DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and notch1b

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:XP_005168706.1 Gene:notch1b / 794892 ZFINID:ZDB-GENE-990415-183 Length:2482 Species:Danio rerio


Alignment Length:2096 Identity:553/2096 - (26%)
Similarity:761/2096 - (36%) Gaps:706/2096 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 FLTNQDIGYKDAILILGNSFSGCLLDGPGLQFVNNSTVQNVVFGHCPLTPGPCSDHDLFTRLPDN 267
            |:.|..:||.|. |.|..:.:.||    |....|..|        |.||    |.|:...:.|..
Zfish    82 FVCNCSLGYTDR-LCLTPTNNVCL----GAPCRNGGT--------CELT----SIHNYRCKCPPG 129

  Fly   268 F----------CLNDPCMGHGTCSSSPEGYECRCTARYSGKNCQKDNGSPCAK--NPCENGGSCL 320
            :          |.::||...|.||.....:.|.||..:||:.|::| .:.||:  :||:|||.| 
Zfish   130 WSGKTCQQADPCASNPCANGGQCSPFDSDFLCHCTPYFSGQTCKQD-VNECAQIPSPCKNGGVC- 192

  Fly   321 ENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYAGARCEV 385
            ||..|.|.|.|...::|:|||   :::..|..:|||:.|.||. .|..:..|.|..|::|..||.
Zfish   193 ENGVGTYHCNCPAEYTGKHCE---SLYQPCNPSPCLHGGTCVQ-KGETSYECSCLPGFSGQNCEE 253

  Fly   386 DTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECD--KNPCLNGGRCFDTYGWYT 448
            :.|:|....|.|.|:|:|.:|.::|.|. ..:||.||..:|:|||  .|.|.|||.|.:|.|.|.
Zfish   254 NIDDCPDHRCLNGGTCVDGVNTYNCQCK-PEWTGQFCTEDVNECDLMPNSCQNGGTCLNTQGGYN 317

  Fly   449 CQCLDGWGGEICDRPM-TCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSC-AQQCPIDS 511
            |.|::||.|:.|...: .|....|..|.||.|:...|.|.||...||.||.:..:| :..|...|
Zfish   318 CVCVNGWTGDDCSENIDDCADAACHTGATCHDRVASFLCECPHGRTGLLCHLDDACISNPCQKGS 382

  Fly   512 EC----VGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPIT 572
            .|    |.||.:|    :.|:|:..|.......|                               
Zfish   383 NCDTNPVNGKAIC----TCPLGYVGPACDQDVDE------------------------------- 412

  Fly   573 TSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQ 637
                                       .||.|.|   |.:.|.|:...|::.|.|..||.|..|:
Zfish   413 ---------------------------CSLGANP---CEHAGKCINTKGSFQCKCLQGYVGARCE 447

  Fly   638 TSTGDGASALALTPINCNATNGKCLNGGTC--SMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPM 700
            ....:..|    ||         |.|..||  .:.|.||.|..||.|..|:       :|..|  
Zfish   448 LDINECLS----TP---------CQNDATCLDQIGGFHCICMPGYEGVFCQ-------INTDE-- 490

  Fly   701 VCVQNQCLCPENKVCNQCATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKICG 765
                             ||:.||.|.|:|:|..| :|:|:|..|::|..|..|:|||...|  |.
Zfish   491 -----------------CASMPCLNNGKCIDKIN-NYQCECPTGFSGSQCQFDIDECASTP--CK 535

  Fly   766 NGI-CKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEV 829
            ||. |.:....|.|.||.|:||.||::|||||||.||..| ||.:.:.::.|||:.|:.|..||:
Zfish   536 NGAKCMDGPNMYTCQCTEGYTGQHCETDVDECLSNPCHYG-TCKDGLASFTCVCRAGFMGRLCEI 599

  Fly   830 DIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDC 894
            :|:||.|.||.||.||.||.|.:.|.|..|..|..|:|::|||..:|| :.|:|||::.|:.|.|
Zfish   600 NINECLSQPCQNGGTCQDRENAYLCVCPKGTAGANCEINLDDCQSNPC-DFGRCIDKINGYECAC 663

  Fly   895 SGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGN 959
            . .||.|:.|.:|||||..|||.||..|:|.|..:.|.|..||....|:..:|||.|||| .:|:
Zfish   664 E-PGYTGKMCNINIDECAINPCHNGGTCVDGVNGFTCLCREGYHDTTCQSQLNECLSNPC-IHGH 726

  Fly   960 CLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNC 1024
            |.::.|                          ||.|:|..|..|.||:||.|||:||||...|.|
Zfish   727 CEDKVN--------------------------GYNCICDSGWSGVNCDINNNECESNPCMNGGTC 765

  Fly  1025 NDGIGTYTCECEPGFEGTHCEINIDECDRYNPC-QRGTCYDQIDDYDCDCDANYGGKNCSVLLKG 1088
            .|....|.|.|..||.|.:|:.||:|| ..||| .:|||.|.:..|.|:|...|.|:||..||..
Zfish   766 KDMTSGYVCTCRAGFSGPNCQTNINEC-ASNPCLNQGTCIDDVAGYKCNCLLPYTGENCETLLAP 829

  Fly  1089 CDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLISVTTEREEGYDINL 1153
            |...||.|||.|..   :|....::|.|..|:||..||                      .|||.
Zfish   830 CGSKPCKNGGVCKE---SEDYESFSCVCPAGWQGQTCE----------------------VDINE 869

  Fly  1154 QFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAI 1218
            ..:....|..:...:                                                  
Zfish   870 CVKNPCRNDAICQNS-------------------------------------------------- 884

  Fly  1219 NTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIM 1283
                             :|||:.      |....|.|.                    .|..|| 
Zfish   885 -----------------IGSYKC------SCKAGYTGR--------------------NCETDI- 905

  Fly  1284 VNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGECTDLWHTFACHCPRPFFGHTCQ 1348
                                          :.||||||.:.|.|.|..:.|||.|...|.|..|:
Zfish   906 ------------------------------DDCKPNPCSNGGFCKDAVNAFACTCLPGFRGGRCE 940

  Fly  1349 HNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIG 1413
            .::....                                              ::|.|       
Zfish   941 EDINECE----------------------------------------------SNPCK------- 952

  Fly  1414 DSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLS 1478
                                              ||.| ..:.|.:.|                 
Zfish   953 ----------------------------------NGAN-CTDCVNSYT----------------- 965

  Fly  1479 TTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVK 1543
                                    .|..||.     :||..|:.|  .:..:|..:..|...|  
Zfish   966 ------------------------CTCPPGF-----SGIHCENNT--PDCTESSCFNGGTCVD-- 997

  Fly  1544 VSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDLCRKNPCLHNAECRNTWNDY 1608
            ..|....|..:.::.|.....:|.                      |...||::...|::::..|
Zfish   998 GINSFTCLCPKGFTGNYCQHDINE----------------------CDSRPCMNGGTCQDSYGTY 1040

  Fly  1609 TCKCPNGYKGKNCQE-IEFCQHVTCPGQSLCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSD 1672
            .|.||.||.|.|||| :.:|:...|....:|:.....|.|...|.:||        .|.      
Zfish  1041 KCTCPQGYHGLNCQELVNWCKPSPCKNGGICRQSGTRYSCQCQTGWTG--------LYC------ 1091

  Fly  1673 DIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFEIGVNGGRVTITWKLSALHFGESARFE 1737
            |:.|.:......:..:|:....|..|..|...|                                
Zfish  1092 DVPSVSCEVAAKQQGVDVVRLCRNSGQCLDAGN-------------------------------- 1124

  Fly  1738 KENTDGEWSRIYLRAHNSKLEGGWKG--WESMVD---PTPAFSTDIDQAAFQSLIATSTQVYLGG 1797
                          .|....:.|:.|  .|..||   |.|..:.           ||.|. ||||
Zfish  1125 --------------THYCHCQAGYTGSYCEEQVDECIPNPCQNG-----------ATCTD-YLGG 1163

  Fly  1798 MPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAELYSRTNVSVQQKAQFRLNATRPEE 1862
            .                    .|  |...|            |...|.|.:      :|.     
Zfish  1164 Y--------------------SC--ECVPG------------YHGVNCSDE------INE----- 1183

  Fly  1863 GCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGDDCGTDIDECL--------NTECLNNGTCINQ 1919
                |....|:|.|.|....:.|.|:|..|.:|..|..:||:|.        ..:|.|.|.|:::
Zfish  1184 ----CLSQPCQNGGTCIDLINTYKCSCPRGTQGVHCEINIDDCTPFTDPITHEPKCFNQGRCVDR 1244

  Fly  1920 VAAFFCQCQPGFEGQHCEQNIDECADQPC--HNGGNCTDLIASYVCDCPEDYMGPQCDVLKQMTC 1982
            |..:.|.|.||:.|:.||.:::||...||  |   :|..|..:|.|:|...|.|..||.:.. .|
Zfish  1245 VGGYHCICPPGYVGERCEGDVNECLSNPCGTH---SCIQLKNNYRCECRTGYTGQHCDKVFD-GC 1305

  Fly  1983 ENEPCRNGSTCQNGFNASTGNNFTCTCVPGFEGPLC--DIPFCEITPCDNGGLCLTTGAVPMCKC 2045
            :.:|||||.||....|  |.:.|.|.|.|||.|..|  |...|....|.|||.|::....|.|.|
Zfish  1306 KGKPCRNGGTCAVASN--TPHGFICKCPPGFTGSTCEYDAHACGSLQCKNGGTCVSGHKSPKCLC 1368

  Fly  2046 SLGYTGRLCEQDI-NECESNPCQNGGQCKDLVGR--YECDCQGTGFEGIRCENDIDECNMEGDYC 2107
            :..:||..|:... ..|.:|||.|||.|:.:...  |.|.|. |.|.|:.|.      .::..:.
Zfish  1369 TPAFTGPECQDPSGGHCTTNPCYNGGTCEYITEEPYYHCICP-TNFNGLFCH------ILDWSFP 1426

  Fly  2108 GGLG----------------RCFNKPGSFQC--ICQKPYC---GAYC--NFTDP---CNATDLC- 2145
            ||.|                :|..|.|:..|  .|....|   |..|  ||.||   |:|...| 
Zfish  1427 GGTGQDITPAPKVSVSCEIEQCKVKKGNKICDSACNNYACDWDGGDCSLNFNDPWKNCSAALQCW 1491

  Fly  2146 --SNGGRCVESC-----------------GAKP--DYYCE-------CPEGFAGKNCT-APITAK 2181
              .|.|:|.|.|                 ...|  |.||:       |.:|.....|. ..:...
Zfish  1492 RYFNNGKCDEQCHNTGCLYDGFDCQRVEAQCNPLYDQYCKDHFADGYCDQGCNNAECEWDGLDCA 1556

  Fly  2182 EDGPSTTDIAIIVIPV 2197
            .|.|......::|:.|
Zfish  1557 NDTPEKLAAGLLVVVV 1572

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058 9/24 (38%)
EGF_CA 386..423 CDD:238011 13/36 (36%)
EGF_CA 425..460 CDD:238011 18/36 (50%)
EGF 466..495 CDD:278437 11/28 (39%)
EGF 605..633 CDD:278437 9/27 (33%)
EGF_CA 716..750 CDD:238011 14/33 (42%)
EGF_CA 753..789 CDD:238011 16/36 (44%)
EGF_CA 792..828 CDD:238011 17/35 (49%)
EGF_CA 830..865 CDD:238011 17/34 (50%)
EGF_CA 868..905 CDD:238011 15/36 (42%)
EGF_CA 907..943 CDD:238011 17/35 (49%)
EGF_CA 1009..1045 CDD:238011 17/35 (49%)
EGF_CA 1047..1082 CDD:238011 16/35 (46%)
Laminin_G_1 1155..1290 CDD:278483 10/134 (7%)
EGF 1316..1346 CDD:278437 15/29 (52%)
Laminin_G_1 1388..1550 CDD:278483 18/161 (11%)
EGF_CA <1593..1622 CDD:238011 11/28 (39%)
Laminin_G_2 1692..1828 CDD:280389 21/140 (15%)
EGF_CA 1901..1937 CDD:238011 13/43 (30%)
EGF_CA 1939..1974 CDD:238011 12/36 (33%)
EGF_CA 2057..2094 CDD:238011 14/39 (36%)
EGF_CA 2096..2133 CDD:238011 10/57 (18%)
EGF_CA 2137..2175 CDD:238011 16/69 (23%)
notch1bXP_005168706.1 EGF_CA 175..213 CDD:238011 17/39 (44%)
EGF_CA 221..252 CDD:238011 11/31 (35%)
EGF_CA 254..290 CDD:238011 13/36 (36%)
EGF_CA 292..329 CDD:238011 18/36 (50%)
EGF_CA 332..367 CDD:238011 12/34 (35%)
EGF_CA 409..447 CDD:238011 14/98 (14%)
EGF_CA 449..485 CDD:238011 14/48 (29%)
EGF_CA 487..523 CDD:238011 16/55 (29%)
EGF_CA 525..561 CDD:238011 17/37 (46%)
EGF_CA 563..598 CDD:238011 17/35 (49%)
EGF_CA 600..636 CDD:238011 17/35 (49%)
EGF_CA 638..672 CDD:238011 15/35 (43%)
EGF_CA 675..711 CDD:238011 17/35 (49%)
EGF_CA 715..747 CDD:238011 16/58 (28%)
EGF_CA 752..786 CDD:238011 16/33 (48%)
EGF_CA 788..824 CDD:238011 17/36 (47%)
EGF_CA 866..902 CDD:238011 10/128 (8%)
EGF_CA 904..940 CDD:238011 17/66 (26%)
EGF_CA 942..978 CDD:238011 12/169 (7%)
EGF_CA 985..1016 CDD:238011 6/32 (19%)
EGF_CA 1018..1054 CDD:238011 13/57 (23%)
EGF 1060..1090 CDD:278437 8/37 (22%)
EGF_CA 1143..1177 CDD:238011 15/79 (19%)
EGF_CA 1181..1216 CDD:238011 11/43 (26%)
EGF_CA 1218..1262 CDD:238011 13/43 (30%)
EGF_CA 1264..1298 CDD:238011 12/36 (33%)
EGF_CA <1309..1340 CDD:238011 16/32 (50%)
NL 1437..1473 CDD:197463 7/35 (20%)
Notch 1481..1516 CDD:278494 8/34 (24%)
NL 1515..1555 CDD:197463 7/39 (18%)
NOD 1561..1612 CDD:284282 2/12 (17%)
NODP 1667..1724 CDD:284987
Ank_2 <1867..1953 CDD:289560
ANK repeat 1874..1920 CDD:293786
ANK 1917..2029 CDD:238125
ANK repeat 1922..1953 CDD:293786
Ank_2 1927..2020 CDD:289560
ANK repeat 1955..1986 CDD:293786
ANK 1984..2108 CDD:238125
ANK repeat 1989..2053 CDD:293786
Ank_2 1994..2086 CDD:289560
ANK repeat 2055..2086 CDD:293786
DUF3454 2404..2467 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 59 1.000 Domainoid score I10661
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.710

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