DRSC/TRiP Functional Genomics Resources

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Protein Alignment crb and svep1

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:XP_695742.6 Gene:svep1 / 567357 ZFINID:ZDB-GENE-110726-1 Length:3615 Species:Danio rerio


Alignment Length:2707 Identity:540/2707 - (19%)
Similarity:798/2707 - (29%) Gaps:1099/2707 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 CLNDPCMGHGTCSSSPEGYECRCTARYSGKNCQKDNGSPCAKNPCENGGSCLENSRGDYQCFCDP 333
            ||.:||...|||.....||.|.|...::|..|:.|. ..|...||:|||.| .:..||:||.|.|
Zfish  1198 CLLNPCQNQGTCEEVGVGYVCTCLPGFTGAKCESDI-DECDSAPCQNGGLC-RDGMGDFQCQCQP 1260

  Fly   334 NHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYAGARCEVDTDECASQPCQNN 398
            ...|..||.|||   .|.::||||.|.||  ......:|.||.|:.|.|||::.:||||.||||.
Zfish  1261 GFVGLLCEAEVN---ECSSSPCLNEGICV--DEVNYFSCSCPDGFTGPRCEMEINECASSPCQNE 1320

  Fly   399 GSCIDRINGFSCDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFDTYGWYTCQCLDGWGGEICDRP 463
            |.|.|...|:.|.|: .|:||..|:.:|:||...||||||.|.|....:.|:|::|:.|.:|...
Zfish  1321 GVCKDLEGGYFCTCA-QGFTGDNCEVDVNECYSAPCLNGGTCVDAINDFRCECVNGYRGRLCQVD 1384

  Fly   464 M-TCQTQQCLNGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQQCPIDSECVGGKCVCKPGSSGP 527
            : .|:...||||.||:|....|.|.|||.:.|..|:.....:.....:...:.|..:..      
Zfish  1385 VDDCELNLCLNGATCVDGVATFTCRCPPGFNGTRCETEMPYSFDLEFEVSGIHGYVMMD------ 1443

  Fly   528 IGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGT------------ 580
             || :|:.|..|    .|...|::...|...|             .|..:.|:            
Zfish  1444 -GH-MPSLTQIT----CTFWMRSSDTVNYGTP-------------VSYAVEGSDNAFLLIDYNGW 1489

  Fly   581 ---TTGSRRPPQQPLQSP--------TQRSAS------LNACPQE--NCLNGGTCLGYSGNYSCI 626
               ..|..|....|..:.        |.||..      ::..|.:  ..|:.||.:  .|..:.:
Zfish  1490 VLYVNGKERITDCPAVNDGLWHHIGVTWRSKDGDWRVYIDGSPSDGGKGLSIGTTI--PGGGALV 1552

  Fly   627 CASGYTGYNCQTSTGDGASAL---------------ALTPINCNATNGKC--------------- 661
            ....      |...|||.:.:               .|||....:....|               
Zfish  1553 LGQD------QDQRGDGFNPVESFVGTLSQLNIWNYVLTPQQIRSLASSCPHDLQKGNVFAWPDF 1611

  Fly   662 LNG--GTCSMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCA----- 719
            |.|  |.........:||            :|..:....|.:...::.:.|.:||...|:     
Zfish  1612 LGGVTGRVKTTSKSIFCA------------DCPLVETSVPHLLSSSKAVSPGSKVQFSCSPGFYL 1664

  Fly   720 ----TQPCQNGG------------EC---VDLPNGD-------------YECK------------ 740
                .|.|.|.|            ||   .||.:|.             |:||            
Zfish  1665 VGEPVQLCLNRGQWSHAEPICERVECGPPPDLEHGQYHGEDFYAGSSVLYQCKPGFYLLGESKMQ 1729

  Fly   741 CTRGWTGRTCGN-----DVDECTLHPKICGNGICKNEKGSYKCYCTPGFTG--------VHC-DS 791
            ||.  .|:..||     |||||:|..:...:..|:|..||:.|.|...::|        |.| |.
Zfish  1730 CTN--NGKWIGNPPACLDVDECSLGSECDEHASCQNTDGSHICTCIAPYSGDGRNCTEPVKCKDP 1792

  Fly   792 DVDEC-------------LSFPCLNG--------ATC-------------------HNKINAYEC 816
            .|.|.             :.|.|..|        .||                   |..:..|..
Zfish  1793 GVPEFGQREGTNFIMGSEVVFSCKEGYELIGSSQLTCTEEGFWKQDVPYCKALSCPHPTLPKYGI 1857

  Fly   817 V--------------CQPGY------EGENCEVDID-----------ECGSNP-------CSNGS 843
            :              |:.||      |.: |:.|:.           .||..|       ..||.
Zfish  1858 LKGANFTYGSKVTFSCEKGYVPLEPIESQ-CQSDLKWSREPHICQPITCGEPPVVDYAEYTLNGK 1921

  Fly   844 --------TCID--RIN---NFTCNCI------PGMTGRICDIDIDDC-----VGDPCLNGGQ-- 882
                    |||:  |:.   ...|...      |.|..|:      ||     :.|..:.|..  
Zfish  1922 IYRSTLSYTCIEGYRLQGAMELQCESSGEWTSPPPMCARV------DCGKPPPLKDAVIKGDNFT 1980

  Fly   883 --------CID---QLGGFRCDCSGTGYEGENCELNIDECLSNPC-----------TNGAKCLDR 925
                    |.|   .||....:|..:|    |...|..:|:...|           ..|.:....
Zfish  1981 LGSKIYYICKDGYTLLGAETQECLPSG----NWTRNSSQCVPRSCGPPPQVDHALPDTGHQLFGD 2041

  Fly   926 VKDYFCDCHNGYKGKN-----CEQD----------INECESNPCQYNGNCLERSNITLYQMSRIT 975
            :..||||  :||...|     |...          |..|.:|.||                 |..
Zfish  2042 IAIYFCD--DGYTAGNNTKLFCNAQGVWAPPDGFGIPHCIANFCQ-----------------RPP 2087

  Fly   976 DLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGI---GTYTCECEP 1037
            |||.......   |...|         ..|.|::.            .|.:|.   .|.|.:|..
Zfish  2088 DLPHAILDSI---NKPKY---------ASNTEVSY------------KCEEGFVLNTTGTLKCLI 2128

  Fly  1038 GFEGTHCEINID----ECDRYNPCQRGTC------YDQIDDYDCD------------CDAN--YG 1078
            |.|.|....:|.    .|.:....::|..      :..:..|.||            |.|:  :|
Zfish  2129 GGEWTPSPSDIGCMPVRCSKPESIEKGYVSGNNYGFGAVIAYSCDKGYFIRGEKKRICKASGEWG 2193

  Fly  1079 G--KNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNC----TCENGFQ-GDKCEKTTTLSMV-- 1134
            |  ..|..:  .|...|.|..| .:...|.:.:::||.    .|.:|:: ..|.|:|...:..  
Zfish  2194 GVLPTCQPI--SCPSPPRLANG-FIQGQIRKNSYVYNSKVTYACNDGYRLTGKPERTCMANKQWS 2255

  Fly  1135 -ATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYI----LELINGRLNLHSSLL 1194
             :.||:.|........||.        || |..|:|.|....|.::    .|||           
Zfish  2256 NSNSLVCVLLTCPTPPDIK--------NG-LYHGSTFEVGSKVEFVCNEGYELI----------- 2300

  Fly  1195 NKWEGVFIGSKLNDSNWHKVFV-----------AINTSHLVLSANDEQA---------------- 1232
                |..:.:.|...||.|..:           .:..:||||...|..:                
Zfish  2301 ----GDTVWTCLKFGNWDKSIIPRCSPVQCPEPPLEENHLVLRGLDSDSGTVELSCEEGYVLHGA 2361

  Fly  1233 -------------IFPV------GSYETANNSQPSFPRTYLGGT--------------------- 1257
                         .|||      |.........||..::|.|..                     
Zfish  2362 RTLRCTPSQEWNDSFPVCKQVFCGPPPEVAFGDPSDTQSYFGSVVTYSCMDGFTLRKEGSVHCQA 2426

  Fly  1258 ---------------------IPNLKSYLRHLTHQPSAFVGCM--QDIMVN--------GKWI-- 1289
                                 |||....::.|.:..:|...|.  .||:.|        |:||  
Zfish  2427 NGNWSKPYPQCIPVECPHPEDIPNGIVDVQGLMYLSTAVYSCKAGYDILGNSTVLCGQSGQWIGG 2491

  Fly  1290 ----------FPDE-QDANISYTKLENVQS---GCPRTEQCK-PN--PCHSNGE-------CTDL 1330
                      .|.| .:.::.|:||:..||   .|.|..:.: |.  .|..||:       |..:
Zfish  2492 IPVCHPVKCAAPKEIPNGSVRYSKLQFSQSITYFCQRGYRIQGPETLTCLENGQWDQEAPTCVPI 2556

  Fly  1331 WHTFACHCPRPF-----------FG----HTC--------QHNMTAATFGHENTTHSAVIVETTD 1372
            :    |..|:|.           ||    ::|        .:::|....|..::....|:.:.  
Zfish  2557 Y----CSPPKPIDNGFVEGRDRKFGVTIFYSCFPGFLLVGNNHLTCEDHGWSSSEPKCVLADC-- 2615

  Fly  1373 VARRAIRSILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPE 1437
                .:...:|...:.:.:|.:.:  |.....::.|..|       :.|||.  |||..      
Zfish  2616 ----GLPPHIDFGDYSKVQELSAE--YDMVTSQQLPVDN-------SFLHGS--LVKYH------ 2659

  Fly  1438 AYTVGGQKLDNGYNHLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLG 1502
                    ..:||.     :....::..:.:||......:.|....:|......|.....:|.||
Zfish  2660 --------CHSGYE-----INGAIMLMCREDGTWNGTAPMCTPAQCEAPPSPENGSVMVTDSALG 2711

  Fly  1503 ATTE---------------------------PGIIPV----PG---------------------- 1514
            :..|                           |..:|:    ||                      
Zfish  2712 SLAEYSCAEGYELNGQTIRQCISGQQWSDDAPRCLPISCGNPGGIANGEVIGKSFHFKELIHYEC 2776

  Fly  1515 -AGIPIEDT-TVPKEADDSRDYFKGIIQDVKVSNG--SLNLIVE----------MYSLNVTDVQV 1565
             :|..:|.. |...:.|...|....:.::|.....  |.:::|.          ::|.|:..:.:
Zfish  2777 HSGFVLEGVETRTCQVDGKWDNKAPLCKEVSCGRPVVSKDVLVRGDDHTFGKRLLFSCNLGFILL 2841

  Fly  1566 NAKPLGAVTIDRASVLPGEVSDDLCRKNPCLHNAECRNTWNDYTCKCPNGYKG--KNCQEIEF-- 1626
            .|..:..:.....:.:|.:.....|.:.|.:.|.  |.|..||      ||.|  :...:|.:  
Zfish  2842 GAPTIVCLANGSWNEVPPKCLPANCGQPPSIENG--RVTGTDY------GYNGMVRYACDIGYVL 2898

  Fly  1627 --------------------CQHVTC-PGQSLCQ--------NLDD--------GYE-------- 1646
                                |..:|| |.:.:..        |.||        |||        
Zfish  2899 TGNPTLICRADGLWDDPPPRCDIITCDPPEDISHGYLNGSSFNFDDIVEYICFPGYEVVGSPILR 2963

  Fly  1647 CVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVI---DIAFRTRAGGTLLYIDNVDG 1708
            |.....:.||                  |.|..|.....||.   .|..|....|..::....||
Zfish  2964 CAAEGVWLGQ------------------VPECRPCVCSPPVFKYGSILGRDHTCGASIWFRCDDG 3010

  Fly  1709 FFEIGVNGGRVTITWKLSALHFGESARFEKENTDGEWS---RIYLRAHNSKLEGGWKGWESMVDP 1770
            :..:|                 ...|..:|   .|.||   .|..|...|             .|
Zfish  3011 YKILG-----------------SSEAICDK---GGVWSPGVPICTRGRCS-------------IP 3042

  Fly  1771 TPAFSTDIDQAAFQSLIATSTQ-----VYLGGMPE---SRQARGS--TLSAQQGSQFKGC----- 1820
            .||....:.|.:....|.|.|.     .:|.|.|.   .|..|..  .||.:..|    |     
Zfish  3043 PPAVPNAVIQGSTAYTIDTVTYRCRPGYHLKGFPHISCGRLGRWGEPNLSCEPIS----CGVPPL 3103

  Fly  1821 VGEARVGDLLLPYFSMA--------ELYSRT-NVSVQQKAQFRLNATR----------------- 1859
            :..|.....:|.|.|.|        ||.::| :::.|....:..:..|                 
Zfish  3104 ISNAETVGAVLTYGSKAQYRCKEGFELATKTDSITCQSDGTWSKHGVRCRPSPCTLPTNLTHVVI 3168

  Fly  1860 ------PEEGCIL--CFQ---------SDCKNDG------------FCQSP-------------- 1881
                  |..|.::  |..         |:|...|            .|:.|              
Zfish  3169 TGKQLTPVGGTVIVSCRPGYYLEGPGLSECTVSGKWSPPLASCLPVICEKPLPILNGLVEGISYN 3233

  Fly  1882 -SDEYACTCQPGF----------EGD-------------DC------------------------ 1898
             .|....|||.||          :||             .|                        
Zfish  3234 YGDVVNFTCQQGFLLQGHSVRTCQGDKTWSGTQPVCAAVSCGPPPVVPNAVASSSGQTYKSIVSY 3298

  Fly  1899 ----GTDIDECLNTECLNNGT-------------C---------------INQVAAFFCQCQPGF 1931
                ||.:.:..|..|..||:             |               ::...|....|..|:
Zfish  3299 TCRQGTSLVDSQNLTCQANGSWSLPTPICEVPGGCEKITDLLNGKVQEHNLSSGRALEFHCNKGY 3363

  Fly  1932 --EGQH---CEQN------IDECADQPC----H----NGGNCTDLI----ASYVCDCP--EDYMG 1971
              :|:.   |..|      ...|..:||    |    ...|.|..:    .|....||  :....
Zfish  3364 TLQGESLVMCVGNGSWSSPFPVCLPKPCPPLPHGWTVGSANATQTVFSVGQSVQVSCPKGQRVKS 3428

  Fly  1972 PQCDVLKQMTCENEP--------CRNGSTC------QNGFNAST----GNNFTCTCVPGF----- 2013
            .|...:..:||.::.        |...| |      .||.....    |:....:|..||     
Zfish  3429 NQGKGIATLTCRSDQTWTPISAVCERVS-CGPPLYVSNGVVRGAVFQFGDMVLYSCYAGFTMEGS 3492

  Fly  2014 -------EGPLCDIPFCEIT---PCDNGGLCLTTGAVPMCKCSLGYTGRLCEQDINECESNPCQN 2068
                   .|.....|.|:..   .|.|||:|.....   |.|..|:.||.||:.|  | ..||.|
Zfish  3493 SRSVCLDNGTWTQPPTCKAVCWRHCQNGGVCQRPNT---CSCPEGWMGRFCEEPI--C-ILPCLN 3551

  Fly  2069 GGQCKDLVGRYECDCQGTGFEGIRCENDIDECNMEGDYCGGLGRCFNKPGSFQCICQKPYCGAYC 2133
            ||:|   |..|:|:|. .|:.|.||.|                          .:|..|      
Zfish  3552 GGRC---VAPYQCECP-AGWTGTRCHN--------------------------AVCSMP------ 3580

  Fly  2134 NFTDPCNATDLCSNGGRCVESCGAKPDYYCECPEGFAGKNCT 2175
                       |.|||||:     :|: .|.|..|:.|.:|:
Zfish  3581 -----------CLNGGRCI-----RPN-RCHCSPGWGGYDCS 3605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 17/36 (47%)
EGF_CA 425..460 CDD:238011 15/34 (44%)
EGF 466..495 CDD:278437 13/28 (46%)
EGF 605..633 CDD:278437 5/29 (17%)
EGF_CA 716..750 CDD:238011 16/82 (20%)
EGF_CA 753..789 CDD:238011 14/43 (33%)
EGF_CA 792..828 CDD:238011 13/95 (14%)
EGF_CA 830..865 CDD:238011 14/71 (20%)
EGF_CA 868..905 CDD:238011 11/54 (20%)
EGF_CA 907..943 CDD:238011 11/51 (22%)
EGF_CA 1009..1045 CDD:238011 8/38 (21%)
EGF_CA 1047..1082 CDD:238011 10/60 (17%)
Laminin_G_1 1155..1290 CDD:278483 40/248 (16%)
EGF 1316..1346 CDD:278437 10/54 (19%)
Laminin_G_1 1388..1550 CDD:278483 32/218 (15%)
EGF_CA <1593..1622 CDD:238011 9/30 (30%)
Laminin_G_2 1692..1828 CDD:280389 30/153 (20%)
EGF_CA 1901..1937 CDD:238011 9/68 (13%)
EGF_CA 1939..1974 CDD:238011 10/54 (19%)
EGF_CA 2057..2094 CDD:238011 15/36 (42%)
EGF_CA 2096..2133 CDD:238011 2/36 (6%)
EGF_CA 2137..2175 CDD:238011 11/37 (30%)
svep1XP_695742.6 VWA 78..253 CDD:278519
GCC2_GCC3 305..355 CDD:285001
CCP 373..429 CDD:153056
CCP 433..489 CDD:153056
CCP 493..550 CDD:153056
HYR 554..636 CDD:280629
DUF5011 637..716 CDD:295940
CCP 721..772 CDD:153056
GCC2_GCC3 1007..1054 CDD:285001
GCC2_GCC3 1061..1108 CDD:285001
GCC2_GCC3 1115..1162 CDD:285001
EGF_CA 1197..1230 CDD:238011 12/31 (39%)
EGF_CA 1232..1268 CDD:238011 15/37 (41%)
EGF_CA 1271..1306 CDD:238011 16/39 (41%)
EGF_CA 1309..1344 CDD:238011 17/35 (49%)
EGF_CA 1346..1382 CDD:238011 15/35 (43%)
EGF_CA 1384..1420 CDD:238011 14/35 (40%)
LamG 1420..1621 CDD:304605 34/233 (15%)
Sushi <1649..1685 CDD:278512 8/35 (23%)
CCP 1690..1743 CDD:153056 12/54 (22%)
EGF_3 1755..1783 CDD:289699 7/27 (26%)
CCP 1789..1843 CDD:153056 9/53 (17%)
CCP 1847..1901 CDD:153056 8/54 (15%)
CCP 1905..1958 CDD:153056 11/52 (21%)
CCP 1963..2017 CDD:153056 11/57 (19%)
CCP 2021..2079 CDD:153056 11/59 (19%)
CCP 2083..2136 CDD:153056 18/93 (19%)
PHA02927 2139..2379 CDD:222943 50/266 (19%)
CCP 2146..2200 CDD:153056 9/53 (17%)
CCP 2204..2257 CDD:153056 12/53 (23%)
CCP 2267..2321 CDD:214478 17/77 (22%)
CCP 2326..2380 CDD:153056 8/53 (15%)
CCP 2384..2438 CDD:153056 5/53 (9%)
CCP 2442..2495 CDD:214478 12/52 (23%)
CCP 2500..2554 CDD:153056 13/53 (25%)
CCP 2558..2611 CDD:153056 8/52 (15%)
CCP 2615..2687 CDD:153056 15/107 (14%)
CCP 2692..2745 CDD:214478 7/52 (13%)
CCP 2750..2804 CDD:153056 7/53 (13%)
CCP 2808..2861 CDD:153056 6/52 (12%)
CCP 2866..2919 CDD:153056 11/60 (18%)
CCP 2924..2978 CDD:153056 13/71 (18%)
CCP 2984..3034 CDD:214478 13/69 (19%)
PHA02927 3034..3269 CDD:222943 44/251 (18%)
CCP 3042..3094 CDD:153056 14/51 (27%)
CCP 3098..3153 CDD:153056 11/54 (20%)
PHA02927 3149..3454 CDD:222943 44/304 (14%)
CCP 3157..3211 CDD:153056 6/53 (11%)
CCP 3216..3269 CDD:214478 10/52 (19%)
CCP 3274..3328 CDD:153056 7/53 (13%)
Sushi 3333..3385 CDD:278512 7/51 (14%)
CCP 3457..3510 CDD:153056 9/52 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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