DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nab2 and sut-2

DIOPT Version :9

Sequence 1:	NP_651243.1	Gene:	Nab2 / 42897	FlyBaseID:	FBgn0028471	Length:	1004	Species:	Drosophila melanogaster
Sequence 2:	NP_001360618.1	Gene:	sut-2 / 178847	WormBaseID:	WBGene00022019	Length:	742	Species:	Caenorhabditis elegans

Alignment Length:	1108	Identity:	222/1108 - (20%)
Similarity:	355/1108 - (32%)	Gaps:	490/1108 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SEIGQKMRSAVKAKLLELGTGGSAGFIDDELPDYVMVMVANKRTKQQMNAELNLFLGDQTDLFVT 71
            ||:.:|:::|::|||.|||.     ::|||||||:|||:|||:.|.||..:||||:|..|..||.
Worm    10 SEVSKKLKAAIRAKLEELGV-----YVDDELPDYIMVMIANKKEKVQMKDDLNLFIGKSTAKFVD 69

  Fly    72 WLHEVLQKLQEVTLPTSSASSKKRKSRGQEKDKKGSKKDKRPHRKSGDELSEPQPSSSDAMPIVS 136
            ||.::..:||       :||:|:.::..:|:||
Worm    70 WLFDLFDRLQ-------NASNKQGETSKKEEDK-------------------------------- 95

  Fly   137 SITDVFAEELLEKAKKTMDIDLSAKDEILHKKKNRKSIEDEDASANRALDVPAVSEIISTTIGVN 201
                          :|.::...:||:   |::|.||
Worm    96 --------------RKELEATAAAKE---HEEKRRK----------------------------- 114

  Fly   202 RQKDLAELAEIQKKIHAAKKHLRQIGEIGDESDEYDEDLLNLSAREESVDQEPEEDPPKLEAPPR 266
                                          |.:|::::|.....||:.
Worm   115 ------------------------------EKEEHEKELQKEKEREKE----------------- 132

  Fly   267 KAKSPIIFNRREKTPEKRPEAEPEIDSRQEEAEEKSPKKDSSADKAKE-DRSERRSVHDRLGSKA 330
                    .:||:..|||.|.|    .|:||             |.|| .||:||    |..|::
Worm   133 --------RQRERDREKRAEEE----KRREE-------------KRKEIQRSKRR----RTRSRS 168

  Fly   331 QTPADRSQRNQKELYVPTHRRRSEPEATKERSQRERTRERRSSRDTSRDTNRNQRQRRSPSPEAP 395
            .|.:|                           :.|..|.|....|  |..:::.|:.|
Worm   169 NTYSD---------------------------EEEHVRARGEKHD--RHHHKDHRRGR------- 197

  Fly   396 STKQRIVSQVIVAVNKPPEPSDDEDMAEKPVNSVIKVKP--RPNVSPRRQACKNLLLRAVADAQR 458
            |.:::|::..||   :....|.|     |.::|.:.||.  ||......:....:.|||:.:|..
Worm   198 SHERKIITSTIV---RQASASPD-----KKLHSTVTVKRNIRPTGDQNIKGRGTMFLRAMNEASV 254

  Fly   459 STILAKTSTQKE--DEDVGKIISSLGKRKSEDKNDQIRKRNRERKRRKRS--------AQGNELF 513
            |.....:|.:.|  .||....:.:|..:.:..|:.:...|:|..:..|.|        |...|.|
Worm   255 SAGYGSSSKRSETHHEDDMSDVEALPSKPASTKSPKKSIRDRMSRISKTSEPPIEEDDAVVLEDF 319

  Fly   514 RRT--TRELVVNVTQRDGKRERRSNERRAEIKVVEEEYTPSLMTEGVETYVPQLLTNVDELDLHI 576
            .:|  ..::::.::   |.||.....|..:..||::.....|:...:||
Worm   320 AQTGGGPQMILKLS---GGREAIKKTRIQDRIVVDDGLRRGLLKRKIET---------------- 365

  Fly   577 SSHDEPSPNSGALKTQFVVTLNGDKALGGKNVKGGASRKRPSNSRKRSTSPVSTPQVSSSNIEPT 641
                    .|||                   ..|.|:.:.|
Worm   366 --------ASGA-------------------SAGAATSEEP------------------------ 379

  Fly   642 STTVDKRRRSNRDR---SFSPSPRQSSGSPSLPTTRSINRNEVRRQPQEIKKIIIKNDTDEDDEM 703
                    :|..||   ..:|| |.|:.:...||.:..|           .:|.|.:|::|.::
Worm   380 --------KSKHDRIIFDITPS-RDSTPTDDSPTMQKWN-----------GQIEIGDDSEESED- 423

  Fly   704 HGSPKKRSPNKRQPAAANGHKDNKDKGKIEEGSTTPPLPAKPKARAEKKASSKEKSVRSNSAETS 768
                                         :|.:......|:.:..|.:::...|:.....:.:.|
Worm   424 -----------------------------DEEAEIDAFVAEARGIARRESFRDEEDELPPTHQLS 459

  Fly   769 SAAKSVSASTSVSTTTKAKHTPIRFTLKSEDEPSASKKRRSGSPDRDVAAPERRRVSIRNPEDRK 833
            ....:...||:..|     :.|...::.||.:     .:..|.     ||.|...|
Worm   460 GGPYAYHHSTAAPT-----YIPTPLSVLSEQQ-----NQMGGG-----AAKEDHHV--------- 500

  Fly   834 YDNLPALSAVSVDSTVLKVNKPKERCKYHPNCTK-QFCEYYHPTAPCKSFPNCKFADKCMYSHPK 897
                                  ||||.:.|.||| ..|.:.|||..||:||||.|..:|::.||.
Worm   501 ----------------------KERCIFWPKCTKGDTCAFMHPTTNCKNFPNCTFGIRCLFIHPP 543

  Fly   898 CKFDMACMSIDCNYAH---GGQRDLSHVQLAAP---PLSS------------------------- 931
            |:||..|....|.:.|   |||:. ...||.:.   ||:|
Worm   544 CRFDRFCTKKHCPFTHHGTGGQQP-GGAQLTSEFKNPLTSSRMLTVPSPFIAATAAAVEELPKPA 607

  Fly   932 ---------------------------------------------HVIPVQNYKSISAPVTSTTA 951
                                                         .|.|||........:....:
Worm   608 ARGALGSLAEKLAASIKKKPAPGAESEKKEEKSDENESKAEEPKAEVAPVQPKPLPDFSIAPLHS 672

  Fly   952 TTMCKYYPNCSKLGCTFYHPKPCRFGKNCVNKLECIFYHPEM-----------------QSKFKW 999
            ..:|:|...|....|.|.|||.||||.||.|. .|.|||...                 .:|:||
Worm   673 MVLCRYAGACRNPICHFKHPKECRFGANCRNP-SCYFYHKPAGAAPTPVAAPIAAESAGAAKYKW 736

  Fly  1000 VAS 1002
            .::
Worm   737 TSA 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nab2	NP_651243.1	zf-CCCH_2	878..896	CDD:291282	8/17 (47%)
sut-2	NP_001360618.1	PWI	15..83	CDD:383025	37/79 (47%)
		zf-CCCH_3	506..>559	CDD:373997	23/52 (44%)
		zf-CCCH_2	525..542	CDD:373157	8/16 (50%)
		zf-CCCH_2	695..710	CDD:373157	9/15 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162475
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3702
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I3127
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D382262at33208
OrthoFinder	1	1.000	-	-		FOG0004764
OrthoInspector	1	1.000	-	-		oto19074
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14738
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2202
SonicParanoid	1	1.000	-	-		X5101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.020