DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and DNER

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_620711.3 Gene:DNER / 92737 HGNCID:24456 Length:737 Species:Homo sapiens


Alignment Length:887 Identity:238/887 - (26%)
Similarity:332/887 - (37%) Gaps:295/887 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   215 ILILGNSFSGCLLDGPGLQFVNNSTVQNVVFGHCPLT-PGPCSDHDLFTRLPDNFCLNDPCMGHG 278
            :|:||        .||     ..|::.|.| ...||: ||||:              ..||...|
Human    21 LLLLG--------AGP-----RGSSLANPV-PAAPLSAPGPCA--------------AQPCRNGG 57

  Fly   279 TCSSSPE------------GYECRCTARYSGKNCQKDNGSPCAKNPCENG--GSCLENSRGDYQC 329
            .|:|.||            ||.|.|.|..||.|||. ...|||.|||.:|  .|...:|...|.|
Human    58 VCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQL-VADPCASNPCHHGNCSSSSSSSSDGYLC 121

  Fly   330 FCDPNHSGQHCE-----------TEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYAGAR- 382
            .|:..:.|.:||           ||.......|..|.......::......:|....:...|.: 
Human   122 ICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRSQATVTLPTWQPKTGQKV 186

  Fly   383 CEVDTDECASQP---CQN---NGSCIDRINGFSCDCSGTGYTGAFCQTNVD-ECDKNPCLNGGRC 440
            .|:..|:....|   |.|   |.|...|:..|....:          |:|. ..|....|.....
Human   187 VEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQN----------TSVKIRQDATASLILLWK 241

  Fly   441 FDTYGWYTCQCLDGWGGEICDRPMTCQTQQCLNGGTCLDKP--------IGF------------- 484
            ....|:..|..:||       |.:|  ..|...|...|::.        |||             
Human   242 VTATGFQQCSLIDG-------RSVT--PLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALR 297

  Fly   485 ------QCLCPPEYTGELCQIAPSCAQQCPIDSECVG-GKCVCKPGSSGPIGHCLPTTTTPTPEQ 542
                  ...|.|   ||      |.|.    |.||.| |||..||..:         |.:.|.|:
Human   298 LTLVVKVSTCVP---GE------SHAN----DLECSGKGKCTTKPSEA---------TFSCTCEE 340

  Fly   543 EPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQ 607
            :                                 .|||.                 ....:||.:
Human   341 Q---------------------------------YVGTF-----------------CEEYDACQR 355

  Fly   608 ENCLNGGTCLGYS-----GNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTC 667
            :.|.|..:|:..:     .|::|:|..||||..||:.    .....|.|         |.||.||
Human   356 KPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK----IDYCILDP---------CRNGATC 407

  Fly   668 --SMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGEC- 729
              |::|..|.|..||.|..||  |...|                        ||:.||||.|.| 
Human   408 ISSLSGFTCQCPEGYFGSACE--EKVDP------------------------CASSPCQNNGTCY 446

  Fly   730 VDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHCDSDVD 794
            ||  ...:.|.|:.|:||.||...:|.|.|.|  |.:|.|::...||||.|.||:.|::|:.:.:
Human   447 VD--GVHFTCNCSPGFTGPTCAQLIDFCALSP--CAHGTCRSVGTSYKCLCDPGYHGLYCEEEYN 507

  Fly   795 ECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPG 859
            ||||.||||.|||.:.:|.|||||...|:|.:||:..|.|.:..|.||:||.....|.||.|.||
Human   508 ECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPG 572

  Fly   860 MTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNID-------ECLSNPCT 917
            .||..|||||::|..:||.:||.|:||..|:.|.|. .|:.|.|||:::.       |.|:|...
Human   573 FTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCP-HGWVGANCEIHLQWKSGHMAESLTNMPR 636

  Fly   918 N------GAKC----------------LDRVKDYFCDCHNGYKGKN--CEQDINECESNPCQYNG 958
            :      ||.|                :.|::         |:|.:  ..::...|.|...::: 
Human   637 HSLYIIIGALCVAFILMLIILIVGICRISRIE---------YQGSSRPAYEEFYNCRSIDSEFS- 691

  Fly   959 NCL---------ERSNITLYQMSRITDLPKVFSQPFSFENAS 991
            |.:         ::|...:|.:|           |.::|:.|
Human   692 NAIASIRHARFGKKSRPAMYDVS-----------PIAYEDYS 722

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058 3/12 (25%)
EGF_CA 386..423 CDD:238011 8/42 (19%)
EGF_CA 425..460 CDD:238011 7/35 (20%)
EGF 466..495 CDD:278437 8/55 (15%)
EGF 605..633 CDD:278437 9/32 (28%)
EGF_CA 716..750 CDD:238011 15/34 (44%)
EGF_CA 753..789 CDD:238011 15/35 (43%)
EGF_CA 792..828 CDD:238011 19/35 (54%)
EGF_CA 830..865 CDD:238011 15/34 (44%)
EGF_CA 868..905 CDD:238011 16/36 (44%)
EGF_CA 907..943 CDD:238011 9/66 (14%)
EGF_CA 1009..1045 CDD:238011
EGF_CA 1047..1082 CDD:238011
Laminin_G_1 1155..1290 CDD:278483
EGF 1316..1346 CDD:278437
Laminin_G_1 1388..1550 CDD:278483
EGF_CA <1593..1622 CDD:238011
Laminin_G_2 1692..1828 CDD:280389
EGF_CA 1901..1937 CDD:238011
EGF_CA 1939..1974 CDD:238011
EGF_CA 2057..2094 CDD:238011
EGF_CA 2096..2133 CDD:238011
EGF_CA 2137..2175 CDD:238011
DNERNP_620711.3 Interaction with NOTCH1. /evidence=ECO:0000250 44..133 34/103 (33%)
EGF_CA 393..428 CDD:238011 14/43 (33%)
EGF_CA 431..465 CDD:238011 16/59 (27%)
EGF_CA 469..503 CDD:238011 15/35 (43%)
EGF_CA 507..541 CDD:238011 19/33 (58%)
EGF_CA 581..617 CDD:238011 16/36 (44%)
Interaction with AP1G1 and somatodendritic targeting. /evidence=ECO:0000250 677..680 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 47 1.000 Domainoid score I12027
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR24044
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.010

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