DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and megf6

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_001073658.1 Gene:megf6 / 567225 ZFINID:ZDB-GENE-070112-1202 Length:1339 Species:Danio rerio


Alignment Length:2125 Identity:396/2125 - (18%)
Similarity:573/2125 - (26%) Gaps:1018/2125 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly   249 PLTPGPCSDHDLFTRLPDNFCLNDPCMGHGT---------CSSSP--EGYECRCTARYS----GK 298
            |..|..|.:.::     ....:..||:...|         |||..  .||| |.|..|:    ..
Zfish    11 PDMPNVCEEQEM-----SMLGVKQPCVQAFTRLVKVWRQGCSSQRWCVGYE-RRTGYYTVYKQVY 69

  Fly   299 NCQKDNGSPCAKNPCENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGACVV 363
            |.:......|.....:.|     ..||              |     :|.:|.:..|.|.|.|  
Zfish    70 NMEMQTVFRCCPGWMQRG-----EERG--------------C-----LHRVCSSGTCFNGGKC-- 108

  Fly   364 IGGSGALTCECPKGYAGARCEVDTDECASQPCQNNGSCIDRINGFSCDCSGTGY---TGAFCQTN 425
             ..:....|:||.|:.|.||:.|.:|||.......|:|.:.|..:.|.|.|...   .|..|| :
Zfish   109 -SETSDHLCQCPDGFEGTRCQYDINECAVSNGGCEGTCCNSIGSYFCKCPGGSKLRDDGKSCQ-D 171

  Fly   426 VDECDKNPCLNGG---RCFDTYGWYTCQCLDGW----GGEICDRPMTCQTQQCLNGG---TCLDK 480
            :|||::   :|||   .|.:|.|.|.|:|.:|:    ....|....:|..:   |||   .|:| 
Zfish   172 IDECEE---MNGGCQQTCVNTLGSYHCECSEGFRIHADARTCIAVNSCSVK---NGGCEHKCVD- 229

  Fly   481 PIG---FQCLCPPEY----TGELCQIAPSCAQQ---CPIDSECVGG--KCVCKPGSSGPIGHCLP 533
             :|   ::|.|...|    .|:.|::...|...   |......|.|  :|.|:.|.:        
Zfish   230 -LGNEQYKCECRSNYQLKRDGKHCELKDPCKDHNGGCSQICTDVNGLVQCSCRTGFT-------- 285

  Fly   534 TTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQR 598
                                                                      |.:..:|
Zfish   286 ----------------------------------------------------------LANDLRR 292

  Fly   599 SASLNAC--PQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKC 661
            ...::.|  .|..|.:|  |:...|::.|:|..|:.         .||.......|.....||..
Zfish   293 CEDIDECVSGQTKCAHG--CVNIPGSFRCVCNPGFE---------LGADGKQCYRIEMEIVNGCE 346

  Fly   662 LNGGTCSMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNG 726
            .|.|.||              .|||...: .|| |.    |.|...|..:.|.|  ..|..|:||
Zfish   347 KNNGGCS--------------HRCEHTTS-GPL-CS----CNQGYQLAEDLKTC--IDTDECENG 389

  Fly   727 GECV-----DLPNGDYECKCTRGWT--GRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGF 784
            ..|.     :.|.| |||.|..|:|  |.|| :|:|||......|.. .|.|..|||:|:|..||
Zfish   390 EACCSHFCKNYPGG-YECGCRPGYTPNGCTC-DDIDECVSETSGCSQ-YCVNSLGSYECFCQVGF 451

  Fly   785 TGVHCDSDVDEC--------------------------LSFPCL----------NGATCH----N 809
               ..|.|...|                          |..|.|          ..|..|    :
Zfish   452 ---RLDYDQKSCSPLYQREVEQEEEDEDLFGSEVEPEVLHLPNLLFRRPPQLLHYTAALHRPYDD 513

  Fly   810 KINAY------------------ECVCQPGYEGENCEVDIDECGSNPCSNGSTCI---DRINNFT 853
            ..::|                  :.:|:.|..|::|.|..::     |.||..|.   ||     
Zfish   514 DTHSYYPEDTHDPEHREELTTISKSMCETGVFGDDCSVSCED-----CVNGGVCAAEKDR----- 568

  Fly   854 CNCIPGMTGRICDIDIDD----------CVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNI 908
            |.|.||.||.||:....:          ||   |.|||:| |.:.| :|.|. .|..|.:||   
Zfish   569 CVCPPGWTGLICNDTCPEGTYGAECNSLCV---CKNGGRC-DPVTG-KCLCP-PGVHGLHCE--- 624

  Fly   909 DECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSR 973
                     ||             |..|:.|:.|.:..|      |..||:|..     ||    
Zfish   625 ---------NG-------------CPQGFYGRLCRRRCN------CPNNGHCHR-----LY---- 652

  Fly   974 ITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDSNPCSK--HG-------------- 1022
                             .|  |:|.||:.||.|.:        ||.|  ||              
Zfish   653 -----------------GG--CLCTPGLYGKFCHL--------PCPKWSHGAGCSEECECVQENS 690

  Fly  1023 -NCNDGIGTYTCECEPGFEGTHCEINIDE------CDRYNPCQRG-TCYDQIDDYDCDCDANYGG 1079
             :|:..:|  ||.|:||:.|..|:.:.|:      |.....|..| :|..:..:....|.|.|.|
Zfish   691 LSCDPQMG--TCLCKPGYHGDRCQTDCDDGYFGVGCHGLCNCSDGKSCDPKTGECQRMCPAGYHG 753

  Fly  1080 KNCSVLLKGCDQN----PCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLIS 1140
            :.|.::   |:..    .|.|...|....::..:....|.||:|:.|..|:|..:..:.......
Zfish   754 EKCQMV---CEAGFWGAGCANVCQCASNAVSCESSSGRCVCESGYTGQHCDKKCSEGLYGADCKQ 815

  Fly  1141 VTTEREEGYDI-NLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGS 1204
            | .|.|.|.:. ::....|...|.:  |:..||..||.                       |.|.
Zfish   816 V-CECENGAECDHVSGACTCAAGWV--GSHCEKRCPVG-----------------------FYGQ 854

  Fly  1205 KL-------NDSNWHKVFVAINTS------HLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGG 1256
            ..       |::..|.:..|...:      |.:|:.       |.|::                 
Zfish   855 DCAQMCQCRNEAQCHHITGACRCTPGWAPPHCILAC-------PAGTF----------------- 895

  Fly  1257 TIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPC 1321
                                                                |...::.|   .|
Zfish   896 ----------------------------------------------------GLNCSQSC---DC 905

  Fly  1322 HSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISM 1386
            |:.|.|..:  :..|.|...:.|..||....:..|| :|.....:.                   
Zfish   906 HNGGSCDPV--SGQCSCAPGWTGDRCQQTCASGWFG-KNCEQKCIC------------------- 948

  Fly  1387 FIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYN 1451
                  |.|                :...:|..:            .|.|..||           
Zfish   949 ------PVG----------------VACDHVTGR------------CGCPAGYT----------- 968

  Fly  1452 HLIEVVRNQTLVQVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAG 1516
                                                                             
Zfish   969 ----------------------------------------------------------------- 968

  Fly  1517 IPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVL 1581
                                                                             
Zfish   969 ----------------------------------------------------------------- 968

  Fly  1582 PGEVSDDLCRKNPCLHNAECRNTWNDYTCKCPNGYKGKNCQEIEFCQHVTCPGQSLCQNLDDGYE 1646
                 .:.|.|                  .||.|..|.||..:  |   :|.|        |.|.
Zfish   969 -----GNSCEK------------------MCPQGRFGLNCSRV--C---SCSG--------DQYR 997

  Fly  1647 CVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFE 1711
            |   ...||                         :.:.:|                         
Zfish   998 C---HHITG-------------------------RCSCQP------------------------- 1009

  Fly  1712 IGVNGGRVTITWKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWESMVDPTPAFST 1776
             |.||.|..:..              :|.|.|.:.:                             
Zfish  1010 -GYNGNRCLLRC--------------REGTYGPYCK----------------------------- 1030

  Fly  1777 DIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAELYS 1841
                                                     |.|                     
Zfish  1031 -----------------------------------------KRC--------------------- 1033

  Fly  1842 RTNVSVQQKAQFRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGDDCGTDID--- 1903
                                         .|.|.|.|...:.  :|.||||:.|.:|.....   
Zfish  1034 -----------------------------SCANGGRCDFRNG--SCICQPGYFGPNCSISCPSGH 1067

  Fly  1904 ---ECLNT-ECLNNGTCINQVAAFFCQCQPGFEGQHCEQNID------ECAD-QPCHNGGNCTDL 1957
               :|... .|...|.|..:...  |.|.||..|..|||...      :|.. ..|.|||.|..:
Zfish  1068 YGRDCAQVCSCGEKGQCHPETGR--CNCAPGTTGLSCEQMCPRGRYGVQCRSFCTCANGGVCDPV 1130

  Fly  1958 IASYVCDCPEDYMGPQCDVL-----KQMTCENE-PCRNGSTCQNGFNASTGNNFT--CTCVPGFE 2014
              :..|.|...:.|..|:.:     ..:.||.: .|:|..||         :.||  |:|..|:.
Zfish  1131 --NGTCRCGLGWTGQHCEKVCVSGHYGVNCEQKCVCQNNGTC---------DRFTGCCSCPSGYY 1184

  Fly  2015 GPLCDIPFCEITPCDNGGLCLTTGAVPMCKCSLGYTGRLCEQDINECESNPCQNGGQCKDLVGRY 2079
            ||.|                       ..:|..|:.|.||.|   .|   .|:.|.||..:.|:.
Zfish  1185 GPAC-----------------------QHRCPAGFFGELCAQ---PC---VCKQGHQCDHVTGKC 1220

  Fly  2080 ECDCQGTGFEGIRCENDIDE----------CNMEGDYCG-GLGRCFNKPGSF--QC--ICQKPYC 2129
            ||.   .|:.|.:||...:.          |:.:|..|. ..|:|...||..  :|  :|...|.
Zfish  1221 ECP---PGYHGNQCEKRCESGRFGRDCAGVCDCDGASCDPTTGQCLCPPGKTGERCEKVCDSRYY 1282

  Fly  2130 GAYCNFTDPCNATDLCSNGGRCVESCGAKPDYYCECPEGFAGKNC 2174
            |..|:|  .|.    |.:||:|....|     :|.||:.:.|..|
Zfish  1283 GPDCSF--QCE----CVHGGQCDPQTG-----HCSCPQTWLGPTC 1316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 11/39 (28%)
EGF_CA 425..460 CDD:238011 13/41 (32%)
EGF 466..495 CDD:278437 10/38 (26%)
EGF 605..633 CDD:278437 9/29 (31%)
EGF_CA 716..750 CDD:238011 14/40 (35%)
EGF_CA 753..789 CDD:238011 14/35 (40%)
EGF_CA 792..828 CDD:238011 11/93 (12%)
EGF_CA 830..865 CDD:238011 12/37 (32%)
EGF_CA 868..905 CDD:238011 13/46 (28%)
EGF_CA 907..943 CDD:238011 5/35 (14%)
EGF_CA 1009..1045 CDD:238011 13/52 (25%)
EGF_CA 1047..1082 CDD:238011 9/41 (22%)
Laminin_G_1 1155..1290 CDD:278483 16/147 (11%)
EGF 1316..1346 CDD:278437 8/29 (28%)
Laminin_G_1 1388..1550 CDD:278483 7/161 (4%)
EGF_CA <1593..1622 CDD:238011 5/28 (18%)
Laminin_G_2 1692..1828 CDD:280389 9/135 (7%)
EGF_CA 1901..1937 CDD:238011 9/42 (21%)
EGF_CA 1939..1974 CDD:238011 9/41 (22%)
EGF_CA 2057..2094 CDD:238011 10/36 (28%)
EGF_CA 2096..2133 CDD:238011 11/51 (22%)
EGF_CA 2137..2175 CDD:238011 11/38 (29%)
megf6NP_001073658.1 EMI 15..83 CDD:284877 15/73 (21%)
FXa_inhibition 134..169 CDD:291342 9/34 (26%)
vWFA <159..209 CDD:294047 16/53 (30%)
FXa_inhibition 258..293 CDD:291342 8/100 (8%)
vWFA <293..332 CDD:294047 11/49 (22%)
FXa_inhibition 345..380 CDD:291342 14/54 (26%)
vWFA <372..413 CDD:294047 15/43 (35%)
vWFA <419..459 CDD:294047 17/44 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.