DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and Notch3

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_064472.3 Gene:Notch3 / 56761 RGDID:620761 Length:2319 Species:Rattus norvegicus


Alignment Length:2163 Identity:529/2163 - (24%)
Similarity:711/2163 - (32%) Gaps:842/2163 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 PCSDHDLFTRLPDNFCLNDPCMGHGTCSSSPEGYE--CRCTARYSGKNCQKDNGSPCAKNPCENG 316
            ||.|             ..||...|.|:......|  |.|...:.|:.||.::  ||...||...
  Rat    43 PCLD-------------GSPCANGGRCTHQQPSREAACLCLPGWVGERCQLED--PCHSGPCAGR 92

  Fly   317 GSCLEN---SRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGY 378
            |.|..:   ....:.|.|.....|..|    ::...|.::||.:...|.| |..|...|.||.||
  Rat    93 GVCQSSVVAGVARFSCRCLRGFRGPDC----SLPDPCFSSPCAHGAPCSV-GSDGRYACACPPGY 152

  Fly   379 AGARCEVDTDEC-ASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFD 442
            .|..|..|.||| |...|::.|:||:....|.|.|. .||||..|:..:..|..:||.|||.|..
  Rat   153 QGRNCRSDIDECRAGASCRHGGTCINTPGSFHCLCP-LGYTGLLCENPIVPCAPSPCRNGGTCRQ 216

  Fly   443 TYG-WYTCQCLDGWGGEICDRPM-TCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQ 505
            :.. .|.|.||.|:.|:.|:..: .|...:|||||||:|....:.|.||||:||:.|        
  Rat   217 SSDVTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFC-------- 273

  Fly   506 QCPIDSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPP 570
                 :|.| .:|..:|                                                
  Rat   274 -----TEDV-DECQLQP------------------------------------------------ 284

  Fly   571 ITTSRTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYN 635
                                            |||.     |||||....|.:||:|.:|:||.:
  Rat   285 --------------------------------NACH-----NGGTCFNLLGGHSCVCVNGWTGES 312

  Fly   636 CQTSTGDGASALALTPINCNATNGKCLNGGTC--SMNGTHCYCAVGYSGDRCEKAENCSPLNCQE 698
            |..:..|.|:|:             |.:|.||  .:...:|.|.:|.:|           |.|..
  Rat   313 CSQNIDDCATAV-------------CFHGATCHDRVASFYCACPMGKTG-----------LLCHL 353

  Fly   699 PMVCVQNQCLCPENKVCNQCATQPCQNGGECVDLPNGDYECKCTRGWTGRTCGNDVDECTLHPKI 763
            ...||.|.  |.|:.:|:   |.|.          :|...|.|..|:||..|..|||||::....
  Rat   354 DDACVSNP--CHEDAICD---TNPV----------SGRAICTCPPGFTGGACDQDVDECSIGANP 403

  Fly   764 CGN-GICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAYECVCQPGYEGENC 827
            |.: |.|.|.:||:.|.|..|:||..|::||:||||.||.|.|||.::|..:.|:|..|:.|..|
  Rat   404 CEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTFC 468

  Fly   828 EVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRC 892
            |||||||.|:||.||..|.||:|.|:|.|..|.:|..|.:|:|:|...||.||.:|:||..|:.|
  Rat   469 EVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYEC 533

  Fly   893 DCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYN 957
            .|: .|:||..||.|:|:|..:||.:| :|:|.:..:.|.|..||.|..||..::||.|.||:|.
  Rat   534 RCA-EGFEGTLCERNVDDCSPDPCHHG-RCVDGIASFSCACAPGYTGIRCESQVDECRSQPCRYG 596

  Fly   958 GNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHG 1022
            |.||              ||            ...|.|.|.||..|.|||:||::|.||||: .|
  Rat   597 GKCL--------------DL------------VDKYLCRCPPGTTGVNCEVNIDDCASNPCT-FG 634

  Fly  1023 NCNDGIGTYTCECEPGFEGTHCEINIDECD----------------------------------- 1052
            .|.|||..|.|.|:|||.|..|.:.|:||.                                   
  Rat   635 VCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFHCLCPPGSLPPLCLPVNH 699

  Fly  1053 --RYNPCQRGTCYDQIDDYDCDCDANYGGKNCSVLL--KGCDQNPCLNGGACLPYLINEVTHLYN 1113
              .:.||..|.|:|....:.|.|:..:.|..||..|  ..|:..||..||.|....|.     ::
  Rat   700 PCAHKPCSHGVCHDAPGGFQCVCEPGWSGPRCSQSLAPDACESQPCQAGGTCTSDGIG-----FH 759

  Fly  1114 CTCENGFQGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRT-TLPNGVLAFGTTGEKNEPVS 1177
            |||..||||.:||   .||....||.......|...|   |... :.|.|               
  Rat   760 CTCAPGFQGHQCE---VLSPCTPSLCEHGGHCESDPD---QLTVCSCPPG--------------- 803

  Fly  1178 YILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETA 1242
                               |:|......:                      ||.|          
  Rat   804 -------------------WQGPRCQQDV----------------------DECA---------- 817

  Fly  1243 NNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSAFVG--CMQDIMVNGKWIFPDEQDANISYTKLEN 1305
             .:.|..|.    ||..||....|.:.|  ..:.|  |.|||                       
  Rat   818 -GASPCGPH----GTCTNLPGSFRCICH--GGYTGPFCDQDI----------------------- 852

  Fly  1306 VQSGCPRTEQCKPNPCHSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVET 1370
                    :.|.||||.:.|.|.|...:|:|.|...|.|..|..::...                
  Rat   853 --------DDCDPNPCLNGGSCQDGVGSFSCSCLSGFAGPRCARDVDEC---------------- 893

  Fly  1371 TDVARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGT 1435
                               ...|.|.    ||          ...:||:            |:.|
  Rat   894 -------------------LSSPCGP----GT----------CTDHVAS------------FTCT 913

  Fly  1436 -PEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRES 1499
             |..|  ||...:                                |.|||               
  Rat   914 CPPGY--GGFHCE--------------------------------TDLLD--------------- 929

  Fly  1500 LLGATTEPGIIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQ 1564
                                                                             
  Rat   930 ----------------------------------------------------------------- 929

  Fly  1565 VNAKPLGAVTIDRASVLPGEVSDDLCRKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQ-EIEFCQ 1628
                                     |..:.|.:...|.:..|.::|.|..||.|.:|| :::.|.
  Rat   930 -------------------------CSPSSCFNGGTCVDGVNSFSCLCRPGYTGTHCQYKVDPCF 969

  Fly  1629 HVTCPGQSLCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFR 1693
            ...|....:|.....|:||.....|||.          |.|...|..|:| |.|           
  Rat   970 SRPCLHGGICNPTHSGFECTCREGFTGN----------QCQNPVDWCSQA-PCQ----------- 1012

  Fly  1694 TRAGGTLLYIDNVDGFFEIGVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLE 1758
                                 ||||...|        |.......|                   
  Rat  1013 ---------------------NGGRCVQT--------GAYCICPPE------------------- 1029

  Fly  1759 GGWKGWESMVDPTPAFSTDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGE 1823
              |.|  .:.|             ..||..|....::|...|.....|.....:..|.:..| .|
  Rat  1030 --WSG--PLCD-------------IPSLPCTEAAAHMGVRLEQLCQAGGQCIDKDHSHYCVC-PE 1076

  Fly  1824 ARVGDLLLPYFSMAELYSRTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACT 1888
            .|:|                              :..|:....|....|::.|.|:.....|.|.
  Rat  1077 GRMG------------------------------SHCEQEVDPCTAQPCQHGGTCRGYMGGYVCE 1111

  Fly  1889 CQPGFEGDDCGTDIDECLNTECLNNGTCINQVAAFFCQCQPGFEGQHCEQNIDECADQP------ 1947
            |..|:.||.|..|:|||.:..|.|.|:||:.||.:.|.|.||..|..||.|.|:|...|      
  Rat  1112 CPAGYSGDSCEDDVDECASQPCQNGGSCIDLVAHYLCSCPPGTLGVLCEINEDDCGPGPSLDSGL 1176

  Fly  1948 -CHNGGNCTDLIASYVCDCPEDYMGPQC------------------DVLKQ-------------- 1979
             |.:.|.|.||:..:.|:||..|.|..|                  |.|:.              
  Rat  1177 RCLHNGTCVDLVGGFRCNCPPGYTGLHCEADINECRPGTCHAAHTRDCLQDPGGHFRCICLPGFT 1241

  Fly  1980 --------MTCENEPCRNGSTCQNGFNASTGNNFTCTCV-------------------------- 2010
                    ..||::||::|..|:.......|..|||.||                          
  Rat  1242 GPRCQTALFPCESQPCQHGGQCRPSLGRGGGLTFTCHCVQPFWGLRCERVARSCRELQCPVGIPC 1306

  Fly  2011 ------------PGFEGPLCDI----------PFCEITPCDNGGLCLTTGAVPM--CKCSLGYTG 2051
                        ||..||.|.:          ..|..|||.:||.||...:||.  |.|:.|:.|
  Rat  1307 QQTARGPRCACPPGLSGPSCRVSRASPSGATNTSCAATPCLHGGSCLPVQSVPFFRCVCAPGWGG 1371

  Fly  2052 RLCE-----QDINE---CESNPCQ--NGGQCKDLVGRYECDCQGTGFEGIRCENDIDECNMEGDY 2106
            ..||     .::.|   |....||  .|.|..|    .||:..|.|::|..|..::|:   ....
  Rat  1372 PRCETPSAAPEVPEEPRCPRAACQAKRGDQNCD----RECNSPGCGWDGGDCSLNVDD---PWRQ 1429

  Fly  2107 CGGLGRCFNKPGSFQC--ICQKPYCGAYCNFTDPCNATDLCSNGGRCVESCGAKPDYYCECPEGF 2169
            |..| :|:....:.:|  .|..|.| .|.||.        |.:||| ..:|  .|.|...|.:.|
  Rat  1430 CEAL-QCWRLFNNSRCDPACSSPAC-LYDNFD--------CYSGGR-DRTC--NPVYKKYCADHF 1481

  Fly  2170 AGKNCTAPITAKEDGPSTTDIAIIVIPVVVVLLLIAGALLGTFLVMARNKRATRGTYSPSAQEYC 2234
            |...|......:|.|....|.|     ..|..||..|.|:.|.|:                    
  Rat  1482 ADGRCDQGCNTEECGWDGLDCA-----SEVPALLARGVLVLTVLL-------------------- 1521

  Fly  2235 NPRLEMDNVLKPPPEERL 2252
                        ||||.|
  Rat  1522 ------------PPEELL 1527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 16/37 (43%)
EGF_CA 425..460 CDD:238011 13/35 (37%)
EGF 466..495 CDD:278437 15/28 (54%)
EGF 605..633 CDD:278437 11/27 (41%)
EGF_CA 716..750 CDD:238011 8/33 (24%)
EGF_CA 753..789 CDD:238011 16/36 (44%)
EGF_CA 792..828 CDD:238011 17/35 (49%)
EGF_CA 830..865 CDD:238011 19/34 (56%)
EGF_CA 868..905 CDD:238011 16/36 (44%)
EGF_CA 907..943 CDD:238011 13/35 (37%)
EGF_CA 1009..1045 CDD:238011 19/35 (54%)
EGF_CA 1047..1082 CDD:238011 11/71 (15%)
Laminin_G_1 1155..1290 CDD:278483 20/137 (15%)
EGF 1316..1346 CDD:278437 13/29 (45%)
Laminin_G_1 1388..1550 CDD:278483 16/162 (10%)
EGF_CA <1593..1622 CDD:238011 8/28 (29%)
Laminin_G_2 1692..1828 CDD:280389 20/135 (15%)
EGF_CA 1901..1937 CDD:238011 16/35 (46%)
EGF_CA 1939..1974 CDD:238011 14/41 (34%)
EGF_CA 2057..2094 CDD:238011 12/41 (29%)
EGF_CA 2096..2133 CDD:238011 8/38 (21%)
EGF_CA 2137..2175 CDD:238011 10/37 (27%)
Notch3NP_064472.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
EGF_CA 160..197 CDD:238011 16/37 (43%)
EGF_CA 238..274 CDD:238011 17/48 (35%)
EGF_CA 276..313 CDD:238011 18/122 (15%)
EGF_CA 316..351 CDD:238011 12/58 (21%)
EGF_CA 393..431 CDD:238011 16/37 (43%)
EGF_CA 433..469 CDD:238011 17/35 (49%)
EGF_CA 471..507 CDD:238011 19/35 (54%)
EGF_CA 509..545 CDD:238011 16/36 (44%)
EGF_CA 547..582 CDD:238011 13/35 (37%)
EGF_CA 585..620 CDD:238011 18/60 (30%)
EGF_CA 622..656 CDD:238011 19/34 (56%)
EGF_CA 660..>688 CDD:238011 3/27 (11%)
EGF_CA 698..731 CDD:238011 8/32 (25%)
EGF_CA 738..772 CDD:238011 14/38 (37%)
EGF_CA 812..848 CDD:238011 12/74 (16%)
EGF_CA 851..886 CDD:238011 15/65 (23%)
EGF_CA 889..924 CDD:238011 12/97 (12%)
EGF_CA 931..962 CDD:238011 8/30 (27%)
EGF_CA 965..1000 CDD:238011 10/44 (23%)
EGF_CA 1087..1122 CDD:238011 10/34 (29%)
EGF_CA 1124..1160 CDD:238011 16/35 (46%)
EGF_CA 1173..1205 CDD:238011 10/31 (32%)
NL 1382..1419 CDD:197463 12/40 (30%)
LNR 1 1389..1429 13/46 (28%)
NL 1423..1460 CDD:197463 11/49 (22%)
LNR 2 1430..1467 14/47 (30%)
LNR 3 1469..1507 11/44 (25%)
Notch 1473..1502 CDD:395019 7/28 (25%)
NOD 1510..1562 CDD:399654 10/50 (20%)
NODP 1580..1639 CDD:400155
JMTM_Notch3 1620..1711 CDD:411987
ANKYR <1779..1895 CDD:223738
ANK repeat 1790..1838 CDD:293786
ANK repeat 1840..1871 CDD:293786
ANK 1 1840..1869
ANKYR 1860..2026 CDD:223738
ANK repeat 1873..1905 CDD:293786
ANK 2 1873..1903
ANK repeat 1907..1938 CDD:293786
ANK 3 1907..1936
ANK repeat 1940..1971 CDD:293786
ANK 4 1940..1969
ANK repeat 1973..2004 CDD:293786
ANK 5 1973..2002
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2026..2046
PHA03247 <2029..2316 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2059..2129
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2197..2319
DUF3454 2213..2269 CDD:403221
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFT
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.710

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