DRSC/TRiP Functional Genomics Resources

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Protein Alignment crb and fbn2b

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_001129262.1 Gene:fbn2b / 571786 ZFINID:ZDB-GENE-090112-3 Length:2868 Species:Danio rerio


Alignment Length:2536 Identity:581/2536 - (22%)
Similarity:828/2536 - (32%) Gaps:964/2536 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   228 DGPGLQFVNNSTVQNVVFGHCPLTPGPCSDHDLFTRLPDNFCLNDPCMGHGTCSSSPEGYECRCT 292
            :|.|.|.:..|.:.......|        .|  ||    |.|||      |.|..:|..|.|.|.
Zfish   438 NGNGGQKIQISQLNETTIDVC--------KH--FT----NLCLN------GRCIPTPTSYRCECN 482

  Fly   293 ARY----SGKNCQKDNGSPCAKNPCENGGSCLENSRGDYQCFCDPNHSG----QHCETEVNIHPL 349
            ..|    .|:....|.   |..|||.| |.|: |::|.|.|.|...:.|    |.|   ::|...
Zfish   483 MGYRQDVRGECIDVDE---CVSNPCVN-GDCV-NTQGSYHCKCHEGYQGTPTKQAC---IDIDEC 539

  Fly   350 CQTNPCLNNGACVVIGGSGALTCECPKGYA----GARCEVDTDECASQPCQNNGSCIDRINGFSC 410
            ........||.||  ...|:..|.|..|:.    |..| :|.||||:.....||.||:....|.|
Zfish   540 IVNGVMCRNGRCV--NTDGSFQCICNAGFEISPDGKNC-IDHDECATTNMCLNGMCINEDGSFKC 601

  Fly   411 DCSGTGY----TGAFCQTNVDECDKNP-CLNGGRCFDTYGWYTCQCLDGWG----GEIC-DRPMT 465
            .|. .|:    .|.:| |::|||..:. |:| |||.:|.|.:.|:|..|..    |.:| |..|.
Zfish   602 ICK-PGFALAPNGRYC-TDIDECHTSGICMN-GRCVNTEGSFRCECPPGLAIDVDGRVCVDTHMR 663

  Fly   466 CQTQQCLNGGTCLDKPI-----GFQCLCP-PEY-TGELCQIAPS---------CA---------- 504
            ......:..|.| .:|.     ..:|.|. ||: .||.||..|:         |:          
Zfish   664 TTCYGAIKMGVC-SRPFPGAVTKSECCCANPEHGFGEPCQPCPAFNSAEFQAVCSSGPGITTDGR 727

  Fly   505 --QQCPIDSE-CVGG---------KCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPA 557
              .:|.:|.: |..|         :|:|.      ||:            |...:.:...:.|..
Zfish   728 DINECALDPDICQNGICENLRGSYRCICN------IGY------------ESDASGKNCVDINEC 774

  Fly   558 IPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGN 622
            :.|.|.....:     .|...|:.|.| .|.....::.::....:|.|....|:| |.|...:|:
Zfish   775 LVNRLLCDNGM-----CRNTPGSYTCS-CPKGFSFKADSETCEDINECDSNPCIN-GICRNIAGS 832

  Fly   623 YSCICASGYTGYNCQTSTGDGASALALTPI--NC--NATNGKC---LNGGT-----CSMNGTHCY 675
            ::|.|:.|        |..|..:.:.:..:  .|  |..:|:|   :||.|     ||..|    
Zfish   833 FNCECSHG--------SKLDSTNTVCVDSMKGTCWLNIQDGRCEVNINGATLKSECCSTLG---- 885

  Fly   676 CAVGYSGDRCEKAENCSP-------LNCQE-------PMVCVQNQCL---------CPE------ 711
            .|.|...:|||....||.       |.|::       |.||...:|:         |||      
Zfish   886 AAWGSPCERCEIDPACSKGFGRMKGLVCEDINECEVFPGVCTNGRCVNTQGSFRCECPEGLTLDG 950

  Fly   712 -NKVCNQCATQPCQ---NGGECVDLPNGDYE---CKCTRG--W---------------------- 745
             .:.|....::.|.   :..|||:...|.|.   |.||.|  |                      
Zfish   951 AGRTCVDVRSEQCYMKWDEDECVEPLPGRYRVDMCCCTVGAAWGVDCEACPKPNTNEFKTICPRG 1015

  Fly   746 ----------TGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGV----HCDSDVDEC 796
                      |||....||:||.:...:|.:|.|:|..||:||.|..||...    :| :|:|||
Zfish  1016 PGIANRGDILTGRPFYKDVNECKVFRGLCTHGTCRNTIGSFKCRCDSGFALTMEERNC-TDIDEC 1079

  Fly   797 LSFPCLNG-ATCHNKINAYECVCQPGYEG-----ENCEVDIDECGSNP--CSNGSTCIDRINNFT 853
            ...|.|.| ..|.|...::||.|..|||.     :|| :|||||..:|  | .|.||::...::.
Zfish  1080 TISPDLCGHGVCVNTPGSFECECFDGYESGFMMMKNC-MDIDECERDPLLC-RGGTCLNTEGSYE 1142

  Fly   854 CNCIPG----MTGRICDIDIDDC-VGDPCLNGGQCIDQLGGFRCDCSGTGY----EGENCELNID 909
            |:|.||    .....|: |:::| :.|.....|||::.:|.::|.|. |||    :.:.| ::||
Zfish  1143 CDCPPGHQLSTEASACE-DVNECQLSDNLCKHGQCVNMVGTYQCSCE-TGYQVTPDRQGC-VDID 1204

  Fly   910 EC--LSNPCTNGAKCLDRVKDYFCDCHNGY----KGKNCEQDINECESNP--CQYNGNCLERSNI 966
            ||  ::..|  ...|.:....|.|.|..||    ..:.| .||:|||..|  |. .|.|      
Zfish  1205 ECTIMNGGC--DTHCTNSEGSYECSCSEGYALMPDLRTC-ADIDECEDTPDICD-GGQC------ 1259

  Fly   967 TLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIG----KNCEININECDSNP---------- 1017
                    |::|            ..|.|:|..|.:.    :.| |::||||.||          
Zfish  1260 --------TNIP------------GEYRCLCYDGFMASMDMRTC-IDVNECDLNPNICLHGDCEN 1303

  Fly  1018 ----------------------------------CSKHGNCNDGIGTYTCECEPGFEGTHCE-IN 1047
                                              |..|..|.:..|::.|.|..|:||...: |:
Zfish  1304 TKGSFICHCQLGYFVKKGSTGCTDVDECEIGAHNCDLHAACVNAPGSFKCRCRDGWEGDGIKCID 1368

  Fly  1048 IDEC--DRYNPCQRGTCYDQIDDYDCDCDANYGG--------KNCSVLLKGCDQNPCLN--GGAC 1100
            :|||  :.:|......|.:....|.|.|...:.|        ..|:..:..|:...|||  ||  
Zfish  1369 VDECVTEEHNCNPNAECLNTPGSYRCSCKEGFNGDGFSCSDMDECADNVNLCENGQCLNAPGG-- 1431

  Fly  1101 LPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLPNGVLA 1165
                       |.|.||.||       |.|....|...|.         :.|.|       .:..
Zfish  1432 -----------YRCECEMGF-------TPTEDSKACQDID---------ECNFQ-------NICV 1462

  Fly  1166 FGTTGEKNEP------VSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLV 1224
            ||:.  :|.|      ..|..||...                 |....|.|  :.|..:|     
Zfish  1463 FGSC--QNLPGMFRCVCDYGYELDRS-----------------GGNCTDIN--ECFDPVN----- 1501

  Fly  1225 LSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVN---- 1285
                            ..|....:.|.:||....|:.:.       .||. |||:...:.|    
Zfish  1502 ----------------CINGVCVNLPGSYLCNCPPDFEL-------NPSG-VGCVDTRVGNCFLD 1542

  Fly  1286 -----------------------------GKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNP- 1320
                                         |.|..|.|....::.|:.:.:   ||..|..:||| 
Zfish  1543 TLDRGDGGISCSAEIGVGVTRASCCCSLGGAWGNPCELCPFVNSTEYKTL---CPGGEGFRPNPI 1604

  Fly  1321 ---------CH------SNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVET 1370
                     |.      ..|.|.:.:.:|.|.||             |..:.:|.|.    |.|.
Zfish  1605 TVILEDIDECQELPGLCQGGNCVNTFGSFQCECP-------------AGYYLNEETR----ICED 1652

  Fly  1371 TDVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAA------KLHGGELLVK 1429
            .|                   |.|..:...|    .....|...:|...      :::||...:.
Zfish  1653 ID-------------------ECTAHIGICG----PGTCYNTLGNYTCVCPPEYMQVNGGNNCMD 1694

  Fly  1430 MQ-------FSGTPE--------------AYTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYF 1473
            |:       |:.|.|              ||.||     ..:|...|....              
Zfish  1695 MRKSVCYRNFNDTCENELSFNMTKKMCCCAYNVG-----KAWNRPCEACPT-------------- 1740

  Fly  1474 RKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEADDSRDY---- 1534
                               ||.:...||.....||.|.....|.||       :.|:.|:.    
Zfish  1741 -------------------PATSEYQLLCGNQAPGFIIDIHTGKPI-------DIDECREIPGIC 1779

  Fly  1535 ---------------------FKGII---QDVKVSNGSLNLIVEMYSLNVTDVQV---------- 1565
                                 :..|:   :|:...|...||.    ..|...:.:          
Zfish  1780 ANGVCINQIGSFRCECPMGFSYNNILLICEDIDECNSGDNLC----QRNANCINIPGSYRCECSA 1840

  Fly  1566 --NAKPLGAVTIDR--ASVLP-----GEVSD-------------------------DLCRKNPCL 1596
              ...|.|| .|||  ...:|     ||..|                         |.|.:.|| 
Zfish  1841 GFKLSPSGA-CIDRNECQEIPNVCSHGECIDTQGSFRCLCHNGFKTTPDQTMCMDIDECDRQPC- 1903

  Fly  1597 HNAECRNTWNDYTCKCPNGYK-------------------------------------------- 1617
            .|..|:||...|.|.|..|::                                            
Zfish  1904 GNGTCKNTVGSYNCLCFPGFELTHNNDCMDIDECSVHASQVCRNGQCINNMGSFKCLCLDGYNLT 1968

  Fly  1618 --GKNCQEIEFCQHVTCPG---QSLCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIV-- 1675
              ||||.:|..|  ||.||   ...|||||..:.|:....:              |.|:|..|  
Zfish  1969 PDGKNCVDINEC--VTLPGACQPGTCQNLDGSFRCICPPGY--------------EVQNDKCVDI 2017

  Fly  1676 SEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFE--------IGVNGGRVTITWKLSALHFGE 1732
            :|.:    ::|.| ..|.|        ..|..|.|:        :..||.|...|        .|
Zfish  2018 NECN----VEPNI-CQFGT--------CKNTPGSFQCICQPGFVLSDNGRRCFDT--------RE 2061

  Fly  1733 S---ARFEKENTDGEWSRIYLRAH--NSKLEGGWKGWESMVDPTPAFSTDIDQAAFQSLIATSTQ 1792
            |   .|||.........|...:|.  .|.|.|  :||.   ||......|.::|||.:|.....:
Zfish  2062 SFCFTRFEAGKCSVPKPRNTTKAKCCCSLLPG--EGWG---DPCELCPRDTEEAAFHTLCPYGHE 2121

  Fly  1793 VYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAELYSRTNVSVQQKAQFRLNA 1857
            ..  ..||.|:            ....||..        |......|...|:.|.:.:..|..|.
Zfish  2122 AV--PKPEGRE------------DMNECVEN--------PEICGNGLCINTDGSFRCECPFGYNL 2164

  Fly  1858 TRPEEGCI----LCFQSDCKNDGFCQSPSDEYACTCQPGFEGDDCGT--DIDE-----------C 1905
            ......|:    ....:.|.| |.|.:....:.|:||.|||.....|  ||:|           |
Zfish  2165 DYTGVNCVDTDECSIGNPCGN-GTCSNVPGGFECSCQEGFEPGPMMTCEDINECAVNPLLCAFRC 2228

  Fly  1906 LNT--------------------------------ECLNNG-TCINQVAAFFCQCQPGF----EG 1933
            :||                                :|.:.| .|.||:..|.|.|.||.    :|
Zfish  2229 VNTFGSYECMCPTGYVLRDDNRMCRDQDECAEGLDDCASRGMACKNQIGTFMCICPPGMTRRPDG 2293

  Fly  1934 QHCEQNIDECADQP--CHNGGNCTDLIASYVCDCPEDY----MGPQC----------DVLKQMTC 1982
            :.| .:::||..:|  |.| |.|.:.:.||.|:|.|.:    .|.:|          :||:.|..
Zfish  2294 EGC-MDLNECRSKPGICKN-GRCVNTVGSYRCECNEGFEASATGTECIDNRKGFCFTEVLQTMCQ 2356

  Fly  1983 ENEPCRNGST----CQNGFNASTGNNF-----------------TCTCVPGFEGPLCDIPFCEIT 2026
            ::...||..|    |.||     |..:                 .|...||:.....||..||:.
Zfish  2357 QSSTNRNTVTKSECCCNG-----GRGWGSLCELCPLPGTIQYKKMCPLGPGYTTDGRDINECEVM 2416

  Fly  2027 P--CDNGGLCLTTGAVPMCKCSLGY----TGRLCEQDINECESNP------CQN----------- 2068
            |  |.| |.|:.:.....|.|::||    ||..| .|::||..:|      |:|           
Zfish  2417 PNLCKN-GQCINSVGSFRCHCNVGYTNDFTGTSC-IDMDECSQSPKPCNFLCKNTEGSYLCSCPR 2479

  Fly  2069 -------GGQCKDL-----------------VGRYECDCQGTGF--EGIRCENDIDECNMEGDYC 2107
                   |..||||                 :|.:.|.|. :||  ....| .|.:||:.:.:.|
Zfish  2480 GYILQPDGKTCKDLDECSTKQHNCQFLCVNTIGGFTCKCP-SGFTQHQTAC-IDNNECSNQPNIC 2542

  Fly  2108 GGLGRCFNKPGSFQCICQKPY----CGAYCNFTDPCNATDLCSNGGRCVESCGAKPDYYCECPEG 2168
            |....|.|.||||.|.|||.:    .|..|:..|.|.....|.:|  |....|.   |.|.||:|
Zfish  2543 GSRASCLNSPGSFNCECQKGFSLDATGLNCDDVDECGGNHRCQHG--CQNMMGG---YRCGCPQG 2602

  Fly  2169 F 2169
            :
Zfish  2603 Y 2603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058 581/2536 (23%)
EGF_CA 386..423 CDD:238011 14/40 (35%)
EGF_CA 425..460 CDD:238011 14/39 (36%)
EGF 466..495 CDD:278437 7/35 (20%)
EGF 605..633 CDD:278437 9/27 (33%)
EGF_CA 716..750 CDD:238011 14/73 (19%)
EGF_CA 753..789 CDD:238011 15/39 (38%)
EGF_CA 792..828 CDD:238011 16/41 (39%)
EGF_CA 830..865 CDD:238011 14/40 (35%)
EGF_CA 868..905 CDD:238011 12/41 (29%)
EGF_CA 907..943 CDD:238011 11/41 (27%)
EGF_CA 1009..1045 CDD:238011 15/79 (19%)
EGF_CA 1047..1082 CDD:238011 9/44 (20%)
Laminin_G_1 1155..1290 CDD:278483 25/173 (14%)
EGF 1316..1346 CDD:278437 10/45 (22%)
Laminin_G_1 1388..1550 CDD:278483 32/216 (15%)
EGF_CA <1593..1622 CDD:238011 13/74 (18%)
Laminin_G_2 1692..1828 CDD:280389 33/148 (22%)
EGF_CA 1901..1937 CDD:238011 17/83 (20%)
EGF_CA 1939..1974 CDD:238011 13/40 (33%)
EGF_CA 2057..2094 CDD:238011 16/79 (20%)
EGF_CA 2096..2133 CDD:238011 16/40 (40%)
EGF_CA 2137..2175 CDD:238011 11/33 (33%)
fbn2bNP_001129262.1 TB 194..227 CDD:279073
EGF_CA 287..328 CDD:214542
TB 344..381 CDD:279073
EGF_CA 495..525 CDD:214542 13/34 (38%)
EGF_CA 535..575 CDD:284955 10/41 (24%)
EGF_CA 577..607 CDD:238011 12/30 (40%)
cEGF 598..621 CDD:289433 7/24 (29%)
EGF_CA 618..658 CDD:214542 14/40 (35%)
TB 675..711 CDD:279073 11/36 (31%)
EGF_CA 728..769 CDD:214542 9/58 (16%)
EGF_CA 770..802 CDD:214542 8/37 (22%)
cEGF 792..815 CDD:289433 3/23 (13%)
TB 867..899 CDD:279073 12/35 (34%)
EGF_CA 915..956 CDD:214542 7/40 (18%)
TB 972..1007 CDD:279073 9/34 (26%)
EGF_CA 1075..1109 CDD:214542 15/33 (45%)
EGF_CA 1118..1150 CDD:214542 14/32 (44%)
vWFA <1200..1240 CDD:294047 12/42 (29%)
Plasmod_Pvs28 1250..1411 CDD:283826 37/188 (20%)
EGF_3 1331..1366 CDD:289699 9/34 (26%)
EGF_3 1372..1407 CDD:289699 7/34 (21%)
EGF_CA 1492..1523 CDD:214542 9/53 (17%)
TB 1553..1588 CDD:279073 4/34 (12%)
EGF_CA 1610..1642 CDD:214542 8/44 (18%)
cEGF 1632..1655 CDD:289433 10/58 (17%)
TB 1708..1745 CDD:279073 9/74 (12%)
EGF_CA 1768..1800 CDD:214542 2/31 (6%)
EGF_CA 1810..>1842 CDD:214542 5/35 (14%)
vWFA <1850..1889 CDD:294047 7/38 (18%)
EGF_CA 1894..1928 CDD:214542 12/34 (35%)
cEGF 1956..1979 CDD:289433 5/22 (23%)
EGF_CA 1976..2008 CDD:214542 12/47 (26%)
vWFA <2010..2054 CDD:294047 12/56 (21%)
TB 2073..2109 CDD:279073 10/40 (25%)
EGF_CA 2173..2212 CDD:214542 11/39 (28%)
vWFA <2211..2250 CDD:294047 6/38 (16%)
EGF_CA 2298..2338 CDD:304395 13/40 (33%)
TB 2358..2390 CDD:279073 7/36 (19%)
EGF_CA 2409..2450 CDD:214542 16/42 (38%)
vWFA <2441..2489 CDD:294047 10/48 (21%)
vWFA <2487..2523 CDD:294047 9/36 (25%)
EGF_CA 2574..>2603 CDD:214542 10/33 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 51 1.000 Domainoid score I11552
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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