DRSC/TRiP Functional Genomics Resources

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Protein Alignment crb and NOTCH4

DIOPT Version :9

Sequence 1:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster
Sequence 2:NP_004548.3 Gene:NOTCH4 / 4855 HGNCID:7884 Length:2003 Species:Homo sapiens


Alignment Length:2090 Identity:466/2090 - (22%)
Similarity:639/2090 - (30%) Gaps:876/2090 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   272 DPCMGHGTCSSSPEGY-ECRCTARYSGKNCQKDNGSPCAK-NPCENGGSC---------LENSRG 325
            :||...|||.|...|. .|:|...:.|:.||..:  ||.. ..|:|||||         |.:|..
Human    33 EPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPD--PCQNAQLCQNGGSCQALLPAPLGLPSSPS 95

  Fly   326 ----DYQCFCDPNHSGQHCETEVNIHPLCQTNPCLNNGACVVIGGSGALTCECPKGYAGARCEVD 386
                .:.|.|.|..:|:.|:.:  :...|..:.|...|.| .|..||...|.|..|:.|.:|:: 
Human    96 PLTPSFLCTCLPGFTGERCQAK--LEDPCPPSFCSKRGRC-HIQASGRPQCSCMPGWTGEQCQL- 156

  Fly   387 TDECASQPCQNNGSCIDRINGFSCDCSGTGYTGAFCQTNVDEC--DKNPCLNGGRCFDTYGWYTC 449
            .|.|::.||.|.|.|:.......|.|. .|:.|..|:.:|:||  |..||..|..|.:|.|.:.|
Human   157 RDFCSANPCVNGGVCLATYPQIQCHCP-PGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQC 220

  Fly   450 QCLDGWGGEICD-RPMTCQTQQCLNGGTCL---DKPIGFQ-CLCPPEYTGELCQIAPSCAQQCPI 509
            .|..|..|..|: |...|..:.|.|||||.   :|...|. |||||.:.|..|::.|        
Human   221 LCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNP-------- 277

  Fly   510 DSECVGGKCVCKPGSSGPIGHCLPTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTS 574
                                                                             
Human   278 ----------------------------------------------------------------- 277

  Fly   575 RTLVGTTTGSRRPPQQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTS 639
                                        :.|....|.|||||......|:|:|...:||::|...
Human   278 ----------------------------DNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSED 314

  Fly   640 TGDGASALALTPINCNATNG--KCLNGGTC--SMNGTHCYCAVGYSGDRCEK-AENCSPLNCQEP 699
            ..:           |. |.|  .|.|||||  |....||.|..|:.|..||: .::|....|...
Human   315 VDE-----------CE-TQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPG 367

  Fly   700 MVCVQN----QCLCPENK---VC---NQCATQPCQNGGECVDLP-NGDYECKCTRGWTGRTCGND 753
            ..|:..    .||||..:   :|   :.|.:|||....:|...| .|...|.|..|::|.||..|
Human   368 STCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQD 432

  Fly   754 VDECTL---HPKICGN-GICKNEKGSYKCYCTPGFTGVHCDSDVDECLSFPCLNGATCHNKINAY 814
            :|||.:   .|..|.: |.|.|..||:.|.|.||:||..|::|.:||||.||..|:||.:.:..:
Human   433 LDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATF 497

  Fly   815 ECVCQPGYEGENCEVDIDECGSNPCSNGSTCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLN 879
            .|:|.||.||:.|||:.:||.|.||.|.:.|.|.:|.|.|.|:||.:|..|:.|||:|...||.|
Human   498 HCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCAN 562

  Fly   880 GGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQ 944
            ||||.||.|.|.|.|. .|:||..|:..:|||||:||..||.|||....:||.|.:|:.|:.||.
Human   563 GGQCQDQPGAFHCKCL-PGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEV 626

  Fly   945 DINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFSQPFSFENASGYECVCVPGIIGKNCEIN 1009
            .:  |..|.||....|.::.:..                          .|:|..|..|  |...
Human   627 PL--CAPNLCQPKQICKDQKDKA--------------------------NCLCPDGSPG--CAPP 661

  Fly  1010 INECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEINIDECDRYNPCQR-GTCYDQIDDYDCDC 1073
            .:.|..:    ||:|...    :|.|:.|:.|..||..:..|.. .||.. ||||.|...|:|.|
Human   662 EDNCTCH----HGHCQRS----SCVCDVGWTGPECEAELGGCIS-APCAHGGTCYPQPSGYNCTC 717

  Fly  1074 DANYGGKNCSVLLKGCDQNPCLNGGACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSL 1138
            ...|.|..||..:..|...||||||:|     |.....|.|||.....|.:|:.:          
Human   718 PTGYTGPTCSEEMTACHSGPCLNGGSC-----NPSPGGYYCTCPPSHTGPQCQTS---------- 767

  Fly  1139 ISVTTEREEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIG 1203
                                                                             
Human   768 ----------------------------------------------------------------- 767

  Fly  1204 SKLNDSNWHKVFVAINTSHLVLSANDEQAIFPVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHL 1268
                                                                             
Human   768 ----------------------------------------------------------------- 767

  Fly  1269 THQPSAFVGCMQDIMVNGKWIFPDEQDANISYTKLENVQSGCPRTEQCKPNPCHSNGECTDLWHT 1333
                                                        |:.|...||.:.|.|.:...|
Human   768 --------------------------------------------TDYCVSAPCFNGGTCVNRPGT 788

  Fly  1334 FACHCPRPFFGHTCQHNMTAATFGHENTTHSAVIVETTDVARRAIRSILDISMFIRTREPTGQVF 1398
            |:|.|...|.|..|:                                                  
Human   789 FSCLCAMGFQGPRCE-------------------------------------------------- 803

  Fly  1399 YLGTDPRKAPTKNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLV 1463
                                     |:|                                     
Human   804 -------------------------GKL------------------------------------- 806

  Fly  1464 QVKLNGTEYFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPGIIPVPGAGIPIEDTTVPKEA 1528
                                                                             
Human   807 ----------------------------------------------------------------- 806

  Fly  1529 DDSRDYFKGIIQDVKVSNGSLNLIVEMYSLNVTDVQVNAKPLGAVTIDRASVLPGEVSDDLCRKN 1593
                                                            |.|          |..:
Human   807 ------------------------------------------------RPS----------CADS 813

  Fly  1594 PCLHNAECRNTWNDYTCKCPNGYKGKNCQEI-EFCQHVTCPGQSLCQNLDDGYECVTNTTFTGQE 1657
            ||.:.|.|:::.....|.||.||.|.:||.: :.|....||..|.|......:.|:....:||  
Human   814 PCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTG-- 876

  Fly  1658 RSPLAFFYFQEQQSDDIVSEASPKQTLKPVIDIAFRTRAGGTLLYIDNVDGFFEIGVNGGRVTIT 1722
              ||.          ::...:..|..|...||::.....||  |.:|:...:|            
Human   877 --PLC----------NLPLSSCQKAALSQGIDVSSLCHNGG--LCVDSGPSYF------------ 915

  Fly  1723 WKLSALHFGESARFEKENTDGEWSRIYLRAHNSKLEGGWKGWESMVDPTPAFSTDIDQAAFQSLI 1787
                                         .|                ..|.|             
Human   916 -----------------------------CH----------------CPPGF------------- 922

  Fly  1788 ATSTQVYLGGMPESRQARGSTLSAQQGSQFKGCVGEARVGDLLLPYFSMAELYSRTNVSVQQKAQ 1852
                                     |||                                  ..|
Human   923 -------------------------QGS----------------------------------LCQ 928

  Fly  1853 FRLNATRPEEGCILCFQSDCKNDGFCQSPSDEYACTCQPGFEGDDCGTDIDECLNTECLNNGTCI 1917
            ..:|.         |....|:|...|.:....|.|.|.||::|.:|..::|.|.:..|.|:|||.
Human   929 DHVNP---------CESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCT 984

  Fly  1918 NQVAAFFCQCQPGFEGQHCEQNIDECADQPCHNGGN--CTDLIASYVCDCPEDYMGPQCDVLKQM 1980
            .:...|.|.|.|||.|..||.::|||.|||||..|.  |..|..::.|.|...:.|..|:| :..
Human   985 PKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEV-EID 1048

  Fly  1981 TCENEPCRNGSTCQNGFNASTGN--NFTCTCVPGFEGPLCD--IPFCEITPCDNGGLCLTT---G 2038
            .|.::||.:|.||:    |:.|:  .|.|.|..|||||.|.  .|.|....|.:|||||.:   |
Human  1049 PCHSQPCFHGGTCE----ATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPG 1109

  Fly  2039 AVPMCKCSLGYTGRLC--EQDINEC-ESNPCQNGGQCKDLVG------RYECD-------CQGTG 2087
            ..|.|.|..||.|..|  ......| ..:||...|.|.:..|      |..|.       ||..|
Human  1110 FPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPG 1174

  Fly  2088 FEGIRCENDIDEC---------NMEGDYCGGLG------------RCFNKPGSFQCICQKPYCGA 2131
            .:|....:....|         |.:|..| .||            ||:......||   .|.|.:
Human  1175 AKGCEGRSGDGACDAGCSGPGGNWDGGDC-SLGVPDPWKGCPSHSRCWLLFRDGQC---HPQCDS 1235

  Fly  2132 -YCNFTD-PCNATDLCS-----------NGGRCVESCGAKPDYYCECPEGFAGKNCTAPITAKED 2183
             .|.|.. .|.....|:           :.|.|.:.|..     .||  |:.|.:|.......|.
Human  1236 EECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNT-----AEC--GWDGGDCRPEDGDPEW 1293

  Fly  2184 GPSTTDIAIIVIPV----------VVVLLLIAGALL-----GTFLVM----ARNKRATRGTYSPS 2229
            |||...:.::..|.          |:.|.|..|..:     |..:|.    ||.:....||..|:
Human  1294 GPSLALLVVLSPPALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGARAEEKLGGTRDPT 1358

  Fly  2230 AQEYCNPRLE 2239
            .||...|:.:
Human  1359 YQERAAPQTQ 1368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
crbNP_001247284.1 LamG 91..228 CDD:238058
EGF_CA 386..423 CDD:238011 11/36 (31%)
EGF_CA 425..460 CDD:238011 14/36 (39%)
EGF 466..495 CDD:278437 14/32 (44%)
EGF 605..633 CDD:278437 10/27 (37%)
EGF_CA 716..750 CDD:238011 11/34 (32%)
EGF_CA 753..789 CDD:238011 17/39 (44%)
EGF_CA 792..828 CDD:238011 16/35 (46%)
EGF_CA 830..865 CDD:238011 15/34 (44%)
EGF_CA 868..905 CDD:238011 20/36 (56%)
EGF_CA 907..943 CDD:238011 17/35 (49%)
EGF_CA 1009..1045 CDD:238011 8/35 (23%)
EGF_CA 1047..1082 CDD:238011 13/35 (37%)
Laminin_G_1 1155..1290 CDD:278483 0/134 (0%)
EGF 1316..1346 CDD:278437 11/29 (38%)
Laminin_G_1 1388..1550 CDD:278483 2/161 (1%)
EGF_CA <1593..1622 CDD:238011 10/28 (36%)
Laminin_G_2 1692..1828 CDD:280389 11/135 (8%)
EGF_CA 1901..1937 CDD:238011 14/35 (40%)
EGF_CA 1939..1974 CDD:238011 14/36 (39%)
EGF_CA 2057..2094 CDD:238011 12/50 (24%)
EGF_CA 2096..2133 CDD:238011 12/58 (21%)
EGF_CA 2137..2175 CDD:238011 9/49 (18%)
NOTCH4NP_004548.3 EGF_CA 194..232 CDD:238011 14/37 (38%)
EGF_CA 314..353 CDD:238011 15/50 (30%)
EGF_CA 432..473 CDD:238011 17/40 (43%)
EGF_CA 475..511 CDD:238011 16/35 (46%)
EGF_CA 515..549 CDD:238011 15/33 (45%)
EGF_CA 551..587 CDD:238011 20/36 (56%)
EGF_CA 590..625 CDD:238011 17/34 (50%)
EGF_CA <699..726 CDD:238011 12/26 (46%)
EGF_CA <736..765 CDD:238011 13/33 (39%)
EGF_CA 769..803 CDD:238011 11/33 (33%)
EGF_CA <899..928 CDD:238011 11/159 (7%)
EGF_CA 931..965 CDD:238011 11/42 (26%)
EGF_CA 970..1004 CDD:238011 14/33 (42%)
Notch 1165..1203 CDD:321927 7/37 (19%)
LNR 1 1170..1213 10/43 (23%)
NL 1207..1245 CDD:197463 8/40 (20%)
LNR 2 1214..1250 9/38 (24%)
Notch 1249..1285 CDD:306554 8/42 (19%)
LNR 3 1251..1294 10/49 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1347..1371 6/22 (27%)
NODP 1380..>1420 CDD:311559
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1485..1508
ANK 1586..1721 CDD:238125
ANK repeat 1586..1630 CDD:293786
ANK 1 1633..1665
ANK repeat 1634..1664 CDD:293786
ANK 1661..1787 CDD:238125
ANK repeat 1666..1698 CDD:293786
ANK 2 1666..1698
ANK 3 1700..1732
ANK repeat 1700..1731 CDD:293786
ANK 4 1733..1765
ANK repeat 1733..1764 CDD:293786
Ank_5 1753..>1851 CDD:330893
ANK 5 1766..1798
ANK repeat 1766..1797 CDD:293786
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1900..1927
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..2003
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 47 1.000 Domainoid score I12027
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100271
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.810

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