DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crb and DLL4

DIOPT Version :9

Sequence 1:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster
Sequence 2:	NP_061947.1	Gene:	DLL4 / 54567	HGNCID:	2910	Length:	685	Species:	Homo sapiens

Alignment Length:	580	Identity:	165/580 - (28%)
Similarity:	229/580 - (39%)	Gaps:	159/580 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   520 CKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLV--GTTT 582
            |:||.......||...             :...:|.|....|::|    |.:.|:...|  .::.
Human    50 CEPGCRTFFRVCLKHF-------------QAVVSPGPCTFGTVST----PVLGTNSFAVRDDSSG 97

  Fly   583 GSRRPPQQPLQSPTQRSASL--------------NACPQEN-----CLNGGTCLG---------- 618
            |.|.|.|.|.......:.||              .|.|.:.     .:.|...:|
Human    98 GGRNPLQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTS 162

  Fly   619 ------YSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGK-----CLNGGTCSMNGT 672
                  ||  |..||:..|.|.||        |.|      |...|..     |...|..|
Human   163 TLTRLRYS--YRVICSDNYYGDNC--------SRL------CKKRNDHFGHYVCQPDGNLS---- 207

  Fly   673 HCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPE-NKVCNQCATQPCQNGGECVDLPNGD 736
               |..|::|:           .||:| :|:..   |.| |..|::.|
Human   208 ---CLPGWTGE-----------YCQQP-ICLSG---CHEQNGYCSKPA----------------- 237

  Fly   737 YECKCTRGWTGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHCDSDVDECLSF-P 800
             ||.|..||.||.|    :||..| ..|.:|.|..   .::|.|..|:.|:.||.|::.|... |
Human   238 -ECLCRPGWQGRLC----NECIPH-NGCRHGTCST---PWQCTCDEGWGGLFCDQDLNYCTHHSP 293

  Fly   801 CLNGATCHNK-INAYECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRI 864
            |.|||||.|. ..:|.|.|:|||.|.:||:::.||.||||.||.:|.|:.:.:.|.|.||..|..
Human   294 CKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLH 358

  Fly   865 CDIDIDDCVGDPCLNGGQCIDQLGG--FRCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVK 927
            |:.....|...||.|||.|.::..|  :.|:|. ..:.|.|||..:|.|.||||.||.:||:|..
Human   359 CEHSTLSCADSPCFNGGSCRERNQGANYACECP-PNFTGSNCEKKVDRCTSNPCANGGQCLNRGP 422

  Fly   928 DYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASG 992
            ...|.|..|:.|..||..:::|..|||.:.|.|.:..|                          |
Human   423 SRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLEN--------------------------G 461

  Fly   993 YECVCVPGIIGKNCEI--NINECDSNPCSKHGNCNDGIG--TYTCECEPGFEGTHCEINI 1048
            ..|.|..|..|:.||:  :|:.|.|:||.....|...:.  |:.|.|..||.|:.||..:
Human   462 LMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011
		EGF_CA	425..460	CDD:238011
		EGF	466..495	CDD:278437
		EGF	605..633	CDD:278437	9/48 (19%)
		EGF_CA	716..750	CDD:238011	8/33 (24%)
		EGF_CA	753..789	CDD:238011	10/35 (29%)
		EGF_CA	792..828	CDD:238011	17/37 (46%)
		EGF_CA	830..865	CDD:238011	15/34 (44%)
		EGF_CA	868..905	CDD:238011	12/38 (32%)
		EGF_CA	907..943	CDD:238011	15/35 (43%)
		EGF_CA	1009..1045	CDD:238011	12/37 (32%)
		EGF_CA	1047..1082	CDD:238011	0/2 (0%)
		Laminin_G_1	1155..1290	CDD:278483
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
DLL4	NP_061947.1	MNNL	27..88	CDD:284966	11/54 (20%)
		DSL	155..217	CDD:279722	19/95 (20%)
		Interaction with Notch1. /evidence=ECO:0000250\|UniProtKB:D3ZHH1	185..187		1/1 (100%)
		Interaction with Notch1. /evidence=ECO:0000250\|UniProtKB:D3ZHH1	191..195		1/3 (33%)
		EGF_CA	284..322	CDD:238011	17/37 (46%)
		EGF_CA	327..360	CDD:238011	15/32 (47%)
		EGF_CA	403..438	CDD:238011	15/34 (44%)
		EGF_CA	<447..476	CDD:238011	11/54 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910