DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and notch2

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_001108566.2 Gene:notch2 / 58065 ZFINID:ZDB-GENE-000329-4 Length:2475 Species:Danio rerio


Alignment Length:1989 Identity:507/1989 - (25%)
Similarity:691/1989 - (34%) Gaps:773/1989 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   255 CSDHDLFTRLPDNFCLNDPCMGHGTCSSSPEG-YECRCTARYSGKNCQKDNGSPCAKNPCENGGS 318
            |.||:            .||: :|||..|..| :.|||...:.|:.|.  :..||....|:|||.
Zfish    28 CIDHE------------KPCV-NGTCVISSNGTHYCRCAPGFLGEYCH--HSDPCNLLYCKNGGE 77

  Fly   319 C---LENSRGDYQCFCDPNHSGQHCETEVN--IHPLCQTNPCLNNGACVVIGGSGALTCECPKGY 378
            |   :....|...|.|....:|:|||.:.|  .:|   .|||.|.|.|::: .:....|:|..|:
Zfish    78 CKVSVAGVPGSPSCVCPLGFAGEHCEIQKNSTCYP---NNPCTNGGKCLLL-PNDQYKCQCALGW 138

  Fly   379 AGARCEVDTDECASQPCQNNGSCIDRIN-GFSCDCSGTGYTGAFCQTNVDEC-DKNPCLNGGRCF 441
            .|..||.: |.|.|.||.|.|.|....| .:||.|: .|:.|:.|..:.||| |...|.|.|.|.
Zfish   139 TGQHCEQE-DACLSSPCANKGICNALPNREYSCTCA-PGFHGSRCLNDTDECVDPLVCKNKGVCV 201

  Fly   442 DTYGWYTCQCLDGWGGEICDRP-MTCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQ 505
            :|.|.|.|.|..|:.|..|..| ..|....|.|||||             ..|.|...:      
Zfish   202 NTIGSYRCNCQPGFTGLDCGSPYFPCSPSPCQNGGTC-------------RQTTETTYV------ 247

  Fly   506 QCPIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPP 570
                        |.|.||.:|                                            
Zfish   248 ------------CHCLPGFNG-------------------------------------------- 256

  Fly   571 ITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYN 635
                                     |....:::.||...|.||.||:.....|:|.|...:||..
Zfish   257 -------------------------TNCEVNIDDCPDHRCQNGATCMDGVNTYNCQCPPEWTGQF 296

  Fly   636 CQTSTGDGASALALTPINCNATNGKCLNGGTCS--MNGTHCYCAVGYSGDRC-EKAENCSPLNCQ 697
            |.....:           |......|.||||||  .||.:|.|..|:||..| |..::|:...|.
Zfish   297 CTDDVDE-----------CRLQPNACQNGGTCSNTRNGYNCVCVNGWSGLDCSENIDDCAAEPCT 350

  Fly   698 EPMVCVQN----QCLCPENK---VC---NQCATQPCQNGGECVDLP-NGDYECKCTRGWTGRTCG 751
            ....|:..    .|.||..|   :|   :.|.:.||:.|..|...| ||.:.|.|..|:.|.||.
Zfish   351 AGSTCIDRVASFVCSCPPGKTGLLCHIDDACISNPCKMGAHCDTNPVNGKFSCNCPSGYKGSTCA 415

  Fly   752 NDVDECTLHPKICGN-GICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAYE 815
            .|:|||.:.|..|.: |.|||.:||:.|.|.||:||..|:.|::||.|.||.|.|||.::|..|.
Zfish   416 EDIDECVIGPNPCEHGGSCKNTEGSFTCNCAPGYTGPRCEQDINECGSNPCQNDATCLDQIGDYT 480

  Fly   816 CVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNG 880
            |:|.||::|.:||.||:||.|:||.|...|:|:::.|.|.|..|.||..|.:|||:|...||.||
Zfish   481 CICMPGFDGTHCENDINECLSSPCLNNGRCLDQVSRFVCECPQGFTGETCQVDIDECASTPCHNG 545

  Fly   881 GQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQD 945
            .:|:|:..|:.|:|: .|:.|..|..||::|...||.:| ||:|.:..:.|||..||.|..|.:.
Zfish   546 AKCLDRPNGYECECA-EGFTGPLCMENINDCEPQPCHHG-KCIDGIATFHCDCLPGYMGPICSEQ 608

  Fly   946 INECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEINI 1010
            |.||:|:|||..|.|::..|                          .|:|.|.||..|:||:||.
Zfish   609 IRECQSDPCQNGGRCVDMVN--------------------------RYQCNCQPGTAGENCQINY 647

  Fly  1011 NECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEINIDECDRYNPCQR-GTCYDQIDDYDCDCD 1074
            ::|.|||| :||.|.|||..|.|.||||:.|..|...|:||.. ||||. |||.|:::.:.|.|.
Zfish   648 DDCASNPC-QHGTCEDGINEYKCVCEPGYTGERCADEINECSS-NPCQSGGTCEDKVNGFKCKCP 710

  Fly  1075 ANYGGKNCSVLLKGCDQNPCLNGGACL----PYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVA 1135
            ....|..|......|.:.||.: |.|:    .||         |.||.|::|..|::        
Zfish   711 VGTYGPLCLSGADRCIRMPCRH-GECIGKQEGYL---------CQCEPGWEGTNCDQ-------- 757

  Fly  1136 TSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGV 1200
                                               ||||.:|                 |..:. 
Zfish   758 -----------------------------------EKNECLS-----------------NPCQN- 769

  Fly  1201 FIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPNLKSYL 1265
              |...||                 ..||...:...|                            
Zfish   770 --GGTCND-----------------RLNDYTCVCARG---------------------------- 787

  Fly  1266 RHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGECTDL 1330
                     |.|...:|.:|                             :|:.|||.:.|.|.|.
Zfish   788 ---------FAGFNCEININ-----------------------------ECESNPCMNQGTCVDG 814

  Fly  1331 WHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTREPTG 1395
            .:::.|||..|:.|..|...:....                                        
Zfish   815 VNSYVCHCKPPYTGKHCLEKLIPCA---------------------------------------- 839

  Fly  1396 QVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQ 1460
                      ..|.:..|                                               
Zfish   840 ----------SQPCQRRG----------------------------------------------- 847

  Fly  1461 TLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVP 1525
             :.|..|:.|.|..|..|  |...||                                       
Zfish   848 -VCQPSLDYTSYTCKCHS--GWEGAQ--------------------------------------- 870

  Fly  1526 KEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDLC 1590
                                                           .|.|:          |.|
Zfish   871 -----------------------------------------------CTEDK----------DEC 878

  Fly  1591 RKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQEIEFCQHVTCPGQSLCQNLDDGYECVTNTTFTG 1655
            :|:||.:.|.|.|....|.|:||.||.|.|||                .|:||   |.:|.    
Zfish   879 KKSPCQNGARCVNIVGSYRCECPPGYSGDNCQ----------------TNIDD---CSSNP---- 920

  Fly  1656 QERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFEIGVNGGRVT 1720
                                                  .|.|||.  :|.|          ||  
Zfish   921 --------------------------------------CRNGGTC--VDKV----------GR-- 933

  Fly  1721 ITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWESMVDPTPAFSTDIDQAAFQS 1785
                                                                             
Zfish   934 ----------------------------------------------------------------- 933

  Fly  1786 LIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAELYSRTNVSVQQK 1850
                    ||                        |  |.|.|           .|..        
Zfish   934 --------YL------------------------C--ECRAG-----------FYGE-------- 945

  Fly  1851 AQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGDDCGTDIDECLNTECLNNGT 1915
                    |.||....|..:.|.|.|.|....:.|.|.|.||::|.:|..||.:|..|.||||||
Zfish   946 --------RCEEEVDECASNPCWNGGHCTDYVNSYTCQCPPGYDGINCERDIPDCTETSCLNNGT 1002

  Fly  1916 CINQVAAFFCQCQPGFEGQHCEQNIDECADQPCHNGGNCTDLIASYVCDCPEDYMGPQCDVLKQM 1980
            |::.:..|.|:|:.||.||:|:..::||...||.|||.|.|.:.::.|:||..|.|..|:.:..:
Zfish  1003 CVDGINHFSCRCRQGFSGQYCQFELNECDSHPCKNGGTCIDGLGTFHCNCPLMYNGKTCESMVNL 1067

  Fly  1981 TCENEPCRNGSTCQNGFNASTGNNFTCTCVPGFEGPLCDIP------------FCEITPCDNGGL 2033
             |....|:||.||     .....|:.|:|.||:.|..||||            ..|...|.:.|.
Zfish  1068 -CSQIKCQNGGTC-----IQKEINWRCSCQPGWTGLYCDIPSMSCHAVALNKGVAENMVCKHAGH 1126

  Fly  2034 CLTTGAVPMCKCSLGYTGRLCEQDINECESNPCQNGGQCKDLVGRYECDCQGTGFEGIRCENDID 2098
            |...|....|:|..||||..||.:|:||.|:||:|||.|.|..|.|:|.|: .||:|:.||.:::
Zfish  1127 CKNIGNTHQCECQKGYTGSYCETEIDECLSSPCRNGGTCVDYQGGYDCKCK-AGFQGVNCEYNVN 1190

  Fly  2099 ECNMEGDYCGGLGRCFNKPGSFQCICQKPYCGAYCNF-TDPCNATDL---CSNGGRCVESCGAKP 2159
            ||  :.:.|...|.|.:....|.|.|.....|..|.. .|.| |.:.   |.|||:||:..|.  
Zfish  1191 EC--QSNPCRNGGTCIDLINHFSCSCPPGTKGLQCEVDVDEC-APEFGPRCKNGGQCVDGVGR-- 1250

  Fly  2160 DYYCECPEGFAGKNCTAPITAKEDGPSTTDIAIIVIPVV 2198
             |.|.||.||||::|...:.....||..:...|..:|::
Zfish  1251 -YTCNCPPGFAGEHCEGDVNECRSGPCYSPGTIDCVPLI 1288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 14/37 (38%)
EGF_CA 425..460 CDD:238011 15/35 (43%)
EGF 466..495 CDD:278437 8/28 (29%)
EGF 605..633 CDD:278437 10/27 (37%)
EGF_CA 716..750 CDD:238011 12/34 (35%)
EGF_CA 753..789 CDD:238011 18/36 (50%)
EGF_CA 792..828 CDD:238011 17/35 (49%)
EGF_CA 830..865 CDD:238011 16/34 (47%)
EGF_CA 868..905 CDD:238011 15/36 (42%)
EGF_CA 907..943 CDD:238011 15/35 (43%)
EGF_CA 1009..1045 CDD:238011 19/35 (54%)
EGF_CA 1047..1082 CDD:238011 14/35 (40%)
Laminin_G_1 1155..1290 CDD:278483 16/134 (12%)
EGF 1316..1346 CDD:278437 12/29 (41%)
Laminin_G_1 1388..1550 CDD:278483 11/161 (7%)
EGF_CA <1593..1622 CDD:238011 13/28 (46%)
Laminin_G_2 1692..1828 CDD:280389 13/135 (10%)
EGF_CA 1901..1937 CDD:238011 18/35 (51%)
EGF_CA 1939..1974 CDD:238011 14/34 (41%)
EGF_CA 2057..2094 CDD:238011 18/36 (50%)
EGF_CA 2096..2133 CDD:238011 9/36 (25%)
EGF_CA 2137..2175 CDD:238011 18/40 (45%)
notch2NP_001108566.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 50 1.000 Domainoid score I11659
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.710

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