DRSC/TRiP Functional Genomics Resources

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Protein Alignment crb and notch3

DIOPT Version :10

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_571624.2 Gene:notch3 / 58066 ZFINID:ZDB-GENE-000329-5 Length:2468 Species:Danio rerio


Alignment Length:2005 Identity:497/2005 - (24%)
Similarity:660/2005 - (32%) Gaps:844/2005 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   312 PCENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGAC--VVIGGSGALTCEC 374
            ||||||.|:     |.:|.|.|.:.|..|:   ::.| |..:||||..||  .|.......||.|
Zfish    30 PCENGGMCI-----DSRCLCRPGYIGSLCQ---HLDP-CHRSPCLNAAACKSQVANSIPQYTCVC 85

  Fly   375 PKGYAGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDK-NPCLNGG 438
            .:|:.|..|.: .|.||:.||.|...|.:..|.::|.|. .||.|..|:.::|||.| ..|||||
Zfish    86 QRGFRGQDCSL-VDACATSPCANGARCTNWNNHYNCSCP-PGYQGKNCRNDIDECRKPGKCLNGG 148

  Fly   439 RCFDTYGWYTCQCLDGWGGEICDRP-MTCQTQQCLNGGTCLDKPIG---FQCLCPPEYTGELCQI 499
            .|.:|:|.:.|:||.|:.|..|:.| ..|...||||||||  ...|   ::|.|.|.:.|..|: 
Zfish   149 ICMNTHGSFRCECLTGYSGRTCEVPTQPCAPSQCLNGGTC--HQTGDHTYECACLPGFRGHNCE- 210

  Fly   500 APSCAQQCPIDS--ECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTL 562
                      |:  :|.|.||:                                 |....:....
Zfish   211 ----------DNVDDCPGHKCM---------------------------------NNGICVDGVN 232

  Fly   563 TTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNAC-PQEN-CLNGGTCLGYSGNYSC 625
            |...:.||..|.:..                     :..:|.| .|.| |.|||||....|.::|
Zfish   233 TYNCQCPPEWTGQYC---------------------AEDVNECLMQPNACHNGGTCFNTIGGHTC 276

  Fly   626 ICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTC--SMNGTHCYCAVGYSGDRCEKA 688
            :|.:|:||.:|..:..|.|:|:             |.||.||  .:....|.|.||.:|      
Zfish   277 VCVNGWTGDDCSENIDDCATAV-------------CFNGATCHDRVASFFCECPVGKTG------ 322

  Fly   689 ENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLP-NGDYECKCTRGWTGRTCGN 752
                 |.|.....||.|                ||..|..|...| ||...|.|..|:.|..|..
Zfish   323 -----LLCHLDDACVSN----------------PCNEGAVCDTNPLNGRAICTCPAGFVGGACNQ 366

  Fly   753 DVDECTLHPKICGN-GICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAYEC 816
            |:|||::....|.: |.|.|.:||::|.|..|:||..|:.|::||||.||.|.|||.::|..:.|
Zfish   367 DMDECSIGANPCEHFGKCVNTEGSFQCQCGRGYTGPRCEIDINECLSMPCQNDATCLDRIGEFTC 431

  Fly   817 VCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGG 881
            :|.|||:|:.||||||||.||||.|...|.|.:|.|||.|.||.||.:|.||||:|...||.||.
Zfish   432 ICMPGYQGKYCEVDIDECESNPCVNDGICRDMVNGFTCTCQPGFTGTMCQIDIDECASTPCQNGA 496

  Fly   882 QCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDI 946
            :|||:..|:.|.|: .|:||..||.|||.|..:||.:|. |:|.:..|.|:|..||.|..||..:
Zfish   497 KCIDRPNGYECRCA-EGFEGRLCESNIDNCKPDPCHHGT-CVDGIASYTCNCEPGYTGYRCENQL 559

  Fly   947 NECESNPCQYNGNCLERSNITLYQMSRIT-------DLPKVFSQPFSF----ENASGYECVCVPG 1000
            |||.|||||..|.|::..|..:.|....|       :.....|.|..:    :..:.|||||.||
Zfish   560 NECHSNPCQNGGKCVDLVNKYICQCQHGTSGTNCEINFDDCASNPCDYGICKDGINRYECVCKPG 624

  Fly  1001 IIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEINIDECDRYNPCQRGTCYDQ 1065
            ..|..|:..|:||.||||...|.|.|....:.|:|..||...:|...:||| ..|||..|||.|.
Zfish   625 FTGPQCKDEIDECQSNPCRNGGTCVDDENGFHCQCPEGFHDPYCYSQVDEC-ASNPCLHGTCRDD 688

  Fly  1066 IDDYDCDCDANYGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTT 1130
            .:.|.|||:..:.||||.:....|..:||.|.|.|...|     :.:.|.|..||:|:.|:    
Zfish   689 PNGYRCDCEPGWVGKNCDLDRNDCLPSPCQNAGTCFDQL-----NGFTCKCRQGFRGNLCQ---- 744

  Fly  1131 LSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLN 1195
                                                                             
Zfish   745 ----------------------------------------------------------------- 744

  Fly  1196 KWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPN 1260
                                |.||                                         
Zfish   745 --------------------VNIN----------------------------------------- 748

  Fly  1261 LKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNG 1325
                                                                  :|..:||.:.|
Zfish   749 ------------------------------------------------------ECASSPCLNQG 759

  Fly  1326 ECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRT 1390
            .|.|...:|.|.|..|:.|.||                                           
Zfish   760 TCVDGVASFTCLCEPPYSGPTC------------------------------------------- 781

  Fly  1391 REPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIE 1455
                                             .|||       ||                   
Zfish   782 ---------------------------------AELL-------TP------------------- 787

  Fly  1456 VVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIE 1520
                                                                             
Zfish   788 ----------------------------------------------------------------- 787

  Fly  1521 DTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEV 1585
                                                                             
Zfish   788 ----------------------------------------------------------------- 787

  Fly  1586 SDDLCRKNPCLHNAECRNT--WNDYTCKCPNGYKGKNC-QEIEFCQHVTCPGQSLCQNLDDGYEC 1647
                |..|||.::|.|.:|  :..|.|.|..|::|..| .:|..|....|..:..|.|...||.|
Zfish   788 ----CSPNPCANHASCVHTPDYLGYQCNCQPGWQGHLCNNDINECTSNPCKNRGTCTNTLGGYVC 848

  Fly  1648 VTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFEI 1712
            .....:||             ...:..:::.||...|                            
Zfish   849 SCRAGYTG-------------PNCETDINDCSPNPCL---------------------------- 872

  Fly  1713 GVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWESMVDPTPAFSTD 1777
              |||..                     |||.                                 
Zfish   873 --NGGSC---------------------TDGV--------------------------------- 881

  Fly  1778 IDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFK-GCVGEARVGDLLLPYFSMAELYS 1841
                                                 :.|: .|          ||.|:.|...:
Zfish   882 -------------------------------------NSFRCSC----------LPGFTGARCAT 899

  Fly  1842 RTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGDDCGTDIDECL 1906
            ..|.                     |....|||.|.|....:.|.|||:|||.|..|.|::.:|.
Zfish   900 ELNE---------------------CQSVPCKNGGTCTDYVNSYTCTCKPGFTGLLCETNVPDCT 943

  Fly  1907 NTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQPCHNGGNCTDLIASYVCDCPEDYMG 1971
            .:.|.|.|||.:.:..|.|.|:.||.|.:|:..::||..|||.|||.|.|.:.||.|.||:.|.|
Zfish   944 ESSCFNGGTCTDGINGFKCTCRTGFTGDYCQYEVNECDSQPCLNGGICQDAMESYRCSCPKGYTG 1008

  Fly  1972 PQCDVLKQMTCENEPCRNGSTCQNGFNASTGNNFTCTCVPGFEGPLCDIP--FCEITP------- 2027
            |:|.........:.||:||..|:.. :||    |||.|:.|:.|..||||  .||:..       
Zfish  1009 PRCQYPVDWCRPSNPCKNGGRCRQK-DAS----FTCDCLGGWSGRYCDIPGVSCEVAARQRGRQT 1068

  Fly  2028 ---CDNGGLCLTTGAVPMCKCSL--------------------------------------GYTG 2051
               |.:||.|:.||....|||..                                      ||.|
Zfish  1069 DELCLHGGHCVNTGNTHYCKCPADYTGSYCESQFDHCEEKPCLNGATCRSYMGGFTCDCMPGYEG 1133

  Fly  2052 RLCEQDINECESNPCQNGGQCKDLVGRYECDC------------------------------QGT 2086
            ..||:::|||:|:||||||.|.||||.|.|.|                              .||
Zfish  1134 NNCEREVNECQSHPCQNGGTCIDLVGHYICSCPPGTLGVLCEINEDDCATPSWPRGMPKCQNNGT 1198

  Fly  2087 --------------GFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPYCGAYCNFTD 2137
                          ||.|.|||.||:||............|...|..:||:|:..:.|..|....
Zfish  1199 CVDRVGGYRCNCPPGFTGERCEGDINECLSNPCNPSNSLDCIQLPNDYQCVCKPGFTGRGCQSRF 1263

  Fly  2138 PCNATDLCSNGGRCVESCGAKPDYYCECPEGFAGKNCTAPITAKE----DGPSTT 2188
            ....:..|.|||.|..|..:.|.|.|.|..|:||.||...:..||    :|.|.|
Zfish  1264 SVCESQPCKNGGVCSLSGSSPPGYSCTCQLGYAGSNCERSMNCKELPCYNGGSCT 1318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF 269..299 CDD:394967
EGF_CA <311..341 CDD:238011 12/28 (43%)
EGF_CA 386..423 CDD:238011 13/36 (36%)
EGF_CA 425..460 CDD:238011 17/35 (49%)
EGF 466..495 CDD:394967 13/31 (42%)
EGF 605..633 CDD:394967 13/29 (45%)
EGF_CA 716..750 CDD:238011 11/34 (32%)
EGF_CA 753..789 CDD:238011 15/36 (42%)
EGF_CA 792..828 CDD:238011 18/35 (51%)
EGF_CA 830..865 CDD:238011 21/34 (62%)
EGF_CA 868..905 CDD:238011 17/36 (47%)
EGF_CA 907..943 CDD:238011 15/35 (43%)
EGF_CA 1009..1045 CDD:238011 14/35 (40%)
EGF_CA 1047..1082 CDD:238011 16/34 (47%)
Laminin_G_1 1155..1290 CDD:395008 3/134 (2%)
EGF 1316..1346 CDD:394967 11/29 (38%)
Laminin_G_1 1388..1550 CDD:395008 5/161 (3%)
EGF_CA <1593..1622 CDD:238011 12/31 (39%)
Laminin_G_2 1692..1828 CDD:460494 8/136 (6%)
EGF_CA 1901..1937 CDD:238011 12/35 (34%)
EGF_CA 1939..1974 CDD:238011 18/34 (53%)
EGF_CA 2057..2094 CDD:238011 24/80 (30%)
EGF_CA 2096..2133 CDD:238011 10/36 (28%)
EGF_CA 2137..2175 CDD:238011 14/37 (38%)
notch3NP_571624.2 EGF_CA 97..131 CDD:238011 13/34 (38%)
EGF_CA 134..171 CDD:238011 17/36 (47%)
EGF_CA 212..247 CDD:238011 9/67 (13%)
EGF_CA 250..287 CDD:238011 16/36 (44%)
EGF_CA 290..325 CDD:238011 14/58 (24%)
EGF_CA 367..405 CDD:238011 15/37 (41%)
EGF_CA 407..443 CDD:238011 18/35 (51%)
EGF_CA 445..481 CDD:238011 21/35 (60%)
EGF_CA 483..519 CDD:238011 17/36 (47%)
EGF_CA 521..556 CDD:238011 15/35 (43%)
EGF_CA 560..594 CDD:238011 13/33 (39%)
EGF_CA 596..631 CDD:238011 10/34 (29%)
EGF_CA 634..668 CDD:238011 14/33 (42%)
EGF_CA 672..705 CDD:238011 16/33 (48%)
EGF_CA 708..744 CDD:238011 12/40 (30%)
EGF_CA 746..781 CDD:238011 13/129 (10%)
EGF_CA 824..860 CDD:238011 10/48 (21%)
EGF_CA 862..897 CDD:238011 15/165 (9%)
EGF_CA 902..936 CDD:238011 15/54 (28%)
EGF_CA 938..974 CDD:238011 12/35 (34%)
EGF_CA 977..1012 CDD:238011 18/34 (53%)
EGF_CA 1015..1050 CDD:238011 13/39 (33%)
EGF_CA 1067..1099 CDD:238011 9/31 (29%)
EGF_CA 1103..1137 CDD:238011 3/33 (9%)
EGF_CA 1140..1175 CDD:238011 18/34 (53%)
EGF_CA <1193..1220 CDD:238011 6/26 (23%)
EGF_CA 1222..1260 CDD:238011 10/37 (27%)
Notch 1392..1423 CDD:459658
Notch 1429..1462 CDD:459658
Notch 1475..1502 CDD:459658
NOD 1507..1562 CDD:462014
NODP 1576..1634 CDD:462229
JMTM_Notch3 1615..1708 CDD:411987
ANK repeat 1791..1839 CDD:293786
ANKYR 1821..2031 CDD:440430
ANK repeat 1841..1872 CDD:293786
ANK repeat 1875..1906 CDD:293786
ANK repeat 1908..1939 CDD:293786
ANK repeat 1941..1972 CDD:293786
ANK repeat 1974..2005 CDD:293786
PHA03247 <2040..2412 CDD:223021
Amelogenin 2232..2325 CDD:197891
Blue background indicates that the domain is not in the aligned region.

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