DRSC/TRiP Functional Genomics Resources

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Protein Alignment crb and notch3

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_571624.2 Gene:notch3 / 58066 ZFINID:ZDB-GENE-000329-5 Length:2468 Species:Danio rerio


Alignment Length:2005 Identity:497/2005 - (24%)
Similarity:660/2005 - (32%) Gaps:844/2005 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   312 PCENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGAC--VVIGGSGALTCEC 374
            ||||||.|:     |.:|.|.|.:.|..|:   ::.| |..:||||..||  .|.......||.|
Zfish    30 PCENGGMCI-----DSRCLCRPGYIGSLCQ---HLDP-CHRSPCLNAAACKSQVANSIPQYTCVC 85

  Fly   375 PKGYAGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDK-NPCLNGG 438
            .:|:.|..|.: .|.||:.||.|...|.:..|.::|.|. .||.|..|:.::|||.| ..|||||
Zfish    86 QRGFRGQDCSL-VDACATSPCANGARCTNWNNHYNCSCP-PGYQGKNCRNDIDECRKPGKCLNGG 148

  Fly   439 RCFDTYGWYTCQCLDGWGGEICDRP-MTCQTQQCLNGGTCLDKPIG---FQCLCPPEYTGELCQI 499
            .|.:|:|.:.|:||.|:.|..|:.| ..|...||||||||  ...|   ::|.|.|.:.|..|: 
Zfish   149 ICMNTHGSFRCECLTGYSGRTCEVPTQPCAPSQCLNGGTC--HQTGDHTYECACLPGFRGHNCE- 210

  Fly   500 APSCAQQCPIDS--ECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTL 562
                      |:  :|.|.||:                                 |....:....
Zfish   211 ----------DNVDDCPGHKCM---------------------------------NNGICVDGVN 232

  Fly   563 TTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNAC-PQEN-CLNGGTCLGYSGNYSC 625
            |...:.||..|.:..                     :..:|.| .|.| |.|||||....|.::|
Zfish   233 TYNCQCPPEWTGQYC---------------------AEDVNECLMQPNACHNGGTCFNTIGGHTC 276

  Fly   626 ICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTC--SMNGTHCYCAVGYSGDRCEKA 688
            :|.:|:||.:|..:..|.|:|:             |.||.||  .:....|.|.||.:|      
Zfish   277 VCVNGWTGDDCSENIDDCATAV-------------CFNGATCHDRVASFFCECPVGKTG------ 322

  Fly   689 ENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLP-NGDYECKCTRGWTGRTCGN 752
                 |.|.....||.|                ||..|..|...| ||...|.|..|:.|..|..
Zfish   323 -----LLCHLDDACVSN----------------PCNEGAVCDTNPLNGRAICTCPAGFVGGACNQ 366

  Fly   753 DVDECTLHPKICGN-GICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAYEC 816
            |:|||::....|.: |.|.|.:||::|.|..|:||..|:.|::||||.||.|.|||.::|..:.|
Zfish   367 DMDECSIGANPCEHFGKCVNTEGSFQCQCGRGYTGPRCEIDINECLSMPCQNDATCLDRIGEFTC 431

  Fly   817 VCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGG 881
            :|.|||:|:.||||||||.||||.|...|.|.:|.|||.|.||.||.:|.||||:|...||.||.
Zfish   432 ICMPGYQGKYCEVDIDECESNPCVNDGICRDMVNGFTCTCQPGFTGTMCQIDIDECASTPCQNGA 496

  Fly   882 QCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDI 946
            :|||:..|:.|.|: .|:||..||.|||.|..:||.:|. |:|.:..|.|:|..||.|..||..:
Zfish   497 KCIDRPNGYECRCA-EGFEGRLCESNIDNCKPDPCHHGT-CVDGIASYTCNCEPGYTGYRCENQL 559

  Fly   947 NECESNPCQYNGNCLERSNITLYQMSRIT-------DLPKVFSQPFSF----ENASGYECVCVPG 1000
            |||.|||||..|.|::..|..:.|....|       :.....|.|..:    :..:.|||||.||
Zfish   560 NECHSNPCQNGGKCVDLVNKYICQCQHGTSGTNCEINFDDCASNPCDYGICKDGINRYECVCKPG 624

  Fly  1001 IIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEINIDECDRYNPCQRGTCYDQ 1065
            ..|..|:..|:||.||||...|.|.|....:.|:|..||...:|...:||| ..|||..|||.|.
Zfish   625 FTGPQCKDEIDECQSNPCRNGGTCVDDENGFHCQCPEGFHDPYCYSQVDEC-ASNPCLHGTCRDD 688

  Fly  1066 IDDYDCDCDANYGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTT 1130
            .:.|.|||:..:.||||.:....|..:||.|.|.|...|     :.:.|.|..||:|:.|:    
Zfish   689 PNGYRCDCEPGWVGKNCDLDRNDCLPSPCQNAGTCFDQL-----NGFTCKCRQGFRGNLCQ---- 744

  Fly  1131 LSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLN 1195
                                                                             
Zfish   745 ----------------------------------------------------------------- 744

  Fly  1196 KWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPN 1260
                                |.||                                         
Zfish   745 --------------------VNIN----------------------------------------- 748

  Fly  1261 LKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNG 1325
                                                                  :|..:||.:.|
Zfish   749 ------------------------------------------------------ECASSPCLNQG 759

  Fly  1326 ECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRT 1390
            .|.|...:|.|.|..|:.|.||                                           
Zfish   760 TCVDGVASFTCLCEPPYSGPTC------------------------------------------- 781

  Fly  1391 REPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIE 1455
                                             .|||       ||                   
Zfish   782 ---------------------------------AELL-------TP------------------- 787

  Fly  1456 VVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIE 1520
                                                                             
Zfish   788 ----------------------------------------------------------------- 787

  Fly  1521 DTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEV 1585
                                                                             
Zfish   788 ----------------------------------------------------------------- 787

  Fly  1586 SDDLCRKNPCLHNAECRNT--WNDYTCKCPNGYKGKNC-QEIEFCQHVTCPGQSLCQNLDDGYEC 1647
                |..|||.::|.|.:|  :..|.|.|..|::|..| .:|..|....|..:..|.|...||.|
Zfish   788 ----CSPNPCANHASCVHTPDYLGYQCNCQPGWQGHLCNNDINECTSNPCKNRGTCTNTLGGYVC 848

  Fly  1648 VTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFEI 1712
            .....:||             ...:..:::.||...|                            
Zfish   849 SCRAGYTG-------------PNCETDINDCSPNPCL---------------------------- 872

  Fly  1713 GVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWESMVDPTPAFSTD 1777
              |||..                     |||.                                 
Zfish   873 --NGGSC---------------------TDGV--------------------------------- 881

  Fly  1778 IDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFK-GCVGEARVGDLLLPYFSMAELYS 1841
                                                 :.|: .|          ||.|:.|...:
Zfish   882 -------------------------------------NSFRCSC----------LPGFTGARCAT 899

  Fly  1842 RTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGDDCGTDIDECL 1906
            ..|.                     |....|||.|.|....:.|.|||:|||.|..|.|::.:|.
Zfish   900 ELNE---------------------CQSVPCKNGGTCTDYVNSYTCTCKPGFTGLLCETNVPDCT 943

  Fly  1907 NTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQPCHNGGNCTDLIASYVCDCPEDYMG 1971
            .:.|.|.|||.:.:..|.|.|:.||.|.:|:..::||..|||.|||.|.|.:.||.|.||:.|.|
Zfish   944 ESSCFNGGTCTDGINGFKCTCRTGFTGDYCQYEVNECDSQPCLNGGICQDAMESYRCSCPKGYTG 1008

  Fly  1972 PQCDVLKQMTCENEPCRNGSTCQNGFNASTGNNFTCTCVPGFEGPLCDIP--FCEITP------- 2027
            |:|.........:.||:||..|:.. :||    |||.|:.|:.|..||||  .||:..       
Zfish  1009 PRCQYPVDWCRPSNPCKNGGRCRQK-DAS----FTCDCLGGWSGRYCDIPGVSCEVAARQRGRQT 1068

  Fly  2028 ---CDNGGLCLTTGAVPMCKCSL--------------------------------------GYTG 2051
               |.:||.|:.||....|||..                                      ||.|
Zfish  1069 DELCLHGGHCVNTGNTHYCKCPADYTGSYCESQFDHCEEKPCLNGATCRSYMGGFTCDCMPGYEG 1133

  Fly  2052 RLCEQDINECESNPCQNGGQCKDLVGRYECDC------------------------------QGT 2086
            ..||:::|||:|:||||||.|.||||.|.|.|                              .||
Zfish  1134 NNCEREVNECQSHPCQNGGTCIDLVGHYICSCPPGTLGVLCEINEDDCATPSWPRGMPKCQNNGT 1198

  Fly  2087 --------------GFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPYCGAYCNFTD 2137
                          ||.|.|||.||:||............|...|..:||:|:..:.|..|....
Zfish  1199 CVDRVGGYRCNCPPGFTGERCEGDINECLSNPCNPSNSLDCIQLPNDYQCVCKPGFTGRGCQSRF 1263

  Fly  2138 PCNATDLCSNGGRCVESCGAKPDYYCECPEGFAGKNCTAPITAKE----DGPSTT 2188
            ....:..|.|||.|..|..:.|.|.|.|..|:||.||...:..||    :|.|.|
Zfish  1264 SVCESQPCKNGGVCSLSGSSPPGYSCTCQLGYAGSNCERSMNCKELPCYNGGSCT 1318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 13/36 (36%)
EGF_CA 425..460 CDD:238011 17/35 (49%)
EGF 466..495 CDD:278437 13/31 (42%)
EGF 605..633 CDD:278437 13/29 (45%)
EGF_CA 716..750 CDD:238011 11/34 (32%)
EGF_CA 753..789 CDD:238011 15/36 (42%)
EGF_CA 792..828 CDD:238011 18/35 (51%)
EGF_CA 830..865 CDD:238011 21/34 (62%)
EGF_CA 868..905 CDD:238011 17/36 (47%)
EGF_CA 907..943 CDD:238011 15/35 (43%)
EGF_CA 1009..1045 CDD:238011 14/35 (40%)
EGF_CA 1047..1082 CDD:238011 16/34 (47%)
Laminin_G_1 1155..1290 CDD:278483 3/134 (2%)
EGF 1316..1346 CDD:278437 11/29 (38%)
Laminin_G_1 1388..1550 CDD:278483 5/161 (3%)
EGF_CA <1593..1622 CDD:238011 12/31 (39%)
Laminin_G_2 1692..1828 CDD:280389 8/136 (6%)
EGF_CA 1901..1937 CDD:238011 12/35 (34%)
EGF_CA 1939..1974 CDD:238011 18/34 (53%)
EGF_CA 2057..2094 CDD:238011 24/80 (30%)
EGF_CA 2096..2133 CDD:238011 10/36 (28%)
EGF_CA 2137..2175 CDD:238011 14/37 (38%)
notch3NP_571624.2 EGF_CA 97..131 CDD:238011 13/34 (38%)
EGF_CA 134..171 CDD:238011 17/36 (47%)
EGF_CA 212..247 CDD:238011 9/67 (13%)
EGF_CA 250..287 CDD:238011 16/36 (44%)
EGF_CA 290..325 CDD:238011 14/58 (24%)
EGF_CA 367..405 CDD:238011 15/37 (41%)
EGF_CA 407..443 CDD:238011 18/35 (51%)
EGF_CA 445..481 CDD:238011 21/35 (60%)
EGF_CA 483..519 CDD:238011 17/36 (47%)
EGF_CA 521..556 CDD:238011 15/35 (43%)
EGF_CA 560..594 CDD:238011 13/33 (39%)
EGF_CA 596..631 CDD:238011 10/34 (29%)
EGF_CA 634..668 CDD:238011 14/33 (42%)
EGF_CA 672..705 CDD:238011 16/33 (48%)
EGF_CA 708..744 CDD:238011 12/40 (30%)
EGF_CA 746..781 CDD:238011 13/129 (10%)
EGF_CA 824..860 CDD:238011 10/48 (21%)
EGF_CA 862..897 CDD:238011 15/165 (9%)
EGF_CA 902..936 CDD:238011 15/54 (28%)
EGF_CA 938..974 CDD:238011 12/35 (34%)
EGF_CA 977..1012 CDD:238011 18/34 (53%)
EGF_CA 1015..1050 CDD:238011 13/39 (33%)
EGF_CA 1103..1137 CDD:238011 3/33 (9%)
EGF_CA 1140..1175 CDD:238011 18/34 (53%)
EGF_CA <1193..1220 CDD:238011 6/26 (23%)
EGF_CA 1222..1260 CDD:238011 10/37 (27%)
Notch 1392..1423 CDD:278494
Notch 1429..1462 CDD:278494
Notch 1475..1502 CDD:278494
NOD 1508..1559 CDD:284282
NODP 1577..1634 CDD:284987
ANKYR <1784..1896 CDD:223738
ANK <1784..1895 CDD:238125
ANK repeat 1791..1839 CDD:293786
ANK repeat 1841..1872 CDD:293786
Ank_5 1861..1916 CDD:290568
ANK 1869..1995 CDD:238125
ANK repeat 1875..1906 CDD:293786
ANK repeat 1908..1939 CDD:293786
Ank_2 1913..2005 CDD:289560
ANK 1936..2057 CDD:238125
ANK repeat 1941..1972 CDD:293786
ANK repeat 1974..2005 CDD:293786
Ank_2 1979..>2039 CDD:289560
Amelogenin 2232..2325 CDD:197891
DUF3454 2384..2445 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I11659
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.710

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