DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and Svep1

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_073725.2 Gene:Svep1 / 64817 MGIID:1928849 Length:3567 Species:Mus musculus


Alignment Length:2780 Identity:590/2780 - (21%)
Similarity:827/2780 - (29%) Gaps:1113/2780 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 KSAAQITSHLLKRAISVYSSPQWIPLFILIYLATDVASVAVPTKEAYFNGSTYLRLTTPMPIWDH 110
            :.||||..|..:.:..|            |:|.||          .|.||.      .|.||   
Mouse   175 QQAAQILRHSRENSTKV------------IFLITD----------GYSNGG------DPRPI--- 208

  Fly   111 SAISFRSCRGGEILA---QQYNKNSIVISVLNDFLQI----------------SLAGPAVH---- 152
             |.|.|.. |.||..   .|.|     |..|||....                :||..|:|    
Mouse   209 -AASLRDF-GVEIFTFGIWQGN-----IRELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLP 266

  Fly   153 -GPNNRLDVKLPYQLLD------NRW-------HTLQF-----KYEYGNLYLHVDRAASIFANST 198
             |...:.|:.....|.:      :|.       ||.||     |..||....|...|.   .:.|
Mouse   267 SGSFIQEDMARCSYLCEAGKDCCDRMASCKCGTHTGQFECICEKGYYGKGLQHECTAC---PSGT 328

  Fly   199 YN--------SQFLTNQDIGY---------KDAILILGNSFSG--C-LLDGPGLQ------FVNN 237
            |.        |..:...|:.:         :|.:...|...||  | ::..|.|:      |:.|
Mouse   329 YKPEASPGGISTCIPCPDVSHTSPPGSTSPEDCVCREGYQRSGQTCEVVHCPALKPPENGFFIQN 393

  Fly   238 STVQNVVFGHCPLTPGP-----------CSDHDLFTRLPDNFC-------LNDPCMGHGTCSSSP 284
             |.:|.....|.:...|           |..:.|::. .::||       |..|..||.:||::.
Mouse   394 -TCKNHFNAACGVRCRPGFDLVGSSIHLCQPNGLWSG-TESFCRVRTCPHLRQPKHGHISCSTAE 456

  Fly   285 ------------EGYE--------CRCTARYSG-------KNC---QKDNG---SP--CAKNPCE 314
                        |||.        |:..|::.|       ::|   ||..|   ||  |.|.|..
Mouse   457 MSYNTLCLVTCNEGYRLEGSTRLTCQGNAQWDGPEPRCVERHCATFQKPKGVIISPPSCGKQPAR 521

  Fly   315 NGGSCLENSRGDY-------------------------------QCFCDPN-------------- 334
            .|.:|..:.|..|                               |..| ||              
Mouse   522 PGMTCQLSCRQGYILSGVREVRCATSGKWSAKVQTAVCKDVEAPQISC-PNDIEAKTGEQQDSAN 585

  Fly   335 ----------HSGQHCETEVNIHPL---------------------------------------- 349
                      :||:  :..|::||.                                        
Mouse   586 VTWQVPTAKDNSGE--KVSVHVHPAFTPPYLFPIGDVAITYTATDSSGNQASCTFYIKVIDVEPP 648

  Fly   350 ----CQTNPCL------------------NNGACVVIGGSGALTCECPKGYAGARCEVDTDECAS 392
                |::.|.:                  |:||.:||..|.......|.|      |......|:
Mouse   649 VIDWCRSPPPIQVVEKEHPASWDEPQFSDNSGAELVITSSHTQGDMFPHG------ETVVWYTAT 707

  Fly   393 QPCQNNGSCIDR--INGFSCDCSGTGYTGAF-CQTNVDECDKNPCLNGGRCFDTYGW-------Y 447
            .|..||.:|...  |.|..|:...|...|.| |..  |....|..|:   |.:.|.:       |
Mouse   708 DPSGNNRTCDIHIVIKGSPCEVPFTPVNGDFICAQ--DSAGVNCSLS---CKEGYDFTEGSTEKY 767

  Fly   448 TCQCLDG-WGGEICDRPMTCQTQQCLNGG-----------TCLDKPIGFQCLCPPEYTGELCQIA 500
            .|...|| |..........|..::..|.|           .|.|..:..:.....|.|  |..:.
Mouse   768 YCAFEDGIWRPPYSTEWPDCAIKRFANHGFKSFEMLYKTTRCDDMDLFKKFSAAFETT--LGNMV 830

  Fly   501 PS-CAQQCPIDSE--------CVGGKCVCKPG-SSGPIG------------HCLPT---TTTPTP 540
            || |.....||..        |:......:.| :.||.|            |.|..   |.|...
Mouse   831 PSFCNDADDIDCRLEDLTKKYCIEYNYNYENGFAIGPGGWGAGNRLDYSYDHFLDVVQETPTDVG 895

  Fly   541 EQEPTTTPRTTPNPNPAIPNTLTTTTKIP-P---------------ITTSRTLVGTTTGS-RRPP 588
            :...:...||.|..:|.|......|..:| |               |.|..|:......: .:.|
Mouse   896 KARSSRIKRTVPLSDPKIQLIFNITASVPLPEERNDTLELENQQRLIKTLETITNRLKSTLNKEP 960

  Fly   589 QQPLQSPTQR----SASLNA------CPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDG 643
            ....|..::.    |.||..      |...:.|.|..|:.        |..| |.|:.:.||   
Mouse   961 MYSFQLASETVVADSNSLETEKAFLFCRPGSVLRGRMCVN--------CPLG-TSYSLEHST--- 1013

  Fly   644 ASALALTPINCNATNGKCLNGGTCSMNG----------TH-------------CYCAVG-YSGDR 684
                      |.:    ||.|......|          ||             ..|..| ||...
Mouse  1014 ----------CES----CLMGSYQDEEGQLECKLCPPRTHTEYLHSRSVSECKAQCKQGTYSSSG 1064

  Fly   685 CEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLPNGDYECKCTRGWTGRT 749
            .|..|:| ||...:|....::..||||       .|...:.|  .||:......|.     .|..
Mouse  1065 LETCESC-PLGTYQPEFGSRSCLLCPE-------TTTTVKRG--AVDISACGVPCP-----VGEF 1114

  Fly   750 CGNDVDECTLHPKICGNGICKNEKGSYKCYCTP--GFTGVHCDSDVDECLSFPCLNGATCHNKIN 812
            ..:.:..|  :|  |.....:...|...|...|  |.|.:...:.:.:|.||.....|       
Mouse  1115 SRSGLTPC--YP--CPRDYYQPNAGKSFCLACPFYGTTTITGATSITDCSSFSSTFSA------- 1168

  Fly   813 AYECV---CQPGYEGENCEVD---IDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDD 871
            |.|.:   ..||:.....||.   ..||..|||.|..||......:.|.|.||.||..|:.|||:
Mouse  1169 AEESIVPLVAPGHSQNKYEVSSQVFHECFLNPCHNSGTCQQLGRGYVCLCPPGYTGLKCETDIDE 1233

  Fly   872 CVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNG 936
            |...||||||.|.||:|||.|:|| .||.|:.||.||:||:|:||.|...|.|.:..|.|.|..|
Mouse  1234 CSSLPCLNGGICRDQVGGFTCECS-LGYSGQICEENINECISSPCLNKGTCTDGLASYRCTCVKG 1297

  Fly   937 YKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGI 1001
            |.|.:||.|:|||:|:||..|..|.::                          ..|:.|.|.||.
Mouse  1298 YMGVHCETDVNECQSSPCLNNAVCKDQ--------------------------VGGFSCKCPPGF 1336

  Fly  1002 IGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEINIDECDRYNPCQ-RGTCYDQ 1065
            :|..||.|::||.|.||.....|.||..::.|:|..||.|||||:||:|| :.|||: :.||.|:
Mouse  1337 LGTRCEKNVDECLSQPCQNGATCKDGANSFRCQCPAGFTGTHCELNINEC-QSNPCRNQATCVDE 1400

  Fly  1066 IDDYDCDCDANYGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTT 1130
            ::.                                           |:|.|:.||.|.:||    
Mouse  1401 LNS-------------------------------------------YSCKCQPGFSGHRCE---- 1418

  Fly  1131 LSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRL-NLHSSLL 1194
                        ||:..|:  ||.|..:        |..|       |:  |::|.| .||:   
Mouse  1419 ------------TEQPSGF--NLDFEVS--------GIYG-------YV--LLDGVLPTLHA--- 1449

  Fly  1195 NKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIP 1259
                       :..:.|.|....||..            .|: ||...::...:|..|...|.: 
Mouse  1450 -----------ITCAFWMKSSDVINYG------------TPI-SYALEDDKDNTFLLTDYNGWV- 1489

  Fly  1260 NLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSN 1324
                                  :.||||             .|:.|    ||....         
Mouse  1490 ----------------------LYVNGK-------------EKITN----CPSVND--------- 1506

  Fly  1325 GECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILD------ 1383
                .:||                              |.|:...:|..|.|.   .:|      
Mouse  1507 ----GIWH------------------------------HIAITWTSTGGAWRV---YIDGELSDG 1534

  Fly  1384 -ISMFIRTREPTGQVFYLGTD-PRKAPTKNIGDSYVA--AKLHGGELL-----VKMQFSGTPEAY 1439
             ..:.|....|.|....||.: .:|....|..:|:|.  ::|:..:.:     ||:..|..||  
Mouse  1535 GTGLSIGKAIPGGGALVLGQEQDKKGEGFNPAESFVGSISQLNLWDYVLSPQQVKLLASSCPE-- 1597

  Fly  1440 TVGGQKLDNGYNHLIEVVRNQTLV----------QVKLNGTEYFRKTLSTTGLLDAQVLYLGGPA 1494
                           |:.|...|.          :||::.:..|   .|....|:..|.:|...:
Mouse  1598 ---------------ELSRGNVLAWPDFLSGITGKVKVDSSSMF---CSDCPSLEGSVPHLRPAS 1644

  Fly  1495 PTRE--SLLGATTEPGI-----------------IPVP-----GAGIP---------IED----T 1522
            ..|:  |.:....:||.                 .|:|     ..|:|         .||    :
Mouse  1645 GNRKPGSKVSLFCDPGFQMVGNPVQYCLNQGQWTQPLPHCERIRCGLPPALENGFYSAEDFHAGS 1709

  Fly  1523 TVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSD 1587
            ||..:. .|..|..|..:.....|||.|.|    |.:..||                       |
Mouse  1710 TVTYQC-TSGYYLLGDSRMFCTDNGSWNGI----SPSCLDV-----------------------D 1746

  Fly  1588 DLCRKNPCLHNAECRNTWNDYTCKCPNGY--KGKNCQEIEFCQHVTCP------------GQSLC 1638
            :....:.|..:|.|.||...|.|.|...|  .||||.|...|:....|            |.::.
Mouse  1747 ECAVGSDCSEHASCLNTNGSYVCSCNPPYTGDGKNCAEPVKCKAPENPENGHSSGEIYTVGTAVT 1811

  Fly  1639 QNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVID---------IAFRT 1694
            .:.|:|:|.|..:|.|..|...    :.:.:.|.:.:|...|.......:|         :.:|.
Mouse  1812 FSCDEGHELVGVSTITCLETGE----WDRLRPSCEAISCGVPPVPENGGVDGSAFTYGSKVVYRC 1872

  Fly  1695 RAGGTLLYIDNVDGFFEIG-------------------VNGGRVTITWKLSALHFGESARFEKEN 1740
            ..|.||.. |........|                   :|.|:    :.||.|.:...|.:..||
Mouse  1873 DKGYTLSG-DEESACLASGSWSHSSPVCELVKCSQPEDINNGK----YILSGLTYLSIASYSCEN 1932

  Fly  1741 TDGEWSRIYLRAHNSKLE----GGWKGWESMVDPT--------PAFSTDI----DQAAFQSLIA- 1788
            .       |.....|.||    |.|    ....|:        |....|.    ....|.:.:| 
Mouse  1933 G-------YSLQGPSLLECTASGSW----DRAPPSCQLVSCGEPPIVKDAVITGSNFTFGNTVAY 1986

  Fly  1789 TSTQVYLGGMPES--RQARGSTLSAQQGSQFKGCVGEARVGDLLLP------YFSMAELYSRTNV 1845
            |..:.|....|::  .||.|...|:........|.....| |...|      :...|..|.....
Mouse  1987 TCKEGYTLAGPDTIVCQANGKWNSSNHQCLAVSCDEPPNV-DHASPETAHRLFGDTAFYYCADGY 2050

  Fly  1846 SVQQKAQFRLNATR---PEEG-----CILCFQSDCKNDGFCQS-PSDEYAC-------------- 1887
            |:...:|...||..   |..|     ||.         .||:. ||..|:.              
Mouse  2051 SLADNSQLICNAQGNWVPPAGQAVPRCIA---------HFCEKPPSVSYSILESVSKAKFAAGSV 2106

  Fly  1888 ---TCQPGFEGDDCGTDIDECLNT----ECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECAD 1945
               .|..||           .|||    |||..|..  ..:....||.|           ..|.:
Mouse  2107 VSFKCMEGF-----------VLNTSAKIECLRGGEW--SPSPLSVQCIP-----------VRCGE 2147

  Fly  1946 QP---------------------CHNGGNCTDLIASYV-------CDCPEDYMGPQCDVLKQMTC 1982
            .|                     ||.|        .|:       |:....:..|      ..||
Mouse  2148 PPSIANGYPSGTNYSFGAVVAYSCHKG--------FYIKGEKKSTCEATGQWSKP------TPTC 2198

  Fly  1983 ENEPCRNGSTCQNGF-NASTGNNFTC----TCVPGF------------------EGPLCDIPF-C 2023
            ....|......:||| ..:||..|..    .|.||:                  :.||...|. |
Mouse  2199 HPVSCNEPPKVENGFLEHTTGRTFESEARFQCNPGYKAAGSPVFVCQANRHWHSDAPLSCTPLNC 2263

  Fly  2024 -EITPCDNG---GLCLTTGAVPMCKCSLGY------------TGRLCEQDINECESNPC------ 2066
             :..|..||   |.....|:.....|:.||            :|:..::...:|....|      
Mouse  2264 GKPPPIQNGFLKGESFEVGSKVQFVCNEGYELVGDNSWTCQKSGKWSKKPSPKCVPTKCAEPPLL 2328

  Fly  2067 QNGGQCKDL---VGRYECDC-QGTGFEGIRCENDIDECNMEGDYCGGLGRC------------FN 2115
            :|....|:|   ||.....| :|...:|    ..:.:|...|.:.|....|            |.
Mouse  2329 ENQLVLKELASEVGVMTISCKEGHALQG----PSVLKCLPSGQWNGSFPICKMVLCPSPPLIPFG 2389

  Fly  2116 KPGS-----------FQCI------------CQK--------PYCG------------------- 2130
            .|.|           :.|:            ||.        |.|.                   
Mouse  2390 VPASSGALHFGSTVKYLCVDGFFLRGSPTILCQADSTWSSPLPECVPVECPQPEEILNGIIHVQG 2454

  Fly  2131 -AYCNFT-DPC--------NATDLCSNGGRCVESCGAKPDYYC---ECPE 2167
             ||.:.| ..|        |||.||...|:.:   |.||  .|   ||||
Mouse  2455 LAYLSTTLYTCKPGFELVGNATTLCGENGQWL---GGKP--MCKPIECPE 2499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058 44/198 (22%)
EGF_CA 386..423 CDD:238011 11/39 (28%)
EGF_CA 425..460 CDD:238011 10/42 (24%)
EGF 466..495 CDD:278437 7/39 (18%)
EGF 605..633 CDD:278437 6/27 (22%)
EGF_CA 716..750 CDD:238011 6/33 (18%)
EGF_CA 753..789 CDD:238011 8/37 (22%)
EGF_CA 792..828 CDD:238011 8/38 (21%)
EGF_CA 830..865 CDD:238011 14/37 (38%)
EGF_CA 868..905 CDD:238011 22/36 (61%)
EGF_CA 907..943 CDD:238011 16/35 (46%)
EGF_CA 1009..1045 CDD:238011 16/35 (46%)
EGF_CA 1047..1082 CDD:238011 10/35 (29%)
Laminin_G_1 1155..1290 CDD:278483 23/135 (17%)
EGF 1316..1346 CDD:278437 2/29 (7%)
Laminin_G_1 1388..1550 CDD:278483 43/216 (20%)
EGF_CA <1593..1622 CDD:238011 12/30 (40%)
Laminin_G_2 1692..1828 CDD:280389 34/173 (20%)
EGF_CA 1901..1937 CDD:238011 10/39 (26%)
EGF_CA 1939..1974 CDD:238011 8/62 (13%)
EGF_CA 2057..2094 CDD:238011 10/46 (22%)
EGF_CA 2096..2133 CDD:238011 13/99 (13%)
EGF_CA 2137..2175 CDD:238011 15/42 (36%)
Svep1NP_073725.2 VWA 85..259 CDD:278519 30/121 (25%)
GCC2_GCC3 311..361 CDD:285001 8/52 (15%)
CCP 379..435 CDD:153056 11/57 (19%)
CCP 439..495 CDD:153056 12/55 (22%)
CCP <514..556 CDD:153056 7/41 (17%)
HYR 560..642 CDD:280629 9/84 (11%)
DUF5011 643..722 CDD:295940 16/84 (19%)
GCC2_GCC3 1004..1051 CDD:285001 12/64 (19%)
GCC2_GCC3 1058..1105 CDD:285001 17/56 (30%)
GCC2_GCC3 1112..1159 CDD:285001 9/50 (18%)
EGF_CA 1195..1228 CDD:238011 14/32 (44%)
EGF_CA 1230..1266 CDD:238011 22/36 (61%)
EGF_CA 1268..1304 CDD:238011 16/35 (46%)
EGF_CA 1306..1342 CDD:238011 15/61 (25%)
EGF_CA 1344..1380 CDD:238011 16/35 (46%)
EGF_CA 1382..1418 CDD:238011 16/79 (20%)
PTX 1423..1621 CDD:238086 58/346 (17%)
Sushi 1627..1684 CDD:278512 10/56 (18%)
CCP 1689..1742 CDD:214478 15/57 (26%)
EGF_CA 1744..1782 CDD:214542 14/60 (23%)
CCP 1788..1842 CDD:153056 11/57 (19%)
CCP 1846..1900 CDD:153056 8/54 (15%)
CCP 1904..1958 CDD:153056 15/68 (22%)
PHA02927 1957..2198 CDD:222943 51/288 (18%)
CCP 1962..2015 CDD:153056 11/52 (21%)
Sushi 2020..2077 CDD:278512 12/57 (21%)
CCP 2082..2135 CDD:153056 14/65 (22%)
CCP 2145..2198 CDD:153056 8/66 (12%)
CCP 2203..2258 CDD:153056 12/54 (22%)
CCP 2263..2318 CDD:153056 10/54 (19%)
CCP 2322..2376 CDD:153056 12/57 (21%)
CCP 2380..2435 CDD:153056 7/54 (13%)
Sushi 2439..2492 CDD:278512 13/57 (23%)
CCP 2497..2550 CDD:153056 3/3 (100%)
CCP 2555..2607 CDD:214478
CCP <2670..2710 CDD:153056
PHA02927 2709..2941 CDD:222943
CCP 2714..2768 CDD:153056
CCP 2772..2826 CDD:153056
CCP 2830..2883 CDD:153056
CCP 2888..2942 CDD:153056
CCP 2946..2999 CDD:153056
CCP <3022..3056 CDD:153056
CCP 3060..3114 CDD:153056
CCP 3118..3172 CDD:153056
Sushi 3177..3227 CDD:278512
PHA02927 3232..3464 CDD:222943
CCP 3237..3291 CDD:153056
CCP 3295..3348 CDD:214478
Sushi 3353..3407 CDD:278512
CCP 3412..3464 CDD:214478
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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