DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and FBN3

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:XP_016882868.1 Gene:FBN3 / 84467 HGNCID:18794 Length:2851 Species:Homo sapiens


Alignment Length:2508 Identity:581/2508 - (23%)
Similarity:827/2508 - (32%) Gaps:911/2508 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   229 GPGLQFVNNSTVQNVVFGHCPLTPGPCSDHDL---FTRLPDNFCLNDPCMGHGTCSSSPEGYECR 290
            |||...:..:|:...:              |:   ||    |.|||      |.|..:|..|.|.
Human   436 GPGNSNIGTATLNQTI--------------DICRHFT----NLCLN------GRCLPTPSSYRCE 476

  Fly   291 CTARYS----GKNCQKDNGSPCAKNPCENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQ 351
            |...|:    |:....|.   |..:||.: |.|: |..|.|.|.|               :|..|
Human   477 CNVGYTQDVRGECIDVDE---CTSSPCHH-GDCV-NIPGTYHCRC---------------YPGFQ 521

  Fly   352 TNP----CLNNGACVVIGG----------SGALTCECPKGYA----GARCEVDTDECASQPCQNN 398
            ..|    |::...|:|.||          .|:..|.|..|:.    |..| ||.:|||:.....|
Human   522 ATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECATSTMCVN 585

  Fly   399 GSCIDRINGFSCDCSGTGYT----GAFCQTNVDECDKNP--CLNGGRCFDTYGWYTCQCLDGWG- 456
            |.|::....|||.|. .|:.    |.:|. ::||| :.|  |:| |.|.:|.|.:.||||.|.. 
Human   586 GVCLNEDGSFSCLCK-PGFLLAPGGHYCM-DIDEC-QTPGICVN-GHCTNTEGSFRCQCLGGLAV 646

  Fly   457 ---GEIC-DRPMTCQTQQCLNGGTCLDKPI-----GFQCLC--PPEYTGELCQIAPS-------- 502
               |.:| |..:.......:..|:|. :|.     ..:|.|  |....||.||:.|:        
Human   647 GTDGRVCVDTHVRSTCYGAIEKGSCA-RPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQA 710

  Fly   503 -CA------------QQCPIDSE-CVGG---------KCVC----KPGSSG----PIGHCLPTTT 536
             |:            .:|.:|.| |..|         :|||    :.|:||    .:..|     
Human   711 LCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDEC----- 770

  Fly   537 TPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRR---PPQQPLQSPTQR 598
                                          .:..:.........:.||..   ||.......|:.
Human   771 ------------------------------ALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEI 805

  Fly   599 SASLNACPQENCLNGGTCLGYSGNYSCICASGY----TGYNCQTSTGDGASALALTPINCNAT-N 658
            ...::.|....|:: |.|...:|:|:|.|..|.    :|..|..|| .|...|.:....|... .
Human   806 CKDVDECLSSPCVS-GVCRNLAGSYTCKCGPGSRLDPSGTFCLDST-KGTCWLKIQESRCEVNLQ 868

  Fly   659 GKCLNGGTCSMNGT-------HC----YCAVGY---SGDRCEKAENCSPLNCQEPMVCVQNQCL- 708
            |..|....|:..|.       .|    .||.|:   :|..|:....|...    |.||...:|: 
Human   869 GASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVNECESF----PGVCPNGRCVN 929

  Fly   709 --------CPE-------NKVCNQCATQPC---QNGGEC-VDLPNGDY---------------EC 739
                    |||       .::|.....:||   .:..|| |.|| |.|               ||
Human   930 TAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLP-GKYRMDVCCCSIGAVWGVEC 993

  Fly   740 K-------------CTRG--------WTGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPG 783
            :             |.||        .:||....||:||.:.|.:|.:|.|:|..||:.|.|..|
Human   994 EACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGG 1058

  Fly   784 FT----GVHCDSDVDECLSFPCLNG-ATCHNKINAYECVCQPGYEG-----ENCEVDIDECGSNP 838
            |.    ..:| :|:|||...|.|.| .||.|...::||.|.||||.     :|| :|:|||..:|
Human  1059 FALDAQERNC-TDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNC-MDVDECARDP 1121

  Fly   839 --CSNGSTCIDRINNFTCNCIPG----MTGRICDIDIDDC-VGDPCLNGGQCIDQLGGFRCDCSG 896
              | .|.||.:...::.|.|.||    ..|..|: |||:| :.|.....|||::.:|.|:|.|. 
Human  1122 LLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACE-DIDECSLSDGLCPHGQCVNVIGAFQCSCH- 1183

  Fly   897 TGYEG----ENCELNIDECLSNPCTNG---AKCLDRVKDYFCDCHNGYK----GKNCEQDINECE 950
            .|::.    :.| ::|:||   ...||   ..|::....|.|.|..||.    |:.| .|::|||
Human  1184 AGFQSTPDRQGC-VDINEC---RVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRAC-ADVDECE 1243

  Fly   951 SNP--CQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIG----KNCEIN 1009
            .||  |. .|:|              |::|            .|:.|:|..|.:.    :.| ::
Human  1244 ENPRVCD-QGHC--------------TNMP------------GGHRCLCYDGFMATPDMRTC-VD 1280

  Fly  1010 INECDSNP--CSKHGNCNDGIGTYTCECEPGF----EGTHCEINIDECD--RYNPCQRGTCYDQI 1066
            ::|||.||  | .||:|.:..|::.|.|:.|:    ..|.|. ::|||:  .:|.....:|.:..
Human  1281 VDECDLNPHIC-LHGDCENTKGSFVCHCQLGYMVRKGATGCS-DVDECEVGGHNCDSHASCLNIP 1343

  Fly  1067 DDYDCDCDANY--GGKNCSVLLKGCDQ-NPCLNGGACLPYLINEVTHLYNCTCENGFQG------ 1122
            ..:.|.|...:  .|..|..|.:...| :.|...|.||     .|...|.|||..||.|      
Human  1344 GSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCL-----NVPGSYRCTCRQGFAGDGFFCE 1403

  Fly  1123 --DKCEKTTTLSMVATSLIS---VTTEREEGYDINLQFRT------TLPNGVLAFGTTGEKNEPV 1176
              |:|.:...|......|.:   ...|.|.|:|.....|.      .....:.|||:.  :|.|.
Human  1404 DRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSC--ENLPG 1466

  Fly  1177 SYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINT--SHLVLSANDEQAIFP--VG 1237
            .:.. :.||...|.....|..:.......:|..|.    |.|||  |:|.....|.: :.|  ||
Human  1467 MFRC-ICNGGYELDRGGGNCTDINECADPVNCING----VCINTPGSYLCSCPQDFE-LNPSGVG 1525

  Fly  1238 SYET-ANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVN----------GK-WIF 1290
            ..:| |.|   .|..|:..|                .:.:.|..:|.|.          |: |..
Human  1526 CVDTRAGN---CFLETHDRG----------------DSGISCSAEIGVGVTRASCCCSLGRAWGN 1571

  Fly  1291 PDEQDANISYTKLENVQSGCPRTEQCKPN----------PCH------SNGECTDLWHTFACHCP 1339
            |.|.....:.|:...:   ||..|..:||          .|.      ..|:|.:.:.:|.|.||
Human  1572 PCELCPMANTTEYRTL---CPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECP 1633

  Fly  1340 RPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTREPTGQVFY--LGT 1402
            ..:  |..:|....... .|.:|||.:....|                          .|  ||.
Human  1634 PGY--HLSEHTRICEDI-DECSTHSGICGPGT--------------------------CYNTLGN 1669

  Fly  1403 DPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1467
            .....|.:.:       :::||...:.|:.|..              :.|.....:|:....|. 
Human  1670 YTCVCPAEYL-------QVNGGNNCMDMRKSVC--------------FRHYNGTCQNELAFNVT- 1712

  Fly  1468 NGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEADDSR 1532
                  ||....:        |..|.|..|             |......||           |.
Human  1713 ------RKMCCCS--------YNIGQAWNR-------------PCEACPTPI-----------SP 1739

  Fly  1533 DYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDLC------- 1590
            ||      .:...|.:...:.::::         .|||   .||....:|...::.:|       
Human  1740 DY------QILCGNQAPGFLTDIHT---------GKPL---DIDECGEIPAICANGICINQIGSF 1786

  Fly  1591 -------------------------RKNPCLHNAECRNTWNDYTCKCPNGYK--------GKN-C 1621
                                     |::||..||:|.|....|.|||..|||        |:| |
Human  1787 RCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKLSPGGACVGRNEC 1851

  Fly  1622 QEI-EFCQHVTCPGQSLCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLK 1685
            :|| ..|.|    |.  |.:.:..|.|:.:..|                       :||..|||.
Human  1852 REIPNVCSH----GD--CMDTEGSYMCLCHRGF-----------------------QASADQTLC 1887

  Fly  1686 PVIDIAFRTRAG-GTLLYIDNVDGFFEIGVNGGRVTITWKLSALHF-------GESARF-EKENT 1741
            ..||...|...| ||   ..|:.|.:......|.| :|.....:.|       |:..|| ...||
Human  1888 MDIDECDRQPCGNGT---CKNIIGSYNCLCFPGFV-VTHNGDCVDFDECTTLVGQVCRFGHCLNT 1948

  Fly  1742 DGEW--------------------------SRIYLRAHNSKLEGGWKGWESMVDPTPAFST---- 1776
            .|.:                          :...|......|||.::    .:.| |.|..    
Human  1949 AGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFR----CICP-PGFQVQSDH 2008

  Fly  1777 --DIDQAAFQ---SLIATSTQVYLGGMPESRQA---RGSTLSAQQGSQF----KGCVGEARVGDL 1829
              |||:.:.:   .|..|.|     ..|.|.|.   .|..||......|    ..|......|..
Human  2009 CIDIDECSEEPNLCLFGTCT-----NSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKC 2068

  Fly  1830 LLPYFSMAELYSRTNVSVQQKAQFRLNAT------RPEEG----CILC-------FQSDCK---- 1873
            .:|                 || |....|      ||.||    |.||       ||..|.    
Human  2069 SVP-----------------KA-FNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHG 2115

  Fly  1874 ----------------------NDGFCQSPSDEYACTCQPG----FEGDDCGTDIDECLNTECLN 1912
                                  .:|.|.:....:.|.|..|    |.|.:| .|.|||.......
Human  2116 AVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINC-VDTDECSVGHPCG 2179

  Fly  1913 NGTCINQVAAFFCQCQPGFE--------------------------------------------G 1933
            .|||.|.:..|.|.|..|||                                            |
Human  2180 QGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDG 2244

  Fly  1934 QHCEQNIDECAD--QPCH-NGGNCTDLIASYVCDCPEDYMGPQCDVLKQMTCENEPCRNGSTCQN 1995
            ..| :::|||||  |.|| .|..|.:||.::.|.||.. |.|.....:..|.:||.......|.|
Human  2245 AMC-RDVDECADGQQDCHARGMECKNLIGTFACVCPPG-MRPLPGSGEGCTDDNECHAQPDLCVN 2307

  Fly  1996 GFNASTGNNFTCTCVPGF-------------EGP--------LCDI------------------- 2020
            |...:|..:|.|.|..||             :||        :|..                   
Human  2308 GRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGR 2372

  Fly  2021 ---PFCEITP----------CDNG----------------------GLCLTTGAVPMCKCSLGY- 2049
               |.||:.|          |.:|                      |.|:.:.....|.|..|| 
Human  2373 GWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYT 2437

  Fly  2050 ---TGRLCEQDINECESNP------CQN------------------GGQCKDL------------ 2075
               |...| .|::||...|      |:|                  |..||||            
Human  2438 PDATATTC-LDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQF 2501

  Fly  2076 -----VGRYECDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPY----CGA 2131
                 ||.:.|.|.....:..:...|.|||:.:...||..|.|.|.||||:|.|.:.:    .|.
Human  2502 LCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGH 2566

  Fly  2132 YCNFTDPCNATDLCSNGGRCVESCGAKPDYYCECPEGF 2169
            .|...:.|:....|.:|  |....|.   |.|.||:||
Human  2567 GCEDVNECDGPHRCQHG--CQNQLGG---YRCSCPQGF 2599

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 13/40 (33%)
EGF_CA 425..460 CDD:238011 16/40 (40%)
EGF 466..495 CDD:278437 6/35 (17%)
EGF 605..633 CDD:278437 9/31 (29%)
EGF_CA 716..750 CDD:238011 16/73 (22%)
EGF_CA 753..789 CDD:238011 15/39 (38%)
EGF_CA 792..828 CDD:238011 18/41 (44%)
EGF_CA 830..865 CDD:238011 14/40 (35%)
EGF_CA 868..905 CDD:238011 13/41 (32%)
EGF_CA 907..943 CDD:238011 12/42 (29%)
EGF_CA 1009..1045 CDD:238011 14/41 (34%)
EGF_CA 1047..1082 CDD:238011 8/38 (21%)
Laminin_G_1 1155..1290 CDD:278483 33/156 (21%)
EGF 1316..1346 CDD:278437 9/45 (20%)
Laminin_G_1 1388..1550 CDD:278483 24/163 (15%)
EGF_CA <1593..1622 CDD:238011 15/37 (41%)
Laminin_G_2 1692..1828 CDD:280389 37/186 (20%)
EGF_CA 1901..1937 CDD:238011 15/79 (19%)
EGF_CA 1939..1974 CDD:238011 17/37 (46%)
EGF_CA 2057..2094 CDD:238011 15/77 (19%)
EGF_CA 2096..2133 CDD:238011 16/40 (40%)
EGF_CA 2137..2175 CDD:238011 11/33 (33%)
FBN3XP_016882868.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I11459
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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