DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crb and fbn2a

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	XP_021334963.1	Gene:	fbn2a / 558217	ZFINID:	ZDB-GENE-090112-4	Length:	698	Species:	Danio rerio

Alignment Length:	770	Identity:	216/770 - (28%)
Similarity:	293/770 - (38%)	Gaps:	223/770 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 CDCSGTGYTGAFCQTNVDECDKNPCLNGGRCFDTYGWYTCQCLDGWGGEICDRPMTCQTQQCLNG 474
            |.|.| |.|...|.|...:.....|:|||.|.|.|    |||..|:.|..|.:|: |: :.|.||
Zfish     2 CTCPG-GQTATTCFTKSSKQCNIRCMNGGVCEDDY----CQCPKGYTGSFCGQPV-CE-KNCQNG 59

  Fly   475 GTCLDKPIGFQCLCPPEYTGELCQ----IAP--------SCAQQCPIDSECVGGKCVCKPGSSGP 527
            |.|:...   :|.|...:||..|:    ..|        .||.|   .||.|..|.:|.......
Zfish    60 GHCIGPN---RCACGYGFTGPQCERDYRTGPCFIQVHSRKCAGQ---SSEFVCSKALCCATVGQA 118

  Fly   528 IGH-CLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTK-------IPPITTSRTLVGTTTGS 584
            .|| |         ||.|   |.::|.....||||.|...:       :|.:......: .|.||
Zfish   119 WGHSC---------EQCP---PISSPCTRGFIPNTRTGACQDVDECKVVPDLCKGGRCI-NTLGS 170

  Fly   585 RRPPQQPLQSPT--QRSASLNACPQ-------ENCLNGGTCLGYSGNYSCICASGY--------- 631
            .:     ...|.  |:..|:..|..       |.....|.|:..:|::||:|.|||
Zfish   171 YQ-----CTCPVGYQQHVSILKCEDVDECSTIERACEAGHCINSAGSFSCVCPSGYVLSADRTRC 230

  Fly   632 ----TGYNCQTSTGDGASALALT----PINCNATNGKCLNGGT----CSMNGTHCY---CAVG-- 679
                ||. |..|..:|..|..::    .|.|....|:|.:..|    |.:.|:..|   |.||
Zfish   231 LDQHTGI-CFASVVNGRCAHEISGRFNKIQCCCDRGRCWSQRTTHEMCPVPGSDEYLRICLVGSA 294

  Fly   680 YSGDRCEKAENCSPLNCQEPMVCVQNQCLCPE--------------------------------- 711
            .||...|..| .||.:.....|...:|.|.|.
Zfish   295 LSGYNEEDPE-MSPHHHSSFSVSPNDQILHPHNGNGQIKPQIRQTPQILQFPQIPQIPRHDNGFK 358

  Fly   712 --------NKVCNQCATQP--CQNGGECVDLPNGDYECKCTRGWTGRTCG--NDVDECTLHPKIC 764
                    |:..|:|...|  |.| |.|:.: ..||.|.|..|:.....|  :|||||...|  |
Zfish   359 PQRPVVSVNETVNRCRLLPNLCLN-GRCIPM-ESDYRCDCNTGFKEDNRGECSDVDECEFDP--C 419

  Fly   765 GNGICKNEKGSYKCYCTPGF---TGVHCDSDVDECL--SFPCLNGATCHNKINAYECVCQPGY-- 822
            .||.|.|..|||.|.|..||   .|.....|:||||  ...|.|| .|.|...:::|:|..|:
Zfish   420 ANGNCINTPGSYYCRCHTGFLRVPGKQTCIDIDECLQNGVLCKNG-RCLNTEGSFQCICNSGFKL 483

  Fly   823 --EGENCEVDIDEC-GSNPCSNGSTCIDRINNFTCNCIPGMT----GRICDIDIDDC-VGDPCLN 879
              :|.|| ||.||| .:|.|.|| .||:...:|.|.|.||.|    ||.| .|||:| ....|:|
Zfish   484 SPDGRNC-VDHDECAATNMCLNG-MCINEDGSFKCVCKPGFTLNSSGRYC-TDIDECRTPGVCMN 545

  Fly   880 GGQCIDQLGGFRCDCSG---TGYEGENCELNIDECLSNPCTNGAK---CL----DRVKDYFCDCH 934
             |:|::..|.|||:|..   .|.:|..|   :|..:.:.|....|   ||    ..|....|.|.
Zfish   546 -GRCVNTQGSFRCECFAGLTVGIDGRTC---VDTHMRSTCYGAVKRGLCLRPFQRAVTKSQCCCA 606

  Fly   935 NGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVP 999
            |.          :.....||                            .|...::::.::.:|..
Zfish   607 NP----------DYAFGEPC----------------------------HPCPAKHSAEFQVLCAS 633

  Fly  1000 GI----IGKNCEININECDSNP--CSKHGNCNDGIGTYTCECEPGFE----GTHC 1044
            |:    .||    :||||..:|  || :|.|.:..|.:.|.|..|:|    |.:|
Zfish   634 GVGFSADGK----DINECALDPDICS-NGVCENLRGNFRCVCNIGYESDQSGRNC 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011	5/12 (42%)
		EGF_CA	425..460	CDD:238011	12/34 (35%)
		EGF	466..495	CDD:278437	9/28 (32%)
		EGF	605..633	CDD:278437	11/47 (23%)
		EGF_CA	716..750	CDD:238011	12/35 (34%)
		EGF_CA	753..789	CDD:238011	19/38 (50%)
		EGF_CA	792..828	CDD:238011	15/41 (37%)
		EGF_CA	830..865	CDD:238011	18/39 (46%)
		EGF_CA	868..905	CDD:238011	15/40 (38%)
		EGF_CA	907..943	CDD:238011	9/42 (21%)
		EGF_CA	1009..1045	CDD:238011	16/42 (38%)
		EGF_CA	1047..1082	CDD:238011
		Laminin_G_1	1155..1290	CDD:278483
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
fbn2a	XP_021334963.1	EGF_CA	148..180	CDD:214542	5/37 (14%)
		vWFA	<188..226	CDD:320736	11/37 (30%)
		TB	247..288	CDD:307020	9/40 (23%)
		EGF_CA	410..>439	CDD:214542	16/30 (53%)
		cEGF	472..495	CDD:315355	8/23 (35%)
		cEGF	513..536	CDD:315355	11/23 (48%)
		EGF_CA	533..573	CDD:214542	16/43 (37%)
		TB	590..630	CDD:307020	9/77 (12%)
		EGF_CA	643..683	CDD:328759	15/40 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11552
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910