DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crb and Pros1

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_112348.2	Gene:	Pros1 / 81750	RGDID:	620971	Length:	675	Species:	Rattus norvegicus

Alignment Length:	735	Identity:	163/735 - (22%)
Similarity:	265/735 - (36%)	Gaps:	232/735 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   703 VQNQCLCPENKVCN-QCATQPCQNGGECVDLPNGDYECKCTRGWTG------------------- 747
            ::.:|:   .::|| :.|.:..:|.      |..||......|..|
  Rat    54 LERECI---EELCNKEEAREVFENN------PETDYFYPKYLGCLGAFRVGAFSAARQSANAYPD 109

  Fly   748 -RTCGNDV-DECTLHPKIC---GNGICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGA-- 805
             |:|.|.: |:|  .|..|   |...||:.:|::.|.|.||:.|..|..|::||.....:||.
  Rat   110 LRSCVNAIPDQC--DPMPCNEDGYLSCKDGQGAFTCICKPGWQGDKCQFDINECKDPSNINGGCS 172

  Fly   806 -TCHNKINAYECVCQPGY----EGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRIC 865
             ||.|...:|.|.|:.|:    ..::|: |:|||...|    |.|    ....|..||
  Rat   173 QTCDNTPGSYHCSCKIGFAMLTNKKDCK-DVDECSLKP----SVC----GTAVCKNIP------- 221

  Fly   866 DIDIDDCVGDPCLNGGQCIDQLGGFRCDC-SGTGYE--GENCELNIDECLSNPCTNGAKCLDRVK 927
                                  |.|.|:| :|..|:  .::|: ::|||..|.|..  .|::...
  Rat   222 ----------------------GDFECECPNGYRYDPSSKSCK-DVDECSENTCAQ--LCVNYPG 261

  Fly   928 DYFCDCHNGYKGKNCEQDINECESNPCQYNGNCL---------------ERSNITLYQMSRITDL 977
            .|.|.| :|.||....||...||..|.     ||               :.:.:.||...|:.|:
  Rat   262 GYSCYC-DGKKGFKLAQDQRSCEGIPV-----CLSLDLDKNYELLYLAEQFAGVVLYLKFRLPDI 320

  Fly   978 PKVFSQPFSFENASGYECVCVPGII------------------GKNCEININECDSNPCSKHGN- 1023
            .: ||..|.|..   |:.   .|||                  || .|:......|...:..||
  Rat   321 TR-FSAEFDFRT---YDS---EGIILYAESLDHSNWLLIALREGK-IEVQFKNEFSTQITTGGNV 377

  Fly  1024 CNDGIGTYTCECEPGFEGTHCEINIDECDR-----------YNPCQRGTCYDQIDDYDCDCDANY 1077
            .|:||...              ::::|.|.           .|..:.|:.:...|.: .|....:
  Rat   378 INNGIWNM--------------VSVEELDDSVSIKIAKEAVMNINKLGSLFKPTDGF-LDTKIYF 427

  Fly  1078 GG---KNCSVLLKGCDQNPCLNG----------GACLPYLINEVTHLYNC--TCENG--FQGDKC 1125
            .|   |..|.|:|..  ||.|:|          ||.....|.|.....:|  |.|.|  :.|
  Rat   428 AGLPRKVESALIKPI--NPRLDGCIRGWNLMKQGALGAKEIVEGKQNKHCFLTVEKGSYYPG--- 487

  Fly  1126 EKTTTLSMVATSLISVTTEREEGYDIN--LQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLN 1188
               :.::..:....:||  ..||:.||  |..|.:...||:....:|   :.|.:.|.|::....
  Rat   488 ---SGIAQFSIDYNNVT--NAEGWQINVTLNIRPSTGTGVMLALVSG---DTVPFALSLVDSGSG 544

  Fly  1189 LHSSLLNKWEGVFIGSK---------LNDSNWHKVFVAINTSHL---------VLSANDEQAIFP 1235
            ....:|     ||:.:.         |......::...||.:.|         |:.:.|.|....
  Rat   545 TSQDIL-----VFVENSVAAHLEAITLCSEQPSQLKCNINRNGLELWTPVRKDVIYSKDLQRQLA 604

  Fly  1236 VGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISY 1300
            :     .:.:......||||| :|::..   ..|...:.:.||| ::.:||..:..||     :.
  Rat   605 I-----LDKTMKGTVATYLGG-VPDISF---SATPVNAFYSGCM-EVNINGVQLDLDE-----AI 654

  Fly  1301 TKLENVQS-GCPRTEQCKPN 1319
            :|..:::: .||...:.:.|
  Rat   655 SKHNDIRAHSCPSVRKIQKN 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011
		EGF_CA	425..460	CDD:238011
		EGF	466..495	CDD:278437
		EGF	605..633	CDD:278437
		EGF_CA	716..750	CDD:238011	9/54 (17%)
		EGF_CA	753..789	CDD:238011	13/39 (33%)
		EGF_CA	792..828	CDD:238011	12/42 (29%)
		EGF_CA	830..865	CDD:238011	10/34 (29%)
		EGF_CA	868..905	CDD:238011	6/39 (15%)
		EGF_CA	907..943	CDD:238011	12/35 (34%)
		EGF_CA	1009..1045	CDD:238011	6/36 (17%)
		EGF_CA	1047..1082	CDD:238011	8/48 (17%)
		Laminin_G_1	1155..1290	CDD:278483	29/152 (19%)
		EGF	1316..1346	CDD:278437	1/4 (25%)
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
Pros1	NP_112348.2	GLA	23..85	CDD:214503	8/39 (21%)
		Thrombin-sensitive	88..116		3/27 (11%)
		EGF_CA	119..155	CDD:238011	13/37 (35%)
		FXa_inhibition	168..199	CDD:291342	9/30 (30%)
		EGF_CA	201..241	CDD:284955	16/76 (21%)
		FXa_inhibition	247..282	CDD:291342	12/37 (32%)
		Laminin_G_1	329..459	CDD:278483	29/153 (19%)
		LamG	514..646	CDD:304605	28/149 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910