DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment crb and megf6b

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:XP_009304569.1 Gene:megf6b / 557764 ZFINID:ZDB-GENE-101112-3 Length:1589 Species:Danio rerio


Alignment Length:2171 Identity:459/2171 - (21%)
Similarity:632/2171 - (29%) Gaps:899/2171 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   249 PLTPGPCSDHDL------------FTRLPDNFCLNDPCMGHGTCSSSPEGYECRCTARYSG-KNC 300
            |..|..|::.::            |||:...:  ...|.|...|    .||| |.||.|:. :..
Zfish    29 PHMPNVCAEKEVKLVAQMQPCVQAFTRMVKAW--KQGCQGQSWC----VGYE-RRTAYYTAYRQV 86

  Fly   301 QKDNGSPCAKNPCENGGSCLENSRGDYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGACVVIG 365
            .:.......|  |..|.|.|....|              |     ::|:|::..|.|.|.|.  .
Zfish    87 YRQEQQTVYK--CCPGWSQLNGEAG--------------C-----LYPVCRSGVCFNGGQCK--E 128

  Fly   366 GSGALTCECPKGYAGARCEVDTDECASQPCQNNGS----CIDRINGFSCDCSG---TGYTGAFCQ 423
            ||..| |.||.|::|..|:.|.:||.    :.||.    |.:.|..|.|.|..   ....|..||
Zfish   129 GSAQL-CVCPAGFSGPSCQYDVNECE----ETNGGCEALCCNTIGSFYCKCPAGQELKEDGKTCQ 188

  Fly   424 TNVDECDKNPCLNGG---RCFDTYGWYTCQCLDG----WGGEICDRPMTCQTQQCLNGGT---CL 478
             ::|||..:   |||   .|.:|.|.|.|||..|    ..|..|....:|...   |||.   |:
Zfish   189 -DIDECQVH---NGGCQHTCVNTRGSYHCQCNAGSRLHVDGRTCIAVQSCGVG---NGGCEHFCV 246

  Fly   479 DKPIG-FQCLCPPEY----TGELCQIAPSCAQQ-------CPIDSECVGGKCVCKPGSSGPIGHC 531
            .:..| .||.|.|:|    .|:.|.:...||:|       |..|.  ...:|.|.||        
Zfish   247 QQTAGHVQCRCRPDYRLDADGKHCTLVNPCAEQNGGCSQMCHRDG--AQARCECHPG-------- 301

  Fly   532 LPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPT 596
                                                                      ..|....
Zfish   302 ----------------------------------------------------------YQLAEDG 308

  Fly   597 QRSASLNACP--QENCLNGGTCLGYSGNYSCICASGY----TGYNCQTSTGDGASALALTPIN-C 654
            :....::.|.  |.:|.:|  |....|::.|:|::.|    .|..|.        .:.:..:| |
Zfish   309 KTCEDIDECALGQTDCAHG--CRNTRGSFMCVCSAAYELGVDGKQCY--------RIEMEIVNSC 363

  Fly   655 NATNGKCLNGGTCSMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQ-NQCLCPENKVCNQC 718
            :..||.|.:....|..|..|.|..||..|...|             .||. |:|:  :...|   
Zfish   364 DHDNGGCSHHCEHSTAGPLCSCNEGYQLDHDHK-------------TCVDINECV--DGSSC--- 410

  Fly   719 ATQPCQNGGECVDLPNGDYECKCTRGWTGRTCG---NDVDECTLHPKICGNG----ICKNEKGSY 776
                |::  :|.:.|.| |||.||.|:...|.|   :|:|||     :..||    .|.|..||:
Zfish   411 ----CEH--DCTNYPGG-YECYCTAGYRLNTDGCSCDDIDEC-----LAVNGGCDHACLNSAGSF 463

  Fly   777 KCYCTPGF-----------------------------------------------------TG-V 787
            :|.|..|:                                                     || :
Zfish   464 QCSCRRGYRLDEDRRSCILMEESVEALSSGQTVNKPGPGPQLTILQDFDQILEKYEDYEDDTGEL 528

  Fly   788 HCDSDVDE---CL--SF---------PCLNGATCHNKINAYEC-----------VCQPGYEGENC 827
            ..:|.:.|   ||  ||         .|:||..|:...||.:|           .|..|:.|.||
Zfish   529 RAESTLAEKFICLNDSFGVDCSLSCEDCVNGGVCNKHRNACDCPDGWTGVVCNETCPEGWFGRNC 593

  Fly   828 EVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGF-- 890
            .:   .|   .|.||..| |.::. :|.|.||::|.:|.        |.|..|     ..|.|  
Zfish   594 SL---LC---KCKNGGVC-DPVSG-SCRCPPGVSGELCQ--------DGCPKG-----LYGKFCN 637

  Fly   891 -RCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPC 954
             ||:|:..|    .|......||.:|...|..|       ...|.....|..|.::        |
Zfish   638 KRCNCANNG----RCHRTYGACLCDPGLYGRFC-------HLPCPKWMFGPGCSEE--------C 683

  Fly   955 QYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEININECDS---- 1015
            |    |::::.|..::...                    :|:|.||..|..|:   :||:|    
Zfish   684 Q----CVQQNTIECHRHHG--------------------DCICKPGYRGHTCK---DECESGFFG 721

  Fly  1016 NPCSKHGNCNDGIGTYTCE-----CEP----GFEGTHCEINIDE------CDRYNPCQRGTCYDQ 1065
            :.|....:|..|:   ||:     |:|    |..|..|:.:..|      |.:...|....| |:
Zfish   722 SACENKCSCPPGV---TCDHVTGACQPKCPAGKTGDKCDQDCVEGRFGIGCSQSCDCSGAPC-DK 782

  Fly  1066 IDDYDCDCDANYGGKNCSVLLKGCDQN-----------PCLNGGACLPYLINEVTHLYNCTCENG 1119
            :.. .|.|.|...||.|.   |.|.:.           .|.|||.|       ......|.|..|
Zfish   783 VTG-QCTCPAGTFGKRCE---KECPEGRWGLGCQEWCPVCENGGRC-------DRRNGTCVCSPG 836

  Fly  1120 FQGDKCEKTTTLSMVATSLISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELIN 1184
            |.|..|:.:.....               :.:..|.|.....||        :..|||       
Zfish   837 FIGRLCQNSCPAGR---------------FGVGCQLRCVCDLGV--------RCNPVS------- 871

  Fly  1185 GRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSF 1249
            ||.:....    |.|         .|..||..|                                
Zfish   872 GRCSCPPG----WTG---------HNCRKVCDA-------------------------------- 891

  Fly  1250 PRTYLGGTIPNLKSYLRHLTHQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTE 1314
                                                |:|..              :.:|.|    
Zfish   892 ------------------------------------GRWGL--------------DCESVC---- 902

  Fly  1315 QCKPNPCHSNGECTDLWHTFACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIR 1379
            .|:    :::|.|..  .|..|||...|.|..|.....|.:||.                     
Zfish   903 DCR----NADGVCDA--QTGRCHCEAGFTGARCDQKCPAGSFGP--------------------- 940

  Fly  1380 SILDISMFIRTREPTGQVFYLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGT------PEA 1438
                                 |...|..........:|     ||....|..::||      |: 
Zfish   941 ---------------------GCKHRCQCENQASCDHV-----GGACTCKTGWTGTFCEKPCPQ- 978

  Fly  1439 YTVGGQKLDNGYNHLIEVVRNQTLVQVK---LNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESL 1500
               |...||               .|.|   |||           ||.|    ::.|....:...
Zfish   979 ---GFYGLD---------------CQQKCVCLNG-----------GLCD----HVSGQCFCKAGW 1010

  Fly  1501 LGATTEPGIIPVPGAGIPIEDTTVPKEADDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQV 1565
            :|..... ..|....|:....|.|... :.|.|...|                        ..:.
Zfish  1011 IGTRCNQ-TCPAGWFGVSCSQTCVCHN-NSSCDAVSG------------------------QCEC 1049

  Fly  1566 NAKPLGAVTIDRASVLPGEVSDDLCRKNPCLHNAECRNTWN----DYTCKCPNGYKGKNCQEIEF 1626
            .|...|.....|.   |..|..|     .|:|...|:|..:    ...|.||:|:.|..||    
Zfish  1050 GAGWTGDTCSQRC---PAGVFGD-----GCVHRCLCQNGASCDPESGHCFCPSGWTGAACQ---- 1102

  Fly  1627 CQHVTCPGQSLCQNLDDGYECVTNTTFTGQERSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIA 1691
               :.||......:..|..|||......||.                                  
Zfish  1103 ---LECPAGRFGSDCQDRCECVNGAQCDGQT---------------------------------- 1130

  Fly  1692 FRTRAGGTLLYIDNVDGFFEIGVNGGRVTIT--WKLSALHFGESARFEKENTDGEWSRIYLRAHN 1754
                                     ||....  |.      ||  |.|.|               
Zfish  1131 -------------------------GRCVCPPGWT------GE--RCENE--------------- 1147

  Fly  1755 SKLEGGWKGWESMVDPTPAFSTDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAQQGSQF-K 1818
              .|.||.|                                             :..:...|. .
Zfish  1148 --CERGWFG---------------------------------------------VGCEDRCQCDH 1165

  Fly  1819 GCVGEARVGDLLLPYFSMAELYSRTNVSVQQKAQFRLNATRPEEGCIL-CFQSDCKNDGFCQSPS 1882
            |.|.....|..|.|                  |.:|  ..|.|:.|:. .|..||.....|.|.|
Zfish  1166 GAVCHHVSGQCLCP------------------AGWR--GRRCEKACLPGSFGQDCVQRCSCPSGS 1210

  Fly  1883 DEY----ACTCQPGFEGDDC------GTDIDECLNT-ECLNNGTCINQVAAFFCQCQPGFEGQHC 1936
            ..:    .|.|.|||.||.|      ||...:|... :|.......:.|.. .|.|.|||.|..|
Zfish  1211 SCHHVTGHCGCAPGFTGDGCEHSCLPGTFGQDCNQVCQCSERNQLCHPVTG-VCYCAPGFTGLKC 1274

  Fly  1937 EQNIDE------CADQ-PCHNGGNCTDLIASYVCDCPEDYMGPQCDVLKQMTCE----NEPCRNG 1990
            ||...:      |..| .|.|||.|  |..|..|.||..::|.||:    .||.    ...|.:.
Zfish  1275 EQTCPQGLYGSGCEHQCECLNGGVC--LSDSGSCQCPAGFIGAQCN----QTCPAGRYGLDCAHV 1333

  Fly  1991 STCQNGF--NASTGNNFTCT----CVPGFEGPLCDIPFCEITPCDNGGLCLTTGAVPMCKCSLGY 2049
            |.|..|.  :.:||.   ||    |.||:.|..|. ..|:   |.|.|:|  .|....|.|:||:
Zfish  1334 SACGTGVRNDPATGR---CTAHQVCPPGWFGSGCS-QRCD---CSNRGVC--DGVSGNCSCALGW 1389

  Fly  2050 TGRLCEQDINECESNP-------CQNGGQCKDLVGRYECDCQGTGFEGIRCENDIDEC--NMEGD 2105
            ||:.|:::..:....|       |||...|..:.|  .|.|: .|:.|..||:   .|  .:.|.
Zfish  1390 TGKHCDKECPDGSFGPDCSLQCSCQNNSTCDRVTG--SCHCR-PGYYGHLCEH---ACPAGLFGS 1448

  Fly  2106 YCGGLGRCFN----KPGSFQCIC----QKPYCGAYC---NFTDPCNATDLCSNGGRCVESCGAKP 2159
            .|.....|.|    .|.:.||:|    ..|.|...|   .|...|:.:..|::|..|....|.  
Zfish  1449 GCQQQCDCMNGASCHPDTGQCVCPAGVHGPRCQHVCAQGRFGVNCSQSCDCADGASCDPVSGR-- 1511

  Fly  2160 DYYCECPEGFAGKNCTAPITAKEDGP 2185
               |.||.|..|..|.:..:....||
Zfish  1512 ---CVCPSGKTGVRCDSDCSVNRFGP 1534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 11/43 (26%)
EGF_CA 425..460 CDD:238011 15/41 (37%)
EGF 466..495 CDD:278437 11/36 (31%)
EGF 605..633 CDD:278437 9/33 (27%)
EGF_CA 716..750 CDD:238011 10/33 (30%)
EGF_CA 753..789 CDD:238011 15/93 (16%)
EGF_CA 792..828 CDD:238011 16/60 (27%)
EGF_CA 830..865 CDD:238011 11/34 (32%)
EGF_CA 868..905 CDD:238011 9/39 (23%)
EGF_CA 907..943 CDD:238011 7/35 (20%)
EGF_CA 1009..1045 CDD:238011 12/48 (25%)
EGF_CA 1047..1082 CDD:238011 10/40 (25%)
Laminin_G_1 1155..1290 CDD:278483 16/134 (12%)
EGF 1316..1346 CDD:278437 9/29 (31%)
Laminin_G_1 1388..1550 CDD:278483 29/170 (17%)
EGF_CA <1593..1622 CDD:238011 9/32 (28%)
Laminin_G_2 1692..1828 CDD:280389 15/138 (11%)
EGF_CA 1901..1937 CDD:238011 9/36 (25%)
EGF_CA 1939..1974 CDD:238011 13/41 (32%)
EGF_CA 2057..2094 CDD:238011 10/43 (23%)
EGF_CA 2096..2133 CDD:238011 11/46 (24%)
EGF_CA 2137..2175 CDD:238011 10/37 (27%)
megf6bXP_009304569.1 EMI 33..102 CDD:284877 17/77 (22%)
FXa_inhibition 152..187 CDD:291342 9/38 (24%)
vWFA <184..227 CDD:294047 18/46 (39%)
FXa_inhibition 234..270 CDD:291342 12/38 (32%)
FXa_inhibition 276..311 CDD:291342 10/102 (10%)
vWFA <308..350 CDD:294047 9/43 (21%)
FXa_inhibition 363..398 CDD:291342 12/47 (26%)
vWFA <396..436 CDD:294047 17/64 (27%)
FXa_inhibition 445..480 CDD:291342 10/39 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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