVANKRTKQQMNAELNLFLGDQTDLFVTWLHEVLQKLQEVTLPTSS--------- 89
            |:|||||:|||||||:::.||..:|:||||:.|..|..|||.||.||:.||...||
Mouse    85 DEELPDYIMVMVANKKSQDQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTEPSSLKSPDASIF 149

  Fly    90 ----ASSKKRKSRGQEKDKKGSKKDKRPHRKSGDELSEPQPSSSDAMPIVSSITDVFAEELLEKA 150
                .|:|...|||          |:|.|     |.:.|..:.|.:.|                .
Mouse   150 DSHVPSNKSSFSRG----------DERRH-----EAAVPPLAVSSSRP----------------E 183

  Fly   151 KKTMDIDLSAKDEILHKKKNRKSIEDEDASANRALDVPAVSEIISTTIGVNRQKDLAELAEIQKK 215
            |:...:..|::::   |..|.:...|:.||          :.::||.      |.|.|.|..:..
Mouse   184 KRDSRVSTSSQEQ---KSTNVRHSYDDGAS----------TRLMSTV------KPLREPAPSEDV 229

  Fly   216 IHAAKKHLRQIGEIGDESDEYDEDLLN------LSAREESVDQEPEEDPPKLE--APP--RKAKS 270
            |           :|..|.|:..::.||      ||.::.:|........|.:|  .||  |.|.:
Mouse   230 I-----------DIKPEPDDLIDEDLNFVQENPLSQKKPTVTLTYGSSRPSIEIYRPPASRNADT 283

  Fly   271 PIIFNRREKTPEKRPEAEPEIDSRQEEAEEKSPKKDSSADKAKEDRSERRSVHDRLGSKAQTPAD 335
            ....||.:..|::                       |||..||:...:...|.: .|...:.|..
Mouse   284 GTHLNRLQLHPQQ-----------------------SSAHAAKQLDVQSSQVSE-AGRLCEPPVL 324

  Fly   336 RSQRNQKELYVPTHRRRSEPEATKERSQRERTRERRSSRDTSRDTNRNQRQRRSPSPEAPSTKQR 400
            .|   .::.|.|..                     |::.|.....:.|.|:|:.|
Mouse   325 SS---VEDTYSPFF---------------------RNNLDKMSIEDENFRKRKLP---------- 355

  Fly   401 IVSQVIVA---VNKPPEPSDDEDMAEK--PVNSVIKV--KP--RPNVSPRRQACKNLLLRAVADA 456
            :||.|:..   .:...|..:|||...:  .::|.:.|  ||  ||::.|.:||.|||:|:|:::|
Mouse   356 VVSSVVKVKRFSHDGEEEEEDEDYGTRIGSLSSSVSVPAKPERRPSLPPSKQANKNLILKAISEA 420

  Fly   457 QRSTILAKTST-----QKEDEDVGKIISSLGKRKSEDKNDQIRKRNRERKRRKRSAQGNELFRRT 516
            |.|  :.||:.     ||:...|..                          |.|::|
Mouse   421 QES--VTKTTNYSAVPQKQTLPVAP--------------------------RTRTSQ-------- 449

  Fly   517 TRELVVNVTQRDGKRERRSNERRAEIKVVEEEYTPSLMTEGVETYVPQLLTNVDELDLHISSHDE 581
             .||:..:.|...:..|.|.      .|.|||
Mouse   450 -EELLAEMVQGQNRAPRISP------PVKEEE--------------------------------- 474

  Fly   582 PSPNSGALKTQFVVTLNGDKALGGKNVKGGASRKRPSNSRKRSTSPVSTPQVSSSNIEPTSTTVD 646
                                      .||..:.|.....:::..|.:....|....:|.:....|
Mouse   475 --------------------------AKGDNTGKSQGTQQRQLLSRLQIDPVMVETMEMSQDYYD 513

  Fly   647 KRRRSNRDRSFSPSPRQSSGSPSLPTTRSINRNEVRRQPQEIKKIIIKNDTDEDDEMHGSPKKRS 711
            .....:.|                  |||.    :.::|:..::|::            :|.:.|
Mouse   514 MESMVHAD------------------TRSF----ILKKPKLSEEIVV------------TPNQDS 544

  Fly   712 PNKRQPA--AANGH-KDNKDKGKIEEGSTTPPLPAKPKARAEKKASSKEKSVRSNSAETSSAAKS 773
            ..|...|  ..:|| ...:|       ...|..||.||...............|:..|.....
Mouse   545 GMKTADALRVLSGHLMQTRD-------LVQPDKPASPKFIVTLDGVPSPPGYMSDQEEEMCFE-- 600

  Fly   774 VSASTSVSTTTKAKHTPIRFTLKSEDEPSASKKRRSGSPDRDVAAPERRRVSIRNPEDRKYDNLP 838
                                .:|..::.|||.|...|     :..|::..:..|..||      |
Mouse   601 --------------------GMKPVNQTSASNKGLRG-----LLHPQQLHLLSRQLED------P 634

  Fly   839 ALSAVSVDSTVLKV-NKPK---ERCKYHPNCTK-QFCEYYHPTAPCKSFPNCKFADKCMYSHPKC 898
            ..|..:.:.|.|.| .||:   |||||.|.|.. ..|.|:||.:|||:|||||||:||::.||.|
Mouse   635 DGSFSNAEMTDLSVAQKPEKLLERCKYWPACKNGDECVYHHPISPCKAFPNCKFAEKCLFVHPNC 699

  Fly   899 KFDMACMSIDCNYAHGGQRDLSHVQLAAPPLSSHVIPVQNYKSISAPVTSTTATTMCKYYPNCSK 963
            |:|..|...||.:.|..:|            :|.:.|    |.:|:|..|:.. .:|:|:|.|.|
Mouse   700 KYDTKCTKADCPFTHMSRR------------ASILTP----KPVSSPAPSSNG-QLCRYFPACKK 747

  Fly   964 LGCTFYHPKPCRFGKNCVNKLECIFYHPEM----QSKFKWV 1000
            :.|.|||||.|||...| .:.:|.||||.:    :...||:
Mouse   748 MECPFYHPKHCRFNTQC-TRPDCTFYHPTITVPPRHALKWI 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nab2	NP_651243.1	zf-CCCH_2	878..896	CDD:291282	12/17 (71%)
Zc3h14	XP_006516390.3	zf-CCCH_2	659..676	CDD:373157	7/16 (44%)
		zf-CCCH_2	739..755	CDD:373157	8/15 (53%)
		zf-CCCH_2	758..774	CDD:373157	7/16 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842451
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3702
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3411
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004764
OrthoInspector	1	1.000	-	-		oto95352
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14738
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2202
SonicParanoid	1	1.000	-	-		X5101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.970