DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and crb2b

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_001038627.1 Gene:crb2b / 568520 ZFINID:ZDB-GENE-060610-1 Length:1458 Species:Danio rerio


Alignment Length:1922 Identity:573/1922 - (29%)
Similarity:816/1922 - (42%) Gaps:534/1922 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   380 GARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTG--YTGAFCQTNVDECDKNPCLNGGRCFD 442
            |..|.|.::.|.|.|||||.:|:..::|:.|.||.:.  |||..|:..:|.||...|        
Zfish    23 GLFCTVSSEVCLSSPCQNNSTCVPTLDGYLCTCSSSPPIYTGPNCERLLDPCDSAGC-------- 79

  Fly   443 TYGWYTCQCLDGWGGEICDRPMTCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQQC 507
                                |.|                                          
Zfish    80 --------------------PST------------------------------------------ 82

  Fly   508 PIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPIT 572
                      |:..|||.                                               
Zfish    83 ----------CIATPGSQ----------------------------------------------- 90

  Fly   573 TSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQ 637
                                                             ||:|:|..|::|.||.
Zfish    91 -------------------------------------------------NYTCLCPDGFSGPNCT 106

  Fly   638 TSTGDGASALALTPINCNATNGKCLNGGTCSMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVC 702
            .:..:..|    .|  |:.....|::|    :||..|:|..||||..|                 
Zfish   107 QNINECHS----NP--CSGVRSFCVDG----VNGYSCHCPSGYSGADC----------------- 144

  Fly   703 VQNQCLCPENKVCNQCATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKICGNG 767
                     ......|:..||.|...||..|:| |||.|..|:.||.|..|:|||...|  |.||
Zfish   145 ---------GTRVRDCSDDPCFNNATCVWAPDG-YECHCAAGFRGRNCEEDIDECLSQP--CRNG 197

  Fly   768 -ICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENCEVDI 831
             ||::..|.|:|||.|||.|.||:.|::||.|.||.|..||.|..:.|.|.|..|:.|.|||||:
Zfish   198 AICQDAVGVYQCYCVPGFQGFHCEIDINECASQPCENNGTCVNGRDRYICECLFGFTGLNCEVDV 262

  Fly   832 DECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSG 896
            |||.::||.||:.|.|.:..:||.|:||..|..|::|||:|...||.:||.|:|.:.|:.|||||
Zfish   263 DECEASPCQNGAVCHDHVGLYTCECVPGYEGINCELDIDECESSPCRHGGVCLDMVNGYECDCSG 327

  Fly   897 TGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCL 961
            ||:.|..|:::|.||.|:||.:||.||:.|..|.|.|..||:|.|||.|::||.|.||:..|.|.
Zfish   328 TGFMGFFCDIDIPECSSDPCQHGATCLEGVNHYTCICWTGYEGVNCELDVDECVSQPCENEGQCF 392

  Fly   962 ERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCND 1026
            :||:.:||::     ||:: ...|||::|:||.|.||.|..|:||.:|:|||:|.||...|:|.|
Zfish   393 QRSDSSLYRV-----LPEL-DTDFSFQSAAGYLCQCVSGFTGENCSVNVNECESAPCENGGSCED 451

  Fly  1027 GIGTYTCECEPGFEGTHCEINIDECDRYNPCQ-RGTCYDQIDDYDCDC------DANYGGKNCSV 1084
            .:..:.|.|.|||.|..||..:|||:. :||| ||.|.|.|:.|.|.|      ...:||.:|||
Zfish   452 LVNAFQCSCPPGFAGAVCETELDECES-DPCQNRGRCEDSINAYICHCPPAEPGHLPWGGPDCSV 515

  Fly  1085 LLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLISV----TTER 1145
            .|.||...||.|...|:| .|....|.:.|.|.:||.|..|:.:||.|:.....:.:    ...|
Zfish   516 QLTGCVDQPCQNNATCIP-SIQHQQHQHTCRCPSGFHGTHCQTSTTFSITRGGYLLIDLHHKNNR 579

  Fly  1146 EEGY------DINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHS-----SLLNKWEG 1199
            ...|      .:.|:|||||.:||:.|  .|.:|.  .::||||.|.|...:     .|..|..|
Zfish   580 SRRYLDSHVPSVQLRFRTTLQDGVIFF--RGGQNH--FFVLELIAGELYCRAQSGDLKLFVKLNG 640

  Fly  1200 VFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRT-YLGGTIPNLKS 1263
            .|     .|..|..|.|:::....|||   |..:...|.:....:.||....| |:|| :|  :.
Zfish   641 DF-----GDGFWRGVSVSVDEGLTVLS---EGEMGEDGGHNQLLSFQPQGLETLYVGG-VP--QE 694

  Fly  1264 YLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGECT 1328
            :: :||...:.||||::|::|:.:.:.|.      |...|:.||.||.|||.|:.|||..:|.|.
Zfish   695 WM-NLTLSRTGFVGCLEDLVVDSEPVLPQ------SLVPLQEVQMGCERTEWCRVNPCSDHGRCV 752

  Fly  1329 DLWHTFACHCPRPFFGHTCQHNMTAATFGHE-NTTHSAVIV---ETTDVARRAIRSILDISMFIR 1389
            |||..:.|.|.||::|..|....|:.||.|| |.:.:|..:   .:.||.         :|:::|
Zfish   753 DLWSNYTCVCHRPYYGEHCSEEHTSWTFSHERNRSFAAFPIMQNHSRDVT---------VSLWLR 808

  Fly  1390 TREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEA--YTVGGQKLDNGYNH 1452
            :|...|.|..|..|         ...|:...|..|.|.:.: :|....|  :...|:|       
Zfish   809 SRHLNGLVLQLQHD---------NQPYLTLFLKNGSLYISI-YSSIRRASDFLTNGEK------- 856

  Fly  1453 LIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGG-PAPTRESLLGATTEPGIIPVPGAG 1516
            |...::.:..| :..|.|:......|...:....|:|||| |.....:|.|.             
Zfish   857 LFMSIKTEPGV-ILFNQTQRIPMIYSGFEVQVGDVVYLGGLPEGENSALWGG------------- 907

  Fly  1517 IPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDR--AS 1579
                             ||||.:|||::.:..|    .|||.:::.     ||..|..:.|  ::
Zfish   908 -----------------YFKGCLQDVRIDDTQL----FMYSGSISQ-----KPQHANYLPRNSSN 946

  Fly  1580 VLPGEVSDDLCRKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQEIEFCQHVTCPGQSLCQNLDDG 1644
            ||.|.|.|..|:..|||:..:|:..|||:.|.||..:.||.|:...:|....|..::.|.:|.||
Zfish   947 VLEGCVGDQTCKMKPCLNGGKCQVIWNDFMCLCPLNFSGKTCETRVWCVSDPCDPRTRCVDLPDG 1011

  Fly  1645 YECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIA--FRTR-AGGTLLYIDNV 1706
            |||:.|.||   |.:.|.|              ::.....:||:.|:  .||| ..||:|...|.
Zfish  1012 YECLANATF---ENNALKF--------------SANGSFFEPVMRISMDLRTREENGTILRSSNG 1059

  Fly  1707 DGFFEIGVNGGRVTITWKLSALHFGESARFEKENT--DGEWSRIYLRAHNSKLEGGWKGWESMVD 1769
            ..||.:|:....:.:.::.|  :..|...|..:.|  ||||.::.|.|.:|::..  ..|...:|
Zfish  1060 IEFFCMGLLNSSIIVKFRDS--NSLEVHAFISDVTVSDGEWHKVELYASSSRISA--FRWHMSID 1120

  Fly  1770 PTPA-FSTDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLPY 1833
            ..|| ||  :..|.......:||                   ......:.||:||.|:|.:.|.:
Zfish  1121 GNPAGFS--LSPAGNVDFFNSST-------------------VMLAENYTGCLGEVRIGGVHLSF 1164

  Fly  1834 FSMAELYSRTNVSVQQKAQF-RLNA-TRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGD 1896
            |      ...|....||.|| |:.. ..|..|||                               
Zfish  1165 F------GPLNEEAPQKTQFIRIGGMLEPHLGCI------------------------------- 1192

  Fly  1897 DCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQPCHNGGNCTDLIASY 1961
              |:.:  ||:..|||||||.:......|:|.||:.|:.|::|||||.:|||.. |:|.||:..|
Zfish  1193 --GSPL--CLSEPCLNNGTCTDLFNLAVCKCAPGWTGERCQENIDECGEQPCVQ-GSCQDLLGDY 1252

  Fly  1962 VCDCPEDYMGPQCDVLKQMTCENEPCRNGSTCQNGFNASTGNNFTCTCVPGFEGPLCDIPF---- 2022
            .|.||..:.|..||| :...|::..|.||.:|     .:|.:.:||.|:||..||.|...|    
Zfish  1253 ECRCPVGFGGKNCDV-EVDQCKDHQCENGGSC-----VATVSGYTCVCLPGHTGPYCRWRFPPRE 1311

  Fly  2023 CEI-TPCDNGGLCLTTGAVPMCKCSLGYTGRLCEQDINECESNPCQNGGQCKDLVGRYECDCQGT 2086
            |:: ..|:|||:|........|.|..|:||..||.||:||.|.||.|||.|   |.|:..     
Zfish  1312 CDVDLQCENGGVCSEGSWGANCTCRPGFTGVRCELDIDECVSEPCLNGGSC---VNRHNL----- 1368

  Fly  2087 GFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPYCGAYCNFTDPCNATDLCSNGGRC 2151
                                                                             
Zfish  1369 ----------------------------------------------------------------- 1368

  Fly  2152 VESCGAKPDYYCECPEGFAGKNCTAPITAKEDGPSTTDIAIIVIPVVVVLLLIAGALLGTFLVMA 2216
                     |:|||...|:|:||  .|| |:.........::::|:..:.:|:|...|...:..|
Zfish  1369 ---------YFCECLPDFSGENC--QIT-KQLQQELWPWLLLLVPLAGLSVLLAALALLCLIFSA 1421

  Fly  2217 RNKRATRGTYSPSAQEYCNPRLEMDNVLKPPPEERLI 2253
            |.||.:.||||||.||....|:||.:|||.|||||||
Zfish  1422 RMKRRSEGTYSPSRQEAAGARMEMGSVLKVPPEERLI 1458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 15/38 (39%)
EGF_CA 425..460 CDD:238011 4/34 (12%)
EGF 466..495 CDD:278437 0/28 (0%)
EGF 605..633 CDD:278437 5/27 (19%)
EGF_CA 716..750 CDD:238011 15/33 (45%)
EGF_CA 753..789 CDD:238011 19/36 (53%)
EGF_CA 792..828 CDD:238011 16/35 (46%)
EGF_CA 830..865 CDD:238011 16/34 (47%)
EGF_CA 868..905 CDD:238011 19/36 (53%)
EGF_CA 907..943 CDD:238011 18/35 (51%)
EGF_CA 1009..1045 CDD:238011 16/35 (46%)
EGF_CA 1047..1082 CDD:238011 16/41 (39%)
Laminin_G_1 1155..1290 CDD:278483 44/140 (31%)
EGF 1316..1346 CDD:278437 14/29 (48%)
Laminin_G_1 1388..1550 CDD:278483 34/164 (21%)
EGF_CA <1593..1622 CDD:238011 12/28 (43%)
Laminin_G_2 1692..1828 CDD:280389 35/139 (25%)
EGF_CA 1901..1937 CDD:238011 14/35 (40%)
EGF_CA 1939..1974 CDD:238011 17/34 (50%)
EGF_CA 2057..2094 CDD:238011 13/36 (36%)
EGF_CA 2096..2133 CDD:238011 0/36 (0%)
EGF_CA 2137..2175 CDD:238011 7/37 (19%)
crb2bNP_001038627.1 EGF_CA 108..144 CDD:238011 13/45 (29%)
EGF_CA 152..183 CDD:238011 14/31 (45%)
EGF_CA 185..221 CDD:238011 20/37 (54%)
EGF_CA 223..259 CDD:238011 16/35 (46%)
EGF_CA 261..297 CDD:238011 16/35 (46%)
EGF_CA 299..335 CDD:238011 19/35 (54%)
EGF_CA 338..374 CDD:238011 18/35 (51%)
EGF_CA 434..470 CDD:238011 16/35 (46%)
EGF_CA 474..>500 CDD:214542 14/26 (54%)
LamG 590..715 CDD:238058 44/140 (31%)
EGF_CA <743..771 CDD:238011 13/27 (48%)
LamG 784..919 CDD:238058 39/191 (20%)
EGF 957..987 CDD:278437 12/29 (41%)
Laminin_G_2 1044..1160 CDD:280389 36/140 (26%)
EGF 1197..1227 CDD:278437 14/29 (48%)
EGF_CA 1231..1265 CDD:238011 17/34 (50%)
EGF_CA 1269..1303 CDD:238011 13/38 (34%)
EGF_CA 1347..1383 CDD:238011 21/119 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H134710
Inparanoid 1 1.050 776 1.000 Inparanoid score I515
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D111153at2759
OrthoFinder 1 1.000 - - FOG0003041
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3765
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.900

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