Protein Alignment Nab2 and zc3h14

DIOPT Version :9

• Sequence 1: NP_651243.1
• Gene: Nab2 / 42897
• FlyBaseID: FBgn0028471
• Length: 1004
• Species: Drosophila melanogaster
• Sequence 2: NP_001020695.2
• Gene: zc3h14 / 562846
• ZFINID: ZDB-GENE-041014-257
• Length: 669
• Species: Danio rerio
• Alignment Length: 1019
• Identity: 243/1019 - (23%)
• Similarity: 377/1019 - (36%)
• Gaps: 382/1019 - (37%)

  Fly     5 LGSEIGQKMRSAVKAKLLELGTGGSAGFIDDELPDYVMVMVANKRTKQQMNAELNLFLGDQTDLF 69
            :|:||.:|:|:|:|.||.|.|     .::|:|||||:|||||||:..|||..:|:||||:.|..|
Zfish     3 IGTEISKKIRTAIKRKLQEFG-----AYVDEELPDYIMVMVANKKNPQQMADDLSLFLGNNTIKF 62

  Fly    70 VTWLHEVLQKLQEVTLPTSSASSKKRKSRGQEKDKKGSKKDKRPHRKSGDELSEPQPSSSDAMPI 134
            ..|||.||:||:.|.:                                     || ||...:  :
Zfish    63 TVWLHGVLEKLRSVAV-------------------------------------EP-PSLGPS--V 87

  Fly   135 VSSITDVFAEELLEKAKKTMDIDLSAKDEILHKKKNRKSIEDEDASANRALDVPAVSEIISTTIG 199
            |.|.|.:.||                        .:|:..|.      ||:   |||
Zfish    88 VHSETSIPAE------------------------NSRRGAEP------RAI---AVS-------- 111

  Fly   200 VNRQKDLAELAEIQKKIHAAKKHLRQIGEIGDESDEYDEDLLNLSAREESVDQEPEEDPPKLEAP 264
             :.:.|.||                  |.:...:.|      |.:::..|     .|.|.:|.:
Zfish   112 -SSRSDKAE------------------GRVSSSAHE------NRASKRGS-----SERPSRLTS- 145

  Fly   265 PRKAKSPIIFNRREKTPEKRPEAEPEIDSRQEEAEEKSPKKDSSADKAKEDRSERRSVHDRLGSK 329
               |..|::    |.:.|...:.:|::|   ::.....|.:.|...      ...::::.|..::
Zfish   146 ---AVKPLM----EASAEAVIDIKPDLD---DDLISYDPVEHSLTS------GHSQALYSRSTAE 194

  Fly   330 AQTPADRSQRNQKELYVPTHRRRSEPEATKERSQRERTRERRSSRDTSRDTNRNQRQRRSPSPEA 394
            .|.||..|.|...:.|     |.|:....::||:    |..|||.::|||.:   |:|::|
Zfish   195 RQRPAVESSRQTADTY-----RSSDISRGQDRSE----RGYRSSAESSRDLS---RKRKAP---- 243

  Fly   395 PSTKQRIVSQVI---------VAVNKPPEPSDDED--MAEKPVNSVIKVKPRPNVSPRRQACKNL 448
                  :.|.|:         :.:....|..:|||  :|.| |:...|.:.:|.:.|.:||.|||
Zfish   244 ------VASSVVRVHRGHERGLEIEDLEEEEEDEDYGLASK-VSLPSKPERKPTLPPAKQANKNL 301

  Fly   449 LLRAVADAQRSTILAKTSTQKEDEDVGKIISSLGKRKSEDKNDQIRKRNRERKRRKRSAQGNELF 513
            :|:|:::||.|  :.||::|                                            :
Zfish   302 ILKAISEAQES--INKTTSQ--------------------------------------------Y 320

  Fly   514 RRTTRELVVNVTQRDGKRERRSNERRAEIKVVEEEYTPSLMTEGVETYVPQ-LLTN------VDE 571
            ....|:.|....:.....:..||   |.|::|:|.         :....|| .|.|      ...
Zfish   321 TVPQRQTVPVAPRTRSASDEMSN---AAIRLVQEH---------LHALTPQDTLHNTQSRGLASR 373

  Fly   572 LDLHISSHDEPSPNSGALKTQFVVTLNGDKALGGKN-VKGGASRKRPSNSRKRSTSPVSTPQVSS 635
            |.|.:...|...|:...|:......|   |||..:: :......::|...|.| .|.|:    .:
Zfish   374 LQLEVPEEDSREPHEYELQVLEAARL---KALDTRSFIMRQPEVEQPPPIRSR-LSAVN----QN 430

  Fly   636 SNIEPTSTTVDKRRRSNRDRSFSPSPRQSSGSPSLPTTRSINRNEVRRQPQEIKKIIIKNDTDED 700
            .|...||..|..|.|:......||                              |.|:..|
Zfish   431 ENAPTTSRMVQARERAEAVGGSSP------------------------------KFIVTLD---- 461

  Fly   701 DEMHGSPKKRSPNKRQPAAANGHKDNKDKGKIEEGSTTPPLPAKPKARAEKKASSKEKSVRSNSA 765
                |.|        .|.|   ::.:::....:|.:||..||              |.:..:|
Zfish   462 ----GVP--------SPLA---NRTDQEMETEDELNTTADLP--------------ENNNNNN-- 495

  Fly   766 ETSSAAKSVSASTSVSTTTKAKHTPIRFTLKSEDEPSASKKRRSGSPDRDVAAPERRRVSIRNPE 830
                        |:.:|:..|.|.                  |.|:..|:....|
Zfish   496 ------------TTTTTSKPAIHL------------------RLGADFRNACDDE---------- 520

  Fly   831 DRKYDNLPALSAVSVDSTVLKVNKPKERCKYHPNC-TKQFCEYYHPTAPCKSFPNCKFADKCMYS 894
                     :..:.|::...|..|..||||:.|.| :...|.|:||...||.||||||||||::.
Zfish   521 ---------VEEMDVEAVQAKRQKLPERCKFWPTCKSGDECLYHHPNTQCKVFPNCKFADKCLFI 576

  Fly   895 HPKCKFDMACMSIDCNYAHGGQRDLSHVQLAAPPLSSHVIPVQNYKSISAPVTSTTATTMCKYYP 959
            ||.||||..|...|..:.|..:|..|:...|||.|:|                     |:|:::|
Zfish   577 HPNCKFDAKCTKADSPFTHVSRRLNSNPTRAAPALTS---------------------TVCRFFP 620

  Fly   960 NCSKLGCTFYHPKPCRFGKNCVNKLECIFYHPEM----QSKFKW 999
            .|.|:.|.|||||||||...| .:.:|.||||.:    :|..||
Zfish   621 GCKKVDCPFYHPKPCRFATQC-KRADCTFYHPAVAVPPRSALKW 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nab2	NP_651243.1	zf-CCCH_2	878..896	CDD:291282	12/17 (71%)
zc3h14	NP_001020695.2	PWI	10..>62	CDD:295364	30/56 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..145		24/136 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	175..298		35/151 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..337		4/64 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	460..504		14/90 (16%)
		zf-CCCH_2	560..578	CDD:291282	12/17 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3702
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4474
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D382262at33208
OrthoFinder	1	1.000	-	-		FOG0004764
OrthoInspector	1	1.000	-	-		oto39014
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14738
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2202
SonicParanoid	1	1.000	-	-		X5101
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.980